Cancer Epigenetics and Nanomedicine

Targeting the Right Player via Nanotechnology

1st Edition - June 26, 2024
Editors: Prashant Kesharwani, Chitra Thakur
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 2 0 9 - 4
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 3 2 1 0 - 0

Cancer Epigenetics and Nanomedicine: Targeting the Right Player via Nanotechnology is a complete package that provides a comprehensive and thorough understanding of the key player… Read more

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Cancer Epigenetics and Nanomedicine: Targeting the Right Player via Nanotechnology is a complete package that provides a comprehensive and thorough understanding of the key players that modulate the various steps of carcinogenesis and malignant progression of the disease and the critical targets to be exploited for developing novel modalities of diagnosis and therapeutics.

Since epigenetic aberrations can be potentially reversed and restored to their normal state through epigenetic therapy, the book also discusses the challenges and the future of the field with the cutting-edge revelations and limitations that this research endeavor can offer, thereby helping the readers to enhance their critical thinking and adopt strategies of therapeutic importance.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
About the editors
Preface
Acknowledgments
Section 1: Overview of cancer, internal and external factors associated with cancer
Chapter 1 Overview of cancer: Mechanisms of carcinogenesis
Abstract
Introduction
Cancer: A historical perspective
Origin of cancer: Theories and drivers of carcinogenesis
Hallmarks of cancer
Epigenetics and cancer
Conclusion
References
Chapter 2 Tumor metabolism and micronutrients: New insights to target malignant tumors
Abstract
Introduction
Role of micronutrients in targeting malignant tumors
Impact of iron levels on cancer proliferation
Targeting intracellular iron levels to induce cellular death
Impact of calcium levels on cancer proliferation
Targeting calcium levels to induce cellular death
Impact of magnesium levels on cancer proliferation
Targeting Warburg effect to induce tumor cell death
Role of glycolytic enzymes in inducing cancer cell death
Other metabolic pathways used by tumor cells
Interplay between glutaminolysis and Warburg effect
Discussion and conclusion
References
Chapter 3 The role of one-carbon amino acids in tumor-immune metabolism: From oncogenesis to therapy
Abstract
Introduction
One-carbon metabolism
One-carbon metabolism and T-cell function
Restriction of AAs as therapy
Conclusion and future directions
References
Chapter 4 Environmental causes of cancer
Abstract
Introduction
Perspectives
References
Chapter 5 Cancer stem cells—Challenges for cancer therapies
Abstract
Introduction
The identification of the CSCs
CSCs in tumorigenesis models
Biology of CSCs
Challenges posed by CSCs in cancer therapies
Perspective
References
Chapter 6 Carving a therapeutic niche for metastatic cancer: Opportunities and challenges
Abstract
Introduction
Conclusion
References
Section 2: Epigenetics and its importance in cancer therapies
Chapter 7 An overview of epigenetics and cancer
Abstract
Role of epigenetics in normal and cancer cells
Epigenetics mechanism and their regulation on cancer
DNA methylation and histone methylation cross-talks
Role of epigenetic dysregulation of noncoding RNAs in cancer
Epigenetic dysregulation in cancer stem cells, a promise for therapeutic intervention
Epigenetics in the clinics: Prognostics, diagnostics, and therapeutic intervention for cancers
Advancements and innovation in epigenetic technologies in investigating mechanisms in cancer cells
References
Chapter 8 Metabolic adaptation and epigenetic modulations: Unraveling tumor plasticity under variable tumor microenvironment
Abstract
Introduction
Metabolic adaptation to TME
Epigenetic and metabolic crosstalk in TME
Epigenetic modifications in shaping the TME
References
Chapter 9 Involvement of epigenetic modifications in cancer stem cells and chemoresistance
Abstract
Tumor heterogeneity and drug resistance
Cancer stem cells: A new dimension to drug resistance
Reprogramming of cancer stem cells and epigenetic modifications
DNA methylation
Histone modifications
Noncoding RNAs
RNA methylation
Epigenetic involvement in drug resistance
Therapeutic targeting of epigenetic alterations in cancers
References
Chapter 10 Cancer biomarkers: Where genetics meets epigenetics
Abstract
Epigenetics in cancer biology
Histone modifications
DNA methylation
Chromatin remodeling complexes
Noncoding RNAs
Conclusion
References
Chapter 11 Epigenetics approach in cancer treatment with focus on lung and breast cancer
Abstract
Introduction to epigenetics in breast and lung cancer
DNA methylation in breast and lung cancer
Chromatin remodeling and HDAC inhibition
Role of miRNAs as epigenetic biomarkers
Scope of epidrugs
Future directions
References
Chapter 12 Dietary components as epigenetic modifiers and their roles in cancer prevention
Abstract
Introduction
Epigenetic mechanisms and its importance in cancer
Crosstalk between dietary components and metabolism in epigenetic regulation
Types of dietary components and their role in epigenetics and chemoprevention
Dietary polyphenols
Epigallocatechin-gallate
Sulforaphane
Resveratrol
Curcumin
Quercetin
Genistein
Conclusion
References
Section 3: Nanomedicine targeting epigenetic machinery in cancer therapy
Chapter 13 Harnessing plant-derived biosynthetic nanomaterials for epigenetic modulation in cancer therapy
Abstract
Introduction
Epigenetic modulation in cancer
Biosynthetic nanomaterials from plants
Epigenetic modulation by biosynthetic nanomaterials
Experimental evidence and preclinical studies
Clinical potential and future directions
Conclusion
References
Chapter 14 Nanotechnology-enhanced immunotherapy for cancer
Abstract
Introduction
The fundamentals of the immune system
T-cell ontogeny
T-cell activation signals
Tumor immunology
Adoptive T-cell therapy for combating cancers
Immune checkpoints and their role in cancer immunotherapy
Nanotechnological advances in immunotherapy
References
Chapter 15 Nanoparticles in metastatic cancer treatment
Abstract
Acknowledgments
Introduction
Understanding metastasis in cancer
NPs for drug delivery
Targeted drug delivery methodologies
Applications in metastatic cancer treatment
Conclusion and future perspectives
References
Chapter 16 Amine-terminated dendrimers: A novel method for diagnose, control and treatment of cancer
Abstract
Introduction
A summary of amine-terminated dendrimers
The application of amine-terminated dendrimers in cancer
Toxicity of dendrimers
Conclusion and future trend
References
Chapter 17 Nanomedicine and epigenome: Possible health risks, benefits, and future perspectives
Abstract
Introduction
Therapeutic implications of nanomaterial in nanomedicine
Potential role of epigenetics in nanomedicine
Types of epigenetic modifications
Role of epigenetic alterations in the safety assessment of nanomaterials
Conclusion and future perspectives
References
Chapter 18 Smart cancer nanomedicine: Challenges and future opportunities
Abstract
Acknowledgments
Introduction
Smart GSH, ROS, and Hypoxia-sensitive nanoparticles
Enzyme-responsive nanomaterials
Conclusion
References
Index

