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Elsevier

Academic Press

  • Design and Applications of Cell-Free Systems Part A

    • 1st Edition
    • Volume 218
    • English
    Design and applications of cell-free systems –Part A represents an important component in the field of biochemistry, duly acknowledging the pioneering effort made by Nobel laureate Eduard Buchner for discovery of fermentation in yeast cell extracts (YCE). CFS requires a core molecular machinery including RNA polymerase, translational apparatus (ribosomes, tRNA synthases, and translation factors), energy-generating molecules, and their cofactors, substrates, and DNA or plasmid templates for obtaining desired products. CFS is a simple, rapid, and sensitive platform, which is devoid of membrane-bound barriers, yet contains all the mandatory substrates, biomolecules, and machineries required for the synthesis of the desired proteins. It has the potential to overcome loopholes in the current in vivo production systems and it is promising tool in both basic and applied scientific research. It facilitates a simplified organization of desired experiments with a variety of reaction conditions, making CFS a powerful tool in biological and translational science research.This volume offers wide range of topics on different aspects of cell free systems design and their applications. It covers introduction to applications of cell-free systems, protocol for cell free design, transcription and translation, computational biology, artificial intelligence, automation and robotics for cell free systems, cell free for biosensor, low cost diagnostics, cell free based high throughput screening, biodesign and incorporation of non-natural amino acids into proteins. This volume helps students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand cell-free systems and their applications in many areas.

  • Antimicrobial Peptides and Proteins

    • 1st Edition
    • Volume 149
    • English
    Antimicrobial Peptides and Proteins, Volume 149 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Nature and mechanistic action of Antimicrobial Peptides, Advances in elucidation molecular targets and mechanisms of action of AMPs: beyond membrane disruption, Discovery, Design, and Applications of Antimicrobial Peptides, Designing Potent Antimicrobial Peptides Against Acinetobacter baumannii: A Combined Approach Using Genetic Algorithms and Machine Learning Strategies, Protection of Diabetic Wound Patients from Invasive Bacterial Infections by Innate Antimicrobial Peptides, and more.Additional chapters explore Bacteriophage Lysins as a potential therapeutic strategy for Methicillin Resistant Staphylococcus aureus infections, Structural insights and therapeutic potential of host defense peptides in combatting antimicrobial resistance, Antimicrobial protein as a cargo for antimicrobial nanomaterials to combat Gram-negative bacteria, Unravelling the Role of Antimicrobial Proteins in Leptospirosis: A Comprehensive Transcriptomic Analysis, and Deciphering Antimicrobial Peptide (AMP) Resistance Mechanisms in Enterococcus faecalis Through Integrated RNA-Seq and Hub Genes Identification.

  • Hungarian Quantum Chemistry: Part A - Early and Recent History

    • 1st Edition
    • Volume 93
    • English
    Hungarian Quantum Chemistry: Part A – Early and Recent History, Volume 93 in the Advances in Quantum Chemistry series, highlights the historical and contemporary contributions of scientists to the field of molecular electronic structure theory. Chapters in this new release include Pioneering attempts in Hungary on treating quantum systems, The Early History of Hungarian Quantum Chemistry: From Physics to Applications in Chemistry and Biology, Contributions of Edward Teller to Molecular Quantum Theory, Quantum Chemistry at the Eötvös Loránd University (Budapest) between 1962 and 1982, and Gödel’s argument, human intelligence and the electronic structure of the substrates of life - the legacy of Janos Ladik.Additional chapters cover István Mayer — chemical concepts in quantum chemistry, János Ángyán, a European Career, Weaving the Fabric of Quantum Chemistry: Hungarians’ Contributions at Home and Abroad, Fifty-five Years of Quantum Chemistry, Kállay Laboratory, Molecular Quantum electro-Dynamics Research Group in Budapest, and The Szalay Group at ELTE.

  • Nutritional Neuroscience

    From Bench to Bedside
    • 1st Edition
    • Reinaldo B. Oria + 2 more
    • English
    Nutritional Neuroscience: From Bench to Bedside navigates the complex connections between nutrition and neurological health, from neurodevelopmental disorders influenced by early-life malnutrition to the neuroprotective effects of functional foods. Each chapter offers a detailed examination of the latest research in the field, spanning the mechanisms of taste and food processing in the brain, the impact of dietary interventions on inflammation and blood–brain barrier function, and the link between metabolic disorders and neurodegenerative diseases. This book sits at the forefront of nutritional neuroscience, where cutting-edge research meets practical application, and equips its readers with a holistic understanding of how nutrition influences brain health at all ages. Bridging the gap between laboratory discoveries and clinical practice, this book offers a roadmap for future research and interventions in the f ield of nutritional neuroscience.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 130
    • English
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. This volume provides invaluable information on the fast-moving field of chemistry research that includes outstanding original reviews on a variety of topics.

