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Elsevier

Books in Cellular biology

  • In Vitro Methods in Cell-Mediated Immunity

    • 1st Edition
    • Barry R. Bloom + 1 more
    • English
    In Vitro Methods in Cell-Mediated Immunity focuses on methods for approaching cell-mediated immune responses in vitro. This book provides, in simplified in vitro systems, a basis for understanding the mechanism of the in vivo response and discusses useful and reliable in vitro tests for cell-mediated immune responses in humans, where in vivo testing is often not possible. The topics discussed include factors and activities produced in vitro by lymphocytes; biological implications of in vitro phenomena; and requirements and prospects for improved methodology. The leucocyte migration technique for in vitro detection of cellular hypersensitivity in man; proliferation of human blood lymphocytes stimulated by antigen in vitro; and virus plaque assay for antigen-sensitive are also elaborated in this text. This publication is a good reference for microbiologist and immunologists, including medical students researching on in vitro models for cell-mediated immune reactions.

  • From Metabolite, to Metabolism, to Metabolon

    • 1st Edition
    • Volume 33
    • Earl R. Stadtman + 1 more
    • English
    Current Topics in Cellular Regulation, Volume 33: From Metabolite, to Metabolism, to Metabolon is a collection of articles on the study of the machinery of the living cell. The book is also a tribute to Paul Srere, an eminent biochemist, on the occasion of his sixty-fifth birthday. The book contains contributions written by students, postdoctoral fellows, and biochemists within Paul Srere's broad sphere of influence. The text provides articles that discuss topics on cellular infrastructure and metabolic organization; how carbohydrates cross the lipid membrane of bacterial cells; and macromolecular processes. The structural aspects of citrate biochemistry; the electron transport systems; nucleotide biosynthesis; enzyme organization and the direction of metabolic flow; and bioengineering applications are tackled as well. Biochemists, cytologists, and cell biologists will find the book very insightful.

  • Search and Discovery

    A Tribute to Albert Szent-Györgyi
    • 1st Edition
    • Benjamin Kaminer
    • English
    Search and Discovery: Tribute to Albert Szent-Györgyi is dedicated to Albert Szent-Györgyi and stems from a Symposium, ""Search and Discovery,"" held in his honor at Boston University School of Medicine. Szent-Györgyi, born in Budapest on September 16, 1893, established the Institute for Muscle Research at the Marine Biological Laboratory in 1947. His influence and impact extend beyond the confines of the laboratory. Throughout his life he was intensely concerned with the serious problems of mankind. He opposed Hitler and Stalin, and was outspoken against the involvement of the U.S. Government in the Vietnam War. Starting with recollections of Albert Szent-Györgyi by John T. Edsall of Harvard University, the remainder of the text is organized into six parts that cover the fields of Szent-Györgyi’s major contributions and interests: metabolism, vitamin C, molecular mechanisms of muscle contraction, submolecular biology and cell growth, and cancer; the social interrelations of science were also not neglected. These milestones form the basis of this volume.

  • Regulated Cell Death Part A

    Apoptotic Mechanisms
    • 1st Edition
    • Volume 544
    • Avi Ashkenazi + 2 more
    • English
    Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches.

  • Quantitative Imaging in Cell Biology

    • 1st Edition
    • Volume 123
    • English
    This new volume, number 123, of Methods in Cell Biology looks at methods for quantitative imaging in cell biology. It covers both theoretical and practical aspects of using optical fluorescence microscopy and image analysis techniques for quantitative applications. The introductory chapters cover fundamental concepts and techniques important for obtaining accurate and precise quantitative data from imaging systems. These chapters address how choice of microscope, fluorophores, and digital detector impact the quality of quantitative data, and include step-by-step protocols for capturing and analyzing quantitative images. Common quantitative applications, including co-localization, ratiometric imaging, and counting molecules, are covered in detail. Practical chapters cover topics critical to getting the most out of your imaging system, from microscope maintenance to creating standardized samples for measuring resolution. Later chapters cover recent advances in quantitative imaging techniques, including super-resolution and light sheet microscopy. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come.

  • International Review of Cell and Molecular Biology

    • 1st Edition
    • Volume 311
    • Kwang W. Jeon
    • English
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2012: 4.973.

  • Cell-wide Metabolic Alterations Associated with Malignancy

    • 1st Edition
    • Volume 543
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods providing a a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.

