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Cellular Endocrinology in Health and Disease
- 1st Edition - February 12, 2014
- Editors: Alfredo Ulloa-Aguirre, P. Michael Conn
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 0 8 1 3 4 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 4 1 6 7 1 2 - 4
Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases.… Read more
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Request a sales quoteCellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. Among these are those whose function was not obvious until recently, including the endocrine functions of bone and the adipose tissue.
Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and P. Michael Conn, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts.
- Covers systemic endocrine action at the cellular level in both health and disease
- Delivers information on the integration of cell identity and endocrinology
- Incorporates recent developments in endocrinology to provide an up-to-date reference to researchers
Researchers in cell biology, biochemistry, endocrinology, graduate students and researchers across basic sciences and biomedicine
List of Contributors
Preface
Chapter 1. Thyroid Hormone Receptors and their Role in Cell Proliferation and Cancer
Thyroid Hormone Action
TRs and Cancer
Inhibition of Tumor Cell Proliferation by the Thyroid Hormone Receptors
The Thyroid Hormone Receptor Antagonizes Ras-Induced Proliferation
The Thyroid Hormone Receptors Antagonize Transformation and Tumorigenesis by Oncogenic Ras
Functional Domains Involved in TR Antagonism of Ras Responses
TRβ1 Suppresses Tumor Invasion and Metastasis
Hypothyroidism Retards Tumor Growth but Increases Metastasis Development
Divergent Effects of TRs on Normal and Transformed Cell Proliferation
Acknowledgements
References
Chapter 2. The Molecular Cell Biology of Anterior Pituitary Cells
Introduction
Anterior Pituitary: Organization, Cell Types, Hormones and Functions
Diseases of the Anterior Pituitary
Phenotypic Profile of Anterior Pituitary Cell Types: Different, Yet Somewhat Similar
Heterogeneity within Anterior Pituitary Cell Types: Similar, Yet Somewhat Different
Patterns of Anterior Pituitary Cell Signaling and Secretion
Paracrine (Local) Regulation and Intercellular Signaling within the Anterior Pituitary
Plasticity of Anterior Pituitary Cell Network Organization and Function
Concluding Remarks
Acknowledgements
References
Chapter 3. Sensing Calcium Levels: The Biology of the Parathyroid Cell
Introduction
Biosynthesis and Metabolism of PTH
Regulation of PTH Secretion and Transcription
Main Mechanisms of Parathyroid Gland Hyperplasia in SHPT
Conclusions
References
Chapter 4. The Biology of Pituitary Stem Cells
Introduction
Location of Proliferating and Differentiating Cells During Pituitary Development
Strategies for Identifying Pituitary Progenitors
Pituitary Progenitors and Disease Pathophysiology
Conclusion
Acknowledgements
References
Chapter 5. The Na+/I− Symporter (NIS) and Thyroid Hormone Biosynthesis
Iodide Metabolism
Molecular Characterization of NIS
Iodide Transport Defect (ITD)
A Novel Mode of NIS Regulation
Concluding Remarks
References
Chapter 6. The Follicle-Stimulating Hormone Signaling Network in Sertoli Cells
Introduction
Is cAMP the Sole Driving Force to FSH Action in Sertoli Cells?
