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Elsevier

Books in Life sciences

  • Decoding Cancer

    Precision Oncology through AI, Machine Learning, and Multi-Omics Analytics
    • 1st Edition
    • Pawan Kumar Maurya + 1 more
    • English
    Decoding Cancer: Precision Oncology through AI, Machine Learning, and Multi-Omics Analytics offers an integrated perspective on how computational technologies are transforming cancer research and care. It bridges cancer biology with advanced data-driven approaches to enable precision oncology. The book covers fundamentals of cancer biology alongside applications of artificial intelligence, machine learning, and big data analytics in biomarker discovery, early detection, and personalized treatment. Chapters explore multi-omics integration, predictive modeling, radiomics, surgical robotics, and ethical considerations, supported by diagrams, case studies, and annotated workflows. For academics and professionals, this resource provides actionable insights into cutting-edge tools and methodologies, helping readers understand how computational oncology accelerates translational research and clinical decision-making. It serves as a comprehensive guide for students, researchers, and clinicians navigating the future of data-driven cancer care.

  • The Autism Spectrum

    Identification, Understanding, and Treatment in Global Context
    • 1st Edition
    • Matthew K. Belmonte + 1 more
    • English
    The Autism Spectrum: Identification, Understanding, and Treatment in Global Context provides an update to the basic and clinical sciences of autism with an understanding of how research and clinical treatments are affected by recent shifts of focus: from diagnostic categories to symptomatic dimensions, from provider-centered to patient-centered treatment approaches, from high-resource, individualistic country insights to those contributed from global cultures.This volume discusses the field’s current state, whence it has come, where it is going, and how to get there. The volume weds basic and clinical understandings, state-of-the-art multivariate analyses, historical and cross-cultural information and relevance, and a patient-centered focus.

  • Interstitial Lung Diseases

    New Frontiers in Research and Clinical Applications
    • 1st Edition
    • Carlo Vancheri + 1 more
    • English
    Interstitial Lung Diseases: New Frontiers in Research and Clinical Applications is the book that professionals working with Interstitial Lung Diseases (ILDs) have been waiting for. ILDs encompass a complex group of diseases, characterized by varying degrees of inflammation and fibrosis in the lungs, leading to diverse clinical presentations and subtle differences in imaging findings. This complexity makes diagnosis challenging for pulmonologists, radiologists, and researchers, who must stay updated on evolving pathophysiology, diagnostic innovations, and new classification systems. This comprehensive, invaluable resource integrates the pathogenic, functional, clinical, and radiological aspects of ILDs, providing clinicians with a practical tool for patient care. This book elucidates the distinguishing features of different ILDs, empowering readers to navigate the diagnostic and therapeutic landscape confidently. It offers a practical, step-by-step approach to diagnosing ILDs and understanding their nuances, structured around the latest scientific evidence. Further, it covers etiology, epidemiology, pathogenesis, diagnostic processes, and therapeutic options, incorporating diagnostic and treatment algorithms to serve as both a reference and a practical guide for clinical decision-making. By filling gaps in the literature, “Interstitial Lung Diseases: New Frontiers in Research and Clinical Applications” equips respiratory professionals with the knowledge and skills necessary to enhance diagnostic accuracy, improve patient management, and foster ongoing innovation in the study of ILDs.

  • Systems Biology of Addiction Medicine

    Gut–Brain Axis, OMICS, and Molecular Technologies
    • 1st Edition
    • Mohammad Shabani + 3 more
    • English
    Systems Biology of Addiction Medicine: Gut–Brain Axis, OMICS, and Molecular Technologies is a cutting-edge reference that explores the complex neurobiological mechanisms underlying substance use disorders (SUD). This volume emphasizes the importance of the microbiome-gut-brain axis (MGBA), multi-OMICS approaches, and molecular tools such as CRISPR-Cas9 in advancing addiction research. It addresses the urgent need for integrated frameworks to understand the bidirectional communication between the gut and brain in disorders like nicotine, opioid, alcohol, neurostimulant, and cannabis use. The book synthesizes foundational knowledge with recent developments, offering detailed methodologies, case studies, and translational strategies that bridge basic science and clinical application. Its comprehensive scope makes it invaluable for researchers and clinicians seeking to develop personalized, evidence-based therapies for SUDs. The contents include dedicated sections on the MGBA's role across various substances, detailed chapters on multi-OMICS, SNP, and immunotherapy techniques, and discussions on emerging molecular technologies like CRISPR. Each chapter combines literature reviews, recent advances, and practical applications, supported by schematic figures designed for clarity. The volume aims to empower neuroscientists, psychiatrists, pharmacologists, and biotech professionals with the latest scientific insights and tools to address the global challenge of addiction. By fostering interdisciplinary understanding, this resource supports hypothesis generation, research innovation, and the development of targeted interventions to improve patient outcomes.

  • Microbiome Profiling, Techniques, and Therapeutic Management

    • 1st Edition
    • Sanjana Mehrotra + 1 more
    • English
    Microbiome and Tumorigenesis: Microbiome Profiling, Techniques, and Therapeutic Management, vol. 2 offers a comprehensive exploration of cutting-edge methodologies and clinical applications in microbiome research. This book focuses on the intersection of microbiome science with cancer therapy, bioinformatics, and environmental influences, making it a valuable resource for researchers, clinicians, and graduate students in biomedical and life sciences. The book is structured into three parts: tools and techniques for microbiome analysis, the role of the microbiome in cancer therapy, and the impact of diet, environment, and epigenetics on microbiome–tumor interactions. Topics include sampling strategies, AI-driven data analysis, microbiome-based biomarkers, and therapeutic interventions, with contributions from experts across academia and industry. This book equips the academic audience with both foundational and advanced insights into microbiome research. It supports interdisciplinary learning, fosters translational thinking, and provides practical knowledge for designing experiments, interpreting data, and developing novel therapeutic strategies.

  • Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine

    • 1st Edition
    • Anthony Chang + 1 more
    • English
    Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. This book vastly improves the speed of adoption of AI in pediatric and neonatal healthcare by providing a framework of AI deployment in children and healthcare. In addition to a large section on the principles and theories of artificial intelligence as well as its application in a number of pediatric subspecialties, the book will have about 50 commentaries that all have the same structure The book is presented in a systematic manner for all clinicians to understand the in-depth thinking of the leaders in the pediatric AI domain from an international perspective. Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. It also offers a framework for success in planning, deployment, implementation, and evaluation of AI models in healthcare. In addition, current state of the art of pediatric subspecialties will be presented with future directions to guide the pediatric and neonatal clinicians. Finally, a colorful collection of commentaries by leaders of AI use in children’s health is inserted throughout the book.

  • Decision Neuroscience

    • 2nd Edition
    • Jean-Claude Dreher
    • English
    Decision Neuroscience: An Integrative Perspective, Second Edition, Volume Two presents the most recent and compelling lesional, neuroimaging, electrophysiological... and computational studies in combination with hormonal and genetic studies that have led to a clearer understanding of the neural mechanisms behind reward and decision-making. The neural bases of reward and decision-making processes are of critical interest to scientists because of the fundamental role that reward plays in a number of behavioral processes (such as motivation learning, and cognition), and because the neural bases have theoretical and clinical implications for understanding dysfunctions of the dopaminergic system in several neurological and psychiatric disorders.This book provides a comprehensive update on groundbreaking work that addresses fundamental questions about the nature of behavior, including how does the brain process reward and how does it make decisions when facing multiple options? It features entirely new content, as well as expanded coverage on drug and behavioral addiction and the role of subthalamus stimulation in neurological disorders and neuroeconomics.

  • The Biomechanics of Osseointegration

    • 1st Edition
    • Adriano Piattelli + 1 more
    • English
    The Biomechanics of Osseointegration offers a comprehensive, evidence-based exploration of the biomechanical, anatomical, and biological principles essential to safe and effective use of dental implants. By integrating core sciences with clinical applications, it equips both current and future practitioners with the tools to deliver long-term success in implant therapy. From fundamental concepts such as bone biology and stress-strain relationships to advanced topics like finite element modeling, fatigue testing, and real-world clinical implications, this work bridges the divide between theory and practice. Readers gain deep insight into the biomechanics of standard, short, pterygoid, and zygomatic implants across varying bone types, loading conditions, and anatomical challenges. Examined are long-term histological findings from retrieved human implants, unpacking the reasons behind the success of design elements such as the Cone Morse connection. Grounded in both research and practical examples—including case studies and data spanning three decades—the importance of connecting basic science with clinical expertise is highlighted. Designed primarily for dentists considering the integration of implantology into their practice, as well as postgraduate students in Periodontology, Prosthodontics, Oral Surgery, and Biomedical Engineering, The Biomechanics of Osseointegration also serves as a valuable resource for undergraduate dental and biomechanical engineering students who are entering the field with limited formal education in implant science. With an interdisciplinary approach and emphasis on biomechanics and biology, it provides a critical foundation for anyone committed to advancing in the field of dental implants—ensuring their work is not only innovative but also grounded in safe and effective treatment principles.

  • Cold-Adapted Enzymes

    Biochemistry and Biotechnology
    • 1st Edition
    • Diego Gomez-Casati + 1 more
    • English
    Cold-Adapted Enzymes: Biochemistry and Biotechnology provides a cutting-edge investigation into the molecular mechanisms, structural dynamics, and regulatory pathways of enzymes adapted to cold environments.Beyond classical microbiology, the book explores cold adaptation from psychrophilic bacteria and Antarctic fungi to microalgae, plants, and mammalian cell physiology. It provides biochemistry insights into carbohydrate (amylases, glucoamylases) and lipid metabolism, proteases, and redox enzymes, alongside the roles of molecular chaperones and prokaryotic proteomics. A key highlight is its focus on next-generation biotechnology, featuring AI-driven protein design, advanced computational modeling, and structural bioinformatics. Bridging foundational science with market reality, the volume explores applications from organic waste valorization to industrial biocatalysis, analyzing the global patent landscape and commercial players.As the latest volume in the Foundations and Frontiers of Enzymology series, this book is an indispensable reference for researchers across biochemistry, biotechnology, structural biology, and microbiology.

  • Biofabrication Technologies for Tissue and Organ Engineering and Manufacturing

    • 1st Edition
    • Lorenzo Moroni + 1 more
    • English
    Biofabrication Technologies for Tissue and Organ Engineering and Manufacturing is the fourth volume in the Regenerative and Transplant Medicine Series. The book offers a range of benefits tailored to its diverse audience. For students in biomedical engineering and related fields it provides a comprehensive understanding of biofabrication technologies in tissue and organ engineering and preparing them for future careers. Researchers and scientists in tissue engineering benefit from staying current with the latest advancements, fostering interdisciplinary collaboration, and offering practical insights for experimental design. Clinicians and healthcare professionals gain a deeper understanding of biofabrication applications, improving patient care and staying informed about emerging technologies. Industry professionals in medical devices and biofabrication find valuable insights for product development and market opportunities, while educators use the textbook to enrich curricula and provide real-world applications for students. Regulatory affairs specialists benefit from updates on ethical considerations and compliance in biofabrication, and government officials gain insights into shaping policies for responsible innovation.The authorship is intentionally diverse, encompassing professionals from various backgrounds, including gender, ethnicity, and geographical location. The authors explore applications of biofabrication technologies across different cultural and medical contexts, including voices from underrepresented groups in the fields of biomedical engineering and biofabrication.

