Design and Applications of Microneedles in Drug Delivery and Therapeutics
- 1st Edition - June 28, 2024
- Imprint: Academic Press
- Editor: Prashant Kesharwani
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 8 8 1 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 8 8 0 - 5
Design and Applications of Microneedles in Drug Delivery and Therapeutics details the design, characterization, and applications of this novel drug delivery system. Microneed… Read more
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Request a sales quoteDesign and Applications of Microneedles in Drug Delivery and Therapeutics details the design, characterization, and applications of this novel drug delivery system. Microneedles offer several advantages over traditional oral and parenteral approaches due to their ability to be fabricated and altered in shape, size and material type, and their convenience to be matched to specific treatment needs. This book covers the materials selection, design and fabrication approaches, and clinical translation of microneedles for a range of therapeutic applications, including cancer therapy, gene and vaccine delivery, wound healing, and more.
This book is a forward-thinking resource for those working in the development of materials and devices for novel drug delivery.
- Introduces the reader to skin anatomy and materials development in regard to microneedles as smart carriers for drug delivery, offering an interdisciplinary approach that will appeal to a wide audience
- Covers a broad range of therapeutic applications, from ocular diseases and photodynamic therapy to sensing and cancer treatment
- Provides an overview of the materials, design, fabrication, clinical translation, commercial aspects of microneedle development, and their applications in drug delivery
Researchers and postgraduate students in the fields of materials science, nanotechnology, pharmaceutical science and biomedical engineering, Clinical scientists and R&D groups developing novel materials for drug delivery and therapeutic applications
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- About the editor
- Acknowledgments
- Chapter 1 Introduction of anatomy of the skin and microneedles as a smart carrier for drug delivery
- Abstract
- 1 Introduction
- 2 Microneedles as a smart carrier for drug delivery
- 3 Applications of microneedles
- 4 Conclusion
- References
- Chapter 2 Nanomedicine's delivery using microneedles
- Abstract
- 1 Stimuli-sensitive MN
- 2 MN activated by external stimuli
- 3 MN sensitive to internal stimuli
- 4 Gene therapy with MN
- 5 MN for ocular drug delivery
- 6 MN for cancer treatment
- 7 Combining NP with MN for vaccine delivery
- 8 Improved delivery of analgesics using NP-modified MNs
- 9 Delivery of cosmetics using NP-modified MNs
- 10 Enhancing the action of hormones using NP-modified MN
- References
- Chapter 3 Types of microneedles for drug delivery
- Abstract
- 1 Limitations of classical routes for drug administration
- 2 Transdermal drug delivery
- 3 Microneedle device (MND) for transdermal drug delivery
- 4 Types of MNDs for drug delivery
- 5 Background of materials for the construction of MNDs
- 6 Manufacturing methods for the construction of MNDs
- References
- Chapter 4 Stimuli-responsive microneedles for drug delivery
- Abstract
- 1 Introduction
- 2 Stimulation of biomaterials
- 3 Stimuli-responsive drug delivery MNs
- 4 Applications of stimuli-responsive MN
- 5 Conclusion
- References
- Chapter 5 Silicon microneedles for drug delivery
- Abstract
- 1 Introduction
- 2 Types of silicon microneedles
- 3 Manufacturing techniques for silicon microneedles
- 4 Clinical trials
- 5 Conclusion and future perspective
- References
- Chapter 6 Polymer-coated polymeric (PCP) microneedles for controlled regional drug delivery
- Abstract
- 1 Introduction
- 2 Polymer-coated polymeric microneedles
- 3 Preparation method of PCP microneedles
- 4 Variables that could affect the coating uniformity and thickness
- 5 Testing the integrity of the coating
- 6 Microscopy
- 7 Coating intactness test using marker molecules
- 8 In vitro release testing (IVRT)
- 9 Applications of PCP MNs
- 10 Conclusions
- References
- Chapter 7 Microneedles for local and transdermal drug delivery
- Abstract
- 1 Introduction
- 2 Local drug delivery
- 3 Systemic drug delivery
- 4 Vaccine administration
- 5 Advantages of microneedles
- 6 Challenges
- References
- Chapter 8 Silicon microneedles for transdermal drug delivery
- Abstract
- 1 Overview
- 2 Review of microneedles and fabrication techniques employed
- 3 Silicon micromachining
- 4 Microneedle fabrication processes
- 5 Microneedles with tip diameter reduction
- 6 Microneedles with tip modification: Incorporation of spontaneously formed microcavities for fluid transport
- 7 Fluid storage in microcavities
- 8 Hollow microneedles
- 9 Conclusions
- References
- Chapter 9 Microneedle for wound healing and dermal application
- Abstract
- Acknowledgment
- 1 Introduction
- 2 Wound healing process
- 3 Transdermal drug delivery
- 4 Microneedles (MNs) for drug delivery
- 5 Conclusion
- References
- Chapter 10 Microneedle for delivery of cosmeceuticals and enhancing skin appearance
- Abstract
- Acknowledgments
- 1 Introduction
- 2 Structure of the skin
- 3 Microneedling technologies: An evolutionary step toward microneedle usage
- 4 Application of various kinds of microneedles
