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Elsevier

Books in Life sciences

  • Raw Materials Purchasing

    An Operational Research Approach
    • 1st Edition
    • Volume 4
    • B. G. Kingsman
    • English
    A systematic study of commodity purchasing analysed from an operational research viewpoint and based on numerous case studies.

  • Immunological Methods

    • 1st Edition
    • Ivan Lefkovits + 1 more
    • English
    Immunological Methods a compendium of basic research techniques being used in one of the largest immunology research institutes, the Basel Institute for Immunology, with particular emphasis given to new methodology. The procedures have been described by individuals judged to be highly expert in their specialties. In many instances the methods developed or adapted to unique uses by the contributors have not previously been described in detail. The book contains 34 chapters covering techniques for detection, isolation, and purification of antibodies (including dansylation, two-dimensional chromatography, isoelectric focusing, polyacrylamide gel electrophoresis, and isotachophoresis); measurement of equilibrium constants (equilibrium dialysis, filtration, and sedimentation); and isotope and fluorescent labeling and detection of cell-surface components. Techniques such as isotope laboratory maintenance; chemical modification of proteins, haptens, and solid supports, and haptenation of viable biological carriers; production of antisera against allotypes and histocompatibility antigens and production of antibody with clonai dominance; histocompatibility and MLR testing; and cell separation by haptenated gels and by velocity sedimentation of rosette-forming cells are also discussed. Other chapters cover detection of antibody-secreting and alloantigen-binding cells; immune responses in vitro and their analysis by limiting dilution; production of T-cell factors; hybridoma production by cell fusion; maintenance of cell lines and cloning in semisolid media; and the mathematical analysis of immunological data.

  • Structure and Functions of Contractile Proteins

    Revisions, Additions, and a Foreword to the English-Language Edition Prepared by the Author
    • 1st Edition
    • Boris F. Poglazov
    • English
    Structure and Functions of Contractile Proteins focuses on the analysis of problems on the structure and functions of contractile proteins in which substantial progress has been achieved. The book first offers information on the protein constitution of myofibrils and myosin, including adenosinetriphosphat... activity, reaction with actin, and myosin molecule. The text also ponders on the polymerization of actin, tropomyosin, and the theory of contraction. Discussions focus on model experiments and molecular basis of contraction; structural interrelations of muscle proteins; features of the process of polymerization of actin; and size of the actin molecule. The text elaborates on the contractile proteins of the elementary motor structures of cells, as well as the chemical composition and physicochemical and enzymic properties of flagella and cilia; achromatin apparatus and movement of chromosomes; and structure of the flagella and cilia. Motor apparatus of bacteriophage and features of the movement of protoplasm and the mechanism of permeability are also discussed. The manuscript is a reliable source of data for readers interested in the structure and functions of contractile proteins.

  • Biotechnological Innovations in Food Processing

    • 1st Edition
    • BIOTOL + 2 more
    • English
    A thorough examination of the ways in which recent biotechnological developments have led to improvements in food processing. Deals with biotechnology based processes currently in use by or available to the food industry. Building on a series of case studies selected to illustrate the diversity of applications it clearly shows that biotechnology can and will benefit the food industry.The need for a cost-effective training scheme for new and existing staff at all levels has been met by the University of Greenwich (formerly Thames Polytechnic) and the Open University of the Netherlands. As part of the European Community Education and Technology Training initiative (COMETT) and in conjunction with a number of other leading UK and European universities, they have developed BIOTOL, a training scheme in biotechnology using open learning materials, which will provide tailor-made courses, flexible in content, pace and place.

  • Centrifugation in Density Gradients

    • 1st Edition
    • C. A. Price
    • English
    Centrifugation in Density Gradients provides information pertinent to the fundamental aspects of density gradient centrifugation. This book discusses the benefits of density gradient centrifugation to membrane-bound particles. Organized into nine chapters, this book begins with an overview of the method of differential or fractional centrifugation. This text then explores the physical basis of density gradient centrifugation. Other chapters deal with the nuts and bolts of density gradient centrifugation, the construction and composition of gradients, the properties and operation of centrifuge systems, and certain arcane but highly useful procedures. This book discusses as well density gradient centrifugation in the analytical ultracentrifuge. The final chapter deals with a collection of protocols for separating particles ranging in size from whole cells to macromolecules. This book is intended to be suitable for readers who need to separate biological particles. Biologists, chemists, biochemists, cytologists, physiologists, scientists, and research workers will also find this book useful.

