Perioperative Neuroscience
Translational Research
- 1st Edition - February 25, 2022
- Imprint: Academic Press
- Editors: Hemanshu Prabhakar, Charu Mahajan, Indu Kapoor
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 0 0 3 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 0 0 4 - 0
Perioperative Neurosciences: Translational Research examines current clinical research focused on complications and the improvement of patient outcomes in neuroanesthesia and neuro… Read more
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Request a sales quotePerioperative Neurosciences: Translational Research examines current clinical research focused on complications and the improvement of patient outcomes in neuroanesthesia and neurocritical care. The book addresses important translational topics including neuroanesthetics, pharmacogenomics, neuroprotection and neurotoxicity. In addition, it covers special considerations for topics such as stroke, traumatic brain injury and pain, as well as for specific patient populations like geriatric and pediatric.
- Addresses translational developments in pharmacogemonics, brain protection and neurotoxicity
- Discusses ethical concerns relevant to clinical research in perioperative neuroscience
- Collates insights from international experts in translating research to practice
Researchers and clinicians in neuroscience and neurology. Trainees and advanced graduate students
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Foreword
- Acknowledgment
- 1. Introduction
- Abstract
- Translational research and neurosciences
- References
- 2. Basic principles of translational research
- Abstract
- Introduction to translational research
- What is translational research?
- History of translational research
- Current concepts and domains
- Ethics and regulations
- Education and careers
- Conclusions
- References
- 3. Anesthetics and translational research
- Abstract
- Introduction
- Induction and emergence from anesthesia processes
- Anesthetics and consciousness: the “awareness” paradox
- General anesthetics and neurodegenerative processes
- Impact on carcinogenic processes
- Perspectives
- Conclusion
- References
- 4. Neurotoxicity and translational research
- Abstract
- Introduction
- Preclinical evidence and the use of animal models
- Anesthesia and neurotoxicity: mechanisms
- From laboratory to clinical trials: evidence in humans
- Exposure to anesthesia and the elderly
- Neuroprotective strategies in the perioperative setting
- Anesthesia and neurotoxicity: future experimental modalities
- Conclusions
- References
- 5. Neuromonitoring and translational research
- Abstract
- Introduction
- Clinical monitoring
- For aneurysmal subarachnoid hemorrhage patients
- For ischemic stroke patients
- Imaging studies
- Intracranial pressure and derived indices
- Parenchymal microtransducer devices
- Optic nerve sheath diameter
- Transcranial Doppler
- Pupillometry
- Jugular venous oxygen saturation
- Brain tissue oxygen partial pressure
- Near infrared spectroscopy
- Electroencephalography
- Evoked potentials
- Conclusion
- References
- 6. Cognition and translational research
- Abstract
- Introduction
- Cognitive dysfunctions in the perioperative period: definition and diagnosis
- Animal models of cognitive dysfunction in perioperative neuroscience
- Anesthetics
- Clinical studies investigating cognitive dysfunction in perioperative neuroscience
- Perioperative care for patients with known presurgery cognition dysfunctions
- Limits of translational research for inconsistencies of evidence from preclinical studies
- Conclusion
- References
- 7. Geriatrics and translational research
- Abstract
- Cellular, biochemical, and molecular biology of aging
- Physiology, immunology, and endocrinology of aging
- Mechanisms and intervention of cellular senescence and stem cell aging
- Computational and functional genomics of aging
- Animal models of aging research
- Geroprotectors as antiaging chemicals
- Human experiments on longevity
- Conclusion
- References
- 8. Pediatrics and translational research
- Abstract
- Introduction
- Preclinical research on perioperative anesthetics neurotoxicity
- Clinical research on perioperative anesthetics neurotoxicity in children
- Reasons for discrepancy between preclinical and clinical data
- Conclusion
- References
- 9. Stroke and translational research
- Abstract
- Animal models for ischemic stroke
- Model for stroke risk factors
- Neuronal protection
- Free radical scavengers
- Delayed neuronal injury
- Inflammation
- Regeneration in stroke and neuronal repair
- Growth promoters
- Other drugs
- Conclusion
- References
- 10. Traumatic brain injury and translational research: pharmacological and nonpharmacological perspectives
- Abstract
- Introduction
- The question/controversy
- Consensus statement
- Conclusion
- Conflict of interest
- Authors’ contribution
- References
- 11. Movement disorders and translational research
- Abstract
- Etiology, diagnosis, and monitoring
- Conclusion
- References
- 12. Epilepsy and translational research
- Abstract
- Introduction
- Diagnostic evaluation
- Treatment
- Future perspective of translational research
- References
- 13. Translational research in delayed cerebral ischemia
- Abstract
- Introduction
- Experimental aneurysmal subarachnoid hemorrhage
- Characteristics of experimental SAH models
- Perspectives on the current status of SAH animal models
- Failure in current SAH studies
- Delayed brain injury
- Delayed cerebral vasospasm: from extravascular blood to vessel lumen
- Microcirculatory spasm and dysfunction
- Microthrombosis: an additional explanation for DCI
- Cortical spreading ischemia
- Are we close to solving the mystery of SAH?