- 5 Different applications of microneedling in dermatology
- 6 Approved microneedle devices
- 7 Advantages of microneedling
- 8 Microneedle design and structure
- 9 Conclusion and future perspective
- References
- Chapter 11 Designing, characterization, and efficacy of microneedle patches in management and treatment of obesity
- Abstract
- 1 Introduction
- 2 Obesity management by other therapies
- 3 Polyphenols in obesity management and treatment
- 4 Microneedle patches
- 5 Conclusion
- References
- Chapter 12 Microneedles for various ocular diseases
- Abstract
- 1 Introduction
- 2 Types of microneedles
- 3 Advantages and disadvantages of microneedle systems for ophthalmic drug delivery
- 4 Conclusion and future prospectives
- References
- Chapter 13 Microneedles deliver drugs to ophthalmic tissue
- Abstract
- 1 Introduction
- 2 Eye structure, disease and treatment
- 3 MN strategy for opthalmic drug delivery
- 4 Challenges and prospective
- References
- Chapter 14 Potential of different types of microneedles in diagnosis and treatment of cancer
- Abstract
- Graphical abstract
- 1 Introduction
- 2 Materials used for manufacturing MNs
- 3 Application of microneedles in cancer
- 4 Cancer diagnosis
- 5 Clinical studies
- 6 Regulatory aspects of microneedles
- 7 Safety of microneedles
- 8 Future perspective and conclusion
- References
- Chapter 15 Microneedle-mediated photodynamic/immunotherapy
- Abstract
- Acknowledgments
- 1 Introduction
- 2 Microneedles
- 3 Photodynamic therapy
- 4 Immunotherapy
- 5 Microneedle-mediated photodynamic/immunotherapy
- 6 Conclusion and future perspectives
- References
- Chapter 16 Microneedle-mediated gene delivery: A promising approach for diverse disease treatment
- Abstract
- 1 Introduction
- 2 The disadvantage of existing methods/existing problems of gene delivery
- 3 MNs for gene delivery
- 4 MNs in combination with other physical technologies
- 5 Application of microneedles in gene delivery
- 6 Challenges/limitations of microneedles in gene delivery
- 7 Conclusions
- 8 Future directions
- References
- Chapter 17 Microneedle-mediated vaccine delivery
- Abstract
- 1 Introduction
- 2 Skin-based vaccination
- 3 Microneedle-mediated vaccination strategies
- 4 Clinical trials of MN-mediated vaccination
- 5 Conclusion and perspective
- References
- Chapter 18 Advancements and applications of 3D-printed microneedles for drug delivery
- Abstract
- Acknowledgments
- 1 Introduction
- 2 Types of fabrication techniques in 3D-printed microneedles
- 3 Factors affecting 3D-printed microneedles
- 4 Evaluation of 3D-printed microneedles
- 5 Combination of 3D-printing microneedles with other technologies
- 6 Future prospects and conclusion
- References
- Chapter 19 Microneedle-based electrochemical sensors for health monitoring
- Abstract
- 1 Introduction
- 2 Microneedle-based electrochemical sensors
- 3 Application in health monitoring
- 4 Remaining challenges and perspectives
- 5 Conclusions
- References
- Chapter 20 Future perspective, clinical translation, commercial challenges, and industrial success with microneedle-based products
- Abstract
- Acknowledgments
- 1 Introduction
- 2 The potential prospects of microneedles in industries
- 3 Applications of various types of microneedles-based products
- 4 Clinical translations and advances
- 5 Challenges faced in the commercial market
- 6 Industrial development, success, and future prospects
- 7 Summary and outlook
- References
- Index
- Edition: 1
- Published: June 28, 2024
- Imprint: Academic Press
- No. of pages: 572
- Language: English
- Paperback ISBN: 9780443138812
- eBook ISBN: 9780443138805
PK
Prashant Kesharwani
Dr. Prashant Kesharwani is assistant professor of Pharmaceutics at Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India. He has more than 12 years of teaching, research, and industrial experience at international levels from various countries, including the United States, Malaysia, and India. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He has more than 350 international publications in well-reputed journals and more than 25 international books (Elsevier). He is a recipient of many research grants from various funding bodies. He is also the recipient of several internationally acclaimed awards, such as “USERN Laureate award”, most prestigious “SERB-Ramanujan Fellowship Award”. He actively participates in outreach and scientific dissemination for the service of the wider community. His Number of citations is = 26779; h-index = 85; i-10 index = 370 (According to google scholar on March 2025). He has more than 30 international publications published in very high impact factor journals (Progress in Polymer Sciences IF 32.063, Molecular Sciences IF 41.444, Progress in Material Sciences IF 48.580, Advanced Materials IF 29.4, Drug Resistance Update IF 22.841 and Material Todays IF 32.072). He has presented many invited talks and oral presentations at prestigious scientific peer-conferences, received international acclaims and awards for research contribution, supervised students/junior researchers and actively participated in outreach and scientific dissemination for the service of the wider community.
Affiliations and expertise
Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, 470003, IndiaRead Design and Applications of Microneedles in Drug Delivery and Therapeutics on ScienceDirect