  • Food Texture and Viscosity: Concept and Measurement

    • 1st Edition
    • Malcolm C. Bourne
    • English
    Food Science and Technology: A Series of Monographs: Food Texture and Viscosity: Concept and Measurement focuses on the texture and viscosity of food and how these properties are measured. The publication first elaborates on texture, viscosity, and food, body-texture interactions, and principles of objective texture measurement. Topics include area and volume measuring instruments, chemical analysis, multiple variable instruments, soothing effect of mastication, reasons for masticating food, rheology and texture, and the rate of compression between the teeth. The book then examines the practice of objective texture measurement and viscosity and consistency, including the general equation for viscosity, methods for measuring viscosity, factors affecting viscosity, tensile testers, distance measuring measurements, and shear testing. The manuscript takes a look at the selection of a suitable test procedure and sensory methods of texture and viscosity measurement. Discussions focus on nonoral methods of sensory measurement; correlations between subjective and objective measurements; variations on the texture profile technique; and importance of sensory evaluation. The publication is a vital source of information for food experts and researchers interested in food texture and viscosity.

  • Laboratory Methods in Microbiology

    • 1st Edition
    • W. F. Harrigan + 1 more
    • English
    Laboratory Methods in Microbiology is a laboratory manual based on the experience of the authors over several years in devising and organizing practical classes in microbiology to meet the requirements of students following courses in microbiology at the West of Scotland Agricultural College. The primary object of the manual is to provide a laboratory handbook for use by students following food science, dairying, agriculture and allied courses to degree and diploma level, in addition to being of value to students reading microbiology or general bacteriology. It is hoped that laboratory workers in the food manufacturing and dairying industries will find the book useful in the microbiological aspects of quality control and production development. The book is organized into two parts. Part I is concerned with basic methods in microbiology and would normally form the basis of a first year course. Abbreviated recipes and formulations for a number of typical media and reagents are included where appropriate, so that the principles involved are more readily apparent. Part II consists of an extension of these basic methods into microbiology as applied in the food manufacturing, dairying and allied industries. In this part, the methods in current use are given in addition to, or in place of, the ""classical"" or conventional techniques.

  • Water-Soluble Vitamins, Hormones, Antibiotics

    • 1st Edition
    • Volume 11
    • Marcel Florkin + 1 more
    • English
    Comprehensive Biochemisty, Volume 11: Water-Soluble Vitamins, Hormones, Antibiotics deals with the organic and physical chemistry of the major organic constituents of living material. This book provides a sound treatment of the important biological high polymers, emphasizing their shape and physical properties. A number of substances peculiar to plants, certain isoprenoids, flavonoids, tannins, lignins, and plant hormones are also covered. This publication likewise discusses the fate of thiamine in living organisms, biologically active isoalloxazines, and auxins with a heterocyclic ring system. Other topics include the yolk-formation hormone of the corpora allata, biochemical aspect of the antibiotics, and miscellaneous antibiotics derivable from amino acids. This volume is a good source for biochemists and specialists conducting work on water-soluble vitamins, hormones, and antibiotics.

