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Stem Cells in Development and Disease
- 1st Edition, Volume 107 - January 15, 2014
- Editor: Michael Rendl
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 4 1 6 0 2 2 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 3 9 1 4 3 5 - 4
This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as… Read more
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Request a sales quoteThis new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging
- Covers the area of Stem Cells in Development and Disease
- International board of authors
- Provides a comprehensive set of reviews covering such topics as Intestinal Stem Cells, Nephron Stem Cells/Progenitors, Skin epithelial Stem Cells and Lung Stem Cells
Researchers in cell, developmental, and molecular biology; genetics
Contributors
Preface
Chapter One: Mechanisms of Pluripotency In Vivo and In Vitro
Abstract
1 Introduction
2 Phases of Lineage Restriction
3 First Lineage Specification—ICM Versus TE Cell Fate
4 Second Lineage Specification—EPI Versus PE Cell Fate
5 Maintenance of Early Cell Lineages—Relevance to Pluripotent Stem Cells
6 Growth Factor Signaling Requirements in EPI-Derived Stem Cells: In Vivo Similarities and Differences
7 Concluding Remarks
Acknowledgments
Chapter Two: Hematopoietic Stem Cell Development
Abstract
1 Introduction
2 Principles of Epigenetic Regulation
3 Epigenetic Regulation of Hematopoiesis
4 Role of Epigenetic Regulators in Hematopoietic Malignancies
5 Conclusions
Acknowledgments
Chapter Three: Intestinal Stem Cells and Their Defining Niche
Abstract
1 The Mammalian Small Intestine
2 Intestinal Stem Cells
3 Characterizing Stem Cell Behavior During Homeostasis and Disease
4 Reconciling the Opposing ISC Models
5 The Stem Cell Niche
6 Studying ISCs Ex Vivo
7 Conclusion
Acknowledgments
Chapter Four: Epithelial Stem Cells in Adult Skin
Abstract
1 Introduction
2 Stem Cells in the Interfollicular Epidermis
3 Stem Cells in the Pilosebaceous Unit
4 Stem Cells in the Sweat Gland
5 Components of Adult Stem Cell Niches in the Skin
6 Stem Cells in Epithelial Skin Cancers
7 Concluding Remarks
Acknowledgments
Chapter Five: The Mammary Stem Cell Hierarchy
Abstract
1 Introduction
2 Identification of Adult Mouse MaSCs
3 The Isolation of Distinct Mammary Luminal Progenitor Cells
4 In Vivo Lineage Tracing in the Mammary Gland
5 Evidence for the Existence of Fetal MaSCs
6 Elucidation of a Functionally Analogous Epithelial Hierarchy in Human Breast
7 Control of MaSCs by Steroid Hormones
8 Molecular Regulators of the Mammary Epithelial Hierarchy
9 Implications of the Differentiation Hierarchy for Breast Cancer
10 Concluding Remarks
Acknowledgments
Chapter Six: Satellite Cells
Abstract
1 Introduction
2 Embryonic Origin of Satellite Cells
3 Adult Satellite Cells: A Heterogeneous Population of Stem Cells and Committed Progenitors
4 Age and Disease-Related Decline in Satellite Cell Function
5 Satellite Cell Transplantation Therapy
6 Concluding Remarks
Acknowledgments
Chapter Seven: Neural Stem Cell of the Hippocampus
Abstract
1 Introduction
2 Origin of Adult Hippocampal Neural Stem Cells: Embryonic Development of the DG
3 Adult Hippocampal Neurogenesis: Heterogeneous Neurogenic NSCs and Niche
4 Adult DG NSC in Epilepsy, Aging, and Depression
5 Conclusions
Acknowledgments
Chapter Eight: Lung Stem and Progenitor Cells in Tissue Homeostasis and Disease
Abstract
1 Introduction
2 Endogenous Lung Stem and Progenitor Cells
3 The Others: Lung Mesenchymal Stromal Cells and Lung Endothelial Progenitor Cells
4 Directing Differentiation: Embryonic Stem Cells and Induced Pluripotent Stem Cells
5 MSCs: Potential Role of Cell-Based Therapy in Lung Disease
6 Stem Cells in Lung Cancer
7 Future Directions
Acknowledgments
Chapter Nine: Spermatogonial Stem Cell Functions in Physiological and Pathological Conditions
Abstract
1 Introduction
2 Spermatogenesis and SSC Biology
3 Origin of SSC Pool
4 Molecular Mechanisms Regulating Maintenance of the SSC Pool
5 TGCT Formation
6 Concluding Remarks
Chapter Ten: The Origin, Biology, and Therapeutic Potential of Facultative Adult Hepatic Progenitor Cells
Abstract
1 Introduction
2 Conditions That Activate HPC Proliferation
3 Origins and Markers for HPCs
4 The Contribution of HPCs to Liver Regeneration
5 Signaling Pathways and Niches That Regulate the Behavior of HPCs
6 Cell Therapy
7 Concluding Remarks
Acknowledgments
Chapter Eleven: Nephron Progenitor Cells
Abstract
1 Introduction
2 Setting the Scene: The Developing Urinary System of the Mammal
3 The Nephrogenic Niche
4 A Subdivision Within the Nephron Progenitor Population: Evidence for More Than One State
5 Roles Played by the CM
6 Balancing Self-Renewal and Differentiation: Signals from the Stroma
7 Influences from Other Cellular Compartments
8 Transcriptional Regulation of the CM
9 Renal Hypoplasia: Time to Reassess What We Know
10 Cessation of Nephrogenesis
11 Conclusion
Acknowledgments
Chapter Twelve: Adult Stem Cell Niches
Abstract
1 Introduction
2 Cellular Organization of Adult SC Niches
3 Molecular Regulators of Adult SC Niches
4 SC Niche Dysfunction in Aging and Cancer
5 Concluding Remarks
Acknowledgments
Chapter Thirteen: Cancer Stem Cells, Pluripotency, and Cellular Heterogeneity
Abstract
1 Cancer Stem Cells: An Overview
2 Control of (Cancer) Stemness by Signaling Pathways: The Embryonic/Germ Cell Connection
3 Conclusions and Future Perspective
Acknowledgments
Chapter Fourteen: Cellular Mechanisms of Somatic Stem Cell Aging
Abstract
1 Introduction
2 Molecular Players of Cellular Aging
3 Extrinsic Regulation of Aged Cellular and Tissue Homeostasis
4 Aging in Tissue-Specific Stem Cells
5 Discussion and Concluding Comments
Acknowledgments
Index
- No. of pages: 472
- Language: English
- Edition: 1
- Volume: 107
- Published: January 15, 2014
- Imprint: Academic Press
- Hardback ISBN: 9780124160224
- eBook ISBN: 9780123914354
MR
Michael Rendl
Affiliations and expertise
Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology; Icahn School of Medicine at Mount Sinai, NY, USARead Stem Cells in Development and Disease on ScienceDirect