On Oxygen
From Air to Tissues
- 1st Edition - November 25, 2024
- Imprint: Academic Press
- Editors: Michael Joyner, Jerome Dempsey
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 1 8 7 7 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 1 8 7 6 - 7
On Oxygen: From Air to Tissues, the latest release in the Fundamentals of Physiology series, provides a fundamental overview of the entire oxygen pathway, sharing key mechanistic… Read more
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Request a sales quoteOn Oxygen: From Air to Tissues, the latest release in the Fundamentals of Physiology series, provides a fundamental overview of the entire oxygen pathway, sharing key mechanistic insights into the alternating conductive and diffusive steps of O2 transport. The book describes specific aspects along each stage of the oxygen route through the body, from the transfer of air to the alveoli, through the lungs, to the ultimate fate of O2 in the mitochondria. Additionally, the effect of specific disease states, aging, and developmental aspects are considered.
This book, published in association with the International Union of Physiological Sciences, acts is a valuable introduction to the full biological journey of oxygen, and is a beneficial guide for students and researchers in physiology, sport science, pulmonology, and related fields.
- Offers a comprehensive, integrated overview of oxygen delivery systems from air to cell and its impact on physiological function
- Covers fundamental aspects of each stage of oxygenation, providing a reductionist approach to complex topics
- Explores physiological responses in the human body at rest and during exercise
- Includes case studies considering various mammals, terrestrial vertebrates, and aquatic animals in discussion of how body size influences key elements of the O2 transport chain
Researchers in the area of physiology, sport science, medicine, pulmonology, cell biology and related biomedical fields, Students in physiology, pulmonology, medicine, cell biology and related areas
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Foreword
- Editorial Advisory Board
- Chapter 1. Introduction
- Abstract
- Overview
- Rationale for On Oxygen
- Target audience(s)
- Scope of On Oxygen
- What is a physiological perspective?
- Some definitions and parameters
- Why exercise?
- Contracting muscles drive physiological responses
- Homeostasis
- Composition of the Air
- Conductive transport and diffusion
- Oxidation
- Summary
- References
- Chapter 2. Exercise hyperpnea: the first step of oxygen delivery
- Abstract
- Introduction
- Fundamental features of the respiratory system to increase O2 uptake and CO2 release
- Breathing mechanics—operating lung volume
- Neural control of exercise hyperpnea/hyperventilation: what we know and do not know
- Ventilatory constraints on hyperpnea: implications for the first step of O2 delivery
- Respiratory and cardiovascular interactions during exercise: implications for O2 delivery
- Mechanical effects of respiration on cardiac function during exercise
- Biological sex differences and aging: implications for exercise hyperpnea
- Exertional dyspnea
- Training effects on the first step in O2 transport
- Environmental hypoxia caveat
- COPD caveat
- Conclusion
- References
- Chapter 3. Pulmonary gas exchange: ventilation–perfusion mismatch, diffusion limitation, and shunt
- Abstract
- Introduction
- Exercise as a stress to pulmonary gas exchange
- Factors affecting ventilation–perfusion matching
- Exercise pulmonary gas exchange response
- Exercise-induced arterial hypoxemia
- Diffusion limitation of CO2
- Mechanisms of increased V̇A/Q̇ inequality with exercise
- Exercise-induced pulmonary edema and the distribution of perfusion
- Shunt during exercise
- Sex differences in pulmonary gas exchange
- Comparison of pulmonary gas exchange limitations in humans and horses
- Summary
- References
- Chapter 4. Getting oxygen from lung to tissues
- Abstract
- Introduction
- Oxygen consumption at rest
- Oxygen consumption during exercise
- Blood pressure and baroreceptor resetting
- Redistribution of blood flow during exercise
- Endurance training and elite athletes
- Conclusion
- References
- Chapter 5. The microcirculation: the connection to everything
- Abstract
- Introduction
- Functional characteristics of the skeletal muscle microcirculation
- Regulation of skeletal muscle oxygen supply
- Adaptability of the muscle microcirculation to activity and inactivity
- Summary and conclusion
- Future research
- References
- Chapter 6. Fundamental principles of oxygen transport in the microcirculation
- Abstract
- Introduction
- Blood flow and convective oxygen transport
- Diffusive oxygen transport
- Oxygen consumption in tissue
- Oxygen penetration distance in tissue
- The Krogh cylinder model for oxygen delivery
- Models for oxygen delivery by microvascular networks
- Control of heterogeneity in microvascular oxygen delivery
- Conclusions
- References
- Chapter 7. Mitochondria: connecting oxygen to life
- Abstract
- Introduction
- Why oxygen?
- The Mitochondrial Electron Transport System: A Marvel of Nature
- From lightning to cellular energy currency
- The interplay of thermodynamic free energies: putting it all together
- Conclusion
- References
- Chapter 8. The pathway for carbon dioxide: from tissues to lungs
- Abstract
- Introduction
- CO2 metabolism and buffering
- Transfer of carbon dioxide to and from blood
- Carbon dioxide transport in the blood
- Flux of carbon dioxide across cellular membranes
- Negative a–A PCO2 differences
- Conclusions
- References
- Index
- Edition: 1
- Published: November 25, 2024
- Imprint: Academic Press
- No. of pages: 400
- Language: English
- Hardback ISBN: 9780443218774
- eBook ISBN: 9780443218767
MJ
Michael Joyner
Michael Joyner, M.D., is a physician-researcher and leading expert on human performance and exercise physiology. He is currently a consultant in the Department of Anesthesiology and Perioperative Medicine and Department of Physiology and Biomedical Engineering at the Mayo Clinic, United States. Using humans as his model system, he has made major contributions to understanding muscle and skin blood flow, blood pressure regulation, and human athletic performance.
Dr. Joyner has been a consultant to the National Institutes of Health (NIH) and NASA and has held leadership positions with prestigious scientific journals. His research lab at Mayo Clinic has been continuously funded by the NIH since 1993, and Mayo Clinic named him a Distinguished Investigator in 2010.
Affiliations and expertise
Consultant, Department of Anesthesiology and Perioperative Medicine, and Department of Physiology and Biomedical EngineeringMayo Clinic, Rochester, Minnesota, USAJD
Jerome Dempsey
Jerome A. Dempsey is the Director of the John Rankin Laboratory of Pulmonary Medicine at the University of Wisconsin, United States. His research interests are concerned with the regulation of breathing in various physiologic states in un-anesthetized humans and animals.
He is involved with the supervision of trainees and instructor in respiratory / exercise / sleep physiology for medical students, undergraduates and graduate students. Dr. Dempsey is the recipient of a number of awards including the Bayliss-Starling Prize Lecture awared by the UK Physiologic Society in 2012 and the 2013 Bodil M. Schmidt-Nielsen Distinguished Mentor and Scientist Award from the American Physiological Society. He is the former Editor-in-Chief of the Journal of Applied Physiology and currently is the CrossTalk Editor for the Journal of Physiology.
Affiliations and expertise
Professor Emeritus and Director, Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin, Madison, Wisconsin, USARead On Oxygen on ScienceDirect