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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • The Cognitive Electrophysiology of Mind and Brain

    • 1st Edition
    • Alberto Zani + 1 more
    • English
    Cognitive electrophysiology is a very well established field utilizing new technologies such as bioelectric events-related potentials (ERP) and magnetic (ERF) recordings to pursue the investigation of mind and brain. Current research focuses on reviewing ERP/ERF findings in the areas of attention, language, memory, visual and auditory perceptual processing, emotions, development, and neuropsychological clinical damages. The goal of such research is basically to provide correlations between the structures of the brain and their complex cognitive functions.This book reviews the latest findings in the areas of attention, language, memory, visual and auditory perception, and brain damage research based primarily on research conducted using ERP recordings. Beyond just compiling the knowledge gained from ongoing research, the authors also identify outstanding problems in the field and predict future developments.

  • Milestones in Neurotoxicity and Neuroprotection: A Tribute to Professor Toshiharu Nagatsu

    • 1st Edition
    • M. Naoi + 4 more
    • English
    This book summarizes recent advances in understanding the mechanism underlying the selective cell death of dopamine neurons in Parkinson's disease. MPTP, endogenous neurotoxins, L-DOPA, and metal were proved to induce apoptosis and necrosis in neurons. The relationship of these causal factors to the pathogenesis of Parkinson's disease was discussed to give us overviews on the role of neurotoxins in this degenerative disorder. This title further presents the intracellular signal transduction, and the related enzymes and other factors involved in dopaminergic neuronal death. Recent results on intracellular mechanism of neuroprotection are presented, suggesting that neuroprotection as a causal therapy of neurodegenerative disorders may become practical in near future. This book shows new neuroprotective agents, such as propargylamine derivatives and neurotrophins, and the intracellular mechanism to prevent the activation of apoptotic cascade in neurons. The authors of this book are active researchers participating in these subjects and the readers will find the knowledge and techniques for the study on neurotoxicity and neuroprotection, and the strategy for future research on these important subjects in clinical and basic neurology and neurosciences.The book is dedicated to Professor Toshiharu Nagatsu, a pioneer in the search for pathogenic factors in Parkinson's disease. The book is reprinted from the journal 'Neurotoxicology and Teratology', Volume 24/5.

  • Brain Mapping: The Methods

    • 2nd Edition
    • Arthur W. Toga + 1 more
    • English
    Investigation of the functional architecture of the human brain using modern noninvasive imaging techniques is a rapidly expanding area of research. A proper knowledge of methodology is needed to appreciate the burgeoning literature in the field. This timely publication provides an excellent catalogue of the main techniques. The authors offer an invaluable analysis of mapping strategies and techniques, providing everything from the foundations to the major pitfalls and practical applications of the modern techniques used in neuroimaging. Contains over 1000 full color pages with more than 200 color figures.

  • Neurophysiology in Neurosurgery

    A Modern Intraoperative Approach
    • 1st Edition
    • Vedran Deletis + 1 more
    • Vedran Deletis
    • English
    Through real-time assessments of how the patient's nervous system is functioning throughout a surgical procedure, Neurophysiology in Neurosurgery presents vital techniques to guide surgeons in their efforts to minimize the risks of unintentional damage to healthy nervous tissue. This book provides a comprehensive overview of the most up-to-date intraoperative neurophysiological techniques and guidelines for the managment of neuroanesthesia during MEP monitoring. Neurophysiology in Neurosurgery is a valuable educational tool that describes the theoretical and practical aspects of intraoperative monitoring through example.

  • Neurobiology of Diabetic Neuropathy

    • 1st Edition
    • Volume 50
    • English
    This volume of International Review of Neurobiology defines primary biochemical causation of diabetic complications, identifies cellular glucose transducers, balancing roles of protein kinase C and MAP kinases, and sets in context the role of apoptosis and the interactive roles of neurons and Schwann cells. It also defines the cell biology of autonomic neuropathy, considers the balanced needs of science, clinical practice, and economics in clinical trial design, provides the definitive evaluation of aldose reductase inhibitors, and explains the failure of nerve growth factor.

