LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code needed.
Genomic Regulatory Systems
In Development and Evolution
- 1st Edition - January 24, 2001
- Author: Eric H. Davidson
- Language: English
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 2 5 5 9 - 4
The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteThe interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist.
* Contents Include
* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution
* Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression
* Regulation of Direct Cell-Type Specification in Early Development
* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution
* Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression
* Regulation of Direct Cell-Type Specification in Early Development
* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Students and professionals in biology, cell biology, and molecular biology.
Preface
1. Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and its Causal Role in Development and Evolution
The Regulatory Apparatus Encoded in the DNA
The Genes and Gene Regulatory Components of Animal Genomes
Overview of Regulatory Architecture
Gene Regulatory Functions in Development
The Regulatory Demands of Development
Pattern Formation
Terminal Differentiation
Genomic Regulatory Sequence and the Evolution of Morphological Features
Regulatory Evolution, and Evolution in General
Bilaterian Phylogeny
2. Inside the cis-Regulatory Module: Control Logic, and How Regulatory Environment is Transduced into Spatial Patterns of Gene Expression
Operating Principles for cis-Regulatory Systems that Mediate Developmental Specification Events
Spatial Repression in cis-Regulatory specification
Two Very Different Examples of Similar Import
cis-Regulatory Design for Autonomous Modular Function
The Generality of Repression
Downstream of Specification
Some Examples
At the Beginning of Embryogenesis
Polyfunctional Downstream Modules
The "Power" of the cis-Regulatory Module
Diverse cis-Regulatory Outputs from a Simple Input
Direct Integration of Noncoincident Spatial Inputs
A cis-Regulatory Logic Device
3. Regulation of Direct Cell-Type Specification in Early Development
The Basic Package for Bilaterian Embryogenesis: Type 1 Specification Processes
Regulatory Mechanism in Territorial Specification of the Sea Urchin Embryo
The Definitive Territories of the Embryo
Early Transcriptional Activation of Cell Type-specific Genes
Initial Regulatory Processes
Multiple Inputs for Endomesoderm Specification
Regulatory Mechanisms Controlling Specification in Ascidian Embryos
Territorial Specification
Mechanisms and Pathways in Mesoderm Specification
Caenorhabditis elegans: The Genomic Apparatus for Endoderm Specification
Endoderm Specification
The Network of Zygotic cis-Regulatory Interactions Required for Endoderm Specification
Short Summary: Quality of Type 1 Regulatory Networks
4. The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
The Evolutionary Significance of "Pattern Formation"
The First Step: Transcriptional Definition of the Domain of the Body Part
Morphological Pieces and Regulatory Subpatterns
Heart Parts
Forelimb and Hindlimb Buds
Transcriptional Domains in the Gut Endoderm
Patterns in the Developing Hindbrain
Appendage Parts and Transcriptional Patterns in Drosophila Imaginal Discs
Glimpses of How It Works
Transcriptional Domains and the Pattern Program for the Drosophila Wing Disc: Modularity and cis-Regulatory Inputs
Patterning the Heart Progenitor Field in Drosophila
Encoding Hindbrain Regulatory Patterns
The Role of Signaling
The Last Routines: Calling in Differentiation Programs
Specification of Peripheral Nervous System Elements in the Drosophila Wing
Installation of Cell Type-specific Differentiation Programs in the Pituitary
Concluding Remark
5. Changes that Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Some Examples: Evolutionary Cooption of Genes to New Pattern Formation Functions
hox Gene Functions and Cooptions of the hox Cluster Patterning System
A Specific Case of A/P Patterning: How a box Gene Does its Job
Evolutionary Changes in box Gene Expression in the Arthropods
Off the A/P Axis
Colinear Expression of box Genes in the Somatocoels of Sea Urchin Larvae
Small Changes
Evolutionary Origins of Body Parts
Polarity in Body Part Evolution
The Case of pax6 and Some Other Amazing Examples
Concluding Comment: Conceiving Evolution as a Process of Change in Regulatory Gene Networks
References
Index
- No. of pages: 261
- Language: English
- Edition: 1
- Published: January 24, 2001
- Imprint: Academic Press
- eBook ISBN: 9780080525594
ED
Eric H. Davidson
Isabelle S. Peter is Assistant Research Professor and Eric H. Davidson is Norman Chandler Professor of Cell Biology in the Division of Biology and Biological Engineering at the California Institute of Technology, Pasadena, California. Over the last seven years they have co-authored a series of works on experimental, conceptual and computational analyses of developmental gene regulatory networks, including their evolutionary significance. The discussions and conceptual explorations occasioned by this collaboration produced the new synthetic views encompassed in this book, building on decades of earlier work summarized in the 2001 and 2006 Academic Press books by Eric H. Davidson.
Affiliations and expertise
Norman Chandler Professor of Cell Biology, California Institute of Technology, Pasadena, CA, USARead Genomic Regulatory Systems on ScienceDirect