cAMP-Independent FSH Signaling in Sertoli Cells
Gene Regulation
Integrating miRNA into the Complexity of the FSH Signaling Network
Cross-Talk with Other Factors to Regulate Cell Fate
Opened Questions
Acknowledgements
References
Chapter 7. Epigenetics of Pituitary Cell Growth and Survival
DNA Methylation
References
Chapter 8. Epigenetic and Developmental Basis of Risk of Obesity and Metabolic Disease
Global Burden of Obesity and Metabolic Disease
Developmental Origins of Health and Disease (DOHaD)
Conceptual Framework
Epigenetics and Development
The Paternal Role
Epigenetic Dysregulation in Later-Life Metabolic Disease
Developmental Epigenomics and Human Health
Acknowledgements
References
Chapter 9. Unraveling the Mechanism of Action of the GnRH Pulse Generator: A Possible Role for Kisspeptin/Neurokinin B/Dynorphin (KNDy) Neurons
Introduction
Early Work on the GnRh Pulse Generator
A New Model for the Neural Elements of the GnRH Pulse Generator
Test of the Model: Data from Sheep and Goats
Test of the Model: Data from Rodents
Conclusions and Important Unresolved Issues
Acknowledgements
References
Chapter 10. Proteomics in Reproduction: The Dialogue Between the Blastocyst and the Endometrium
Introduction
Proteomics/Secretomics of the Human Embryo
Proteomics of the Human Endometrium
Proteomics of the Human Endometrial Fluid
Proteomics of Endometriosis
Proteomics in Other Endometrial Pathologies
Conclusions
References
Chapter 11. Transcriptome Analysis of Adrenocortical Cells in Health and Disease
Introduction
Strategies for Determining a Transcriptome
Data Mining
Transcriptome Analysis of Adrenal Glands and Adrenocortical Cell Lines Under Adrenocorticotropic Hormone Stimulation
Transcriptome Analysis of Different Zones
Transcriptome Analysis of Adrenocortical Cells in a Mouse Model of Human Lipoid Adrenal Hyperplasia
Perspective
Acknowledgements
References
Chapter 12. Bone as an Endocrine Organ
Introduction
The Regulation of Energy Metabolism by Bone
Coordinated Regulation of Bone Mass and Energy Metabolism: The View Point of the Pancreas
Osteocalcin Regulation of Testosterone Production by the Leydig Cells of the Testis
Osteocalcin Reproductive Function is Mediated by a G-Coupled Receptor, Gprc6a
Osteocalcin Regulates Male Fertility Independently of the Hypothalamo–Pituitary Axis
Insulin Signaling in Osteoblasts as a Determinant of Osteocalcin Reproductive Function in the Mouse
Conservation of the Reproductive Function of Osteocalcin in Humans
References
Chapter 13. Regulation of Steroidogenesis
Introduction
Classes of Steroidogenic Enzymes
Steroid Hormone Biosynthesis
Tissue-Specific Pathways of Steroidogenesis
Chronic Regulation of Steroidogenesis
Acute Regulation of Steroidogenesis
Post-Translational Differential Regulation of Steroidogenic Enzymes
Conclusion
References
Chapter 14. Adipose Tissue as an Endocrine Organ
Adipose Tissue Biology and Function
Adipokine Secretion and Interaction with Other Tissues
Adipose Tissue Dysfunction During Obesity
Adipose Tissue as a Therapeutic Target and Future Perspectives
References
Chapter 15. Insulin-Secreting Cell Lines: Potential for Research and Diabetes Therapy
Introduction
Key Features of Primary β-Cells
Rodent and Human Insulin-Secreting Cell Lines
Stem Cell-Derived Insulin-Secreting Cells
Use of Insulin-Secreting Cell Lines for Research
Potential Use of Insulin-Secreting Cell Lines for Diabetes Therapy
References
Chapter 16. Architecture and Morphology of Human Pancreatic Islets
Introduction
Understanding of Human Biology has Greatly Increased
Morphology and Cellular Composition of the Human Islet
Vascularization and Innervation within the Islet
Summary and Future Directions for Research
Acknowledgements
References
Chapter 17. Computational Models to Decipher Cell-Signaling Pathways
Introduction
The Growing Complexity of Hormone-Induced Signaling Mechanisms
Pathway-Selective Ligands
Generation of Adapted Signaling Data
Iterative Dialog Between Modeling and Experimentation
Building the Static Model