  • In Situ Hybridization Protocols for the Brain

    • 2nd Edition
    • Volume 47
    • English
    This volume of the International Review of Neurobiology was written to assist researchers without any previous experience with in situ hybridization, allowing them to follow the protocols and expect good results. It contains all the information required for newcomers to achieve successful in situ hybridization results, and methods for improving the technique of those already utilizing it. Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction

    • 1st Edition
    • Volume 19
    • L. Kaczmarek + 1 more
    • English
    That molecular neurobiology has become a dominant part of neuroscience research can be credited to the discovery of inducible gene expression in the brain and spinal cord. This volume deals with genes, whose expression patterns in the vertebrate central nervous system were the first to be revealed and then the most extensively investigated over the last 15 years. Immediate early genes (IEG) and their protein products, especially those acting as regulators of transcription (inducible transcription factors, ITF) have proven to be very valuable tools in functional neuroanatomy and neurophysiology, as they are rapidly and transiently induced in specific neurons in response to various modes of stimulation. Thus, they have been used to map neuronal populations selectively responsive to a variety of conditions, such as sensory and learning experience, electrical stimulation of specific circuits, seizures, and neurodegeneration.Th... single volume, written by the most prominent authors in the field, brings together for the first time information about the most widely studied IEG/ITF in a whole variety of phenomena of neuronal activation. It starts with a critical appraisal of the technologies employed for the studies on gene, protein, and transcription factor activity in the nervous system. Several chapters present exhaustive examples of expression patterns of the ITF in "vocal" avian brain, mammalian brain sensory regions, areas involved in regulation of circadian rhythms, and the spinal cord. The next parts cover functional and regular aspects of individual IEG/ITF expression: c-fos in learning and memory, c-jun and others in neuropathology and neuronal stress responses, Elk-1, egr family, and CREB in neuronal plasticity and learning. This volume will be useful as a major reference on this topic. Furthermore, it attempts to unravel the seemingly overwhelming complexity of the phenomena of gene expression in the central nervous system.

  • Encyclopedia of the Human Brain

    • 1st Edition
    • Vilayanur S. Ramachandran
    • English
    In the past decade, enormous strides have been made in understanding the human brain. The advent of sophisticated new imaging techniques (e.g. PET, MRI, MEG, etc.) and new behavioral testing procedures have revolutionized our understanding of the brain, and we now know more about the anatomy, functions, and development of this organ than ever before. However, much of this knowledge is scattered across scientific journals and books in a diverse group of specialties: psychology, neuroscience, medicine, etc. The Encyclopedia of the Human Brain places all information in a single source and contains clearly written summaries on what is known of the human brain. Covering anatomy, physiology, neuropsychology, clinical neurology, neuropharmacology, evolutionary biology, genetics, and behavioral science, this four-volume encyclopedia contains over 200 peer reviewed signed articles from experts around the world. The Encyclopedia articles range in size from 5-30 printed pages each, and contain a definition paragraph, glossary, outline, and suggested readings, in addition to the body of the article. Lavishly illustrated, the Encyclopedia includes over 1000 figures, many in full color. Managing both breadth and depth, the Encyclopedia is a must-have reference work for life science libraries and researchers investigating the human brain.

  • Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 41
    • Brian H. Ross
    • English
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work. Volume 41 includes in its coverage chapters on multimedia learning, brain imaging, and memory, among others.

  • Hormones, Brain and Behavior

    • 1st Edition
    • Donald W. Pfaff
    • English
    Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields.

  • Epilepsy, Infantile Spasms, and Developmental Encephalopathy

    • 1st Edition
    • Volume 49
    • English
    Epilepsy, Infantile Spasms, and Developmental Encephalopathy explores the nature and bases of infantile spasms - a major representative of the catastrophic developmental seizure disorders seen in early childhood. Although this topic has received considerable attention as a clinical disorder, the underlying pathogenesis of infantile spasms remains poorly understood. The aim is not simply to describe and label the clinical phenomenology associated with infantile spasms, but rather to work toward an understanding of the underlying mechanisms and of effective treatment strategies. The result is a volume with a high density of exciting ideas that can be taken to the bedside or to the laboratory for further study.Approaching the subject from an interdisciplinary perspective, this book integrates clinical and basic science in its discussion of infantile spasms as representative of a common developmental brain disorder. It also provides experimentally testable hypotheses to direct further research, and presents reviews of the literature associated with suggested underlying mechanisms.

  • Do Seizures Damage The Brain

    • 1st Edition
    • Volume 135
    • T. Sutula + 1 more
    • English
    What are the consequences, if any, of repeated brief seizures that are the defining feature of epilepsy? A firm answer to this question has been surprisingly elusive for a variety of reasons. Clearly there is a subset of patients who appear to tolerate seizures with relatively limited long-term consequences, and not all patients are destined to progress to intractability with frequent seizures and disability. This variability and individual susceptibility has made it difficult to make statements that fairly apply to the full range of people with epileptic disorders, whose disorders span a broad spectrum from mild with excellent control and few limitations, to severe with multiple daily seizures and pronounced disability that affects employment, educational performance, an personal life.This volume seeks to explore the spectrum of severe to more subtle damage that may be a consequence of seizures. The contributing authors have addressed these questions and related issues using a variety of methods in experimental models and in patients with epilepsy.

