Clinical Application of Repurposed Drugs
- 1st Edition, Volume 207 - June 28, 2024
- Imprint: Academic Press
- Editor: Vijai Singh
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 4 1 1 4 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 4 1 1 5 - 4
Clinical Application of Repurposed Drugs, Volume 207 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new vo… Read more
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Request a sales quoteClinical Application of Repurposed Drugs, Volume 207 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on Drug repurposing for viral disease, Drug repurposing for bacterial infections, Drug repurposing for parasitic protozoan diseases, Drug repurposing for fungal infections, Drug repurposing for treating anxiety and depression, Drug repurposing for personalized medicine, Drug repurposing for cancer, Drug Repurposing: A multi targeted approach to treat cardiac disease from existing classical drugs to modern drug discovery, and much more.
Additional chapters cover Drug repurposing in MASLD and MASH-cirrhosis: targets and treatment approaches based on pathways analysis, Drug repurposing for respiratory infections, Drug repurposing for rare disease, Drug repurposing for neurological disorders, Drug repurposing for metabolic disorders: scientific, technological and economic issues, Drug repurposing for regenerative medicine and cosmetics: scientific, technological and economic issues, and Exploring Cutting-Edge Omics-Driven Strategies for Drug Repurposing – An Insight into the Tools of the Trade.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Progress in Molecular Biology and Translational Science series
- Includes the latest information on Clinical Applications of Repurposed Drugs
Students, researchers, clinicians, entrepreneurs, and stakeholders
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Drug repurposing for bacterial infections
- Abstract
- Abbreviations
- 1 Introduction
- 2 AMR in bacterial infections
- 3 Drug repurposing approaches for curbing AMR
- 4 Success stories of drug repurposing for bacterial infections
- 5 Challenges and opportunities in repurposing for antibacterials
- 6 Conclusion and future recommendations
- References
- Chapter Two: Drug repurposing for parasitic protozoan diseases
- Abstract
- Abbreviations
- 1 Introduction
- 2 Critical protozoan infections in humans
- 3 Anti-parasitic drug repurposing approaches
- 4 Repurposed drugs against protozoans’ infections
- 5 Antiprotozoal drugs under investigation for use against other diseases
- 6 Conclusion and future perspective
- References
- Chapter Three: Drug repurposing for fungal infections
- Abstract
- 1 Introduction
- 2 Antifungal drugs: action and mechanism of resistance
- 3 Repurposing of non-antifungal drugs as a potential antifungal activity
- 4 Conclusion and future perspectives
- Conflict of interest
- References
- Chapter Four: Exploring the potential of drug repurposing for treating depression
- Abstract
- 1 Introduction
- 2 History
- 3 Pathogenesis of depression
- 4 Different types of drug repurposing
- 5 Approaches to target depression
- 6 Current management of depression
- 7 Conclusion and future remarks
- References
- Chapter Five: Drug repurposing for personalized medicine
- Abstract
- 1 Introduction
- 2 Drug repurposing for precision treatment in breast cancer
- 3 Drug repurposing for glioblastoma
- 4 Drug repurposing for drug-resistant hepatocellular carcinoma
- 5 Drug repurposing for anxiety disorders
- 6 Drug repurposing for severe COVID-19
- 7 Conclusion and future perspectives
- References
- Chapter Six: Drug repurposing for cancer
- Abstract
- 1 Introduction
- 2 Concept of drug repurposing
- 3 Major categories of drugs used for repurposing in cancer therapy
- 4 Current technologies and approaches towards drug repurposing
- 5 Clinical trials and outcomes for drug repurposing in case of cancer
- 6 Future treatment strategies and regulatory considerations
- 7 Discussion
- 8 Future perspective
- 9 Conclusion
- Acknowledgments
- References
- Chapter Seven: Drug repurposing: A multi targetted approach to treat cardiac disease from existing classical drugs to modern drug discovery
- Abstract
- Abbreviations
- 1 Introduction
- 2 Types of CVDs (thrombosis, atherosclerosis, plaque instability, endothelial dysfunction and cardiac failure)
- 3 The reimagined role of existing drugs in cardiovascular diseases
- 4 Cytokine inhibiting therapies
- 5 Pharmacological agents and their biological targets in cardiovascular diseases (CVD)
- 6 Nano therapy for cardiovascular disease
- 7 Plant-based compounds for the management of cardiovascular disorders