  • The Role of Chromosomes in Development

    • 1st Edition
    • Michael Locke
    • English
    The Role of Chromosomes in Development is a collection of papers that deals with structural patterns and functional organization of chromosomes. Some papers discuss chromosomal proteins, DNA replication sequences in higher animals, and the implications of localized DNA synthesis in polytene chromosomes. Several papers describe chromosomal RNA, nuclear RNA fractions, genetic control, and the regulation of developmental pathways. One paper concerns the "bithorax" series that controls the development of certain body segments of the fly in a polarized and coordinated manner reminiscent of the genes in the operons of microorganisms. The bithorax genes evidently exploit and amplify a gradient arising from an anteroposterior gradient during mitotic division rates. The bithorax genes produces a whole set of new substances that repress certain systems of cellular differentiation, letting other systems to emerge and develop. Another paper investigates the hypothesis of diploid subnuclei as the architectural subunit of the ciliate macronucleus, as well as the hypothesis of "allelic repression" as the basis for certain examples of subnuclear differentiation. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology.

  • Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism

    • 1st Edition
    • Volume 542
    • English
    Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.

  • Stem Cells

    Scientific Facts and Fiction
    • 2nd Edition
    • Christine L. Mummery + 3 more
    • English
    The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies.

  • Development and Differentiation in the Cellular Slime Moulds

    Proceedings of the International Workshop Held at Porto Conte, Sardinia on 12—16 April, 1977
    • 1st Edition
    • P. Cappuccinelli + 1 more
    • English
    Developments in Cell Biology, Volume 1: Development and Differentiation in the Cellular Slime Moulds is a collection of papers from the proceedings of the International Workshop held at Porto Conte, Sardinia on April 12-16, 1977. This collection of papers deals with a single group of organisms, the cellular slime molds, particularly with Dictyostelium discoideum. Dictyostelium is dealt, firstly, according to cell differentiation and pattern formation common in this type of organism. These examples are further explored in the Dictyostelium discoideum slug, through the control of morphogenesis. Further research shows that two compounds, 3'5' cyclic AMP and NH3, can affect the course of morphogenesis in D. discoideum. Techniques for cell fusion and mutation induction in D. discoideum, especially as a result of DNA damage following radiation and chemicals, are analyzed. Other studies show that formation and maintenance of stable contacts between cells appear to be necessary for the normal cell cycle involved in the growth of D. discoideum. The changes in plasma membrane protein analyzed using SDS-polyacrylamide gel electrophoresis are examined. Results show that detection and quantitation of tubulin in Dictyostelium discoideum is important when studying the differentiation processes of a wide range of cellular activities. Because many D. discoideum mutants fail to reach proper development, the method for selecting the aggregation of defective mutants of D. discoideum is emphasized. This book is of interest to those whose work involves these organisms and to researchers, professors, and students whose disciplines are in Developmental Biology or Mycology.

  • Subcellular Components

    Preparation and Fractionation
    • 2nd Edition
    • G. D. Birnie
    • English
    Subcellular Components: Preparation and Fractionation talks about cells and particles' components, including their preparation and fractionation. The book includes theories and answers to questions that are relevant to the study. The first chapter of the book details various facts about homogenization of mammalian cells. This chapter presents the results of studies on solid tissues and single-cell suspensions; the author then offers his conclusion of the study. The next two chapters highlight the methods on isolating nuclei, including the guides for standard assessment and the procedure of isolation, along with analysis of nuclei biochemical properties. The main topics in Chapter 4 are mitochondria from animal tissues and yeasts; this chapter also discusses the preparation for a rat-liver, blowfly flight-muscle, yeast, and brain mitochondria. The chapter that follows widely talks about lysosomes, including its historical background, centrifugal method, and related topics. In the next several chapters, the topics covered include purification, isolation, preparation, and separation of cells including plasma-membrane, polysomes, ribosomes, microsomes, and microvilli. The book serves as a great reference for undergraduates and postgraduates in the field, as it contains a thorough discussion of various relevant studies.

