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    • Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

      • 1st Edition
      • June 25, 2024
      • Wendy Fantl
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 2 0 9 6
      • eBook
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      Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms. Understanding the intricate coordination of highly diverse cell types within healthy tissues and organs is essential for grasping their functionality. This coordination, often disrupted in disease, hinges on proteins—the primary drivers of cellular function. By examining protein abundance and activation states in single cells, researchers can identify key cell populations involved in both healthy and diseased states, including those influencing disease initiation, progression, and therapeutic responses. Single-cell multiplex proteomic platforms have recently emerged as powerful tools for biomedical research. Their strengths lie in revealing cell types that are rare or subtly different and would otherwise go undetected in bulk cellular analyses. This unique capability enables deeper insights into cellular behavior and disease mechanisms.This book offers comprehensive overviews of technologies developed for multiplex single-cell proteomic analyses. It begins with the pioneering work from Professors Scott Tanner, Mitchell Winnick and Garry Nolan resulting in the development and early application of the mass cytometer, (CyTOF). The instrument merges flow cytometry with time-of-flight mass spectrometry and analyzes cells labelled with metal tagged antibodies. These components work together to enable CyTOF to perform highly multiplexed protein analysis at the single-cell level, offering a powerful tool for understanding complex cellular behaviors and interactions.Recogni... that cellular organization is critical for tissue function, subsequent chapters explore advanced multiplex imaging platforms including Imaging Mass Cytometry (IMC), Multiplexed Ion Beam Imaging (MIBI), CODetection by InDExing, and Chip Cytometry. Later chapters present recent advances in these imaging platforms and data analysis approaches - Combined Nucleic Acid and Protein Quantification in situ, Tissue Schematics, and High-definition CODEX for 3D Multiplex Spatial Cell Phenotyping. These techniques integrate deep phenotyping with spatial mapping to provide unprecedented insights into cellular interactions within tissues. The book also highlights computational approaches essential for managing and interpreting the vast datasets generated by these technologies. Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Platforms help researchers in many fields, including developmental biology, cancer biology, immunology, neuroscience, and drug discovery gain an understanding about the theories and detailed methodologies behind these technologies. Integrating proteomics with genetic, epigenetic, and transcriptomic platforms, this book aims to inspire new research opportunities, ultimately advancing the development of reliable biomarkers and improving patient outcomes.

    • On Epigenetics and Evolution

      • 1st Edition
      • June 25, 2024
      • Carlos M. Guerrero-Bosagna
      • English
      • Paperback
        9 7 8 0 4 4 3 1 9 0 5 1 3
      • eBook
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      On Epigenetics and Evolution, a new volume in the Translational Epigenetics series, introduces key themes from current epigenetic evolution research, with contributions from leading scientists around the world that investigate the role of epigenetic mechanisms in evolution from a variety of different angles, with each contribution combining theory, current research overviews, and applications. This book gives researchers, students, and clinicians a better understanding of the origin of genotypic and phenotypic variability, the role of epigenetics in development and inheritance, how epigenetics may affect speciation, and the evolution of epigenetic mechanisms in different taxa, and helps them apply their learnings across new research. Other modalities and subtopics explored include epigenetics in neutral and also adaptive evolution; epigenetic evolution in plants, invertebrates, and vertebrates; and the role of epigenetics in human evolution and its societal impact.

    • Resilient Health

      • 1st Edition
      • June 24, 2024
      • Judy Kuriansky + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 8 5 2 9 8
      • eBook
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      Resilient Health: Leveraging Technology and Social Innovations to Transform Healthcare for COVID-19 Recovery and Beyond presents game-changing and disruptive technological innovations and social applications in physical and mental healthcare around the world for the post-COVID age and beyond, addressing the urgent need for care. In this first-of-its kind comprehensive volume, experts and stakeholders from all sectors - government and the public and private sectors - offer models and frameworks for policy, programming, and financing to transform healthcare, address inequities, close the treatment gap, and “build back better,” especially for under-resourced vulnerable communities globally, to “leave no one behind” and advance development globally. Contributions from world experts cover 8 essential parts: The context and challenges for resilient health systems to shape the future; developments and directions (AI, VR, MR, IVAs and more); an innovations toolbox, also targeted for special populations and settings (women, youth, ageing, migrants, disabled persons, indigenous peoples, in the workplace); the role of stakeholders (governments, the United Nations bodies, and the public and private sector); forums and networks; innovative financing; resources, lessons learned and the way forward.