  • Redefining the MicroRNA Functionality in Cancer Diagnostics and Therapeutics

    • 1st Edition
    • Vivek Kumar + 2 more
    • English
    Redefining the MicroRNA Functionality in Cancer Diagnostics and Therapeutics is an authoritative volume that explores the pivotal role of microRNAs (miRNAs) in precision oncology. The book integrates fundamental biology, cutting-edge bioinformatics, and translational research, providing a comprehensive overview of miRNA mechanisms, regulation, and clinical applications. It emphasizes technological advances such as single-cell profiling, CRISPR engineering, and AI-driven diagnostics. The content covers miRNA biology, multi-omics integration, innovative therapeutic strategies, and clinical translation, including liquid biopsies and biosensors.In addition, it also addresses industry and regulatory aspects, offering practical insights for translating research into clinical and commercial settings. Rich with case studies and visual aids, the book bridges the gap between bench research and bedside implementation. For the academic audience, this book offers a multidisciplinary resource that enhances understanding of miRNA-based diagnostics and therapeutics, fostering innovation and accelerating clinical adoption in cancer care.

  • Statistics in Medicine

    • 5th Edition
    • Robert H. Riffenburgh + 1 more
    • English
    Statistics in Medicine, 5th Edition serves as an essential resource for health care students, professionals and researchers seeking to understand the application of statistical methods in medical research. This comprehensive text encompasses a wide range of topics, from foundational concepts to advanced techniques, ensuring that readers are well-equipped to design, analyse, and interpret health-related studies. The book includes updated chapters on critical subjects such as missing data, regression models for discrete outcomes, polytomous response regression, classification and regression trees, and the integration of machine learning and AI with statistical methodologies. Each chapter provides practical examples and step-by-step methods, helping readers understand complex concepts while reinforcing learning through exercises and real-world applications. For the academic audience, this book offers a user-friendly approach to medical statistics, making it accessible even to those with limited statistical training. By bridging the gap between theory and practice, it empowers health care professionals to conduct rigorous research, interpret findings accurately, and contribute meaningfully to advancements in medical science.

  • Flow Cytometry-Based Diagnosis for Inborn Errors of Immunity

    • 1st Edition
    • Reza Yazdani
    • English
    Flow Cytometry-based Diagnosis for Inborn Errors of Immunity addresses the need for a practical, comprehensive reference on applying flow cytometry to the diagnosis, classification, characterization, and prognostic evaluation of inborn errors of immunity (IEI). As flow cytometry becomes central to identifying and characterizing IEI, clinical immunologists and basic immunology researchers require an accessible resource that bridges fundamental principles with disease-specific diagnostic applications, alongside guidance valuable to laboratory professionals, students, and early-career practitioners.The reference covers flow cytometry principles, emerging technologies, technical considerations, and quality standards, alongside a framework for classifying IEI, before turning to practical diagnostic approaches for major disease categories. Protocols, diagnostic algorithms, immunophenotyping strategies, and functional assays demonstrate how flow cytometry rapidly identifies cellular and functional abnormalities to support diagnosis, while addressing its complementary role alongside molecular testing, narrowing candidate diagnoses, guiding genetic testing, and confirming genetic findings. Discussion of predictive and prognostic markers and international clinical experience extends its relevance across high-resource and resource-limited settings.Flow Cytometry-based Diagnosis for Inborn Errors of Immunity equips clinicians, laboratory professionals, and researchers with the knowledge and tools to translate flow cytometric findings into accurate diagnosis and informed patient care, strengthening the diagnostic pathway for IEI.

  • Avian Models of Development

    • 1st Edition
    • Volume 173
    • English
    Avian Models of Development provides practical and experimental approaches for using avian systems to study developmental processes. It covers key methods, model applications, and emerging techniques that support research in embryogenesis, tissue formation, gene function, and developmental mechanisms.

  • Neurological and Neuropsychiatric Disorders

    Substance Use and Addictive Behaviors
    • 1st Edition
    • Alexander Baldacchino + 1 more
    • English
    Neurological and Neuropsychiatric Disorders: Substance Use and Addictive Behaviors is an essential resource that delves into the intricate relationship between substance use, addictive behaviors, and their profound impact on neurological and neuropsychiatric health. The book presents a comprehensive examination of the various disorders and conditions that arise from, or are exacerbated by, substance use and addictive behaviors, offering a multidisciplinary approach to understanding these complex interactions. This volume provides a detailed and updated exploration of the neurological and neuropsychiatric consequences of substance use and addictive behaviors.By compiling the latest research and clinical insights, this volume aims to fill a critical gap in the existing literature, which often treats substance use disorders and neurological impacts as separate entities. This integrated approach is crucial for both researchers and clinicians who need a thorough understanding of the co-morbidities associated with addiction. This book solves the problem of fragmented knowledge by offering a unified perspective that is crucial for developing effective treatment strategies and understanding the full spectrum of addiction-related disorders.