  • Protides of the Biological Fluids

    Proceedings of the Twenty-Ninth Colloquium, 1981
    • 1st Edition
    • Volume 29
    • H. Peeters
    • English
    Protides of the Biological Fluids: An International Review Series Devoted to Proteins and Related Studies, Volume 29: Membrane Proteins, Receptor Ligand Interactions, Monoclonal Antibodies, New Methods focuses on membrane proteins, receptor-ligand interactions, and monoclonal proteins as a reagent. The selection first offers information on H-Y and sex determination and aspects of the difficulties to purify membrane proteins. Topics include solubilization by acylation, influence of supporting media on the aggregation of proteins, solubilization with detergents and organic solvents, and membrane proteins - giant detergent molecules. The text then examines the application of group-specific reagents for hydrophobic labeling and crosslinking of membrane proteins and comparison of secreted and membrane-bound human immunoglobulins M and D. The publication tackles sialoglycoproteins (glycophorins) in the plasma membranes of different cells and their receptor functions and the structures and antigenic properties of human erythrocyte membrane sialoglycoproteins. Discussions focus on the primary structure of human erythrocyte glycophorins, molecular structure of the MN bloodgroup substance, and genetic variants of glycophorin A. The book also takes a look at the glycoproteins of the human syncytiotrophoblasti... plasma membrane and structure and function of a membrane glycoprotein encoded in the adenovirus genome. The selection is a valuable reference for readers interested in membrane proteins, receptor ligand interactions, and monoclonal antibodies.

  • Microbial Transformations of Steroids

    A Handbook
    • 1st Edition
    • William Charney + 1 more
    • English
    Microbial Transformations of Steroids: A Handbook aims to provide those who wish to use microbial transformations of steroids with a single source book starting from 1937 to the present. The handbook first offers information on the history of the microbial transformations of organic compounds, including earliest works on the study of nonsteroids and steroids; significance of discovery of anti-inflammatory action of cortisone; first hydroxylations and dehydrogenations; manufacture of natural and synthetic corticosteroids; and trends in research. The text then ponders on chemical classification of microbial transformations of steroids, as well as the role of enzymes in microbial transformations and the classes of reactions. The publication elaborates on the construction and use of the table. Topics include order of the table, nomenclature, description of the transformation leading to the product, yield, organism, and constants. The book also focuses on taxonomy and use of the table, including system of classification, specific notes on divisions of the table, and source of cultures. The handbook is a valuable source of data for readers interested in the microbial transformations of steroids.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 8
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 8 covers the significant progress in understanding the lipid chemistry and biochemistry of plants and animals. This volume contains seven chapters and begins with a discussion of the various aspects of cholesterol turnover in man and the possible mode of action of hypocholesterolemic regimens. The next chapters deal with the arterial composition and metabolism, with particular emphasis to esterified fatty acids and cholesterol, as well as the important role of essential fatty acids in mammalian development, health, and disease. A chapter emphasizes the participation of lipids in membrane structure. The remaining chapters explore the chemistry and biochemistry of phospholipids and glycolipids. These chapters also consider rumen metabolism and the surface chemistry of lipids. This book will prove useful to biochemists, organic chemists, physicians, and researchers.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 1
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 1 provides information pertinent to the structure and behavior of lipids through sulfolipids. This book presents the advances on fat absorption and transport. Organized into 10 chapters, this volume begins with an overview of the methods for the analysis of glycerine mixtures that require the determination of the fatty acid composition of the whole mixture and of its component fraction. This text then examines lipids as molecules of biological interest having little or no solubility in water. Other chapters cover the advances in cholesterol metabolism, Vitamin E as it affects lipid metabolism, and a discussion on atherosclerosis. This book discusses as well all areas of lipid research ranging from physical chemistry to physiology and pathology. The final chapter deals with sulfolipid, which appears to be concentrated in the lamellar membranes of the chloroplasts of plants. This book is a valuable resource for physical chemists, biologists, and pathologists.

