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    • Clinical Application of Repurposed Drugs

      • 1st Edition
      • Volume 207
      • June 28, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 4 1 1 4 7
      • eBook
        9 7 8 0 4 4 3 2 4 1 1 5 4
      Clinical Application of Repurposed Drugs, Volume 207 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on Drug repurposing for viral disease, Drug repurposing for bacterial infections, Drug repurposing for parasitic protozoan diseases, Drug repurposing for fungal infections, Drug repurposing for treating anxiety and depression, Drug repurposing for personalized medicine, Drug repurposing for cancer, Drug Repurposing: A multi targeted approach to treat cardiac disease from existing classical drugs to modern drug discovery, and much more.Additional chapters cover Drug repurposing in MASLD and MASH-cirrhosis: targets and treatment approaches based on pathways analysis, Drug repurposing for respiratory infections, Drug repurposing for rare disease, Drug repurposing for neurological disorders, Drug repurposing for metabolic disorders: scientific, technological and economic issues, Drug repurposing for regenerative medicine and cosmetics: scientific, technological and economic issues, and Exploring Cutting-Edge Omics-Driven Strategies for Drug Repurposing – An Insight into the Tools of the Trade.

    • Design and Applications of Microneedles in Drug Delivery and Therapeutics

      • 1st Edition
      • June 28, 2024
      • Prashant Kesharwani
      • English
      • Paperback
        9 7 8 0 4 4 3 1 3 8 8 1 2
      • eBook
        9 7 8 0 4 4 3 1 3 8 8 0 5
      Design and Applications of Microneedles in Drug Delivery and Therapeutics details the design, characterization, and applications of this novel drug delivery system. Microneedles offer several advantages over traditional oral and parenteral approaches due to their ability to be fabricated and altered in shape, size and material type, and their convenience to be matched to specific treatment needs. This book covers the materials selection, design and fabrication approaches, and clinical translation of microneedles for a range of therapeutic applications, including cancer therapy, gene and vaccine delivery, wound healing, and more.This book is a forward-thinking resource for those working in the development of materials and devices for novel drug delivery.

    • Error Control, Adaptive Discretizations, and Applications, Part 1

      • 1st Edition
      • Volume 58
      • June 28, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 4 4 8 8
      • eBook
        9 7 8 0 4 4 3 2 9 4 4 9 5
      Error Control, Adaptive Discretizations, and Applications, Volume 58, Part One highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this release cover hp adaptive Discontinuous Galerkin strategies driven by a posteriori error estimation with application to aeronautical flow problems, An anisotropic mesh adaptation method based on gradient recovery and optimal shape elements, and Model reduction techniques for parametrized nonlinear partial differential equations.

    • Peritoneal Tumor Microenvironment of Cancers on Cancer Hallmarks

      • 1st Edition
      • June 27, 2024
      • Yong Sang Song + 6 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 4 0 4 0 3
      • eBook
        9 7 8 0 1 2 8 2 4 0 4 1 0
      Peritoneal Tumor Microenvironment of Cancers on Cancer Hallmarks: Perspectives of Translational Medicine provides readers with cutting-edge knowledge on tumor microenvironment. By exploring multiple aspects on tumor microenvironment, it gives an integrative insight on cancer diseases ranging from diagnosis to prediction of prognosis and individualized treatment. The book discusses topics such as clinical significance of tumor microenvironment, tumorigenesis and cancer progression, histopathological features of cancer in peritoneum, immune cells in tumor, exosomal cell-to-cell interactions, and therapeutic approaches to target tumor microenvironment. In addition, it discusses tumor evolution during chemotherapy and metastasis and future perspectives on identification and validation of biomarkers using liquid biopsy. This book is a valuable resource for cancer researchers, oncologists, medical doctors, and several members of biomedical field who want to understand the complex microenvironment of peritoneal tumors.

    • Prosopis Juliflora

      • 1st Edition
      • June 27, 2024
      • Pratiksha Patnaik + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 9 8 2 4 7
      • eBook
        9 7 8 0 1 2 8 1 9 8 2 5 4
      Prosopis (Prosopis juliflora) is a xerophyte which, in its native habitats has been a desert plant. As long as it was confined to that habitat, P. juliflora was a great resource, improving the region’s micrometeorology, binding its sandy soil, and providing shelter, fuel, feed, food, medicines, and cosmetics to the people of such regions. In particular, for the economically weaker inhabitants, P.juliflora was a lifeline.But when P. juliflora was indiscriminately introduced in other regions of the world in a hope to derive similar benefits from it, things began to go awry. Indeed, among the invasive species of plants which are spreading at an alarming rate in the tropical and sub-tropical regions of the world, P.juliflora is arguably the most hardy and resilient. It is growing so explosively that it even enters roads and homes, driving humans out of their dwellings. The resulting damage to biodiversity is enormous. This book highlights the dual role played so far by P. juliflora and itemizes the facets that make it a blessing in some contexts and a bane in other contexts.Authored by leading experts in the field, Prosopis juliflora: Attributes, Impact, Utilization is the first title of its kind to comprehensively discuss this hardy plant species. It will be an essential read for students, researchers and governmental agencies interested in plant biology, forestry, plant ecology, invasive plant species and environmental science.