  • Sustainable Solutions for Food Waste

    From Recovery to Resource Efficiency
    • 1st Edition
    • Gulsun Akdemir Evrendilek
    • English
    SSustainable Solutions for Food Waste: From Recovery to Resource Efficiency examines the magnitude, causes, and environmental impacts of food waste and presents sustainable strategies for its reduction, recovery, and valorization. The book highlights innovative technologies and practical approaches for transforming food and agricultural waste streams into valuable products and resources.Featuring contributions from experts in the field, it provides comprehensive perspectives on waste generation, management, utilization, and valorization across diverse food and agricultural industries, including grape and winery, fruit juice, olive and olive oil, tea and coffee, brewery and distillery, dairy, citrus, meat, seafood, seaweed, tropical fruits, vegetables, tuberous plants, rice, and medicinal and aromatic plants.Organized into four sections, the book addresses food waste, sustainability, valorization, and resource efficiency. Section 1 introduces the magnitude, causes, environmental impacts, and sustainable management of food waste. Section 2 focuses on waste from major food-processing industries. Section 3 explores waste utilization and valorization from plant-based and agricultural sources. Section 4 examines innovative technologies, circular economy approaches, resource recovery, sustainable food-waste management, and business models for resource efficiency.

  • Protein-Based Hydrogels

    Exploring the Roles of Protein Hydrogels in Membrane-less Organelles, Disease Mechanisms, and Therapeutic Applications
    • 1st Edition
    • Vladimir N. Uversky + 1 more
    • English
    Protein-Based Hydrogels: Exploring the Roles of Protein Hydrogels in Membrane-less Organelles, Disease Mechanisms, and Therapeutic Applications presents a comprehensive overview of natural and engineered protein hydrogels, examining their critical roles in cellular organization, disease pathology, and therapeutic innovation. This book contributes unique value by integrating fundamental biology, cutting-edge biotechnology, and translational biomedical science to address emerging questions about protein phase separation and gelation. Structured into three sections, the book begins by exploring the physiological functions of protein hydrogels in phase-separated organelles, cellular stress sensing, memory formation, and compartmentalization... It then investigates the pathological consequences of hydrogel dysregulation, including their roles in neurodegenerative diseases, cancer, and viral infections. Finally, it examines biomedical applications such as controlled drug delivery, regenerative medicine, biosensing, and the design of synthetic organelles. Each chapter is contributed by a leading expert, offering multidisciplinary perspectives from biochemistry, molecular biology, bioengineering, and medical research. This book is a valuable resource for academic researchers, graduate students, and professionals working in protein engineering, structural biology, molecular medicine, and pharmaceutical sciences. It supports readers in understanding the full spectrum of protein hydrogel biology—from cell physiology to disease mechanisms and therapeutic design—making it especially relevant for those interested in neurodegeneration, cancer biology, and translational bioengineering.

  • The Human Electroretinogram

    A Diagnostic Guide
    • 1st Edition
    • Benedetto Falsini
    • English
    The Human Electroretinogram: A Diagnostic Guide describes the physiological basis and clinical applications of the human electroretinogram (ERG). Several sub-types of ERGs are evoked by Full-Field stimuli, with characteristics that depend critically on the properties of the stimulus. This book discusses the human retina’s high sensitivity to light and its ability to respond robustly to even single quanta of light. Specifically, it clarifies that the major components of flash ERG, the a-wave and b-wave, are generated by photoreceptors and bipolar cells, respectively. This book explores how changes in light intensity, adaptation, and temporal frequency can alter the contributions of different retinal generators (e.g., rods, cones, and bipolar cell subtypes). In addition to Full Field ERG, other important diagnostic electroretinograms including focal, multifocal, and pattern ERGs are clarified. This book uniquely illustrates the combined use of these ERG tools, allowing clinicians to perform a functional dissection of the retina and achieve a layer-by-layer analysis.The approach of The Human Electroretinogram: A Diagnostic Guide correlates with retinal layer evaluations performed using modern multimodal imaging techniques, such as optical coherence tomography (OCT). ERG analysis exemplifies a critically important tool for early diagnosis, follow-up, and treatment monitoring of retinal diseases involving different retinal layers. This book is essential in providing ophthalmological professionals with the know-how to manage the interplay between these numerous elements.

  • Advancements in Digital Cytopathology and Artificial Intelligence

    • 1st Edition
    • Keluo Yao + 2 more
    • English
    Advancements in Digital Cytopathology and Artificial Intelligence offers an extensive and reliable resource for those intrigued by the opportunities for employing artificial intelligence in cytopathology, within both clinical and research settings. The book provides advances in research and commercial technologies, regulatory and business environment updates and special considerations in cytopathology that impacts AI applications in the medical field. It describes the current state of cytopathology digitization and AI technologies, the current cytopathology practice environment, including laws and compliance issues in the context of digitization and AI technologies. This an essential reference for cytologists and trainees who are interested in AI and digital pathology and AI researchers and industry partners who are interested in developing applications for cytopathology.

  • Gallin and Ognibene's Principles and Practice of Clinical Research

    • 5th Edition
    • John I. Gallin + 2 more
    • English
    Gallin and Ognibene’s Principles and Practice of Clinical Research, 5th Edition is the definitive text on clinical research, written by internationally recognized experts in their field, from the US National Institutes of Health, the US Food and Drug Administration, academia, and global researchers. The new edition contains fully updated chapters, with more than 50 new authors and 15 new chapters. The book continues a strong emphasis on study design and biostatistics in clinical research, with new chapters containing fresh information on a variety of topics, including chapters on how to engage a full range of research participants and research opportunities for people involved in patient care including surgeons, pharmacists, and other clinical researchers. For the international researcher, two new chapters detail international clinical research experiences in South Africa and India. As with the 4th edition, the new edition provides readers with summary questions and answers after select chapters.

