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1st Edition - June 1, 2024
Editor: Wendy Fantl
Revealing Unchartered Biology with Single Intact Cells: Case Studies explores the path to research success, key projects, the role of techniques, the selection process, other… Read more
LIMITED OFFER
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Revealing Unchartered Biology with Single Intact Cells: Case Studies explores the path to research success, key projects, the role of techniques, the selection process, other alternatives considered, what other paths have led to dead ends, detailed protocols followed, and how the analysis of generated data allowed researchers to visualize unchartered biology. Focusing on the research journey that led to the publication of each article, the book's editors interviewed the researchers on the use of the Multiplex Single Cell technique and how it helped hone in on the biological quest. These methods can be expanded to a wide variety of research objectives.In conclusion to each chapter, the authors critically review their process and provide suggestions of improvement or alternate techniques that could be employed. This book is the ideal reference for researchers new to the world of single-cell multiplex techniques. The discussion on failures encountered along the research path provides insights on how to avoid repeating the same errors.
I. Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front by Schürch et al.
1. Revealing Unchartered Biology
2. Research methods and protocols used in the experiment
3. Failures encountered along the research path, suggestions of improvement and additional techniques to employ in similar research
II. Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry by Gonzalez et al.
4. Revealing Unchartered Biology
5. Research methods and protocols used in the experiment
6. Failures encountered along the research path, suggestions of improvement and additional techniques to employ in similar research
III. Mass cytometry of Hodgkin lymphoma reveals a CD41 regulatory T-cell–rich and exhausted T-effector microenvironment, by Cader et al.
7. Revealing Unchartered Biology
8. Research methods and protocols used in the experiment
9. Failures encountered along the research path, suggestions of improvement and additional techniques to employ in similar research
IV. Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates by Simoni et al.
10. Revealing Unchartered Biology
11. Research methods and protocols used in the experiment
12. Failures encountered along the research path, suggestions of improvement and additional techniques to employ in similar research
V. High-resolution myogenic lineage mapping by single-cell mass cytometry by Porpiglia et al.
13. Revealing Unchartered Biology
14. Research methods and protocols used in the experiment
15. Failures encountered along the research path, suggestions of improvement and additional techniques to employ in similar research
VI. Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models, by Ajami et al.
16. Revealing Unchartered Biology
17. Research methods and protocols used in the experiment
18. Failures encountered along the research path, suggestions of improvement and additional techniques to employ in similar research
VII. Conclusion
WF