  • Mammalian Cell Membranes

    General Concepts
    • 1st Edition
    • G. A. Jamieson + 1 more
    • English
    Mammalian Cell Membranes, Volume 1: General Concepts is a collection of papers that deals on the physical and chemical studies focusing on membrane structure and function. This collection reviews the interpretation of the anatomy of the mammalian cell, including its separation and cultivation. The different methods of isolation of its surface membrane are then evaluated to bring some understanding of the subject. More descriptions of the various physical techniques adopted to membrane constituents and to cell membrane research, such as nuclear magnetic resonance, electron spin resonance, fluorescence, and flash photolysis spectroscopy are given. Discoveries of mitochondrial DNA and other techniques have increased investigation of the synthesis and components of functional mitochondria, leading to different perspectives on models of membrane structure. This book can serve the needs of biochemists and microbiologists in advancing their work, research, and understanding of mammalian cell membranes.

  • Nuclear Pore Complexes and Nucleocytoplasmic Transport - Methods

    • 1st Edition
    • Volume 122
    • English
    Volume 122 of Methods in Cell Biology describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (including mammalian cells, Xenopus, C. elegans, yeast). The volume enables investigators to analyze nuclear pore complex structure, assembly, and dynamics; to evaluate protein and RNA trafficking through the nuclear envelope; and to design in vivo or in vitro assays appropriate to their research needs. Beyond the study of nuclear pores and transport as such, these protocols will also be helpful to scientists characterizing gene regulation, signal transduction, cell cycle, viral infections, or aging. The NPC being one of the largest multiprotein complexes in the cell, some protocols will also be of interest for people currently characterizing other macromolecular assemblies. This book is thus designed for laboratory use by graduate students, technicians, and researchers in many molecular and cellular disciplines.

  • Cellular Immunology LabFax

    • 1st Edition
    • English
    LABFAX volumes are purpose-designed data reference books for practicing scientists. Each book presents the key information for a major subject in one place and so saves hours of searching. The authors and editors of each LABFAX volume have searched the original literature for the accurate data they know the subject specialist needs.Cellular Immunology Labfax is a detailed compendium of information on the tissues and cells of the immune system, cell lines and hybridomas, antigens and receptors, the major histocompatibility complex, soluble immunoregulatory molecules, in vivo procedures, important features of species used in immunological research, and much more.The contents of Cellular Immunology Labfax have been carefully chosen to complement the data presented in Immunochemistry Labfax. It is therefore the companion volume to this text.

  • Cellular Pathology Technique

    • 4th Edition
    • C. F. A. Culling + 2 more
    • English
    Cellular Pathology Technique aims to maintain the twin objectives of producing a comprehensive bench book and a text for students that will take the Special Examination in Cellular Pathology of the Institute of Medical Laboratory Sciences. The organization of this fourth edition has been reshaped. Some sections were expanded such as those about the theory of staining, and new chapters were added dealing with immunolocalization, the endocrine system, and quantification. This book is organized into 10 parts. The introductory part provides basic information on cells and tissues and outlines the methodology in cellular pathology techniques. This is followed by chapters that deal with various aspects of cellular pathology including tissues, cells and cell products of special interests, electron microscopy, and immunocytochemistry. This book will be of interest to students of cellular pathology and those in the medical profession.

  • Cell Biology of the B Cell Receptor

    • 1st Edition
    • Volume 123
    • Hidde Ploegh
    • English
    Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

  • Control of Energy Metabolism

    • 1st Edition
    • Britton Chance + 2 more
    • English
    Control of Energy Metabolism: A Colloquium of the Johnson Research Foundation focuses on the processes, reactions, and approaches involved in the control of energy metabolism. The selection first offers information on the respiratory chain as a model for metabolic control in multi-enzyme systems, dynamics and control in cellular reactions, and computer-based analysis of biochemical data. The text then explores purification and properties of rabbit skeletal muscle phosphofructokinase; multiple forms of heart phosphofructokinase; and mechanisms of inhibition and activation of phosphofructokinase in Novikoff ascites tumor cells. Discussions focus on the properties of purified phosphofructokinase; effect of heart extracts on reactivation of phosphofructokinase; active and inactive forms of phosphofructokinase; and effect of hexose phosphate and adenylic nucleotides on reactivation of phosphofructokinase. The manuscript takes a look at enzyme and metabolite profiles; coordinated stimulation of hexokinase and phosphofructokinase by phosphate in a reconstituted system of glycolysis; control of hexokinase in ascites tumor glycolysis; and cation flux across the mitochondrial membrane as a possible pacemaker of tissue metabolism. The selection is a vital reference for biochemists and researchers interested in the control of energy metabolism.