  • Changing Views of Cajal's Neuron

    • 1st Edition
    • Volume 136
    • E.C. Azmitia + 4 more
    • English
    Cajal is the Father of Neuroscience and his personal view of the Neuron has dominated the field for over 100 years. No single person has been able to challenge his global perspective of the neuron gained by Cajal's work in neuroanatomy, development, physiology, evolution and medicine. However, over 30 neuroscientists from around the world have accepted the challenge of writing a review article on "Changing Views of Cajal's Neuron". Many of these experts admitted they could only add to Cajal's theory and they carefully provided their new findings based on modern methods of microscopy, molecular biology or neurobiology. Other experts recognized specific areas where Cajal's ideas of neurons needed to be altered and refined. Key knowledge necessary to understand plasticity or development is now available and permits a changed view. A few of the authors directly challenged some of the most widely accepted and cherished theories of Cajal: the neuron as an isolated unit, function of dendrites, the direction of electrical conductivity and the importance of plasticity in the adult brain. In total, the collection of articles provides a fascinating perspective to the enormous force of Cajal's genius in the 21st Century view of the neuron.

  • Universes in Delicate Balance: Chemokines and the Nervous System

    • 1st Edition
    • R.M. Ransohoff + 4 more
    • English
    It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of inflammation, immunity and hematopoietic development.Only recently have the two fields, neurobiology and immunology, displayed mutual interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12) and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12 and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue.This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced 'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described, as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions are separately treated in varying contexts.The field of 'neurobiology of chemokines' has not lain fallow during the last ten years. During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium and angiogenesis.Underst... human disease is the goal of much of this research. New discoveries are being made and reported at a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines and discussing the relations of chemokine science to animal models and human disease.

  • Growth and Lactogenic Hormones

    • 1st Edition
    • Volume 2
    • L. Matera + 1 more
    • English
    For more than seventy years evidence has accumulated documenting the existence of a bi-directional communication network between growth hormone and the immune system. In the past twenty years there has been a tremendous proliferation of information detailing the workings of the growth hormone and insulin-like growth factor axis. A multitude of growth factors and binding proteins have been identified. More and more evidence supporting the important role of the growth hormone IGF network in the well functioning of the normal immune system has been documented. Clearly the challenge today is not to prove, but to understand, the neuroimmune regulatory role of GLH in its entire complexity.The ultimate goal of this volume and of all the other volumes of this series is to promote the understanding of the science and to ease human suffering.

  • Brain Lipids and Disorders in Biological Psychiatry

    • 1st Edition
    • Volume 35
    • E.R. Skinner
    • English
    Leading authorities examine the possible role of brain lipids in the development of conditions such as schizophrenia, depression, Alzheimer's disease and personality disorders and violence. A better understanding of the underlying causes of these debilitating medical disorders is of utmost importance and may contribute towards a means of prevention, amelioration and cure. The book is intended to stimulate further interest and lead to increased research in this important development area.

  • Handbook of Complementary and Alternative Therapies in Mental Health

    • 1st Edition
    • Scott Shannon
    • English
    Scott Shannon is an MD, president elect of the American Holistic Medical Association, and considered a national expert on holistic psychiatry. In this book he brings together a comprehensive overview of CAM treatments, with information on their effectiveness and safety for specific patient populations and for use in treating specific disorders. Modalities covered include Acupuncture, Nutritional Medicine, Herbal Medicine, Meditation, Biofeedback, Aromatherapy and others. Coverage also includes chapters on the best CAM modalities for treatment of Anxiety and PTSD, Depression, ADD, and Addictions. Each chapter will be in a similar template, beginning with a description of the treatment, its safety, compatibility with conventional treatments and/or contrindications, scientific documentation of its efficacy, discussion of which disorders it is best used for, and references.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 31
    • English
    The aim of Advances in the Study of Behavior remains as it has been since the series began: to serve the increasing number of scientists who are engaged in the study of animal behavior by presenting their theoretical ideas and research to their colleagues and to those in neighboring fields. We hope that the series will continue its "contribution to the development of the field", as its intended role was phrased in the Preface to the first volume in 1965. Since that time, traditional areas of animal behavior have achieved new vigor by the links they have formed with related fields and by the closer relationship that now exists between those studying animal and human subjects.Advances in the Study of Behavior, Volume 31 continues to serve scientists across a wide spectrum of disciplines. Focusing on new theories and research developments with respect to behavioral ecology, evolutionary biology, and comparative psychology, these volumes foster cooperation and communications in these dense fields.