  • Asiatic-Pacific Ticks

    Species of Medical and Veterinary Importance
    • 1st Edition
    • Ze Chen + 1 more
    • English
    Asiatic-Pacific Ticks: Species of Medical and Veterinary Importance provides the most comprehensive and updated research on the taxonomy, biology, and bionomics of tick species native to the Palearctic and Oriental zoogeographic regions. It synthesizes all current research on each species using global perspectives, as these species begin to spread beyond their native habitats.Written and edited by international experts on the ticks of eastern Asia, this book covers the 12 primary species, including the Asian longhorned tick and those under the Hyalomma genus. Each chapter begins by discussing the species’ classification history, followed by identification descriptions for all active life stages, and a detailed discussion of biology and bionomics. The chapters end with a discussion of pathogenic agents associated with each species and their context for human and animal ecology.Asiatic-Paci... Ticks: Species of Medical and Veterinary Importance is a vital resource for entomologists, both in human-medical and veterinary focuses. Public health personnel and parasitologists tracking diseases in tick species will also find this useful.

  • Nutritional and Health Aspects of Food in Oceania

    • 1st Edition
    • Diana Bogueva + 1 more
    • English
    Nutritional and Health Aspects of Food in Oceania provides an analysis of traditional and ethnic foods from Australia, New Zealand, Fiji, Papua New Guinea, Tonga, Hawaii, Samoa, Tuvalu, Solomon Islands, and New Caledonia. The book addresses the history of use, origin, composition, preparation, ingredient origin, nutritional aspects, and effects on health for various foods and food products in each of these countries. In addition, it presents both local and international regulations while also providing suggestions on how to harmonize these regulations to promote global availability of these foods.

  • Healthcare 4.0

    Pharmaceutical Advancement in the Digital Age
    • 1st Edition
    • Atheer Awad + 1 more
    • English
    Healthcare 4.0: Pharmaceutical Advancement in the Digital Age is a well-structured and easy to understand book that discusses digital health technologies in context of their pharmaceutical applications and the future they hold for this sector. The contents of the book are structured in four parts, covering digital health, software technologies, hardware technologies and the outlook and impact of these innovations to pharmaceutical care. Topics covered include artificial intelligence (AI) and machine learning, blockchain, computational modelling, Telemedicine and Telepharmacy, and virtual/augmented/mi... reality and associated hardware (such as sensors, robotics, smartphones and 3D printing).This book is the perfect resources for academics and corporate researchers in pharmacy, pharmacists, physicians and pharmacy technicians to better understand and position themselves to benefit from the technological developments impacting pharma

  • Innovation in Emergency Medicine

    Technology Development and Commercialization Handbook
    • 1st Edition
    • Nancy Patterson + 3 more
    • English
    Innovation in Emergency Medicine: Technology Development and Commercialization Handbook is a step-by-step guide to emergency medicine technology innovation reflecting recent trends of industry globalization and value-conscious healthcare. Written by a team of medical, engineering, and business experts, the authors provide a comprehensive resource that leads engineers, clinicians, students, researchers, and entrepreneurs through a clear process for the identification, invention, and implementation of new solutions. Case studies on innovative products from around the world, successes and failures, practical advice, and end-of-chapter 'Getting Started' sections encourage readers to learn from real projects and apply important lessons to their own work. This new volume in the Clinical and Medical Innovation Series will be of interest to every biomedical engineer and those working in emergency medicine who has ever had a good idea for an invention but does not know where and how to start bringing it to the bedside.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 138
    • English

  • 3D Bioprinting and Bio-Regenerative Medicine for Personalized Oncology

    Innovations for Personalized Oncology
    • 1st Edition
    • Ashok Kumar + 2 more
    • English
    3D Bioprinting and Bio-Regenerative Medicine for Personalized Oncology: Innovations for Personalized Oncology presents a comprehensive exploration of the transformative role of 3-D bioprinting and bio-generative engineering in modern medicine, with a specific focus on precision oncology. By examining innovative applications of these technologies, the book aims to bridge the gap between emerging scientific advancements and their practical implications in clinical settings. It delves into how patient-specific models of human tissues and organs can revolutionize drug testing, disease diagnostics, and personalized treatment plans, ultimately enhancing the quality of cancer care.Addressing critical challenges in oncology, this book highlights how 3-D bioprinting and bio-generative engineering can improve the accuracy of drug efficacy evaluations, reduce reliance on animal testing, and tackle the pressing issue of organ shortages for transplantation. Furthermore, it emphasizes the ethical considerations and regulatory challenges associated with integrating these technologies into everyday oncology practice, ensuring a balanced perspective on their adoption.

  • Advances in Agronomy

    • 1st Edition
    • Volume 203
    • English
    Advances in Agronomy, Volume 203, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.

  • Virtual Possibilities

    Extended Reality as Assistive Technology for Inclusive Care
    • 1st Edition
    • Samiya Khan
    • English
    Virtual Possibilities: Extended Reality as Assistive Technology for Inclusive Care provides invaluable insights for researchers and related medical professionals into the transformative potential of virtual reality as a technological aid. The book navigates through the diverse applications of virtual reality in healthcare, transcending traditional uses such as medical training and therapeutic interventions. It is a dedicated examination of virtual reality's role in social care, addressing the unique needs of individuals across the spectrum, from differently abled individuals and children with learning disabilities to those grappling with disorders, trauma, and the elderly. It presents the state-of-the-art in this field, acting as a bridge, facilitating the translation of theory into practice and fostering ongoing research. Users will find this to be a valuable resource for researchers, professionals, and policymakers interested in the future applications of virtual reality in healthcare and social care.