  • Normal and Malignant Cell Growth

    Recent Results in Cancer Research: Fortschritte der Krebsforschung, Progrès dans les Recherches sur le Cancer
    • 1st Edition
    • R. J. M. Fry + 2 more
    • English
    Normal and Malignant Cell Growth is a compendium of papers from the "Proceedings of the Third Cancer Training Grant" of the University of Chicago that deals with the processes associated with malignant neoplasia, as well as the cell proliferation kinetics of normal tissues. One paper presents the techniques used in the study on the proliferation kinetics of hemopoietic stem cells, suggesting that the hemopoietic stem cell population is not homogenous but consists of a "primitive pluripotential stem cell." A series of experiments at the Brookhaven National Laboratory investigates the relationship of cell survival, specifically that of stem cells, to the survival of the irradiated test animal. One result of the experiment shows a rapid migration of a number of stem cells from shielded marrow into unshielded marrow at the pressure of a rapid circulating pool. The numbers of stem cells are somewhat dependent on the dose given to the unshielded marrow, and are greater with the greater dose. Another paper also investigates the four methods that are used in the study of cellular kinetics in human tumors. This compendium can prove helpful for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

  • Recombinant DNA Laboratory Manual

    • 1st Edition
    • Judith W. Zyskind + 1 more
    • English
    Recombinant DNA Laboratory Manual is a laboratory manual on the fundamentals of recombinant DNA techniques such as gel electrophoresis, in vivo mutagenesis, restriction mapping, and DNA sequencing. Procedures that are useful for studying either prokaryotes or eukaryotes are discussed, and experiments are included to teach the fundamentals of recombinant DNA technology. Hands-on computer sessions are also included to teach students how to enter and manipulate sequence information. Comprised of nine chapters, this book begins with an introduction to bacterial growth parameters, how to measure bacterial cell growth, and how to plot cell growth data. The discussion then turns to the isolation and analysis of chromosomal DNA in bacteria and Drosophila; plasmid DNA isolation and agarose gel analysis; and introduction of DNA into cells. Subsequent chapters deal with Tn5 mutagenesis of pBR329; DNA cloning in M13; DNA sequencing; and DNA gel blotting, probe preparation, hybridization, and hybrid detection. The book concludes with an analysis of lambda phage manipulations. This manual is intended for advanced undergraduate or beginning graduate students and should also be helpful to established investigators who are changing their research focus.

  • The Cell: Supplementary Volume

    Biochemistry, Physiology, Morphology
    • 1st Edition
    • Jean Brachet + 1 more
    • English
    The Cell: Biochemistry, Physiology, Morphology, Volume VI: Supplementary Volume focuses on the advancements of processes, technologies, and approaches employed in studies on the structure and functions of cells. The selection first offers information on the cytoplasm of Protozoa, fungi, and the aspects of the form and function of plant cells. Topics include special structures, basic genetics, physiology, life cycles and sexuality, special fungal genetics, basal bodies or kinetosomes, mitochondria, and symbiotes in Protozoa. The text then elaborates on sensory and connective tissue cells.Discussions focus on some catabolic processes of connective tissues, formation and cytology of connective tissues, nature of the extracellular constituents, and pseudosensory, neurosensory, and true sensory cells. The selection is a vital reference for researchers interested in the biochemistry, physiology, and morphology of cells.

  • The Cell Surface: Mediator of Developmental Processes

    • 1st Edition
    • Stephen Subtelny + 1 more
    • English
    The Cell Surface: Mediator of Developmental Processes contains the papers presented at the 38th Symposium of the Society for Developmental Biology, held at the University of British Columbia in Vancouver, Canada in June 1979. The compendium is divided into three parts. The first part provides a summary of the status of the knowledge about the cell surface, which includes the plasma membrane, its associated cytoskeleton and the variety of surface-associated macromolecules. The second portion focuses on the early development of the cell surface. A wide spectrum of techniques, systems, and results in the study of the cell surface are presented. The last part shows a variety of experimental systems in which the cell surface figures prominently in important developmental events. The results from experiments on plant symbiosis, mammalian teratocarcinomas, adhesion and cell shape, and various extracellular macromolecules are detailed extensively. Cytologists, microbiologists, biologists, and other scientists in allied fields will find the publication very insightful.