- 8 Plant-derived commercial drugs for heart diseases
- 9 Cross-talk between diabetes/Covid 19 infections and heart disease
- 10 Conclusion
- 11 Future perspective and challenges
- Acknowledgment
- References
- Chapter Eight: Drug repurposing in MASLD and MASH-cirrhosis: Targets and treatment approaches based on pathways analysis
- Abstract
- 1 Introduction
- 2 Methodology and prediction approaches
- 3 Modeling results
- 4 Prediction of drug target by integrating the gene lists
- 5 Discussion
- 6 Conclusions and future remarks
- References
- Chapter Nine: Drug repurposing for respiratory infections
- Abstract
- Abbreviations
- 1 Introduction
- 2 Strategy of drug development
- 3 Medications for the treatment of COVID-19
- 4 Strategies for the in-silico repurposing of drugs to discover new anti-COVID-19 drugs and drug targets
- 5 Conclusion
- References
- Further reading
- Chapter Ten: Drug repurposing for rare diseases
- Abstract
- Abbreviations
- 1 Introduction
- 2 Uncommon medical conditions: rare diseases
- 3 Direct attention towards the practical application of concepts through the examination of real-life examples and case studies
- 4 Advancements in repurposing: efforts to further the field
- 5 Conclusion and future remarks
- References
- Chapter Eleven: Drug repurposing for neurodegenerative diseases
- Abstract
- 1 Introduction
- 2 Neurodegenerative diseases
- 3 Drug repurposing: The fundamental concept
- 4 Identifying potential targets in drug repurposing
- 5 Repurposed drugs for neurodegenerative diseases
- 6 Future directions
- 7 Conclusion
- Acknowledgments
- References
- Chapter Twelve: Drug repurposing for metabolic disorders: Scientific, technological and economic issues
- Abstract
- Abbreviations
- 1 Introduction
- 2 Scientific evidences of drug repurposing for metabolic disorders
- 3 Technological issues of drug repurposing for metabolic disorders
- 4 Economic issues of drug repurposing for metabolic disorders
- 5 Conclusion, limitations and future directions
- Acknowledgement
- References
- Chapter Thirteen: Drug repurposing for regenerative medicine and cosmetics: Scientific, technological and economic issues
- Abstract
- 1 Introduction
- 2 Scientific evidence of drug repurposing for regenerative medicine and cosmetics
- 3 Technological issues of drug repurposing for regenerative medicine and cosmetics
- 4 Economic issues of drug repurposing for regenerative medicine and cosmetics
- 5 Conclusion, limitations and future directions
- References
- Chapter Fourteen: Exploring cutting-edge strategies for drug repurposing in female cancers – An insight into the tools of the trade
- Abstract
- Abbreviations
- 1 Introduction
- 2 Breast cancer
- 3 Ovarian cancer
- 4 Endometrial cancer
- 5 Cervical cancer
- 6 Conclusion
- References
- Index
- Edition: 1
- Volume: 207
- Published: June 28, 2024
- No. of pages (Hardback): 448
- No. of pages (eBook): 300
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443241147
- eBook ISBN: 9780443241154
VS
Vijai Singh
Dr Vijai Singh is a Professor and Dean (Research & Innovation) at School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. He was an Associate Professor in the Department of Biosciences, School of Sciences, Indrashil University, Rajpur, Mehsana, Gujarat, India. Prior this this, he was an Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, India and also an Assistant Professor in the Department of Biotechnology at the Invertis University, Bareilly, India. Prior to that, he was a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He received his Ph.D. in Biotechnology from the National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India with a research focus on the development of molecular and immunoassays for diagnosis of Aeromonas hydrophila. His research interests are focused on building novel biosynthetic pathways for production of medically and industrially important biomolecules. Additionally, his laboratory is working on CRISPR-Cas9 tools for genome editing. He has more than 11 years of research and teaching experience in synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has published 100 articles, 70 chapters, 15 books and 3 patents. He serves as an associate editor, editorial board member, and reviewer of several peer-reviewed journals. He is also a member of the Board of Study and Academic Council of Indrashil University and is the Member Secretary of the Institutional Biosafety Committee (IBSC) at the same University.
Affiliations and expertise
Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, IndiaRead Clinical Application of Repurposed Drugs on ScienceDirect