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Epigenetics of Alzheimer's and Parkinson's Disease Part A

  • 1st Edition, Volume 118 - May 1, 2027
  • Latest edition
  • Editors: Subashchandrabose Chinnathambi, Ainara Castellanos-Rubio
  • Language: English

Epigenetics of Alzheimer's and Parkinson's Disease Part A, published as Volume 118 of the serial Advances in Genetics, provides a focused survey of the epigenetic mechanism… Read more

Description

Epigenetics of Alzheimer's and Parkinson's Disease Part A, published as Volume 118 of the serial Advances in Genetics, provides a focused survey of the epigenetic mechanisms underlying two of the most prevalent neurodegenerative disorders. Contributions from international researchers examine microRNA-based therapeutic strategies, exosome-mediated pathways, noncoding RNA regulation, DNA and histone modifications, and gene-environment-epigenome interactions in Alzheimer's and Parkinson's disease. The volume offers researchers a current reference point for understanding how epigenetic regulation contributes to disease onset and progression, and how these mechanisms might be targeted therapeutically.

Key features

  • Surveys epigenetic mechanisms — miRNA, noncoding RNA, DNA/histone modification — implicated in Alzheimer's and Parkinson's disease
  • Covers exosome-mediated pathways and gene-environment-epigenome interactions in neurodegeneration
  • Authored by international contributors across genetics, molecular biology, and neuroscience
  • Provides a reference point for both mechanistic understanding and emerging epigenetic-targeted therapeutic strategies
  • Part of the long-running Advances in Genetics serial, maintaining continuity with established editorial standards

Readership

Neuroscientists and molecular geneticists studying neurodegenerative disease; epigenetics and RNA biology researchers; clinical researchers investigating Alzheimer's and Parkinson's disease pathogenesis; graduate students and postdoctoral fellows in neurogenetics and epigenetics.

Table of contents

  • Therapeutic Intervention of Alzheimer's and Parkinson's Diseases by Targeting miRNAs
  • Exosome Pathways in Parkinson's Disease
  • Epigenetic Modification in AD/PD
  • Noncoding RNAs as Epigenetic Regulators in Parkinson's Disease
  • Epigenetic Modification in Alzheimer's Disease
  • Gene-Environment-Epigenome Interactions in Alzheimer's and Parkinson's Disease

Product details

  • Edition: 1
  • Latest edition
  • Volume: 118
  • Published: May 1, 2027
  • Language: English

About the editors

SC

Subashchandrabose Chinnathambi

Subashchandrabose Chinnathambi is Additional Professor at the Department of Neurochemistry, National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India. His scientific interests include physiopathology of neurodegenerative disorders, Tau Cytoskeleton, Tau-GPCR, purinergic and chemokine receptors, Tau stem cells, animal models, neuropharmacology, therapeutic approaches targeting Tau oligomers, and biomarkers for neurodegeneration. He serves on the editorial board for various international cell biology journals and is also a regular invited speaker at a number of meetings and workshops. Dr. Chinnathambi has more than 16 years of research experience in the area of neuroscience and Tau-related research in Alzheimer’s Disease.

Affiliations and expertise
Additional Professor, Department of Neurochemistry, National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India

AC

Ainara Castellanos-Rubio

Ainara Castellanos-Rubio obtained her PhD on Genetics from the University of the Basque Country (Spain) in 2010. During her PhD, she studied gene expression alterations and genetic polymorphisms associated to Celiac Disease. She did a short term research stay in the University of Tampere (Finland) under the supervision of Dr. Marku Makki and Dr. Katri Lindfors where she used three dimensional cell cultures to describe different pathways involved in Celiac Disease development. On 2011 she joined the Laboratory of Dr. Sankar Ghosh in Columbia University (NY, USA) where she carried out her postdoctoral studies. During her postdoctoral training, she studied the implication of long noncoding RNAs (lncRNAs) in the immune and inflammatory response and she discovered and functionally characterized a novel lncRNA involved in the susceptibility to Celiac Disease. Dr. Castellanos-Rubio is an Ikerbasque Associate in the University of the Basque Country, where she leads her own group. She is interested in the involvement of noncoding RNAs in the pathogenesis of autoimmune and inflammatory diseases and studies the influence of disease associated SNPs in the functional disturbance of these RNAs. More recently, she has become interested on the epitranscriptomic alterations involved in different aspects of RNA regulation and her group studies how SNPs and environmental factors can alter these epitranscriptomic signals influencing the inflammatory response that finally evolves in disease development.
Affiliations and expertise
University of the Basque Country and Ikerbasque, Basque Foundation for Science, Leioa, Spain