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Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism

1st Edition, Volume 542 - May 23, 2014

Editors: Lorenzo Galluzzi, Guido Kroemer

Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 4 1 6 6 1 8 - 9
eBook ISBN:
9 7 8 - 0 - 1 2 - 4 1 6 6 5 7 - 8

Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research method… Read more

Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism

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Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.