  • Vision: From Neurons to Cognition

    • 1st Edition
    • Volume 134
    • C. Casanova + 1 more
    • English
    Internationally renowned researchers discuss how the various parts of the brain process and integrate visual signals, providing up to date original findings, reviews, and theoretical proposals on visual processing.This book addresses the basic mechanisms of visual perception as well as issues such as neuronal plasticity, functional reorganization and recovery, residual vision, and sensory substitution. Knowledge of the basic mechanisms by which our brain can analyze, reconstruct, and interpret images in the external world is of fundamental importance for our capacity to understand the nature and causes of visual deficits, such as those resulting from ischemia, abnormal development, neuro-degenerative disorders, and normal aging. It is also essential to our goal of developing better therapeutic strategies, such as early diagnosis, visual training, behavioral rehabilitation of visual functions, and visual implants.

  • The Cat Primary Visual Cortex

    • 1st Edition
    • Bertram Payne + 1 more
    • English
    Written by experts on the forefront of investigations of brain function, vision, and perception, the material presented is of an unparalleled scientific quality, and shows that analyses of enormous breadth and sophistication are required to probe the structure and function of brain regions. The articles are highly persuasive in showing what can be achieved by carrying out careful and imaginative experiments. The Cat Primary Visual Cortex should emerge as essential reading for all those interested in cerebral cortical processing of visual signals or researching or working in any field of vision.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 48
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • Febrile Seizures

    • 1st Edition
    • Tallie Z. Baram + 1 more
    • English
    Febrile Seizures is written by the most active researchers and clinicians in epilepsy research today. This book presents the latest developments in this field as well as the current state of knowledge in the following: New imaging tools and emerging data, visualizing effects of febrile seizures on the brain; New genetic methodologies; The use of animal models to permit scientific analysis of the electrophysiology and molecular biology of the seizure.

  • Neurosteroids and Brain Function

    • 1st Edition
    • Volume 46
    • English
    International Review of Neurobiology, Volume 46 presents in-depth reviews on such ground-breaking topics as assembly and intracellular trafficking of GABA A receptors, D-1 dopamine receptors, and Alzheimer's disease. This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field.

  • The Maternal Brain

    Neurobiological and Neuroendocrine Adaptation and Disorders in Pregnancy and Post Partum
    • 1st Edition
    • Volume 133
    • J.A. Russell + 3 more
    • English
    The adaptive changes within the central nervous system that prepare the body for the physiological requirements of pregnancy and motherhood are of major significance, and many scientists around the world are involved in elucidating these systems in humans and other mammals. The adaptive changes encompass diverse scientific disciplines, including neuroendocrinology, neuroscience and psychology; and failure of appropriate adaptation in mothers can lead to disorders that have profound and long lasting consequences for individuals and for society.This volume contains review articles written by the symposium speakers at a conference held in Bristol in July 1999 entitled: "The Maternal Brain: an International Meeting on Neurobiological and Neuroendocrine Adaptation and Disorders in Pregnancy and Postpartum".This was the first conference to address The Maternal Brain, and comprised wide ranging topics from molecular analysis of physiological systems using transgenic animals, through plasticity at the neurotransmitter and neuronal level, to the description of behavioural adaptation in terms of endocrinology, emotionality and its underlying causes, and analysis of psychosis; all in the peripartum period.

  • Ibogaine: Proceedings from the First International Conference

    • 1st Edition
    • Volume 56
    • English
    Alkaloids are a major group of natural products derived from a wide variety of organisms and are widely used as medicinal and biological agents. This series is world-renowned as the leading compilation of current reviews of this vast field. Volume 56 presents the Proceedings from the First International Conference on Ibogaines, held in November of 1999 at New York University's School of Medicine. In essence, it presents significant new data on neurobiological, clinical, sociocultural, and policy aspects of ibogaine.Ibogaine is a natural product derived from the bark of the root of the African shrub Tabernathe iboga. It has a history of use as a medicinal and ceremonial agent in West Central Africa, and has been alleged to be effective as a treatment for substance dependence. The study of Ibogaine may shed light on the neurobiology of addiction and lead to the development of new medication for the treatment of addiction. Currently, there is lack of formal approval for the use of ibogaine, and the demand of the addicts themselves has led to a distinctive unofficial network which has provided ibogaine treatment in non-medical settings. If critical safety concerns can be adequately addressed, ibogaine may provide an inexpensive and practical treatment approach, well adapted to environments where resources are severely limited and there is pressing need for clinical services for heroin addicts, such as Eastern Europe.

  • The Mouse Brain in Stereotaxic Coordinates: Compact Second Edition

    • 2nd Edition
    • George Paxinos + 1 more
    • English
    The Mouse Brain in Stereotaxic Coordinates, Second Edition has been the acknowledged reference in this field since the publication of the first edition, and is now available in a Compact Edition. This will provide a more affordable option for students, as well as researchers needing an additional lab atlas. This version includes the coronal diagrams delineating the entire brain as well as the introductory text from the Deluxe edition. It is an essential reference for anyone studying the mouse brain or related species.