Building and Parameterizing the Dynamical Model
Conclusion
References
Chapter 18. Defects in Ovarian Steroid Hormone Biosynthesis
Introduction
Mutations and Polymorphisms in Genes Affecting Ovarian Steroidogenesis
Mutations and Polymorphisms in Genes Encoding Steroidogenic Enzymes
Pathophysiology and Genetics of Polycystic Ovary Syndrome
References
Chapter 19. Control of the GnRH Pulse Generator
Introduction: The GnRH Pulse Generator
Roles of the Kiss1/Kiss1R System in the Control of GnRH Neurons
Partners of Kiss1/Kiss1R in the Control of GnRH Neurons: NKB and Dynorphin
Interplay between Kisspeptins, NKB and Dynorphin in the Control of GnRH: The KNDy Paradigm
Re-Shaping the KNDy Paradigm: Differential Roles of Kisspeptins versus NKB on LH and FSH Secretion
Future Perspectives and Concluding Remarks
Acknowledgements
References
Chapter 20. Endocrinology of the Single Cell: Tools and Insights
Introduction
Single-Cell Studies: Benefits and Pitfalls
Single-Cell Tools and Outcomes
Parallel Applications in Single-Cell Analysis: The Secretory Process
References
Chapter 21. Intracellular Trafficking of G Protein-Coupled Receptors to the Plasma Membrane in Health and Disease
Introduction
The ER Quality Control System
GPCR Motifs, Post-Translational Modifications and Structural Features that Promote/Limit ER-Golgi Export and Anterograde Trafficking to the PM
Protein Misfolding and Disease
Acknowledgements
References
Chapter 22. Iodothyronine Deiodinases: Emerging Clinical Crossroads
Introduction
Deiodinases
Clinical Crossroads of Deiodination
Concluding Remarks
Acknowledgements
References
Chapter 23. MicroRNAs and Long Non-Coding RNAs in Pancreatic Beta Cell Function
Introduction
miRNAs: Biosynthesis and Mechanism of Action
Role of miRNAs in Beta Cell Development
Role of miRNAs in Beta Cell Function
Modulation of miRNA Under Physiological and Pathological Conditions
Long Non-Coding RNAs and their Possible Role in Beta Cells
Conclusions
Acknowledgements
References
Index
- No. of pages: 414
- Language: English
- Edition: 1
- Published: February 12, 2014
- Imprint: Academic Press
- Hardback ISBN: 9780124081345
- eBook ISBN: 9780124167124
AU
Alfredo Ulloa-Aguirre
Alfredo Ulloa-Aguirre, M.D., D.Sc. is senior scientist in the Research Center for Population Health at the National Institute of Public Health and Professor of
the National University of Mexico (UNAM), where he heads the Research Support Network of the National Institutes of Health in Mexico City. He received his
graduate training in internal medicine and reproductive endocrinology at the National Institute of Medical Sciences and Nutrition SZ and earned the Doctoral degree in Medical Sciences from the UNAM. He received postdoctoral training at the University of Pennsylvania, Philadelphia PA, and has been visiting scientist at the Oregon National Primate Resarch Center, OHSU, Beaverton OR, and the Institut National de la Recherche Agronomique, in Tours, France (Le Studium Scientist). He is currently a member of the Studium Consortium for Research and Training in Reproductive Sciences (sCORTS, Le Studium, Orléans, France). An internationally recognized physician-scientist, Dr Ulloa-Aguirre has developed programmes in both clinical and basic research. His laboratory focuses on the structure-function relationship of gonadotropins and gonadotropin receptors as well as on the gonadotropin-releasing hormone receptor, with particular emphasis on the factors and mechanisms that control intracellular trafficking of these receptors. He is the author or co-author of over 165 research publications and several book chapters.
Affiliations and expertise
Research Center for Population Health, National Institute of Public Health; National University of Mexico (UNAM), Mexico City, MexicoPC
P. Michael Conn
P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.
Affiliations and expertise
Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center, TX, USARead Cellular Endocrinology in Health and Disease on ScienceDirect