  • The Retinoids: v. 2

    • 1st Edition
    • BAERT ET BAERT ET AL
    • English
    The Retinoids is a collection of papers that deals with the biochemistry and metabolism of the retinoids and of specific retinoid-binding proteins that are found in plasma and in cells. Some papers describes the biosynthesis and metabolism of retinol, with plasma retinol-binding protein, with intracellular retinoid-binding proteins, as well as with the metabolism and role of retinoids in the eye. Other papers review the metabolism of retinoic acid and synthetic retinoids, the cellular and molecular mechanisms of action of the retinoids, and applied biology of the retinoids. Several papers discuss toxicology, teratology, immunology, and the applications of retinoids in the fields of cancer and dermatology. One paper describes the transport of retinoic acid and other acidic retinoids in plasma in association with serum albumin. Another paper hypothesizes that vitamin A affects differentiation at the cellular level and addresses how tissue specificity of this action can arise. One paper examines the role of retinoid-binding proteins in vertebrate visual system, particularly how these proteins transport retinoids in the serum, cell sap, and interstitial spaces of the eye. The collection can prove useful for biologists, microbiologists, cellular biologists, students and professors of biology, oncology, ophthalmology or dermatology.

  • Carbohydrates

    • 1st Edition
    • Volume 5
    • Marcel Florkin + 1 more
    • English
    Comprehensive Biochemisty, Volume 5: Carbohydrates deals with the organic and physical chemistry of the major organic constituents of living material. This book discusses the general structure of monosaccharides, detection and estimation of aldonic acids, intramolecular rearrangement of N-glycosides, and preparation of sugar phosphates. The deacetylation of glycoside acetates, naturally occurring oligosaccharides of human milk, and molecular weight of polysaccharides are also elaborated. This text likewise covers the biogenesis and fate of pectic substances in plant tissues, complex polysaccharides of gram-positive bacteria, galactosaminoglycan of Aspergillus parasiticus, and chemical structure of heparin sulfate. This volume is a good source for biochemists and researchers conducting work on carbohydrates.

  • The Chlorophylls

    • 1st Edition
    • Leo P. Vernon + 1 more
    • English
    The Chlorophylls reviews developments in study of chlorophylls, and at the same time summarizes the state of knowledge in the more established areas of the physics, chemistry, and biology of chlorophylls. The book is organized into four sections. The first section deals with the chlorophylls as chemical entities, and treats their isolation, analysis, chemistry, and synthesis. The second concerns chlorophylls in real and colloidal solution and in the solid state in vitro, and includes the effects of aggregation on visible, infrared, and NMR spectral properties. The third section treats the biosynthesis, organization, and properties of chlorophylls in the plant and bacterial cell, and the fourth is concerned with the photochemical and photophysical behavior of chlorophylls in vitro and in vivo. It is hoped that this work will help those investigating selected aspects of chlorophyll to keep abreast of other methods and approaches, and will provide the interested scientist with a modern, conceptually organized treatment of the subject.

  • Ion Transport in Prokaryotes

    • 1st Edition
    • Barry P. Rosen + 1 more
    • English
    Ion Transport in Prokaryotes provides an advance treatise on ion transport and prokaryotic organisms. This book is divided into three main topics—cation transport systems, anion transport systems, and plasmid-encoded transport systems. This compilation specifically discusses the proton transport and proton-motive force in prokaryotic cells, potassium transport in bacteria, and bioenergetic functions of sodium ions. The calcium transport in prokaryotes, phosphate transport in prokaryotes, and transport of organic acids in prokaryotes are also elaborated. This text likewise covers the chloride, nitrate, and sulfate transport in bacteria and bacterial magnesium, manganese, and zinc transport. This publication is recommended for biologists, specialists, and students interested in the bacterial ion transport system.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 14
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 14 is a five-chapter text that covers other important aspects of lipid chemistry, including an enzyme controlling cholesterol biogenesis, fatty acid activation, and lipid synthesis. The first chapter concerns with the control of activity of ?-hydroxy-?-methylgl... coenzyme A reductase. The second chapter deals with the specificity, localization, and function of fatty acid activation. The third chapter describes the interaction between polyene antibiotics and sterols. This chapter specifically tackles some antibiotic activity to understand membrane function and in vivo hypolipidemic activity. The fourth chapter focuses on the lipids in plant cultures, while the fifth chapter looks into the methods of synthesis of acylglycerols and phosphoglycerides. This book will prove useful to lipid chemists, biochemists, and researchers.

