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Elsevier

Books in Molecular biology cellular biology and genetics

This collection offers insights into gene expression, cell signalling, and genetic regulation. Supporting researchers, clinicians, and students, it features advanced techniques, genetic engineering, and disease mechanisms, fostering innovations in personalized medicine, regenerative therapies, and molecular diagnostics.

  • Thermobiology

    • 1st Edition
    • Volume 19
    • J.S. Willis
    • English
    Notwithstanding widespread studies and even several biological journals devoted to temperature, it is difficult to perceive a field of thermobiology as such. Interest in the effects of temperature of biological systems is fragmented into specific thermal ranges and often connected with particular applications: subzero cryobiology and preservation of cells and tissues or survival of poikilotherms, para-zero cryobiology and preservation of whole organs and survival of whole animals, intermediate ranges and physiological adaption and regulation, high temperatures and use of heat for killing cancer cells, very high temperatures and limits of biological structure. Yet it has not always been so, and there are good reasons why it need not remain so. General and comparative physiologists such as W.J. Crozier, H. Precht, J. Belehradek, F. Johnson, C.L. Prosser, and others have sought throughout this century to lay foundations for unified approaches to temperature in biological systems.Recent findings also serve to suggest principles and processes that span the range of temperatures of biological interest. Microviscosity of membranes is an issue originally of interest to low temperature biologists but with relevance to limiting high temperatures; conversely for protein structure. Certain "heat shock proteins" now appear to be responses to generalized stress, including low temperature.Inevitab... the chapters of this book reflect the "zonal" character of thermobiology: two chapters (by Storey and Raymond) deal with protection against subfreezing temperatures; three (Hazel, membrane structure, Dietrich, microtubular structure, and Kruuv, cell growth) deal with the effects of and modulation to cool-to-moderate superfreezing temperatures, one (Willis) with modulation (of membrane ion transport) to moderate-to-high temperatures and two (Li, heat shock proteins and Lepock, proteins in general) with stressfully high temperatures. Explicit in each of these chapters, however, are principles and issues that transcend the parochialism of the temperature range under consideration.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 71
    • English
    Volume 71 of Advances in Cancer Research begins with Morgan and Kastan presenting data on the roles of p53 and ATM in cell cycle progression and cell death in response to DNA damage and how this information may lead to targets for improved cancer therapies. Kok et all. Review the methodological advantages and limitations to localizing tumor suppressor genes, especially those on the short arm of chromosome 3. Peltomaki and de la Chapelle describe research on mismatch repair genes and their effects on colorectal cancer. McKenna and Cotter present findings on the functions and failures of apoptosis in the hematopoietic system. Ravitz and Wenner review TGF-B and how it controls and affects cell cycle progression in a variety of cell types. Andrew Simpson presents data on the mutation frequencies of microsatellites in human carcinogenesis. Naor and colleagues present research on a multitude of tumors expressing levels of CD44 and discuss how CD44 may be used as a target for cancer therapy. Luisa Villa discusses various aspects of HPV and the potential clinical use of HPV testing in cervical cancer prevention programs. Last, Disis and Cheever review the studies that define HER-2/neu specific immunity in patients with cancer and the current vaccine strategies for generating specific immunity.

  • The Chemokine Factsbook

    Ligands and Receptors
    • 1st Edition
    • Krishna Vaddi + 2 more
    • English
    How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalog of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy-to-follow format. Taken together they compile everything you want to know about proteins but are too busy to look for. The Chemokine FactsBook contains more than 40 entries on chemokines, and chemokine receptors from human or other origin, including IL-8, MCP-1, C5-a, RANTES, Lymphotactin, and CC CKR-1. The text provides information on tissue sources, target cells, physicochemical properties, transcription factors, regulation of expression in disease, receptor-binding characteristics, gene structure and location, amino acid sequences, and accession numbers and references.

  • The Kinin System

    • 1st Edition
    • Stephen G. Farmer
    • English
    Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef'... DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases.

  • International Review of Cytology

    • 1st Edition
    • Volume 171
    • English
    International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Advances in Space Biology and Medicine

