
Aphasia
- 1st Edition, Volume 185 - January 23, 2022
- Imprint: Elsevier
- Editors: Argye Elizabeth Hillis, Julius Fridriksson
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 3 8 4 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 4 7 9 - 2
Aphasia, Volume 185 covers important advances in our understanding of how language is processed in the brain and how lesions or degeneration in the left hemisphere affect langua… Read more

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Request a sales quoteAphasia, Volume 185 covers important advances in our understanding of how language is processed in the brain and how lesions or degeneration in the left hemisphere affect language processing. This new release reviews research regarding how language recovers from brain injury, along with new interventions developed to enhance recovery, including language rehabilitation, noninvasive brain stimulation and medications. Sections cover neuroanatomy and neurophysiology of language networks, focus on mechanisms of recovery (and decline) of language, and include chapters on intervention, including recently developed behavioral therapies, brain stimulation, medications, and a review of studies of treatment for both post-stroke aphasia and primary progressive aphasia.
- Summarizes advances made in understanding language processing
- Discusses how lesions and brain degeneration affect language production and comprehension
- Identifies language networks based on functional imaging and lesion mapping
- Provides interventions for recovery, including brain stimulation, behavioral interventions and medication
- Explores post-stroke aphasia and primary progressive aphasia
Clinical neurologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Handbook of Clinical Neurology 3rd Series
- Foreword
- Preface
- Contributors
- Section 1: History and conceptual models of language and the brain
- Chapter 1: History of aphasia: A broad overview
- Abstract
- Introduction
- Early Mentions
- Case Descriptions
- Toward an Explanation
- Localization of Speech Production
- Localization of Language Comprehension
- Diagrams
- Grammatical Disorders
- Against Localization
- Assessment
- Rehabilitation
- Epilogue
- Acknowledgments
- Chapter 2: Broca-Wernicke theories: A historical perspective
- Abstract
- Introduction
- Learning From History
- The Era of Localization
- Precursors of Broca: Gall, Bouillaud
- Broca
- Wernicke
- Diagram Makers
- Against the Localistic Language Models
- Intraoperative Electric Stimulation Mapping
- The Lesion-Deficit Approach Revisited
- Functional Systems
- Section 2: Neuroanatomy of speech and language
- Chapter 3: Vascular syndromes: Revisiting classification of poststroke aphasia
- Abstract
- History of Localization and Classification: Contributions of Early Researchers
- Vascular Territories
- Vascular Syndromes
- Recovery and Transition Over Time
- Summary
- Chapter 4: The dual stream model of speech and language processing
- Abstract
- The Wernicke-Lichtheim-Geschwind Model
- Problems With the Classical Model
- The Dual-Stream Organization of the Brain
- Foundations of the Hickok-Poeppel Dual-Stream Model
- The Hickok-Poeppel Dual-Stream Model
- Taking Dual-Stream Parallels Seriously: Implications for the Study and Evolution of Language
- Homologous Neurocomputational Architectures for Dorsal Stream Speech and Nonspeech Motor Control
- The Model From the Perspective of Language Production and the Expressive-Receptive Asymmetry
- Situating Syntax in the Model
- Summary
- Chapter 5: Types of motor speech impairments associated with neurologic diseases
- Abstract
- Introduction
- A Detailed View of the Dysarthrias
- Special Considerations Based on Mechanism of Injury
- Assessment and Treatment Considerations
- Conclusions
- Acknowledgements
- Chapter 6: Clinical and neuroimaging characteristics of primary progressive aphasia
- Abstract
- Introduction
- Semantic Variant Primary Progressive Aphasia
- Nonfluent Primary Progressive Aphasia
- Logopenic Variant Primary Progressive Aphasia
- Chapter 7: The role of disrupted functional connectivity in aphasia
- Abstract
- Introduction
- A Brief Connectivity Primer
- Disrupted Functional Connectivity in Poststroke Aphasia (PSA)
- Disrupted Functional Connectivity in Primary Progressive Aphasia (PPA)
- Methodologic Considerations and Current Limitations
- Conclusions
- Chapter 8: The role of disrupted structural connectivity in aphasia
- Abstract
- Contributions of Lesion Symptom Mapping
- Caveats of Lesion Symptom Mapping
- Measuring Structural Connectivity
- Models of Language Processing Based on Brain Connections
- Key Regions and Connections Associated With Language Function
- Conclusions
- Appendix: Resources for researchers
- Section 3: Language recovery
- Chapter 9: Functional MRI evidence for reorganization of language networks after stroke
- Abstract
- Introduction
- fMRI in Neuroimaging Research
- fMRI in Poststroke Aphasia
- fMRI Evidence in Poststroke Treatment-Induced Language Recovery
- Conclusions
- Chapter 10: The contribution of positron emission tomography to the study of aphasia
- Abstract
- Introduction
- FDG-PET
- Amyloid PET
- TAU-PET
- Neuroinflammation PET
- Conclusions
- Chapter 11: Electrophysiologic evidence of reorganization in poststroke aphasia
- Abstract
- Introduction
- Electrophysiologic Methods
- Evidence From the Event-Related Potential
- Evidence From Spectral Power Differences
- Overall Summary
- Chapter 12: Assessment of language impairment and function
- Abstract
- Purposes of Aphasia Assessment
- LANGUAGE Checklist for Aphasia Assessment
- Screening and Tracking Aphasia
- Section 4: Language intervention
- Chapter 13: Behavioral interventions for poststroke aphasia
- Abstract
- Behavioral Interventions for Poststroke Aphasia
- The ICF and Aphasia