  • Bacteriocins of Lactic Acid Bacteria

    • 1st Edition
    • Dallas G. Hoover + 1 more
    • English
    Bacteriocins of Lactic Acid Bacteria is based on the 1990 Annual Meeting of the Institute of Food Technologists held in Dallas, Texas. It describes a number of well-characterized bacteriocins and, where possible, discusses practical applications for those that have been defined thus far from the lactic acid bacteria. The book begins with an introductory overview of naturally occurring antibacterial compounds. This is followed by discussions of methods of detecting bacteriocins and biochemical procedures for extraction and purification; genetics and cellular regulation of bacteriocins; bacteriocins based on the genera of lactic acid bacteria Lactococcus, Lactobacillus, Pediococcus, and Leuconostoc, and related bacteria such as Carnobacterium and Propionibacterium; and the regulatory and political aspects for commercial use of these substances. The final chapter sets out the prognosis for the future of this dynamic area. The information contained in this book should benefit those with interest in the potential for industrial use of bacteriocins as preservative ingredients. Anyone interested in lactic acid bacteria or the biosynthesis, regulation, and mechanisms of inhibition of these proteinaceous compounds will also appreciate the material presented. These include food scientists, microbiologists, food processors and product physiologists, food toxicologists, and food and personal product regulators.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 13
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 13 is a four-chapter text that emphasizes the biological aspects of lipoproteins. The first chapter reviews the status of lipoprotein metabolism, specifically the functional, structural, and metabolic interrelationships of lipoproteins. The second chapter covers aspects of lipid metabolism in diabetes and the stresses that can cause alterations in carbohydrate metabolism. The third chapter discusses the developments in understanding the physicochemical basis of gallstone formation. The fourth chapter deals with the biosynthesis and composition of milk fat. This chapter also presents a summary of some of the important features of milk fat production processes. This book will prove useful to lipid chemists, biochemists, physicians, and researchers.

  • Nucleotide Metabolism

    An Introduction
    • 1st Edition
    • J. Frank Henderson + 1 more
    • English
    Nucleotide Metabolism: An Introduction is a textbook exclusively focusing on the study of the aspects of nucleotide metabolism. The book intends to present the chemistry and metabolism of nucleotides, one of the oldest subjects of biochemistry. The text is divided in two parts. Part I considers the general aspects of nucleotide metabolism such as the history of the discovery of nucleotides; functions of nucleotides in cells; and group-transfer reactions during nucleotide metabolism. Part II deals with the synthesis, formation, and conversion of purine ribonucleotides. Biochemists, pharmacologists, and researchers in the fields of medicine and pharmaceuticals will find the book invaluable.

  • The Foundations of Genetics

    • 1st Edition
    • F. A. E. Crew
    • J. M. Dodd + 1 more
    • English
    The Foundations of Genetics describes the historical development of genetics with emphasis on the contributions to advancing genetical knowledge and the various applications of genetics. The book reviews the work of Gregor Mendel, his Law of Segregation, and of Ernst Haeckel who suggested that the nucleus is that part of the cell that is responsible for heredity. The text also describes the studies of W. Johannsen on "pure lines," and his introduction of the terms gene, genotype, and phenotype. The book explains the theory of the gene and the notion that hereditary particles are borne by the chromosomes (Sutton-Boveri hypothesis). Of the constituent parts of the nucleus only the chromatin material divides at mitosis and segregates during maturation. Following studies confirm that the chromatin material, present in the form of chromosomes with a constant and characteristic number and appearance for each species, is indeed the hereditary material. The book describes how Muller in 1927, showed that high precision energy radiation is the external cause to mutation in the gene itself if one allele can mutate without affecting its partner. The superstructure of genetics built upon the foundations of Mendelism has many applications including cytogenetics, polyploidy, human genetics, eugenics, plant breeding, radiation genetics, and the evolution theory. The book can be useful to academicians and investigators in the fields of genetics such as biochemical, biometrical, microbial, and pharmacogenetics. Students in agriculture, anthropology, botany, medicine, sociology, veterinary medicine, and zoology should add this text to their list of primary reading materials.