  • Euphorbiaceae Family Oriented Drug Discovery

    Exploration of Isolation, Identification, Total Synthesis, and Drug Discovery Based on Natural Products from Euphorbiaceae Family
    • 1st Edition
    • Bingjie Li + 1 more
    • English
    Euphorbiaceae Family Oriented Drug Discovery, Exploration of Isolation, Identification, Total Synthesis, and Drug Discovery Based on Natural Products from Euphorbiaceae Family, a volume in the Drug Discovery Opinions series, aims to comprehensively explore the isolation, identification, synthesis, and drug discovery based on natural products derived from the Euphorbiaceae family. Focused on the isolation, identification, synthesis of bioactive compounds, and drug discovery techniques, the contents of the book are organized into ten chapters. The book opens with an introduction to the Euphorbiaceae family, its botanical overview, medicinal significance, and the importance of exploring its natural products for drug discovery.The next chapters focus on specific techniques for identification and synthesis of natural products, cover the antitumor activities and mechanisms of action of natural products, and discuss the specific antimicrobial properties and mechanisms of action. Final sections discuss anti-inflammatory properties, pharmacology, drug discovery processes for Euphorbiaceae Natural Products, and describe challenges and future directions in research. The final chapter presents final considerations, summarizing key findings and insights from the book.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 137
    • English
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Microbiome-Drug Interactions in Neurological Disorders: Pharmacological Mechanisms, Targets, and Therapeutic Advances

    • 1st Edition
    • Volume 109
    • English
    Advances in Pharmacology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Epigenetics of Alzheimer's and Parkinson's Disease Part A

    • 1st Edition
    • Volume 118
    • English
    Epigenetics of Alzheimer's and Parkinson's Disease Part A, published as Volume 118 of the serial Advances in Genetics, provides a focused survey of the epigenetic mechanisms underlying two of the most prevalent neurodegenerative disorders. Contributions from international researchers examine microRNA-based therapeutic strategies, exosome-mediated pathways, noncoding RNA regulation, DNA and histone modifications, and gene-environment-epi... interactions in Alzheimer's and Parkinson's disease. The volume offers researchers a current reference point for understanding how epigenetic regulation contributes to disease onset and progression, and how these mechanisms might be targeted therapeutically.

  • Clinical Management of Pancreatic Cancer

    From Diagnosis to Palliative Care
    • 1st Edition
    • Takuji Okusaka + 1 more
    • English
    Clinical Management of Pancreatic Cancer: From Diagnosis to Palliative Care provides comprehensive guidance and support at every step of the pancreatic cancer journey, covering all aspects from initial diagnosis to compassionate and holistic care, ensuring healthcare professionals have the knowledge and resources they need for effective management and improved quality of life. The book not only presents the latest advancements in pancreatic cancer management, including innovative surgical techniques, targeted therapies, radiotherapy approaches, and palliative care interventions but also focuses on maintaining and improving patients' quality of life throughout their journey, incorporating palliative medicine and supportive care to alleviate symptoms and enhance overall well-being. IN 4 sections and 29 chapters Clinical Management of Pancreatic Cancer: From Diagnosis to Palliative Care Advocates for patient-centered care by emphasizing communication, shared decision-making, and tailoring treatment approaches to individual needs and preferences. It raises awareness about pancreatic cancer, its challenges, and the importance of early detection, while also dispelling misconceptions and offering hope through informed management strategies. The book also highlights the significance of palliative medicine and comprehensive supportive care to manage symptoms, alleviate pain, and address psychosocial and emotional needs of both patients and their families.Clinical Management of Pancreatic Cancer: From Diagnosis to Palliative Care serves as a bridge between research and clinical practice, offering researchers a broader perspective and equipping clinicians with a valuable resource that enhances their knowledge, decision-making, and patient care skills in the realm of pancreatic cancer management.

  • Clinical Brain Stimulation Part A

    • 1st Edition
    • Volume 308
    • English
    Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Genome Editing and Human Health

    • 1st Edition
    • Volume 157
    • English

  • Bioinformatics, Computational Biology, and Multi-Omics–Driven Probiotic Design for Gut Microbiome Engineering

    • 1st Edition
    • Naheed Mojgani + 3 more
    • English
    Bioinformatics, Computational Biology, and Multi Omics–Driven Probiotic Design for Gut Microbiome Engineering presents an interdisciplinary framework for applying artificial intelligence to microbiome science, probiotic development, and personalized nutrition. The book integrates bioinformatics, computational biology, and clinical insight to address current challenges in gut microbiome research and translation. The volume covers AI driven microbiome profiling, multi omics integration, computational modeling of host–microbe interactions, and predictive analytics. It progresses from foundational concepts to advanced applications, including AI assisted probiotic design, gut–brain axis research, regulatory considerations, and real world case studies supporting translational and clinical relevance. The book equips bioinformaticians, translational microbiome researchers, and clinician scientists with actionable methodologies, conceptual clarity, and validated examples. It supports evidence based decision making, accelerates translational research, and bridges discovery science with implementation in personalized nutrition and probiotic innovation.

  • Epigenetics and miRNA in Neurodegenerative Diseases

    From Molecular Mechanisms to Clinical Applications
    • 1st Edition
    • Lance R. McMahon + 2 more
    • English
    Epigenetics and miRNA in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications explores the crucial role of epigenetic modifications and microRNAs in the onset, progression, and treatment of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, ALS, and Huntington’s disease. This comprehensive book bridges cutting-edge molecular research with real-world clinical applications, covering biomarker discovery, novel therapeutics, gene editing, and AI-driven bioinformatics. With clear explanations, case studies, and future perspectives, it serves as an essential resource for researchers, clinicians, and biotech professionals working toward innovative solutions for neurodegenerative disease diagnosis and treatment

  • Drug Repurposing in Cancer Research

    • 1st Edition
    • Ranjita Shegokar + 1 more
    • English
    Drug Repurposing in Cancer Research investigates the innovative use of drug repurposing in oncology, focusing on emerging and re-emerging cancer types. The book provides a comprehensive yet concise overview of current trends, making it an essential resource for academics and professionals in the field. Structured into 21 chapters, the book presents foundational facts alongside practical and clinically relevant data. It covers topics ranging from market dynamics to AI-driven transformations in cancer treatment, highlighting the rapid advancements in oncology. This compilation ensures that readers are equipped with the latest information necessary for effective research and development. For pharmaceutical researchers, biomedical scientists, and clinicians, "Drug Repurposing in Cancer Research" offers valuable insights into the growing demand for innovative cancer treatments. It serves as a timely resource for understanding the potential of repurposed drugs, supporting efforts in cancer prevention and treatment strategies.