  • Advances in Agronomy

    • 1st Edition
    • Volume 195
    • English
    Advances in Agronomy, Volume 195, the latest release in this leading reference on agronomy, contains a variety of updates and highlights advances in the field. Chapters in this new release include Mapping of soil elements for precision agriculture using neutron-gamma technology, Digital agriculture to transform decision support systems: state of the art and prospects, Nanoparticles: Dual Role in Alleviating Abiotic Stresses and Boosting Nutrient Efficiency for Sustainable Agriculture, Research on soil erosion under natural rainfall in Brazil: A meta-analysis, Implication of sewage sludge use for sustainable soil management: Soil health and carbon sequestration under the EU 'Soil Deal for Europe’, and more.An additional section covers Climate Resilient Sustainable Agriculture To Ensure Global Food Security.

  • Genetic Regulation of Immune Response Pathways

    • 1st Edition
    • Volume 115
    • English
    Genetic Regulation of Immune Response Pathways, Volume 115 in the Advances in Genetics series, highlights new advances in the field, with this new volume presenting comprehensive chapters on a variety of timely topics. Chapters explore the genetic regulation of immune cells upon activation, IFN response regulation during viral infections, and the role of noncoding RNAs—including lncRNAs and ncRNAs—in immune regulation and inflammation. Additional sections examine the JAK-STAT signaling pathway in inflammatory and autoimmune diseases as a potential therapeutic target, long noncoding RNAs as key regulators of autoimmunity, and the importance of appropriate cytokine expression in maintaining immune response homeostasis.Together... these contributions provide valuable insights into the molecular and genetic mechanisms underlying immune-mediated processes.

  • Implementing R for Statistics

    • 1st Edition
    • Muhammad Imran + 3 more
    • English
    Implementing R for Statistics provides comprehensive coverage of basic statistical concepts using this important open-source programming language tool, from installing R and RStudio, to exploring its basic structure and uses, to extending some core functions such as vectors, basic mathematical operations, and data frames. The book will help readers understand the latest advances in the R programming language, as R allows for sophisticated and elegant data visualization. Illustrated examples are an integral part of the text, carefully designed to apply the core principles illustrated in the text to emerging topics in the field.The text also focuses on exploiting the flexible and user-friendly nature of R. Basic concepts and recent advances in the field, including understanding the R basics, as well as implementing and practicing them in statistics, are also covered. This first edition is an essential text for students, lecturers, data scientists, and applied researchers in all areas of statistics, as well as in related fields such as biostatistics, health care, finance, risk management, social sciences, market research, and environmental and climate research.

  • Current Trends in Breast Cancer Pathology, Screening, Diagnosis and Treatments

    • 1st Edition
    • Firdos Alam Khan
    • English
    Current Trends in Breast Cancer Pathology, Screening, Diagnosis and Treatments offers an extensive examination of the intricate landscape of breast cancer. This reference not only traverses the entire spectrum from pathology to advanced treatment methodologies but also provides the complexities of bioinformatics research and basic research. By presenting information in a manner that is easily digestible, this book caters to researchers and students across various levels of expertise, facilitating a broader understanding of the subject. Spanning 12 detailed chapters, this book unravels the intricacies of breast cancer development. It provides insights into the cellular and molecular pathologies that underlie the disease, outlines the various stages of breast cancer, and elucidates the diverse methods employed in screening and diagnosis. Moreover, this book explores the available treatment modalities, offering a nuanced perspective on the challenges inherent in breast cancer diagnosis and treatment. This book goes beyond a retrospective analysis and adopts a forward-thinking approach. It not only addresses the current challenges but also casts a forward-looking gaze, identifying potential future research avenues in this critical field. This foresight is essential in shaping the trajectory of advancements in breast cancer research and treatment. Tailor-made for a broad audience, including health professionals, scientists, researchers, health practitioners, and students, its thorough examination of current paradigms ensures that readers gain a nuanced understanding of the complexities involved in breast cancer.

  • Revolutionizing Drug Development

    Harnessing AI and Computational Biology
    • 1st Edition
    • Jen-Tsung Chen
    • English
    Revolutionizing Drug Development: Harnessing AI and Computational Biology presents cutting-edge artificial intelligence (AI) tools, such as machine- and deep-learning models and generative AI, to assist structure-based drug design and clinical trial design and integrate with drug development programs. This book summarizes technical advancements of AI-based technologies and computational biology approaches, highlighting their applications in developing new drugs through discovery, repurposing, and designing, for advancing R&D in the pharmaceutical industry and benefiting precision medicine. This book serves as an ideal reference for students, teachers, professors, and researchers in biological and biomedical sciences, particularly the topics related to bioinformatics, systems biology, pharmacology, and drug development. The readers can efficiently and precisely overview this burning field, which might inspire their future directions of research in drug development and AI-based digital biology.

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