International Review of Cell and Molecular Biology

Contributors
Chapter One: Structure and Function of POTRA Domains of Omp85/TPS Superfamily
Abstract

1 Introduction

2 Omp85/TPS Superfamily Architecture

3 Function of Omp85 Family of Proteins

4 Functions of Two-Partner Secretion B Proteins

5 Phototrophic Members of Omp85/TPS

6 POTRA Domains Mode of Action

7 Concluding Remarks

Chapter Two: Molecular Cell Biology and Immunobiology of Mammalian Rod/Ring Structures
Abstract

1 Introduction

2 Conserved RR Structures Across Species

3 Known Components of RR

4 Biological Function of RR

5 Immunobiology of RR—Autoimmune Response

6 Concluding Remarks and Future Perspectives

Acknowledgments

Chapter Three: Modulation of Glycan Recognition by Clustered Saccharide Patches
Abstract

1 Introduction: Glycome Complexity in Nature

2 Glycan Recognition by GBPs

3 Concept of CSPs

4 Evidence for CSPs on Heavily Glycosylated Proteins

5 Clustered Patches of Sialylated Gangliosides on Cell Surfaces

6 Clustered Patches of Sialylated Glycoproteins on Cell Surfaces

7 Enzyme Recognition of Clustered Glycans: O-Sialoglycoprotein Endopeptidase

8 CSPs on Pathogens

9 Glycosynapses: Cell Interactions and Signaling via CSPs

10 Recognition of Combined Saccharide–Peptide Patches

11 Experimental Recreation of CSPs

12 Conclusions and Perspectives

Acknowledgments

Chapter Four: New Insights into the Molecular Mechanisms of Mitosis and Cytokinesis in Trypanosomes
Abstract

1 Introduction

2 Cell Structure of T. brucei

3 Cell Cycle of T. brucei

4 Regulation of Mitosis

5 Mechanisms of Cytokinesis

6 Conclusions and Perspectives

Acknowledgments

Chapter Five: Reprogramming and Carcinogenesis—Parallels and Distinctions
Abstract

1 Introduction

2 Overview of Reprogramming Methods

3 Reprogramming, Antiproliferative Response, Apoptosis, and Senescence

4 Reprogramming and Autophagy

5 Reprogramming Factors and Carcinogenesis

6 Stemness Factors as Transcription Factors—Effects in Transformation and Reprogramming

7 Differences and Similarities between iPS Cells and CSC

8 Interaction of Biomaterials with Cells

9 Closing Remarks

Acknowledgments

Chapter Six: New Insights into Functions, Regulation, and Pathological Roles of Tight Junctions in Kidney Tubular Epithelium
Abstract

1 Introduction

2 Structure and Function of TJs

3 “Nonclassic” Functions of TJs

4 Regulation of TJs

5 Kidney Disease and TJs

6 Concluding Remarks

Acknowledgments

Chapter Seven: Making of a Retinal Cell: Insights into Retinal Cell-Fate Determination
Abstract

1 Introduction

2 Retinal Cell-Fate Specification

3 Extrinsic Signaling

4 Intrinsic Signals and Retinal Development

5 Recent Discoveries Contributing to Retinal Fate Decisions

6 “Omics” Approaches to Understanding Retinal Cell-Fate Decisions

7 Additional Factors Contributing to Retinal Fate Determination

8 Recent Perspectives

Chapter Eight: Adhesion Networks of Cnidarians: A Postgenomic View
Abstract

1 Introduction

2 Cnidarian Genomes

3 The Anatomy of N. vectensis and Hydra Polyps

4 ECM in Cnidarians

5 Functional Importance of Cell–ECM Interactions for Tissue Organization and Regeneration in Cnidarians

6 Cell–Cell Adhesion Molecules in Cnidarians

7 Conclusions and Future Directions

Acknowledgment

Index