    • 1st Edition
    • Volume 6
    • S.L. Bonting
    • English
    The sixth volume in Space Biology and Medicine is a volume with contributors from all spacefaring nations. Although all space agencies must currently operate under server budgetary restraints, progress in the field of space biology and medicine continues. The preparations for the International Space Station, in which Russia is going to participate with the United States, Europe, Japan, and Canada, are also continuing. For the longer term, studies for a Lunar Station are in progress. The contributions to this volume are witness of all these activities.Two chapters deal with the effects of weightlessness on the immune system. Taylor and colleagues review the effects in vivo, indicating a reduction of the immune function in space. The blunting of the immune function after short-term flights resembles that after acute stress on the ground, while long-term effects compare to those caused by chronic stress. Cogoli and Cogoli-Greuter describe studies on single cells, which show that proliferation and cytokine expression of T-lymphocytes are reduced in microgravity, possibly through a non-equilibrium thermodynamic effect.Preparation for long-term space missions is the express purpose of four contributions in this volume. Kanas considers the usefulness of space simulation studies by means of extended isolation and confinement on Earth, and points to be examined in future projects of this kind. Volumes 3 and 5 in this series were dedicated to two ESA projects of this nature. Grigoriev and Egorov describe a medical monitoring system for long-term missions. Schwartzkopf reports on the design of life support systems using plant cultivation for food and oxygen regeneration, with particular reference to a future Lunar base. Wolf describes a small-scale bioregenerative system based on an algal bioreactor.The use of medicinal drugs by astronauts is the subject of two chapters by Pavy-Le Traon, Saivin and colleagues. The resistance of bacteria to antibiotics can be changed in weightlessness, and no suitable drug against bone demineralisation in space is available. The pharmacokinetics of drugs is also changed, mainly due to the fluid shift in space. Smith and colleagues provide a comprehensive review of our present knowledge of the regulation of body fluid volume and electrolyte levels and the hormonal regulation mechanisms involved. The effects of weightlessness on the function of the vestibular system, which are the cause of space motion sickness in astronauts during the first week in space, are reviewed by Kornilova.Finally there are two chapters on the effects of gravity on non-human creatures. Izumi-Kurotani describes behaviour and stature of frogs during spaceflight, as well as some histological and biochemical changes in organs and tissues after return to Earth. Merkys and Darginaviciene have studied the mechanism of the plant gravitropic response (spatial orientation along the gravity vector) in space an on Earth, and conclude that flows of calcium ions and the growth hormone indole acetic acid in opposite directions appear to be involved.

  • Advances in Molecular and Cellular Endocrinology

    • 1st Edition
    • Volume 1
    • D. LeRoith
    • English
    Historically the field of endocrine research has always been at the forefront of scientific endeavors. The investigators of these important breakthroughs in research have been rewarded by numerous Nobel awards. In the field of diabetes alone, Nobel prizes have been awarded to researchers who discovered insulin, characterized the protein and invented radioimmunoassays using insulin as a paradigm. Not surprisingly, biomedical researchers have always been attracted by the endocrine system and other similar systems of intercellular communication.Over the past two decades, endocrine research has developed rapidly and adapted modern molecular and cellular biology techniques for its specific use. These changes have allowed researchers in the field to maintain their edge. Thus, endocrine disease-related genes have been characterized and mutations in these genes have helped explain common and less common endocrine disorders. Our understanding of the regulation of gene expression has been greatly enhanced by molecular techniques.In an attempt to bring investigators up to date with the recent advances in this exploding field we have decided to publish a series entitled Advances in Molecular and Cellular Endocrinology. Internationally famous investigators have agreed to participate and their contributions are appreciated.Volume 1 has focused on aspects of the hypothalamic-pituita... axis including GnRH and GH gene regulation, molecular aspects of insulin, insulin-like growth factors and glucagon. In addition, reviews on the recently cloned calcium receptor and steroid receptor interactions with DNA are presented.

  • Some Aspects of Oncology

    • 1st Edition
    • Volume 1
    • G. Heppner + 1 more
    • English
    The present volume is the first in the advances in oncobiology series. It is meant to be useful not only to clinical and non-clinical oncologists but also to graduate students and medical students. The individual chapters are presented as self-contained summaries of current knowledge rather than as reviews. The last chapter deals with the subject of chemotherapy.

  • Advances in Genetics

    • 1st Edition
    • Volume 35
    • English
    Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.This volume of Advances in Genetics continues the series goal to present both human and molecular genetic reviews in a timely fashion. Anderson and Kay investigate CAB gene expression in the regulation of gene transcriptions in plants. Harmon and Allan offer a historical overview of apoptosis and its recent heightened interest. Developments involving four X-linked disorders and their resulting increased susceptibility to infection are presented by Smithand Notarangelo. Dickson and colleagues present research on the role of dystrophin in Duchenne muscular dystrophy and the potential feasibility of gene therapy in curing this disease as well as other diseases involving the heart and central nervous system. The relationship between mice and humans and the ways in which they help each other understand gene function and relationship is presented by Elizabeth Fisher. Timmons and Shearn summarize what information has been learned about prune, Killer of prune, and the prune/Killer of prune lethal interactions: rare genetic phenomena in Drosophila melanogaster. Meiotic recombination, via the breaking and rejoining of DNA and the subsequent reciprocal exchange and the cytological evidence of the exchange, are explored by Ross et al. Last, Coonar and McKenna discuss the four major cardiomyopathies, focusing on recent advances in hypertrophic cardiomyopathy.

  • Non-Radioactive Labelling

    A Practical Introduction
    • 1st Edition
    • A. J. Garman
    • English
    Biological Techniques is a series of volumes aimed at introducing to a wide audience the latest advances in methodology. The pitfalls and problems of new techniques are given due consideration, as are those small but vital details not always explicit in the methods sections of journal papers.In recent years, most biological laboratories have been invaded by computers and a wealth of new DNA technology and this will be reflected in many of the titles appearing in the series.The books will be of value to advanced researchers and graduate students seeking to learn and apply new techniques, and will be useful to teachers of advanced undergraduate courses involving practical or project work.Labelled biomolecules are an essential tool in life science research, and non-radioactive labels are becoming increasingly important due to their convenience of measurement, greater safety and lack of disposal problems compared to radioactive labels.This book provides practical information, background theory and protocols to allow a beginner to label many types of biomolecules, including proteins, peptides, nucleic acids and small molecules.This book is essential for biochemists, molecular biologists and cell biologists wanting to use non-radioactively labelled molecules.

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