    • Pili in Mycobacterium Tuberculosis

      • 1st Edition
      • June 27, 2024
      • Ali Akbar Velayati + 1 more
      • English
      • Paperback
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      • eBook
        9 7 8 0 4 4 3 2 1 7 1 3 5
      Pili in Mycobacterium Tuberculosis: Structure, Function, and Therapeutic Advances discusses the types of pili produced by the tuberculosis-causing bacterium, Mycobacterium tuberculosis (MTB). The book examines the structure of pili shown under electron and atomic force microscopy and, by using whole genome sequencing, outlines the importance of pili in MTB. It also explores the role of pili in bacteria–host interactions and in drug development and delivery.The book provides an overview of the structure, synthesis, and function of pili in bacteria. This includes taxonomy and the role of pili in diseases. It also examines the structure of pili and the preparation of MTB for electronic and atomic microscopy. It explores the various life cycles of pili, the susceptibility patterns of MTB, the differences of pili formation in MTB, and their role in increase surveillance. It goes on to discuss the expression and function of pili using whole genome sequencing and PCR-based methods and delves into bacteria–host interactions. Lastly, it explores the development of new drugs and their therapeutic delivery by pili.

    • Mechanics in Development and Disease

      • 1st Edition
      • Volume 160
      • June 27, 2024
      • English
      • Hardback
        9 7 8 0 1 2 8 2 4 0 3 2 8
      • eBook
        9 7 8 0 1 2 8 2 4 0 3 3 5
      Mechanics in Development and Disease, Volume 160 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Gut developmental mechanics, Long bone developmental mechanics, Cranial plate fusion developmental mechanics, Mechanobiology and vasculogenesis, Morphogenesis and mechanics of the developing inner ear, Morphogenesis and mechanics of body wall closure in mammals, Salivary bud developmental mechanics, Lateral plate mesoderm developmental mechanics, Biomechanics of human embryo implantation, gastrulation, and organ formation, Mechanics of lung development across species, Mechanics early development in vertebrates.

    • Cancer Epigenetics and Nanomedicine

      • 1st Edition
      • June 26, 2024
      • Prashant Kesharwani + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 3 2 0 9 4
      • eBook
        9 7 8 0 4 4 3 1 3 2 1 0 0
      Cancer Epigenetics and Nanomedicine: Targeting the Right Player via Nanotechnology is a complete package that provides a comprehensive and thorough understanding of the key players that modulate the various steps of carcinogenesis and malignant progression of the disease and the critical targets to be exploited for developing novel modalities of diagnosis and therapeutics.Since epigenetic aberrations can be potentially reversed and restored to their normal state through epigenetic therapy, the book also discusses the challenges and the future of the field with the cutting-edge revelations and limitations that this research endeavor can offer, thereby helping the readers to enhance their critical thinking and adopt strategies of therapeutic importance.

    • Macrophages Biology and Tissue Inflammation in Health and Disease

      • 1st Edition
      • June 26, 2024
      • Stuart Goodman + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 1 7 5 4 2
      • eBook
        9 7 8 0 1 2 8 2 1 7 6 2 7
      Macrophages Biology and Tissue Inflammation in Health and Disease outlines the important role of macrophages—keys cells in the innate immune system—as regulators and orchestrators of inflammation and repair in health and disease. It contains chapters by leading authors on the basic and translational aspects of macrophage biology, covering how to maintained tissue homeostatis and how to deal with internal and external biological threats.

    • Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

      • 1st Edition
      • June 25, 2024
      • Wendy Fantl
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 2 1 3 3
      • eBook
        9 7 8 0 1 2 8 2 2 2 1 4 0
      Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: ApplicationsHealthy tissues and organs rely on the precise coordination of diverse cell types, each responding to external and internal signals. Disease disrupts this coordination. Since proteins drive cellular function, analyzing their abundance and activation states in single cells helps identify key cell populations in health and disease. Bulk protein analyses mask critical differences between individual cells. Additionally, the arrangement of cells into neighborhoods through cell-cell interactions is essential for tissue function. Over the last decade, single-cell proteomic phenotyping combined with positional information has become crucial for understanding biology in health and disease. This has led to the development of multiple technology platforms, profoundly impacting fields including developmental biology, cancer biology, immunology, neuroscience, and drug discovery. This book focuses on the application of single-cell multiplex proteomic platforms to various biological systems. These platforms have proved to be essential in biomedical research, advancing our understanding of complex biological systems at the cellular level. Compelling studies where authors use these technologies to answer previously unanswerable questions are featured. Exploring this "Uncharted Biology" opens new avenues for scientific inquiry and clinical translation, covering areas including oncology, immunology, metabolomics, stem cell research, preclinical models, and translational research. The initial chapters discuss incorporating these technologies into core facilities and consortia, providing access for multiple users and integrating datasets from other omics technologies. The following chapters cover applications in diverse areas such as muscle stem cell function in skeletal muscle regeneration, metabolic regulome profiling, translational studies, developing predictive biomarkers for patients receiving immune checkpoint inhibitors, and pre-clinical studies of lung cancer. These applications demonstrate how advanced single cell proteomic technologies are reshaping our understanding of complex biological systems and enhancing clinical translation. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Applications highlights the transformative benefits of single-cell proteomics, offering insights into cellular mechanisms underlying health and disease and inspiring further exploration into "Uncharted Biology." It is an essential resource for researchers, clinicians, and students aiming to advance biomedical science and improve therapeutic outcomes.

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