  • The Mouse Brain in Stereotaxic Coordinates

    • 2nd Edition
    • George Paxinos + 1 more
    • English
    The Mouse Brain in Stereotaxic Coordinates, Second Edition is the most comprehensive and accurate atlas of the mouse brain ever published. The first edition of this book has become the acknowledged reference in its field. In the second edition, the authors incorporated lower brainstem sections, an entire sagittal plane of section and revised all delineations, especially of the cortex. This guide is essential to those who study the brain of this species or any similar species, including hamsters. The large, spiral-bound format makes it easy to see the details in each illustration or photograph and compare them to animal models in the lab.

  • New Foundation of Biology

    • 1st Edition
    • Volume 1
    • I. Berczi + 1 more
    • English
    A new scientific discipline, acknowledged 65 years after its discovery, was the focus of the first Conference on Neuroimmune Biology in Canada. The papers presented at the conference, and in this volume, are dedicated to Dr. Hans Selye who is recognized as discovering the existence of a hypothalamic-pituita... axis. This axis plays an important role in the adaptation of higher animals and man to various physical, chemical, biological and emotional challenges.The conference and participants also honored Dr. Andor Szentivanyi whose opening paper, "Studies on the hypothalamic regulation of histamine synthesis", is contained in the introduction to this book. Dr. Szentivanyi has dedicated his long research career to the clarification of the role of the central nervous system in immune and inflammatory reactions, and his experimental results are presented here.With an ultimate goal to achieve a more thorough understanding of higher organisms in their entire complexity, this book, the first in the series http://serval.elsevi... Biology presents a coordinated and integrated view of the growing body of knowledge rapidly accumulating in this area.

  • Advances in Neural Population Coding

    • 1st Edition
    • Volume 130
    • M.A.L. Nicolelis
    • English
    A collective research effort by scientists working in laboratories around the world, this book addresses issues covering all aspects of neural population coding. This volume, with contributions from distinguished neuroscientists, is divided into six sections containing a historical overview of the concept of neural population, introducing a series of new experimental paradigms and analytical techniques for investigating potential neural coding schemes and four sections focusing on recent advances in population coding in a broad range of areas of brain research.

  • The Laboratory Computer

    A Practical Guide for Physiologists and Neuroscientists
    • 1st Edition
    • John Dempster
    • English
    The Laboratory Computer: A Practical Guide for Physiologists and Neuroscientists introduces the reader to both the basic principles and the actual practice of recording physiological signals using the computer. It describes the basic operation of the computer, the types of transducers used to measure physical quantities such as temperature and pressure, how these signals are amplified and converted into digital form, and the mathematical analysis techniques that can then be applied. It is aimed at the physiologist or neuroscientist using modern computer data acquisition systems in the laboratory, providing both an understanding of how such systems work and a guide to their purchase and implementation.

  • Neuro-informatics and Neural Modelling

    • 1st Edition
    • Volume 4
    • F. Moss + 1 more
    • English
    How do sensory neurons transmit information about environmental stimuli to the central nervous system? How do networks of neurons in the CNS decode that information, thus leading to perception and consciousness? These questions are among the oldest in neuroscience. Quite recently, new approaches to exploration of these questions have arisen, often from interdisciplinary approaches combining traditional computational neuroscience with dynamical systems theory, including nonlinear dynamics and stochastic processes. In this volume in two sections a selection of contributions about these topics from a collection of well-known authors is presented. One section focuses on computational aspects from single neurons to networks with a major emphasis on the latter. The second section highlights some insights that have recently developed out of the nonlinear systems approach.

  • Cellular and Molecular Neurobiology (Deluxe Edition)

    • 2nd Edition
    • Constance Hammond
    • English
    This Second Edition is the new, thoroughly revised edition of the established and well-respected authoritative text in the field. Cellular and Molecular Neurobiology is hypothesis-driven and firmly based on numerous experiments performed by experts in the field. Seven new chapters (five new and two totally rewritten) complement and expand on the First Edition and are written in a way that encourages students to ask questions. Additionally, new, groundbreaking research data on dendritic processing is presented in a very easy-to-understand format.

  • Batten Disease: Diagnosis, Treatment, and Research

    • 1st Edition
    • Volume 45
    • English
    This title will present all current knowledge of Batten disease from research to clinical evaluation. NCL is not well recognized in underdeveloped countries because the diagnostic technology is lacking. With the information in this volume, however, a specific diagnosis of NCL could be made. Also, specific familial mutations obtained through genetic tests may guide prenatal diagnoses for at-risk families.