    • Encyclopedia of Adolescence

      • 2nd Edition
      • June 24, 2024
      • Wendy Troop-Gordon + 1 more
      • English
      • Hardback
        9 7 8 0 3 2 3 9 6 0 2 3 6
      • eBook
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      Encyclopedia of Adolescence, Second Edition presents a comprehensive overview of the theories, methods, and empirical evidence needed to understand this critical developmental period. Split across 3 volumes, and spanning over 130 chapters, the title begins with an overview of the history of the study of adolescence and the emerging theories and tools used to study adolescent development, as well as normative changes of adolescence, encompassing a broad range of adolescent experiences. It then examines the interpersonal and socioecological contexts which are both shaped by the adolescent and play a formative role in the adolescent’s development.In conclusion, the book examines those experiences that can compromise healthy development in adolescence and the specific mental health challenges that are common or emergent during the adolescent years. This updated edition addresses identified gaps in the earlier edition, and in similar works, expanding coverage to topics that have often been overlooked but are key experiences, tasks, or contexts affecting adolescent development.

    • Enzymatic Processes for Food Valorization

      • 1st Edition
      • June 23, 2024
      • Monica L. Chavez Gonzalez + 3 more
      • English
      • Paperback
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      • eBook
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      Enzymatic Processes for Food Valorization describes the most recent research in the field of catalysis for food valorization, revealing the impact of the implementation of enzymatic catalysis in the different stages that make up the production processes. Sections review advances in food processing using enzymes, explore the use of enzymes on by-products for the release of compounds of interest, and show recent trends in biocatalysis and its application in the food industry. Written by a team of international experts, this is an invaluable guide for professionals in the area of enzyme technology applied in the food industry, as well as technicians and scientists involved in the use of enzymes on food waste for the valorization and/or recovery of compounds.

    • Executive Brain Vitality

      • 1st Edition
      • June 22, 2024
      • Michael Hoffmann
      • English
      • Paperback
        9 7 8 0 4 4 3 2 9 8 3 9 4
      • eBook
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      Executive Brain Vitality: Achieving Optimal Brain Health and Maintenance presents research on the effect of brain exercise as a preventative measure for neurodegenerative diseases and other conditions. This volume examines the neurological impact of such exercises from research to clinical application, offering up-to-date research and practical steps. The current book will be of interest to researchers in neurodegeneration and chronic disease as well as practitioners and clinicians interested in the preventative approach in medicine.

    • Metabolic Steatotic Liver Disease

      • 1st Edition
      • June 21, 2024
      • Mindie Nguyen + 1 more
      • English
      • Paperback
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      • eBook
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      Metabolic Fatty Liver Disease: Current Knowledge, Therapeutic Treatments, and Future Directions provides the most updated research findings and defines the current data gaps on metabolic fatty liver disease. The book extensively covers key areas in metabolic fatty liver disease research, including epidemiology (adults and children), economic burden, patient-reported outcome burden, natural history, current treatments, current diagnostic methods, controversies (NAFLD/MAFLD), current guidelines, fatty liver disease in the presence of other liver diseases as well as guidance on future research. This book will provide translational researchers with a current and comprehensive resource dedicated to all aspects of research in metabolic fatty liver disease, identify current gaps in research and make future research recommendations. It also offers clinicians a look at important background information in metabolic fatty liver disease and thoroughly reviews the latest research in this area to inform treatment outcomes.

    • Fundamentals of Radiation Oncology

      • 4th Edition
      • June 20, 2024
      • Hasan Murshed
      • English
      • Paperback
        9 7 8 0 4 4 3 2 2 2 0 8 5
      • eBook
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      Fundamentals of Radiation Oncology: Physical, Biological, and Clinical Aspects, Fourth Edition, is written by a team of renowned experts. This book is a must-have resource for anyone practicing radiation oncology. From basic principles to more-advanced planning and delivery of radiation therapy to treat cancer, this book is a go-to resource for mastering the art and science of radiation oncology.

    • Advances in Biomembranes and Lipid Self-Assembly

      • 1st Edition
      • Volume 39
      • June 20, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 6 3 4 5
      • eBook
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      Advances in Biomembranes and Lipid Self-Assembly, Volume 39 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

    • Biochar Production for Green Economy

      • 1st Edition
      • June 20, 2024
      • Shiv Vendra Singh + 4 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 5 5 0 6 2
      • eBook
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      Biochar Production for Green Economy: Agricultural and Environmental Perspectives addresses the advancements and developments for the efficient diversification of biochar toward achieving improved agricultural and environmental benefits. This comprehensive and cohesive volume is the first to address the potential multi-and transdisciplinary opportunities of effective biochar production and use. Including the potential applicability of not only crop waste biochar but weeds, agroforestry, agroindustry, municipal waste, as well chapters explore surface modified, enriched or tailored biochar for soil amendment, GHGs mitigation, bioremediation of organic, inorganic, metals and other emerging pollutants, as well as soil remediation. It also covers the trending multidisciplinary approaches of nanotechnology, surface chemistry and thermal decomposition advancements being adopted for capacity enhancement and versatile applicability in the field of agriculture, environment science and green energy synthesis. Composition and characteristics of tailored biochar, their interactions, and transformation into the soil and water ecosystem are illustrated. This book is a valuable resource for those pursuing biochar related areas as well as those seeking environmentally sustainable solutions to crop, soil or water issues.

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