Prashant Kesharwani

Dr. Prashant Kesharwani is an assistant professor of pharmaceutics at School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. He has more than 12 years of teaching, research, and industrial experience at international levels from various countries, including the United States, Malaysia, and India. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He has more than 300 international publications in well-reputed journals and more than 25 international books (Elsevier). He is a recipient of many research grants from various funding bodies. He is also the recipient of several internationally acclaimed awards, such as “USERN Laureate award”, most prestigious “Ramanujan Fellowship Award”. He actively participates in outreach and scientific dissemination for the service of the wider community.

Affiliations and expertise

Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

Chitra Thakur

Dr. Chitra Thakur is an Assistant Professor-Research in the Department of Pathology at the Stony Brook Cancer Center, New York, USA. She is a cancer biologist and has expertise in molecular oncology, mouse models of human cancers, analyzing big data in translational research, toxicology, and epigenetics in human cancers. She is the recipient of several internationally acclaimed awards such as the “DFG German Excellence Initiative Award,”, “NIH-Big Data Training for Translational Omics Research” and “American Cancer Society IRG”. With more than 45 research articles published in mainstream scientific journals, she has contributed significantly towards the understanding of the molecular mechanisms in human cancers. She is engrossed in cancer research, teaching, and community outreach initiatives, hence fostering the scientific community and health care professionals engaged in cancer diagnosis, and treatment.

Affiliations and expertise

Research Assistant Professor, Stony Brook Cancer Center, Stony Brook University, New York, United States of America