The Role of Chromosomes in Development
- 1st Edition - February 16, 2016
- Latest edition
- Editor: Michael Locke
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 5 4 2 1 - 0
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 6 3 6 5 - 6
The Role of Chromosomes in Development is a collection of papers that deals with structural patterns and functional organization of chromosomes. Some papers discuss chromosomal… Read more
The Role of Chromosomes in Development is a collection of papers that deals with structural patterns and functional organization of chromosomes. Some papers discuss chromosomal proteins, DNA replication sequences in higher animals, and the implications of localized DNA synthesis in polytene chromosomes. Several papers describe chromosomal RNA, nuclear RNA fractions, genetic control, and the regulation of developmental pathways. One paper concerns the "bithorax" series that controls the development of certain body segments of the fly in a polarized and coordinated manner reminiscent of the genes in the operons of microorganisms. The bithorax genes evidently exploit and amplify a gradient arising from an anteroposterior gradient during mitotic division rates. The bithorax genes produces a whole set of new substances that repress certain systems of cellular differentiation, letting other systems to emerge and develop. Another paper investigates the hypothesis of diploid subnuclei as the architectural subunit of the ciliate macronucleus, as well as the hypothesis of "allelic repression" as the basis for certain examples of subnuclear differentiation. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology.
Contributors and Presiding Chairman
Dedication
The Role of Chromosomes in Development
Text
References
Structural Patterns and the Functional Organization of Chromosomes
Replication
Repository Function
Variation
Discussion and Summary
References
Chromosomal Proteins
Proteins and Chromosome Structure
The Acidic Nuclear Proteins
The Acidic Proteins and Gene Modulation
The Histones and Gene Modulation
Structure of the N-Proline Histone
Mechanisms of Gene Modulation
Functional State of the Genome
Summary
References
Binding of Actinomycin as a Model for the Complex-Forming Capacity of DNA
Text
References
DNA Replication Sequences in Higher Animals
Introduction
Materials and Methods
The Relationship Between Heteropyknosis, Gene Inactivation, and DNA Replication
The Terminal Stages of DNA Replication
Late Replication and Metaphase Chromosome Morphology
The Commencement of DNA Replication
Quantitative Autoradiography of Chromosomes
Discussion
References
Localized DNA Synthesis in Polytene Chromosomes and Its Implications
Text
References
Chromosomal RNA and Other Nuclear RNA Fractions
Chromosomal RNA
Nucleolar RNA
Nuclear Sap RNA
Summary
References
Genetic and Functional Mosaicism in the Mouse
Genetic Mosaicism
Functional Mosaicism
Summary
References
Genetic Repression of R Action in Maize
Experimental Materials and Methods
Paramutation of Rr in Rr Rst and Rrrr Heterozygotes
Partial Reversion of Paramutant R
Changes in Action of Rr and Rg Alleles from Stock Cultures in Heterozygotes with Each Other
Acquisition of Paramutagenicity by Rr in Stippled Heterozygotes
Association of the R Locus with Paramutation
Continuous Variation in Paramutation
Compound Nature of the Stippled Allele
Progressive Paramutation in Successive Generations
Occurrence of Paramutation in Somatic Cells
Manifestation of Paramutation in Sporophytic Tissues
The Origin and Geographic Distribution of Paramutable and Nonparamutable R Alleles
R Action in Structurally Altered Chromosome 10
Paramutability of Rr When Carried by Chromosome K10
Level of R Action in Relation to Mode of Sexual Transmission
Effects on Rr and Rst of High Energy Irradiation
Is a Gene-Dependent Cytoplasmic Particle Associated with R Paramutation?
Paramutation in Other Organisms
Summary and Discussion
References
Genetic Control and Regulation of Developmental Pathways
Introduction
Genetic Methods for the Analysis of Development
The Bithorax Pseudoallelic Series
Developmental Effects of the Bithorax Mutants
Gene Dosage Studies
Somatic Mosaics
Cis-Trans Effects
The Trans-Vection Effect
Discussion
Summary
References
Macronuclear Differentiation and Subnuclear Assortment in Ciliates
Morphological Nuclear Differentiation
Caryonidal Distribution: Mating Type Differentiation in Syngen 1, Paramecium aurelia
Subnuclear Assortment: Mating Type Differentiation in Syngen 1, Tetrahymena pyriformis
Subnuclear Assortment: Allelic Repression or Heterozygote Resolution?
Conclusion
References
Author Index
Subject Index
- Edition: 1
- Latest edition
- Published: February 16, 2016
- Language: English