- Future directions
- Conclusion
- References
- 14. Translation research in pain medicine
- Abstract
- Translational research
- Types of pain
- Models in pain management
- Current trends in care
- Immense opportunity for translational research in pain medicine
- References
- 15. Ethical considerations in translational research
- Abstract
- Introduction
- Evolution of translational research ethics
- Ethical considerations in translational research
- Ethical issues in vulnerable neurological population
- References
- Index
- Edition: 1
- Published: February 25, 2022
- No. of pages (Paperback): 260
- No. of pages (eBook): 260
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323910033
- eBook ISBN: 9780323910040
HP
Hemanshu Prabhakar
Dr. Hemanshu Prabhakar, MD, PhD, FSNCC, is a Professor at the Department of Neuroanaesthesiology and Critical Care at the All India Institute of Medical Sciences (AIIMS), New Delhi, India. He is a recipient of the AIIMS Excellence Award 2012 for his notable contribution to academia and has published over 350 papers in peer-reviewed national and international journals. Dr. Prabhakar is a Reviewer for various national and international journals and is also a Review Author for the Cochrane Collaboration. He has a special interest in the evidence-based practice of neuroanesthesia and ERAS. Dr. Prabhakar is a Member of various national and international neuroanesthesia societies and is the Past Secretary of the Indian Society of Neuroanesthesia and Critical Care (ISNACC) and the Society of Neurocritical Care (SNCC). He is also the Immediate Past President of the SNCC. To date, he has published more than 25 books on neuroanesthesia and neurocritical care. He is featured in the Limca Book of Records as a prolific Writer in the field of neuroanesthesiology. He actively collaborates on research activities among the low-income and middle-income countries.
Affiliations and expertise
Department of Neuroanaesthesiology and Critical Care, Neurosciences Center, AIIMS, New Delhi, IndiaCM
Charu Mahajan
Charu Mahajan, MBBS, MD, DM is currently working as an Additional Professor in the Department of Neuroanaesthesiology and Critical Care at All India Institute of Medical Sciences, New Delhi. She has research experience of over a decade backing her profile and has been awarded with the prestigious NBM Gold medal in the subject of surgery in the year 2003. She has more than 50 publications to her name in the form of books and journal alike. She is also the reviewer of various prestigious national journals like the Neurology India and Indian Journal of Anaesthesia and is the member of various scientific bodies such as the SNACC, ISNACC and ISA.
Affiliations and expertise
Department of Neuroanaesthesiology and Critical Care, Neurosciences Center, AIIMS, New Delhi, IndiaIK
Indu Kapoor
Indu Kapoor, MBBS, MD from the prestigious institute Lady Hardinge Medical College [LHMC] and MD from UCMS Delhi is currently serving as an Additional Professor in the department of Neuroanaesthesiology and Critical Care at All India Institute of Medical Sciences, New Delhi. She has more than 80 research papers published in national and international journals across the globe and numerous chapter contributions in reputed titles. She has also been awarded with the reputed Dr. TN. JHA Memorial Award by the Indian Society of Anaesthesiologists and Smt. Chandra and Sh. Narayan Wadhwani Memorial Award.
Affiliations and expertise
Department of Neuroanaesthesiology and Critical Care, Neurosciences Center, AIIMS, New Delhi, IndiaRead Perioperative Neuroscience on ScienceDirect