  • Mitochondria Part A

    • 1st Edition
    • Volume 216
    • English

  • Smart and Sustainable Healthcare Systems

    From Algorithms to Patient Outcomes
    • 1st Edition
    • Shivi Sharma + 3 more
    • English
    Smart and Sustainable Healthcare Systems: From Algorithms to Patient Outcomes addresses the transformative evolution in healthcare driven by artificial intelligence, machine learning, telemedicine, and digital health technologies. This reference responds to the growing need for sustainable, personalized, and efficient healthcare delivery by bridging technical innovation with clinical application across diverse medical and engineering disciplines. The content spans intelligent decision support systems, IoT and wearable technologies, secure electronic medical records, telemedicine solutions, and automation in diagnostics and treatment. The book includes detailed chapters on AI in clinical pathways, predictive healthcare analytics, brain tumor classification, and sustainable telehealth innovations, complemented by real-world case studies and future outlooks. This reference benefits researchers, healthcare engineers, clinicians, and policymakers by providing in-depth exploration of emerging technologies, challenges, and practical solutions in Healthcare 4.0. It promotes sustainable healthcare practices, ethical AI use, and advances in telemedicine, equipping professionals with knowledge to design and implement intelligent healthcare systems that enhance patient care and resource efficiency.

  • Structure, Function, and Regulation of G Protein-Coupled Receptors Part A

    • 1st Edition
    • Volume 748
    • English
    G protein-coupled receptors constitute one of the largest classes of cell surface receptors in the human genome and drug targets for approximately one third of the currently prescribed medicines. The has been a tremendous advance in understanding the activation, signaling, and regulation of these receptors over the past couple of years using cellular, biochemical, structural, and pharmacological approaches. These two volumes of Methods in Enzymology cover these recent advances in the form of short overview of the key topics as well as step-by-step protocols developed to probe the functional attributes of these versatile receptors.

  • Autophagy and Neurodegeneration

    • 1st Edition
    • Volume 409
    • English

  • Pediatric Culinary Medicine

    Evidence, Opportunities, and Practice
    • 1st Edition
    • Maria R. Mascarenhas + 2 more
    • English
    Pediatric Culinary Medicine: Evidence, Opportunities, and Practice is a groundbreaking resource authored by diverse pediatric leaders, offering a comprehensive exploration of the rapidly evolving field of food as medicine. This book uncovers the history, benefits, and current research landscape, highlighting future opportunities for advancing pediatric health & development through culinary approaches. It provides practical insights into supporting children from diverse cultural and socioeconomic backgrounds, including those managing chronic conditions and those seeking to optimize wellness. Perfect for both newcomers and seasoned practitioners, this book will inspire innovative ways to integrate food into pediatric care. Packed with expert knowledge, this volume covers the evolution of culinary medicine, current research gaps, and practical strategies for real-world application in a pediatric setting. It features detailed chapters on dietary patterns that promote child health, culturally relevant practices, and policy opportunities, along with pathways for training and education, offering essential guidance for translating culinary medicine into meaningful, sustainable programs that improve pediatric health outcomes. Designed to serve a broad audience, Pediatric Culinary Medicine: Evidence, Opportunities, and Practice is an invaluable tool for researchers seeking to identify gaps and develop impactful studies and for pediatric healthcare providers aiming to implement evidence-based practices. It provides the foundational knowledge, successful models, and training resources needed to harness the power of food to transform child health. This book is a must-have for anyone committed to shaping the future of pediatric nutrition and wellness through culinary medicine.

  • Flavoproteins and Flavoenzymes

    • 1st Edition
    • Volume 747
    • English
    Flavoproteins and Flavoenzymes, Volume 738 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Kirisu2 and KiPaD: global analysis of rapid flavoprotein redox kinetics from stopped-flow multi, ilagros Mendina, A Generic First Approach to Dissecting Flavoenzyme Catalytic Cycles, Removing Covalent Constraints of Protein Loops and Lids by a Split-Gene Strategy, Designing Oxygen Reaction Sites in Flavoprotein Dehydrogenases, Converting Noncovalent Flavoproteins into Covalently Flavinylated Proteins, Complexities of Riboflavin Biosynthesis, Reactions of Riboflavin Catabolism, and much more.Additional sections cover Ferredoxin-dependent thioredoxin reductase, Thermophilic Methylenetetrahydrof... Reductases, Ion-Pumping NADH:Quinone Oxidoreductase, Loading E. coli Dihydroorotate Dehydrogenase with Coenzyme Q, and Single-Component Halogenases.