  • Introduction to Genetics

    Science of Heredity
    • 1st Edition
    • A. J. S. McMillan
    • English
    Introduction to Genetics: Science of Heredity presents a linear programmed text about hereditary and genetics. This book discusses a variety of topics related to heredity and genetics, including chromosomes, genes, Mendelism, mitosis, and meiosis. Organized into six chapters, this book begins with an overview of some of the experiments that first provide an understanding of heredity and laid the foundation of the science of genetics. This text then provides detailed information about the cell and explains how the essential parts of it reproduce and divide. Other chapters consider how the chromosome theory can explain not only the facts of Mendelism, but also the many complications that arise in genetics. This book discusses as well the problems that can happen during the process of mitosis and meiosis. The final chapter deals with the practical problems that confront the plant breeder. This book is a valuable resource for teachers and students of biology.

  • Gene Activity in Early Development

    • 1st Edition
    • Eric H. Davidson
    • English
    Gene Activity in Early Development reviews the state of knowledge regarding genomic function in the programming and operation of what Bonnet, in 1762, described as "the miracle of epigenesis." The book is divided into four sections. Section I is concerned with gene activity in early embryogenesis, with the time of onset and the nature of embryo genome control, and with recent attempts to analyze the shifting patterns of gene expression as development proceeds. Section II reviews various classic and recent studies relevant to the phenomenon of cytoplasmic localization of morphogenetic potential and discusses the significance, from a contemporary vantage point, of this often neglected area of developmental biology. Section III deals with genomic function in oogenesis, beginning with a general survey of what could be described loosely as the natural history of the oocyte nucleus, and proceeding to current attempts to understand the character and the ultimate function of the oocyte gene products. Section IV discusses various aspects of the general problem of gene regulation in animal cells.

  • The Antibody Molecule

    • 1st Edition
    • Alfred Nisonoff + 2 more
    • F. J. Dixon + 1 more
    • English
    The Antibody Molecule reviews the literature leading to current knowledge of the structure of immunoglobulins. The book begins by outlining some of the basic structural characteristics of immunoglobulins without citing the references on which the information is based. Separate chapters follow covering the chemical nature of the active site of an antibody molecule and mechanisms of interaction with hapten; the general structural features and properties of the various classes of human immunoglobulin; and amino acid sequences of human and mouse L chains and of human and rabbit H chains. Subsequent chapters deal with the evolution of the immunoglobulin classes; special properties of mouse, guinea pig, rabbit, and horse immunoglobulins; idiotypic specificities of immunglobulins; and the genetic control of antibodies. This book is meant for immunologists who have not personally observed the development of this exciting period in the history of immunology. It will also provide useful supplemental reading for the serious student or investigator who wishes to become familiar with the nature of the antibody molecule, its genetic control, and mode of action.

  • Immunological Tolerance

    Mechanisms and Potential Therapeutic Applications
    • 1st Edition
    • David H. Katz + 1 more
    • English
    Immunological Tolerance: Mechanisms and Potential Therapeutic Applications documents the proceedings of a conference held at Brook Lodge, Michigan, April 27-May 1, 1974. The conference brought together many of the investigators who have actively contributed to furthering knowledge and understanding of immunological tolerance. It will be immediately clear to the reader that the conference was structured in a way to consider phenomena of tolerance and immune suppression as interrelated entities with a certain degree of emphasis on the possible common cellular mechanisms involved. The volume contains 36 contributions presented during the seven sessions of the conference. The papers presented in Session I examined T-cell tolerance. The presentations in Session II focused on B cell tolerance. The papers in Sessions III and IV focused on the mechanisms of B cell and T cell tolerance, respectively. Session V dealt with the activity of suppressor cells as a mechanism of tolerance. The papers in Session VI investigated the suppressive activity of antibody and antigen-antibody complexes. In Session VII a final General Discussion was held in order to identify what has been established concerning the phenomenology and mechanisms of specific immunological tolerance, what are the major unresolved issues, and what approaches appear most promising to answer these questions.

