Molecular biology cellular biology and genetics print books and ebooks | Elsevier

Batten Disease: Diagnosis, Treatment, and Research

1st Edition
Volume 45
April 13, 2001
English
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This title will present all current knowledge of Batten disease from research to clinical evaluation. NCL is not well recognized in underdeveloped countries because the diagnostic technology is lacking. With the information in this volume, however, a specific diagnosis of NCL could be made. Also, specific familial mutations obtained through genetic tests may guide prenatal diagnoses for at-risk families.

Regulators and Effectors of Small GTPases, Part F: Ras Family I

1st Edition
Volume 332
April 3, 2001
John N. Abelson + 1 more
English
Paperback
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The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today, truly an essential publication for researchers in all fields of life sciences.This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325 and 329) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in these aspects of cell biology at the molecular level.

Aquaporins

1st Edition
Volume 51
March 28, 2001
English
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Aquaporins summarizes the present knowledge in this expanding field of research, starting with the structural analysis of water channel proteins. Subsequent chapters begin with mammalian aquaporins, examining physiology and pathophysiology, analysis of knock-out model animals, and the regulation of aquaporin function. Also covered is the distribution and regulation of aquaporins in plants and the function of water and glycerol channels in microbial systems.

The Role of DNA Damage and Repair in Cell Aging

1st Edition
Volume 4
March 9, 2001
B.A. Gilchrest + 1 more
English
Hardback
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Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determin... cellular capacity to repair environmentally-indu... DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging.As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters.This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.

International Review of Cytology

1st Edition
Volume 204
February 22, 2001
English
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International Review of Cytology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Current Topics in Developmental Biology

1st Edition
Volume 51
February 22, 2001
English
Paperback
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In the embryonic stage of a multicellular organism, precise arrangements of different cell types arise. These cell types eventually become the tissues and organs of the organism if it is an animal, for instance. Developmental biology is the study of this process in both plants and animals and covers the entire development stage of the organism.Current Topics in Developmental Biology provides a comprehensive survey of the major topics in this rapidly advancing field. The volumes are valuable to researchers in animal and plant development as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. With over thirty years of publication, this series is the longest-running forum for contemporary issues in developmental biology.

Hypertheromphilic Enzymes, Part A

1st Edition
Volume 330
February 8, 2001
English
eBook
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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymologyis one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.This volume and its companions (Volumes 31 and 334) cover all current knowledge concerning hyperthermophilic enzymes. Major topics in this volume include enzyme discovery, saccharolytic enzymes, and proteolytic enzymes.

Regulators and Effectors of Small GTPases, Part E: GTPases Involved in Vesicular Traffic

1st Edition
Volume 329
January 25, 2001
English
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eBook
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Small GTPases play a key role in many aspects of contemporary cell biology: control of cell growth and differentiation; regulation of cell adhesion and cell movement; the organization of the actin cytoskeleton; and the regulation of intracellular vesicular transport.This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in these aspects of cell biology at the molecular level.

Genomic Regulatory Systems

1st Edition
January 24, 2001
Eric H. Davidson
English
eBook
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The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist.

The Oncobiology of the Prostate

1st Edition
Volume 3
December 20, 2000
D.P. Wood + 1 more
English
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Prostate cancer (PCa) is the most common newly diagnosed cancer among men in the United States today. With the advent of the prostate-specific antigen (PSA) test, the number of newly diagnosed cases has increased tremendously. The rates of PCa have increased so dramatically over the last decade that the age-adjusted incidence rate of PCa is no greater than that for any other cancer among men in the United States. Although PCa rates have risen steadily since 1973, there has been a dramatic acceleration in the late 1980s which has been associated with the introduction and use of PSA for screening and early detection. There is now some evidence that the rates may be levelling off and even decreasing in some areas. After lung cancer, PCa is the leading cause of death due to cancer in men in the United States. Although PCa can occur in younger men, it is essentially a cancer of elderly men. The highest rates of PCa in the world occur among African-American men in the United States. African-Americans have higher rates than Caucasians at all age levels in the United States, and adjusting for social-economic status does not appear to account for this difference to any appreciable extent. There is no clear reason why PCa rates are so much greater among African-Americans compared with Caucasians in the United States. The reported rates in Africans are substantially lower than those of an African-American, suggesting that environmental factors have an influence on PCa. In spite of this substantial impact on our society. PCa remains a relatively understudied disease, with an essentially unknown etiology. The reviews contained in this book are by no means exhaustive. We have, however, attempted to provide information regarding the pathology of prostate cancer, the status of diagnostic and prognostic markers, as well as a discussion of our understanding of the molecular basis for the disease. The biology of prostate cancer is covered with a discussion on the role of apoptosis in prostate cancer and the suggestion of it being the target for new therapeutic development, as well as the role played by integrins and angiogenesis. The status of current therapies, both hormonal and chemotherapy, are also discussed. This volume should provide a useful background for individuals wishing to commence an in-depth understanding of prostate cancer.

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