  • Computing the Brain

    A Guide to Neuroinformatics
    • 1st Edition
    • Michael A. Arbib + 1 more
    • English
    Computing the Brain provides readers with an integrated view of current informatics research related to the field of neuroscience. This book clearly defines the new work being done in neuroinformatics and offers information on resources available on the Web to researchers using this new technology. It contains chapters that should appeal to a multidisciplinary audience with introductory chapters for the nonexpert reader. Neuroscientists will find this book an excellent introduction to informatics technologies and the use of these technologies in their research. Computer scientists will be interested in exploring how these technologies might benefit the neuroscience community.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 30
    • English
    Advances in the Study of Behavior, Volume 30 continues to serve scientists across a wide spectrum of disciplines. Focusing on new theories and research developments with respect to behavioral ecology, evolutionary biology, and comparative psychology, these volumes foster cooperation and communications in these dense fields. The aim of Advances in the Study of Behavior remains as it has been since the series began: to serve the increasing number of scientists who are engaged in the study of animal behavior by presenting their theoretical ideas and research to their colleagues and to those in neighboring fields. We hope that the series will continue its "contribution to the development of the field", as its intended role was phrased in the Preface to the first volume in 1965. Since that time, traditional areas of animal behavior have achieved new vigor by the links they have formed with related fields and by the closer relationship that now exists between those studying animal and human subjects.

  • Cerebral Vasospasm

    • 1st Edition
    • R. Loch Macdonald + 1 more
    • English
    Bryce Weir is a high-profile, respected neurologist. Dr. Macdonald is a colleague of Dr. Weir's and is a "rising star" in the field of neurology.This book is the first to cover all aspects of cerebral vasospasm in depth. It takes the reader from the first descriptions of this puzzling and deadly phenomenon to the latest laboratory evidence explaining its pathophysiology. Packed with clinical pearls, it is a must for neurosurgeons, interventional radiologists, neurologists, and neuropathologists.

  • Functional Neurobiology of Aging

    • 1st Edition
    • Patrick R. Hof + 1 more
    • English
    Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments.

  • Experimental Design

    A Handbook and Dictionary for Medical and Behavioral Research
    • 1st Edition
    • Volume 14
    • J. Krauth
    • English
    Scientists planning experiments in medical and behavioral research will find this handbook and dictionary an invaluable desk reference tool. Also recommended as a textbook for students of Experimental Design or accompanying courses in Statistics. Principles of experimental design are introduced, techniques of experimental design are described, and advantages and disadvantages of often used designs are discussed.This two-part volume, a handbook of experimental design and a dictionary providing short explanations for many terms related to experimental design, contains information that will not quickly become outdated.

  • Functional Neural Transplantation II. Novel Cell Therapies for CNS Disorders

    • 1st Edition
    • Volume 127
    • S.B. Dunnett + 1 more
    • English
    The first edition of Functional Neural Transplantation, appearing in 1994, was commissioned to provide a systematic overview of the main areas of active research into the use of neural transplantation for functional repair at that time. There have though been major developments in the field over the last decade. First, whereas many of the model systems are the same, the sophistication of the research has developed dramatically. Secondly, there has been a major change in focus related to the nature of the optimal reparative process, moving away from a primary goal involving repair by replacement of lost cells, to strategies based on halting or reversing the disease process itself. Thirdly, the last decade has (not surprisingly) seen an expansion in the breadth of clinical applications for transplantation not only of primary embryonic neural tissues but also the initial applications of cells and cell lines.In order to address these recent developments as we enter the 21st century, 10 years after conception and 6 years after the publication of Functional Neural Transplantation, the Editors have now sought to co-ordinate and edit an updated version, Functional Neural Transplantation II.Functional Neural Transplantation II is not just a revised edition of the previous volume, but an entirely new and complementary second volume to update the field to 'state of the art' for the new millennium. For many major topic areas (such as functional repair in neurodegenerative disorders of the basal ganglia) there has been a continual flow of significant advances. Although these topics are covered in both volumes, the Editors have sought to avoid duplication by requiring that the present coverage emphasises the major developments over the last decade while relying on the first volume for the background overviews. Other topics though are entirely new in the present volume, such as novel applications of neural transplantation to other major clinical relevance such as retinal repair or alleviation of pain. A key departure of the present volume is the addition of several early chapters addressing the technical and developmental issues associated with identification of alternative sources of cells for transplantation - cell lines, immortalised cells, precursor/stem cells and xenotransplantation.

  • Brain Plasticity and Epilepsy: A Tribute to Frank Morrell

    • 1st Edition
    • Volume 45
    • English
    This volume of International Review of Neurobiology integrates the latest developments in normal and abnormal neuroplasticity and epilepsy, and considers their implications for understanding the basic mechanisms of normal and pathological behaviors. The chapters are written by leaders in the field, and provide comprehensive coverage of the subject, from molecular neurobiology to behavior. This book will help neuroscientists gain a better understanding of the application of fundamental neuronal mechanisms of plastic change to problems relevant to the diagnosis, treatment, and prevention of human disease, particularly epilepsy.