  • Molecular and Cellular Aspects of Muscle Function

    Proceedings of the 28th International Congress of Physiological Sciences Budapest 1980, (including the proceedings of the satellite symposium on Membrane Control of Skeletal Muscle Function)
    • 1st Edition
    • E. Varga + 2 more
    • English
    Advances in Physiological Sciences, Volume 5: Molecular and Cellular Aspects of Muscle Function covers the proceedings of the 28th International Congress of Physiological Sciences, held in Budapest in 1980 (including the proceedings of the satellite symposium on Membrane Control of Skeletal Muscle Function). The book focuses on the molecular and cellular facets of skeletal muscle function. The selection first offers information on the mechanical properties of cross-bridges and their relation to muscle contraction; molecular basis of functional specialization in muscle as induced by innervation; and electrical properties of crustacean muscle membranes. The text then ponders on contractile protein isoforms in developing muscle; effect of age and exercise on minced gastrocnemius muscle regeneration; and contractile proteins of rat gastrocnemius during its regeneration after mincing. The publication examines the behavior of myosin projections in frog striated muscle during isometric contraction; energetics of contracting muscle and its relation to crossbridge mechanisms; and time course of chemical change and energy production during contraction of frog skeletal muscle. The physiological analysis of human myopathy and adaptation in normal and diseased muscle are also discussed. The selection is a vital source of data for readers interested in the cellular and molecular aspects of muscle function.

  • Exchangers

    • 1st Edition
    • Volume 73
    • English
    Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in understanding the current state and future prospects of a particular field. This volume on exchangers, in conjunction with a previous volume on cotransporters (volume 70), represents an up-to-date, systematic, and comprehensive review of all the major secondary active carrier proteins responsible for the absorption, secretion, and general transport of ions and solutes in mammalian organ systems and additional species. Each chapter is devoted to a specific transporter or a grouping of related transporters based on the well-recognized nomenclature of the SoLute Carrier (SLC) gene family. This book provides readers with the latest mechanistic information on the function and structure of specific transporters, as well as their history and physiological significance.

  • International Review of Cell and Molecular Biology

    • 1st Edition
    • Volume 310
    • Kwang W. Jeon
    • English
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2012: 4.973.

  • Reconstituting the Cytoskeleton

    • 1st Edition
    • Volume 540
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers cytoskeletal structure, including such topics as rotational movement of formins studied by fluorescence polarization microscopy, in vitro assembly assays for bacterial actin filaments, and modulators of microtubule plus end growth.

  • Cancer

    Oxidative Stress and Dietary Antioxidants
    • 1st Edition
    • Victor R. Preedy
    • English
    Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this. Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.

  • Micropatterning in Cell Biology, Part C

    • 1st Edition
    • Volume 121
    • English
    This new volume of Methods in Cell Biology looks at micropatterning in cell biology and includes chapters on protein photo-patterning on PEG with benzophenone, laser-directed cell printing and dip pen nanolithography. The cutting-edge material in this comprehensive collection is intended to guide researchers for years to come.

  • Cellular Endocrinology in Health and Disease

    • 1st Edition
    • Alfredo Ulloa-Aguirre + 1 more
    • English
    Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. Among these are those whose function was not obvious until recently, including the endocrine functions of bone and the adipose tissue. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and P. Michael Conn, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts.

  • International Review of Cell and Molecular Biology

    • 1st Edition
    • Volume 309
    • Kwang W. Jeon
    • English
    International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology, both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Methods of Adipose Tissue Biology Part A

    • 1st Edition
    • Volume 537
    • English
    Methods of Adipose Tissue Biology is a must-have for anyone interested in obesity or the physiology of white or brown adipose tissues. It contains state-of-the-art methods from researchers who are world leaders in this field. Detailed lab protocols include methods to visualize adipocytes and adipose tissues in humans and experimental models, converting stem cells into white and brown adipocytes in vitro, evaluating aspects of adipocyte metabolism, inducibly knocking out genes in adipose tissues, and evaluating transcriptional control of adipogenesis on a global scale.

  • Micropatterning in Cell Biology, Part B

    • 1st Edition
    • Volume 120
    • English
    This new volume of Methods in Cell Biology is the second volume describing micropatterning, complementing Volume 120. Chapters are written by experts in the field and include cutting-edge material.

  • Micropatterning in Cell Biology, Part A

    • 1st Edition
    • Volume 119
    • English
    This new volume of Methods in Cell Biology looks at micropatterning in cell biology and includes chapters on protein photo-patterning on PEG with benzophenone, laser-directed cell printing and dip pen nanolithography. The cutting-edge material in this comprehensive collection is intended to guide researchers for years to come.