- Linguistic Processes and Aphasia
- Intervention Planning in Aphasia
- Classifying Behavioral Interventions for Poststroke Aphasia
- Alternate Models of Service Delivery for Aphasia
- Conclusion
- Chapter 14: Behavioral interventions for primary progressive aphasia
- Abstract
- Introduction
- Clinical Assessment in PPA
- Restitutive Interventions
- Compensatory Interventions
- Communication Partner Training
- Technology-Mediated Intervention
- Person-Centered Treatment
- Additional Considerations
- Chapter 15: Noninvasive brain stimulation to augment language therapy for poststroke aphasia
- Abstract
- Noninvasive Brain Stimulation for Neurorehabilitation in PostStroke Aphasia
- Rationale for Administering NIBS to Treat PostStroke Aphasia
- Language Processes Shown to Improve Following NIBS
- Using NIBS to Enhance Outcomes of Behavioral Therapy
- Current Limitations and Knowledge Gaps
- Concluding Remarks
- Chapter 16: Noninvasive brain stimulation to augment language therapy for primary progressive aphasia
- Abstract
- Introduction
- Non-invasive Brain Stimulation
- Augmenting Language Therapy With Neuromodulation in Primary Progressive Aphasia
- Augmenting Untrained Tasks With Neuromodulation in Primary Progressive Aphasia
- Predicting Response to Treatment With Noninvasive Brain Stimulation
- Future Directions
- Chapter 17: Better language through chemistry: Augmenting speech-language therapy with pharmacotherapy in the treatment of aphasia
- Abstract
- Introduction
- Catecholamines
- Glutamate and GABA
- Acetylcholine
- Serotonin
- Final Thoughts
- Acknowledgment
- Section 5: Recent advances
- Chapter 18: Ethical considerations in the management of poststroke aphasia
- Abstract
- Introduction
- Informed Consent: Competence and Decision-Making Capacity
- Establishing DMC
- Patient Autonomy and Quality of Life
- Conclusions
- Chapter 19: Genetics in aphasia recovery
- Abstract
- Introduction
- Genetics of Aphasia Recovery
- Genetics of Stroke Recovery
- Conclusion
- Chapter 20: Sign language aphasia
- Abstract
- Introduction
- American Sign Language
- Deaf Language
- Neurobiology of Sign Language
- Sign Language Aphasia
- Concluding Remarks
- Acknowledgments
- Index
- Edition: 1
- Volume: 185
- Published: January 23, 2022
- Imprint: Elsevier
- No. of pages: 336
- Language: English
- Hardback ISBN: 9780128233849
- eBook ISBN: 9780128234792
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Argye Elizabeth Hillis
Dr. Argye Elizabeth Hillis is a Professor of Neurology, with joint faculty appointments in Physical Medicine and Rehabilitation and in Cognitive Science at Johns Hopkins University. Dr. Hillis serves as the Executive Vice Chair of the Department of Neurology, and Director of the Cerebrovascular Division of Neurology.
Dr. Hillis is Deputy Editor of Stroke and Associate Editor of Aphasiology and has served as Co-Editor-in Chief of Behavioural Neurology, Associate Editor of Brain, Annals of Neurology, American Journal of Speech-Language Pathology, Cognitive Neuropsychology, and Language and Cognitive Processes. She also currently serves on the editorial boards of Annals of Neurology and International Journal of Stroke. Dr. Hillis was the 2003 recipient of the Derek Denny Brown Neurological Scholar Award from the American Neurological Association and the Norman Geschwind Award in Behavioral Neurology from the American Academy of Neurology. Her current research is supported by the National Institutes of Health (NINDS and NIDCD). She is on the Board of Directors of the World Stroke Organization.
Dr. Hillis' current research combines longitudinal task-related and task-free functional imaging and structural imaging from the acute stage of stroke through the first year of recovery, with detailed cognitive and language assessments to improve our understanding how language and other cognitive and emotional functions recover after stroke. She is investigating the most effective timing of neuromodulatory treatments, such as transcranial direct current stimulation and medications, to augment behavioral therapies after stroke. Her other avenue of research involves novel treatment studies and longitudinal imaging and language studies of Primary Progressive Aphasia. (PPA). She is currently studying three forms of treatment of PPA: language therapy and transcranial Direct Current Stimulation (in studies funded by NIDCD) and neurofeedback with aphasia therapy.
Affiliations and expertise
Professor of Neurology, with joint faculty appointments in Physical Medicine and Rehabilitation and in Cognitive Science, Johns Hopkins University, USAJF
Julius Fridriksson
Dr. Fridriksson is a Professor and Interim Vice President for Research, University of South Carolina. He research focuses on the rehabilitation of aphasia and the neurobiology of speech and language processing. Dr. Fridriksson has a long history of external research funding (exceeding $40M), primarily from the National Institutes of Health (NIH). He also leads UofSC’s Center for the Study of Aphasia Recovery with collaborators at Johns Hopkins, the University of California-Irvine, and Emory University.
A USC Health Science Distinguished Professor and Co-Director of the McCausland Center for Brain Imaging since 2012, Dr. Fridriksson’s prior teaching experience includes various UofSC professorial positions of increasing responsibility, 2001-2021; and Research Fellow, University of Arizona, 1998-2001.
Dr. Fridriksson earned his Ph.D. in Speech and Hearing Sciences from the University of Arizona and both his M.A. in Speech-Language Pathology and B.A. in Communicative Disorders from University of Central Florida.
Affiliations and expertise
Professor and Interim Vice President for Research, Communication Sciences and Disorders, University of South Carolina, Columbia, SC, United StatesRead Aphasia on ScienceDirect