  • Exploring the Thalamus

    • 1st Edition
    • S. Murray Sherman + 1 more
    • English
    The thalamus is a group of cells placed centrally in the brain that serve a critical role in controlling how both sensory and motor signals are passed from one part of the cerebral cortex to another. Essentially, all information reaching the cerebral cortex and thus consciousness is relayed through the thalamus. The role of the thalamus in controlling the flow of information (such as visual, auditory, and motor) to the cortex has only recently begun to be understood. This book provides an in-depth look at the function of the thalamus and its role as relayer of information to the cerebral cortex. The authors explore how the thalamus controls messages that are passed to the cortex and they introduce the novel suggestion that the thalamus serves a critical role in controlling how messages pass from one part of the cortex to another. Exploring the Thalamus is a comprehensive, up-to-date reference for researchers. It discusses problems concerning the function and structure of the thalamus and concludes each chapter with thought-provoking questions regarding future research.

  • Channelopathies

    • 1st Edition
    • F. Lehmann-Horn + 1 more
    • English
    This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease are especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.

  • Cognition, Emotion and Autonomic Responses: The Integrative Role of the Prefrontal Cortex and Limbic Structures

    • 1st Edition
    • Volume 126
    • H.B.M. Uylings + 4 more
    • English
    Since the publication of the previous volume on the prefrontal cortex: its structures, function and pathology in Progress in Brain Research some ten years ago, new data has emerged on the prefrontal cortex and its connections and interactions with structures involved in emotional, motivational and autonomic responses. Cognition, memory and decision making appear to be influenced by emotional and autonomic responses from viscera and the internal state of the organism (e.g. 'gut feelings') induced by the outside world. This resulted in a renewed interest in the interactions of circuits involved in cognition, memory and decision making with those involved in emotional and motivational responses. Therefore, the 21st International Summer School of Brain Research, held in Amsterdam, 23-27 August 1999, was entirely devoted to the question to which extent the prefrontal cortex and related limbic structures function as an integrative center for these interactions.

  • Nervous System Plasticity and Chronic Pain

    • 1st Edition
    • Volume 129
    • J. Sandkühler + 2 more
    • English
    The mechanisms underlying the various forms of neuropathic pain are explored by leading experts in the field. The reviews provide state-of-the-art knowledge in pain research from the molecular and cellular level up to imaging of pain in the human cortex and to the perception of pain. In a truly interdisciplinary approach pain researchers and pain therapists give insights into the latest developments in the field. Some symptoms of neuropathic pain can now be understood at the molecular level, e.g. by modifications in the subunit composition of sodium channels or by the molecular properties of the vanilloid receptor. Synaptic mechanisms similar to those involved in learning and memory formation have now been discovered in pain pathways and real-time images of brain activity in human patients give novel insights into the differential processing of sensory-discriminati... versus emotional-aversive aspects of pain. This volume also documents another remarkable achievement in pain research during the past decade: The development of a common language and the assimilation of scientific concepts across disciplines. When reading the contributions, it becomes clear that new concepts and ideas developed in one arena of pain research have had impact on concepts and hypotheses important to other fields of pain research. Much of the foundation on which future pain research will rest is described in this volume. Numerous cross-references between the chapters and a detailed subject index make this book highly accessible to the reader.

  • Volume Transmission Revisited

    • 1st Edition
    • Volume 125
    • L.F. Agnati + 3 more
    • English
    Volume Transmission Revisited describes the mounting evidence that cells of the central nervous system are able to communicate via a host of chemical signals that flow through the extracellular space. Volume transmission (VT) constitutes a novel and complementary communication system to classical synaptic transmission. The new modality, which does not require specific connections between cells, leads to a reconsideration of the spatial relationships of neurons and glia, brings a new dimension to network modelling and is relevant to both short term interactions and long term tonic states of the brain.The reader will find 29 chapters describing many of the major discoveries in VT during the last decade.The most striking feature of this publication is the collecting together of many compelling examples of the ubiquitous nature of VT. These point to its increasing relevance from basic neuroscience research to clinical practice. Those working in other areas will find numerous invaluable examples of how leading investigators have gone about assembling evidence for VT.