  • Stem Cells in Development and Disease

    • 1st Edition
    • Volume 107
    • English
    This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging

  • International Review of Cell and Molecular Biology

    • 1st Edition
    • Volume 308
    • Kwang W. Jeon
    • English
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2012: 4.973.

  • Toxicogenomics-Based Cellular Models

    Alternatives to Animal Testing for Safety Assessment
    • 1st Edition
    • Jos Kleinjans
    • English
    Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing.

  • Endosome Signaling Part B

    • 1st Edition
    • Volume 535
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the second of two volumes on endosome signaling and includes chapters on such topics as measurement of entry into the endosomal compartment by multi-parametric image analysis, assessment of peptide internalization and endosomal signaling, and VEGF-A in endosomal signaling.

  • Endosome Signaling Part A

    • 1st Edition
    • Volume 534
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of two volumes on endosome signaling and includes chapters on such topics as measurement of entry into the endosomal compartment by multi-parametric image analysis, assessment of peptide internalization and endosomal signaling, and VEGF-A in endosomal signaling.

  • Light and Video Microscopy

    • 2nd Edition
    • Randy O. Wayne
    • English
    The purpose of this book is to provide the most comprehensive, easy-to-use, and informative guide on light microscopy. Light and Video Microscopy will prepare the reader for the accurate interpretation of an image and understanding of the living cell. With the presentation of geometrical optics, it will assist the reader in understanding image formation and light movement within the microscope. It also provides an explanation of the basic modes of light microscopy and the components of modern electronic imaging systems and guides the reader in determining the physicochemical information of living and developing cells, which influence interpretation.

  • Cell Press Reviews: Stem Cells to Model and Treat Disease

    • 1st Edition
    • Cell Press
    • English
    Cell Press Reviews: Stem Cells to Model and Treat Disease informs, inspires, and connects stem cell researchers and clinicians at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publication offers a broad view of some of the most compelling topics in stem cell research including: Safety and efficacy of stem cell treatments Stem-cell-based organ regeneration Integrating stem cells into personalized drug discovery Using pluripotent stem cells for treating neurological disease Engineering hematopoietic stem cells for innovative therapies Contributions come from leading voices in the field, including:- Shinya Yamanaka, Recipient of the 2012 Nobel Prize for Physiology or Medicine, Recipient of the 2012 Millennium Technology Prize, Professor and Director of the Center for iPS Cell Research and Application at Kyoto University, Senior Investigator at the Gladstone Institute of Cardiovascular Disease, L.K. Whittier Foundation Investigator in Stem Cell Biology and Professor at the University of California, San Francisco- George Q. Daley, Samuel E. Lux IV Professor of Hematology/Oncology at Harvard Medical School and Director for the Stem Cell Transplantation Program at Boston Children’s Hospital- Irving Weissman, Member of National Academy of Sciences, Virgina & D.K Ludwig Professor for Clinical Investigation in Cancer Research, and Director for Institute of Stem Cell Biology and Regenerative Medicine at Stanford University of Medicine Cell Press Reviews: Stem Cells to Model and Treat Disease is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.

  • Cell Press Reviews: Core Concepts in Cell Biology

    • 1st Edition
    • Cell Press
    • English
    Written by leading cell biologists and curated by Cell Press editors, reviews in the Cell Press Reviews: Core Concepts in Cell Biology publication informs, inspires, and connects cell biologists at all stages in their careers with timely, comprehensive insight into the most recent exciting developments across cell biology and hot topics within core areas of the field including: Signaling mechanisms and membrane biology Cytoskeletal self-organization and cell polarity Organelle dynamics and biogenesis Morphogenesis and cell motility Chromatin and genome organization in nuclear function Contributions come from leading voices in cell biology, who are defining the future of their field, including:- Tom Misteli, National Cancer Institute - Galit Lahav, Harvard Medical School - Scott D. Emr, Cornell University - David G. Drubin, University of California, Berkeley - Tom Rapoport, Harvard Medical School - Anthony A. Hyman, Max Planck Institute of Molecular and Cell Biology, Dresden This publication is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.

  • Methods for Analysis of Golgi Complex Function

    • 1st Edition
    • Volume 118
    • English
    This new volume of Methods in Cell Biology looks at methods for analyzing of golgi complex function. Chapters cover such topics as in vitro reconstitution systems, fluorescence-based analysis of trafficking in mammalian cells and high content screening. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come.

