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Cancer
Oxidative Stress and Dietary Antioxidants
- 1st Edition - March 1, 2014
- Editor: Victor R Preedy
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 0 5 2 0 5 - 5
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 0 2 6 7 - 1
- eBook ISBN:9 7 8 - 0 - 1 2 - 4 0 5 5 2 4 - 7
Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the poten… Read more
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Request a sales quoteCancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this.
Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.
- Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease
- Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments
- Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams
- Nutritionists and dietitians will gain an understanding of cell signaling, and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods
Nutritionists, dieticians, and cancer researchers
Preface
List of Contributors
Section 1 Oxidative Stress and Cancer
Chapter 1. The Role of Oxidative Stress in Breast Cancer
Introduction
Oxidative Stress as a Driver of Breast Cancer Development and Progression
Oxidative Stress Response and Adaptation Mechanisms in Breast Cancer
Interesting Findings, Limitations, and Future Directions
Concluding Remarks
Summary Points
Chapter 2. Oxidative Stress and Prostate Cancer
Introduction
Causes of Oxidative Stress in Prostate Cancer
Role of Oxidative Stress in Pathogenesis of Prostate Cancer
Prostate Cancer Risk Factors and Their Links to Oxidative Stress
Conclusions
Summary Points
Chapter 3. Oxidative Stress in Lung Cancer
Introduction
Lung Cancer
Etiology of Lung Cancer
Tobacco Smoking and Oxidants
Silica and Oxidants
Asbestos and Oxidants
Domestic Cooking and Oxidants
Role of Oxidants in Normal Physiology
Inflammation and Oxidative Stress
Oxidative Stress Leads to DNA Mutations and Lung Cancer
Lipid and Protein Peroxidation
Oxidant/Antioxidant Disequilibrium
Antioxidants and Lung Cancer Chemoprevention
Conclusion
Summary Points
Chapter 4. Oxidative Stress and Stomach Cancer
Introduction
H. pylori and Oxidative Stress
Ethanol
Nonsteroidal Anti-Inflammatory Drugs and Aspirin
Ischemia/Reperfusion Injury
Reactive Oxygen Species
Reactive Nitrogen Species
Antioxidants and Stomach Cancer
Conclusion
Summary Points
Chapter 5. The Role of Oxidative Stress in Ovarian Cancer: Implications for the Treatment of Patients
Introduction
Ovarian Biology
Common Ovarian Cancer Mutations Linked to ROS
Antioxidant Mechanisms in the Ovary
Antioxidant Therapies, Ovarian Cancer
Conclusion
Summary Points
Chapter 6. Role of Oxidative Stress in Human Papillomavirus-Driven Cervical Carcinogenesis
Introduction
Cervical Cancer
HPV Structure
Oxidative Stress and Cervical Cancer
Concluding Remarks
Summary Points
Chapter 7. Inflammation and Oxidative DNA Damage: A Dangerous Synergistic Pathway to Cancer
Introduction
Oxidative DNA Damage
Role of Inflammation in Induction of Oxidative Stress and DNA Damage Leading to Cancer
Nontargeted Effects, Inflammation, Oxidative Stress and DNA Damage
Radiation-Induced Inflammation
Conclusion
Summary Points
Section 2 Antioxidants and Cancer
Chapter 8. Molecular Approaches Toward Targeted Cancer Therapy with Some Food Plant Products: On the Role of Antioxidants
Introduction
Oxidative Stress and Reactive Oxygen Species (ROS): The “Rusting Disorder”
Oxidative Stress: Definition, Sources, and Chemistry in General
Cancer: Definition and the Impact of Food and Food Habits
Finding out the Culprit: Genome versus Oxidative Stress
Aims of Targeted Cancer Therapy
Cancer Therapeutics by Targeting Antioxidative Mechanisms
ROS-Related Signaling Pathways for Targeted Cancer Therapy
Carotenoids (Beta Carotene and Lycopene)
Grapes
Ginger
Spinach
Future Perspectives
Summary Points
Chapter 9. Oxidative Stress and Antioxidant Herbs and Spices in Cancer Prevention
Introduction
Antioxidants in Diet and Human Health
Dietary Phytochemicals as Antioxidants
Antioxidant Phytochemicals and Cancer Prevention
Terpenoids and Cancer Prevention
Chinese Herbs and Cancer Prevention
Summary Points
Chapter 10. The Indian Blackberry (Jamun), Antioxidant Capacity, and Cancer Protection
Introduction
Extraction and Chemical Composition of Jamun Pulp
Antioxidant Potential of Jamun and Its Components
Antioxidant Activity of Individual Anthocyanidins
Jamun Extracts Inhibit Oxidative DNA Damage
Anticancer Effects of Jamun Bioactives
Efficacy of Jamun in Preventing Estrogen-Mediated Mammary Tumorigenesis
Bioavailability of Berry Bioactives
Availability of Jamun as Functional Foods
Conclusion
Summary Points
Chapter 11. Preventive Effects of Broccoli Bioactives: Role on Oxidative Stress and Cancer Risk
Introduction
Cruciferous Vegetables Intake and Cancer Risk
Antioxidants and Other Bioactive Compounds in Broccoli
Cancer Preventive Mechanisms of Isothyocianates and Indoles