  • Gold Nanoparticle Therapeutics in Alzheimer's Disease

    Revolutionizing Diagnosis and Treatment
    • 1st Edition
    • Arun Kumar Singh + 2 more
    • English
    Gold Nanoparticle Therapeutics in Alzheimer's Disease: Revolutionizing Diagnosis and Treatment is an essential resource that delves into the groundbreaking use of nanotechnology in the fight against one of the most challenging neurodegenerative disorders. This volume offers an in-depth exploration on how gold nanoparticles can be used to enhance the diagnosis, treatment, and overall understanding of Alzheimer's disease. By examining the molecular mechanisms that enable nanoparticles to cross the blood-brain barrier, the book highlights their role in inhibiting amyloid fibrils and their potential as precise diagnostic tools.Covering a wide range of topics, this comprehensive guide serves as an invaluable reference for researchers, clinicians, and industry professionals at the forefront of Alzheimer's research and nanomedicine.

  • Pioneering Precision in Cancer Treatment through 3D Bioprinting

    • 1st Edition
    • Anand Krishnan + 3 more
    • English
    Pioneering Precision in Cancer Treatment through 3D Bioprinting explores the transformative impact of 3D bioprinting on cancer therapy. This groundbreaking book examines innovative techniques revolutionizing cancer care, from creating patient-specific tumor models to accelerating drug discovery and enabling personalized treatments. It offers a comprehensive look at how 3D bioprinting is reshaping oncology. The book details the creation of intricate tumor models that mimic the in vivo environment, enabling precise drug testing and individualized treatment plans. It highlights 3D bioprinting's role in drug screening, tumor modeling, and creating implantable scaffolds for cancer treatment.By manipulating cell arrangements and microenvironments, 3D bioprinting produces accurate cancer models. For the academic audience, this book blends bioengineering, medical insights, and real-world applications. It provides valuable case studies and developments in 3D cancer model creation, enhancing the understanding of oncogenesis, tumor progression, and therapy responses.

  • The Neurobiological Underpinnings of Addiction Medicine

    Focusing on Novel Approaches
    • 1st Edition
    • Mohammad Shabani + 3 more
    • English
    The Neurobiological Underpinnings of Addiction Medicine: Focusing on Novel Approaches provides a comprehensive review of the biological mechanisms that drive addiction and innovative strategies for treatment. This book begins by examining the crucial role of the microbiome and the gut-brain axis in various substance use disorders, including opioid, alcohol, neurostimulant, and cannabis use disorders. It highlights how gut health can significantly influence addiction behaviors and treatment outcomes. Following this, the second section discusses the interplay between addiction and neuropsychiatric disorders such as depression, anxiety, schizophrenia, ADHD, bipolar disorder, PTSD, and OCD.This section emphasizes the impact of neurotransmitter systems and intracellular pathways on the development and persistence of these disorders. The final section introduces cutting-edge methodologies reshaping addiction research, including multi-OMICS approaches and the implications of CRISPR-Cas9 technology. By integrating these diverse topics, this book offers vital insights for clinicians and researchers alike.

  • Network Pharmacology

    Exploring New Horizons in Drug Discovery
    • 1st Edition
    • Veeranoot Nissapatorn + 4 more
    • English
    Network Pharmacology: Exploring New Horizons in Drug Discovery explores the innovative network pharmacology approach—which examines the intricate interactions between disease targets and metabolites—offering a systems-based perspective that is essential for modern drug discovery. Readers will find in-depth discussions on metabolite databases, computational tools, and the role of natural products in drug discovery. Notable topics include network-based approaches to drug repurposing, personalized medicine, and the implications of traditional medicine in pharmacological research, all supported by real-world case studies and advanced computational methodologies.By integrating multiomics data, including metabolite profiling, the book addresses the limitations of conventional methods and opens new pathways for understanding disease mechanisms and therapeutic responses. This is a foundational guide for researchers, pharmaceutical scientists, and academic scholars across diverse fields such as pharmacology, metabolomics, and systems biology.

  • Protein Misfolding

    • 1st Edition
    • Timir Tripathi
    • English
    Protein Misfolding explores the structural and biochemical foundations of protein misfolding, highlighting its wide-reaching implications for cellular function, disease progression, and biomedical innovation. This book provides a comprehensive understanding of how proteins deviate from their native conformations and the resulting biological consequences. Focusing on both physiological and pathological misfolding, the volume covers essential topics such as folding quality control, molecular chaperones, degradation pathways, and proteostasis. It presents in-depth analyses of protein aggregation mechanisms, amyloid formation, and misfolding-associate... diseases including Alzheimer's, Parkinson's, and prion-related disorders. Additional chapters explore structural approaches to understanding misfolded states, computational modeling of aggregation kinetics, and current efforts to design therapeutics that restore folding homeostasis or prevent toxic accumulation. The book also addresses the cellular response to misfolding stress and the integration of folding dynamics with cellular signaling pathways. This book is a valuable resource for researchers, educators, and professionals in biochemistry, structural biology, molecular medicine, biotechnology, and related disciplines. It supports efforts to understand the fundamental principles of protein structure and function, while offering insight into emerging therapeutic strategies and future research directions in disease-focused protein science.

  • Rational 'Co-Design' of Targeted Anticancer Therapeutics

    Integrating Immuno-Oncology, Biomaterials, and Translational Systems
    • 1st Edition
    • Y. Manojkumar + 3 more
    • English
    Rational 'Co-Design' of Targeted Anticancer Therapeutics: Integrating Immuno Oncology, Biomaterials, and Translational Systems presents a unified, system level framework that designs molecules, carriers, and delivery pathways concurrently for clinically translatable cancer therapies. The book details how electronic structure, molecular recognition, biomaterial compatibility, immune microenvironment dynamics, and ADMET/AI models integrate into end to end decision frameworks—from in silico prediction to experimental validation and regulatory readiness. Readers gain a pragmatic path to faster, safer translation: case informed guidance, co design checklists, and criteria for affordability, scalability, and sustainability enable researchers and advanced students to move beyond fragmented, sequential development toward robust therapeutic systems.

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