  • Inhibitors of the Ras Superfamily G-proteins, Part B

    • 1st Edition
    • Volume 34
    • English
    Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins.

  • Functional Organization of Vertebrate Plasma Membrane

    • 1st Edition
    • Volume 72
    • English
    Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume covers recent breakthroughs in understanding the molecular and cellular basis for patterning vertebrate plasma membranes. A special emphasis is placed on physiological function with chapters covering signaling in the nervous system and heart, vision, and the immune system.

  • Atlas of Human Anatomy

    Splanchnology · Ductless Glands · Heart
    • 17th Edition
    • Ferenc Kiss + 1 more
    • English
    Atlas of Human Anatomy, Volume Two compiles illustrations that categorize the anatomy of the human body. This book is divided into five main topics. The first three topics focus on three systems of the body—digestive system, respiratory system, and urogenital system. Some of the organs identified in the digestive system include the salivary glands, pharynx, esophagus, stomach, small intestine, large intestine, and rectum. The parts of the respiratory system, such as the nose, nasal cavity, larynx, trachea, and lungs are also cited. The anatomy of the urogenital system that consists of the reproductive organs and urinary system are likewise named. The last two topics distinguish the structure of the ductless glands and heart. This volume is recommended for medical students and clinicians conducting work on the human anatomy.

  • Advances in Cellular Neurobiology

    Volume 4
    • 1st Edition
    • Sergey Fedoroff + 1 more
    • English
    Advances in Cellular Neurobiology, Volume 4 focuses on the central nervous system. This book is divided into three main sections—cell differentiation and interaction, aging and pathology, and methodologies. The topics discussed include advances in the neurobiology of oligodendroglia; neuronal differentiation in reaggregate cell cultures; and morphological aspects of brain edema. The cell biological aspects of Down's syndrome; isolation and culture of cells of the dorsal root ganglia; and growth requirements of neural cells in vitro are also deliberated in this text. This publication is intended for neurologists, but is also beneficial to students researching on the anatomy and functional relation of the brain and spinal cord.

  • Estuarine variability

    • 1st Edition
    • Douglas A. Wolfe
    • English
    Estuarine Variability illustrates particular aspects of research related to estuarine variability. This book discusses geographic variability, temporal variability, process variability, spatial variability, and modeling of estuarine variability. Examples around the globe that illustrate the sources and nature of variability exhibited by estuarine systems are also described in detail. This compilation emphasizes various approaches that capture important aspects of spatial and temporal variability in models that can guide estuarine management decisions and focus further research. The differences that appear at various times within estuaries, or that exist among estuaries at any given time are likewise considered. This text is suitable for researchers and specialists conducting work in the field of estuarine research.

  • Extracellular Matrix Assembly and Structure

    • 1st Edition
    • Peter D. Yurchenco
    • English
    The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix.

  • Atlas of Human Tumor Cell Lines

    • 1st Edition
    • Robert K.M. Hay + 2 more
    • English
    Human tumor cells in culture are valuable for studying cancer causes and properties. This convenient reference provides useful information for cancer researchers on commonly used, established tumor cell lines of the major human organ systems.Atlas of Human Tumor Cell Lines includes data about morphological, metabolic, genetic, and growth characteristics of human tumor cells, with morphological characteristics presented in more than 250 photomicrographs. It also contains information for establishing and maintaining human tumor cell lines in culture, and each chapter covers future perspectives.

  • New Protein Foods

    Animal Protein Supplies
    • 1st Edition
    • Aaron M. Altschul
    • English
    New Protein Foods Volume 3: Animal Protein Supplies Part A reviews issues, states questions, and proposes answers with regard to the supplies of animal protein for human consumption. The text is divided into four parts. Part I deals with the issues on animal protein supplies and the trends in human population, food, and income. Part II covers topics such as the evolution of animal protein in the human diet, the competition between animals and man for agricultural resources, and the energy cost of food production by animals. Part III focuses on marine animals and includes topics such as the progress and prospects of fish farming as well as marine invertebrates. Part IV tackles related technologies such as the use of amino acids as supplement in animal feeds and the application of technology for the preservation of meat products. The book is recommended for biologists, food technologists, and agriculturists who would like to know more about animal proteins as food and the advancements and issues related to it.