  • Advances in Lipid Research

    Skin Lipids
    • 1st Edition
    • Volume 24
    • Peter M. Elias
    • English
    Advances in Lipid Research, Volume 24 provides information pertinent to the fundamental aspects of skin lipids. This book discusses the importance of epidermal lipids for cutaneous barrier function. Organized into 11 chapters, this volume begins with an overview of the biochemical, metabolic, and structural aspects of the role of lipids in permeability barrier formation and maintenance. This text then examines the lipid biophysics of the intercellular lipid domains in the stratum corneum, and the regulation of percutaneous absorption by these domains. Other chapters consider the lipid content and metabolism of cultured keratinocytes, which are grown under standard conditions and in various in vitro systems that attempt to produce an epidermal equivalent. This book discusses as well the important field of lipid signaling mechanisms in the epidermis. The final chapter deals with the clinical, pathophysiological, and therapeutic applications of vitamin D. This book is a valuable resource for chemist, cytochemists, and clinicians.

  • Pyruvate and Fatty Acid Metabolism

    • 1st Edition
    • Volume 18
    • Marcel Florkin + 1 more
    • English
    Comprehensive Biochemistry, Volume 18S: Pyruvate and Fatty Acid Metabolism focuses on the processes, methodologies, principles, and reactions involved in pyruvate and fatty acid metabolism, including broad outlines of the metabolism of amino acids, proteins, carbohydrates, lipids, and their derived products. The selection first ponders on pyruvate dehydrogenase complex and citric acid cycle. Numerical analyses of the various reaction sequences are presented. The text also takes a look at fatty acid metabolism. Discussions focus on fatty acid oxidation and biosynthesis, elongation and desaturation of fatty acids, and control of fatty acid oxidation and biosynthesis. The book is a valuable reference for researchers interested in pyruvate and fatty acid metabolism.

  • The Mollusca

    Environmental Biochemistry and Physiology
    • 1st Edition
    • Volume 2
    • Peter W. Hochachka + 1 more
    • English
    The Mollusca, Volume 2: Environmental Biochemistry and Physiology provides information pertinent to the advances in the traditional areas of biochemistry and in other developed areas that have become a part of molluskan biochemistry. This book discusses the developments in the various aspects of molecular biomechanics and environmental biochemistry. Organized into 10 chapters, this volume begins with an overview of the comparative studies of the structure–function relationships in molluskan oxygen carriers. This text then describes the specific types and classes of molluskan respiratory proteins. Other chapters consider the nature and distribution of respiratory proteins in mollusks. This book discusses as well the oxygen equilibrium properties of gastropod hemocyanins. The final chapter deals with host–symbiont interactions in mollusks. This book is a valuable resource for researchers of the Mollusca and other phyla, as well as to teachers and qualified graduate students. Biochemists and physiologists will also find this book useful.

  • Peptides

    Proceedings of the Sixth European Symposium, Athens, September 1963
    • 1st Edition
    • L. Zervas
    • English
    Peptides covers the proceedings of the Sixth European Peptide Symposium, held in Athens, Greece on September 1963. This symposium brings together numerous works on the synthesis, reactions, biological activity, and physico-chemical properties of peptides. This book is organized into seven sections encompassing 46 chapters. The first three sections describe the methods of peptide synthesis, racemization, and degradation of peptide chains. These sections examine the developments in non-enzymatic selective modification and cleavage of peptides, as well as the oxidative modification of specific peptide chain. The succeeding section highlights the total synthesis of natural peptides and peptide analogues and the evaluation of the structure-activity relationships and biological properties of these peptides. These topics are followed by discussions on the synthetic pathways and properties of certain special peptides, along with the accompanying synthesis problems with uncommon amino acids and abnormal peptides. This final section explores the gas-chromatographic studies on the physic-chemical properties of peptides. This book will prove useful to organic chemists, biochemists, and peptide researchers.