  • Glutamate

    • 1st Edition
    • Volume 18
    • J. Storm-Mathisen + 1 more
    • English
    The volume presents a comprehensive and up-to-date treatise of the glutamatergic synapse and its environment. Particular emphasis is on the localizations of the molecular constituents of the synaptic machinery. Immunogold and other high-resolution methods are used extensively. Each chapter presents new data that have not previously been reviewed. The material presented forms the basis for work directed to understanding the functional properties of excitatory synapses in greater depth, to discover mechanisms of neurological and psychiatric disorders and novel methods for treatment. Chapter 1 deals with the transmitter molecule itself, mechanisms of release and pathways for glutamate synthesis. The anatomy of glutamatergic nerve projection pathways in different brain regions is dealt with. In Chapter 2, focus is on aspartate, the enigmatic congener of glutamate, and its possible role in excitatory neurotransmission. Chapters 3 through 6 deal with glutamate receptors. Metabotropic glutamate receptors are presented in Chapter 3. Chapter 4 presents an in situ hybridization atlas of the different classes of ionotropic glutamate receptors. The localizations of these receptors at the regional and synaptic level are presented in Chapter 5. The ways in which the receptors are brought to the synapse and held in position are the subject of Chapter 6. Chapter 7 deals with the enzymes responsible for formation and catabolism of glutamate. In Chapter 8, the regulation of extracellular glutamate levels by glutamate transporters is discussed. The final two chapters of the volume focus on two "model synapses" that, due to special features, lend themselves particularly well to demonstrating properties of glutamatergic synapses. The hair cell-to-afferent nerve terminal synapses in the inner ear (Chapter 9), with their supporting cells, share essential properties with glutamatergic synapses in the central nervous system. The salient features of the latter are illustrated by the synapses of the giant reticulo-spinal axons of the lamprey, used to unravel molecular mechanisms of the cycling of synaptic vesicles (Chapter 10).

  • Neural Plasticity and Regeneration

    • 1st Edition
    • Volume 128
    • F.J. Seil
    • English
    While a cure for spinal cord injury remains elusive, the contents of this volume convey a sense of progress towards this goal. More has been learned about the primary and secondary consequences of spinal cord injury and more is being understood about recovery mechanisms that are intrinsic to the nervous system and that might be further encouraged. Expanding the control capacity of uninjured portions of the nervous system may be one approach to improving the functional capabilities of those afflicted with this disorder. New therapies in the form of transplantable cells that can encourage growth or myelination or prevent secondary damage or that can substitute for injured cells appear promising for future applications. Genetic and tissue engineering studies give us further hope, and under continuous development are novel drugs with greater specificity and fewer detrimental effects and improved delivery methods for such drugs. The volume is organized into six topic sections, including I) Strategies for Spinal Cord Injury Repair, II) Plasticity of the Injured Spinal Cord: Retraining Neural Circuits to Promote Motor Recovery, III) Impact of Neuroprosthetic Applications on Functional Recovery, IV) Neurotrophins and Activity-Dependent Plasticity, V) Candidate Cells for Transplantation into the Injured CNS and VI) New Directions in Regeneration Research. Both clinical and experimental animal studies are presented in the first three sections, while predominantly basic research is the focus of the second half of the book.

  • Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 40
    • English
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work. Volume 40 includes in its coverage chapters on memory, categorization, implicit and explicit learning, and the effects of rewards and punishments on learning.

  • Physiological Imaging of the Brain with PET

    • 1st Edition
    • Albert Gjedde + 3 more
    • English
    Physiological Imaging of the Brain with PET provides the latest techniques and applications for PET as a tool to study the physiology of the brain, and is sponsored by the International Society of Cerebral Blood Flow and Metabolism. It covers all of the fundamental disciplines of PET in one volume. Written by international experts in brain imaging, it is a useful reference for the active brain PET scientist, and a valuable introduction to students, clinicians, and researchers who wish to take advantage of the capabilities of this technique to study the normal and diseased brain.

  • MRI Atlas of the Human Cerebellum

    • 1st Edition
    • Jeremy D. Schmahmann + 4 more
    • English
    The MRI Atlas of the Human Cerebellum constitutes the most complete, detailed work on the human cerebellum to date. This definitive work provides images in the three cardinal planes (sagittal, transverse, and coronal) at closely spaced intervals of 2 millimeters. The images are derived from MRI scans of one individual and from postmortem sections of another. It is the only such atlas set within the universally accepted framework of the Talairach stereotaxic system, derived from standard landmarks in the brain. The book includes a new nomenclature system (labeling system) which is easier to use, aids in understanding the organization of the cerebellum, and is consistent with earlier work on the anatomy of the cerebellum in animals and the development of the human cerebellum in infants.Recent studies have shown that the cerebellum is involved in much more than motor coordination alone: also in higher functions including memory, language, emotion, and attention, as well as sensory discrimination. This atlas facilitates this new era of study of the cerebellum, allowing investigators to identify cerebellar structures with precision. Everyone concerned with the anatomy, function, or dysfunction of the cerebellum should have a copy.

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