Modulation of Phase I and Phase II Biotransformation Enzymes
Anti-Inflammatory Activity
Stimulation of Apoptosis
Regulation of Estrogen Receptor
Epigenetic Regulation
Other Mechanisms
Role of Broccoli Intake on Markers of Oxidative Stress and Cancer Risk in Human Intervention Studies: The Case of Smokers
Closing Remarks and Conclusions
Summary Points
Chapter 12. Resveratrol and Lycopene in the Diet and Cancer Prevention
Introduction
Resveratrol
Lycopene
Conclusions
Summary Points
Chapter 13. Iron, Oxidative Stress, and Cancer
Introduction
Epidemiological Evidences
Iron Homeostasis and Cancer Development: Mechanistic Views
Summary Points
Chapter 14. Role of Black Chokeberries in Breast Cancer: A Focus on Antioxidant Activity
Oxidative Stress in Breast Cancer
Dietary Antioxidants and Their Role in Cancer
Activity of Black Chokeberries in Breast Cancer
Summary Points
Chapter 15. Curcumin, Oxidative Stress, and Breast Cancer
Introduction
Estrogens (17β-estradiol) and Oxidative Stress
Oxidative Stress
Curcumin as an Antioxidant
Effect of Curcumin on a Multifunctional Nuclear Transcription Factor and Manganese Superoxide Dismutase (MnSOD) Protein Expression
Effects of Curcumin on Lipid Peroxidation
Oxidative Stress and Genomic Instability
Summary Points
Chapter 16. Antioxidant Vitamins and Genetic Polymorphisms in Breast Cancer
Introduction
Effect of Antioxidant Vitamin on Breast Cancer Incidence
Antioxidant Vitamins and Genomic Integrity: Developmental and Degenerative Correlates
Interaction between Genetic Polymorphism and Antioxidant Vitamins on Breast Cancer Risk
Chapter 17. Dietary Antioxidants in Prostate Cancer
Introduction
Dietary Antioxidants
Summary
Review of Main Points
Chapter 18. Curcumin Analogs, Oxidative Stress, and Prostate Cancer
Introduction
Prostate Cancer and Oxidative Stress
Curcumin, Curcuminoids, and Curcumin Analogs
The Potential of Curcumin, Curcuminoids, and Curcumin Analogs as Oxidant Agents in Prostate Cancer
Summary Points
Chapter 19. Oxidative Stress and Inflammatory Factors in Lung Cancer: Role of n-3 PUFAs
Introduction
General Information Concerning EPA and DHA
Conclusions
Summary Points
Chapter 20. Antioxidative Stress Actions of Cocoa in Colonic Cancer
Introduction
Chemopreventive Mechanism of Cocoa Polyphenols in Cultured Colon Cancer Cells
Chemopreventive Mechanism of Cocoa in an In Vivo Model of Colon Cancer
Human Studies
Summary Points
Chapter 21. Green Tea Polyphenols and Reduction of Oxidative Stress in Liver Cancer
Introduction
Oxidative Stress Associated with HCCs
Antitumor Effects of GTPs
Combined Effects of Green Tea and Anticancer Drugs
Metabolism of GTPs in the Human Body
Previous Reports of GTPs and HTLV-1-Associated T-Cell Leukemia (Adult T-Cell Leukemia)
Controversial Results Concerning the Efficacy of GTPs
Summary Points
Chapter 22. Quercetin’s Potential to Prevent and Inhibit Oxidative Stress-Induced Liver Cancer
Introduction
Role of Oxidative Stress in the Development of Liver Cancer
Antioxidants as the Oxidative Stress Scavenger
Summary Points
Chapter 23. Capsaicin Mediated Oxidative Stress in Pancreatic Cancer
Introduction
Apoptotic Pathways
ROS and ETC Complex in the Mitochondria
Thioredoxin and Ask-1 Signaling Pathway
Suppression of Pancreatitis by Capsaicin
Summary Points
Chapter 24. Tocotrienols in Pancreatic Cancer Treatment and Prevention
Introduction
Source of Tocotrienols
Use of Tocotrienols in Cancer
Oxidative Stress in Cancer and the Preventive Role of Tocotrienols
Effect of Tocotrienols in Mediating Cellular Pathways
Tocotrienols in Pancreatic Cancer
In Vitro Data in Pancreatic Cancer
In Vivo Data in Pancreatic Cancer
Conclusion and Future Direction
Summary Points
Chapter 25. Fern Extract, Oxidative Stress, and Skin Cancer
Introduction
Photoprotective Agents
Molecular, Cellular, and Clinical Evidence of Antioxidant Properties of Fernblock®
Potential Use of Fernblock® in the Treatment of Other Pathological Skin Conditions
Fernblock: A Road to (Present and Future) Photoprotection
Summary Points
Chapter 26. Skin Cancer, Polyphenols, and Oxidative Stress
Introduction
Oxidative Stress, Inflammation, and Associated Signal Transduction Pathways: Fundamental Biology, the Alteration, and Counteraction by Polyphenols
ECM Remodeling and Associated Growth Factors: Fundamental Biology, the Alteration, and Counteraction by Polyphenols
Conclusion
Summary Points
Chapter 27. Pterostilbene Protection and Bladder Cancer Cells
Introduction
Pterostilbene
Pterostilbene and Bladder Cancer
Summary Points
Index
Color Plates
- No. of pages: 308
- Language: English
- Edition: 1
- Published: March 1, 2014
- Imprint: Academic Press
- Hardback ISBN: 9780124052055
- Paperback ISBN: 9780128102671
- eBook ISBN: 9780124055247
VP
Victor R Preedy
Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.
Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK Visiting Professor, University of Hull, UKRead Cancer on ScienceDirect