Skip to main content
Elsevier

Structure, Function, and Regulation of G Protein-Coupled Receptors Part A

  • 1st Edition, Volume 748 - May 1, 2027
  • Latest edition
  • Editors: David Christianson, Arun K. Shukla, Karen N. Allen
  • Language: English

G protein-coupled receptors constitute one of the largest classes of cell surface receptors in the human genome and drug targets for approximately one third of the currently… Read more

Description

G protein-coupled receptors constitute one of the largest classes of cell surface receptors in the human genome and drug targets for approximately one third of the currently prescribed medicines. The has been a tremendous advance in understanding the activation, signaling, and regulation of these receptors over the past couple of years using cellular, biochemical, structural, and pharmacological approaches. These two volumes of Methods in Enzymology cover these recent advances in the form of short overview of the key topics as well as step-by-step protocols developed to probe the functional attributes of these versatile receptors.

Key features

  • Contributions by the leaders in the field of GPCR biology
  • Focus on recently developed and broadly applicable methods and advances
  • Chapters are based on most recent advances in the field with futuristic outlook

Readership

Anyone involved in research focused on G protein-couples receptors (GPCRs) would find these volumes highly valuable and these will particularly appeal to the researchers involved in cutting-edge research and development on GPCRs

Table of contents

1. TBD
Ruth Huttenhain

2. TBD
Laura Wingler

3. TBD
Dawn Thompson

4. TBD
Martin Gustavsson

5. TBD
Ka Young Chung

6. TBD
Nagarajan Vaidehi

7. TBD
JoAnn Trejo

8. TBD
Mone Zaidi

9. TBD
Antonella Ciancetta

10. TBD
Jihye Seong

11. TBD
Beata Jastrzebska, Mingda Liu and Zaiddodine Pashandi

12. TBD
Tracy Handel

13. TBD
Rajan Lamichhane

14. TBD
Josef Lazar

15. TBD
Yan Zhang

16. TBD
Birgül Necla

17. TBD
Hannes Schihada

18. TBD
Sudarshan Rajagopal

19. TBD
susruta majumdar

20. TBD
David Ascher

21. TBD
Cesare Orlandi

22. TBD
Hyung Ho Lee

23. TBD
Andy Chevigne

24. Negative-staining electron microscopy screening of GPCR signaling complexes for structural analysis
Arun K. Shukla

25. Expression and purification of GPCR-G-protein stabilizing antibody fragment ScFv16 in bacterial expression system
Arun K. Shukla

Product details

  • Edition: 1
  • Latest edition
  • Volume: 748
  • Published: May 1, 2027
  • Language: English

About the editors

DC

David Christianson

After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.

Affiliations and expertise
Roy and Diana Vagelos Professor in Chemistry and Chemical Biology, Department of Chemistry and Chemical Biology, University of Pennsylvania, Philadelphia, USA

AS

Arun K. Shukla

Dr. Arun K. Shukla is a world leader in the field of GPCR biology and he is currently a Professor in the Department of Biological Sciences and Bioengineering at the Institute of Technology, Kanpur in India. Dr. Shukla’s research program is focused on understanding the structure, function and regulation of G protein-coupled receptors with a long-term of designing novel therapeutics with minimized side-effects.
Affiliations and expertise
Professor, Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, India

KA

Karen N. Allen

Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering
Affiliations and expertise
Department of Chemistry, Metcalf Center for Science and Engineering, Boston University, Boston, MA, USA