  • Biochemistry and Oral Biology

    • 2nd Edition
    • A. S. Cole + 1 more
    • English
    Biochemistry and Oral Biology presents a unique exposition of biochemistry suitable for dental students. It discusses the structural basis of metabolism and the general principles of nutrition. It addresses the soft tissues, hard tissues, and the biology of the mouth. Some of the topics covered in the book are the free radical production; scope of biochemistry; characteristics of atoms; structure and properties of water; molecular building materials; ionization of proteins; affinity chromatography of proteins; structural organization of globular proteins; classification of enzymes; and biochemically important sugar derivatives. The naturally occurring fatty acids are fully covered. The nucleic acid components are discussed in detail. The text describes in depth the energy equivalents of different nutrients. The physiological effects of dietary fiber vitamin D deficiency are completely presented. A chapter is devoted to the alternative methods of fluoride administration and description of vitamins. The book can provide useful information to dental students, and researchers.

  • Current Topics in Bioenergetics

    Volume 14
    • 1st Edition
    • C. P. Lee
    • English
    Current Topics in Bioenergetics, Volume 14 provides information pertinent to the structure and function relationship of energy-transducing membranes. This book presents a number of biochemical and biophysical approaches that are valuable in some systems. Organized into five chapters, this volume begins with an overview of cytochrome oxidase, a noncrystallizable membrane protein. This text then determines the interaction of small organic molecules with biological membranes on a molecular level. Other chapters consider the various physical techniques that are used to investigate the structural and dynamic properties of proteins, lipids, and membranes, including neutron diffraction, X-ray diffraction, electron microscopy, optical rotatory dispersion, nuclear magnetic resonance, fluorescence spectroscopy, and Raman spectroscopy. This book discusses as well the biological importance of metal ions. The final chapter deals with optical activity spectroscopy as a recognized tool for the examination of the conformation of biological macromolecules. This book is a valuable resource for biochemists, biophysicists, and biologists.

  • Current Topics in Bioenergetics

    Volume 4
    • 1st Edition
    • D. Rao Sanadi
    • English
    Current Topics in Bioenergetics, Volume 4 provides information pertinent to the molecular basis for energy transduction in membranous systems. This book presents the developments of relevant techniques in the field of bioenergetics. Organized into eight chapters, this volume begins with an overview of nonequilibrium and fluorescent probes that deal with relatively unexplored areas. This text then discusses the problem of pathways and mechanisms of energy transformations in the cell. Other chapters consider the transport of ions across the plasma membrane of nearly all living cells, which is a necessary condition for the maintenance of the vital life processes. This book discusses as well that bacterial synthesis offers basic and valuable information of general significance and remarkably stimulating challenges with direct bearing on different aspects of the problem of the basic mechanisms involved in biological electron transport-coupled energy conversion. The final chapter deals with the general models for the transport of sodium and potassium. This book is a valuable resource for biologists and biochemists.

  • Immunointervention in Autoimmune Diseases

    Papers Based on an International Meeting in Paris, France, in June 1988
    • 1st Edition
    • J. F. Bach
    • English
    Immunointervention in Autoimmune Diseases is a collection of papers presented at the 1988 International Meeting by the same title, held in Paris, France. This text contains 21 chapters and begins with surveys of the role of antigen in autoimmune responses and the moving boundaries between physiology and pathology of immunity. The succeeding chapters deal with the regulation, immunosuppressive therapy, infections, and immunointervention of autoimmune disorders. These topics are followed by discussions of specific immunosuppressive therapy for a particular disease, including type I diabetes, T-cell leukemia, and systemic lupus erythomatosus. This work also explores the principles of allograft, the use of monoclonal antibody, and OKT3. The remaining chapters consider the maintenance of autoimmunity and the risk/benefit in immunointervention for autoimmune diseases. This book will prove useful to immunologists, pathologists, physiologists, and researchers.

  • Fusarium

    Mycotoxins, Taxonomy, Pathogenicity
    • 1st Edition
    • Volume 2
    • J. Chelkowski
    • English
    Specialists from a number of different disciplines have contributed to this book which presents actual basic and applied findings on Fusarium species, on their metabolites and taxonomy, in connection with pathogenicity to cereal plants and potato tubers. Over 100 metabolites produced by Fusaria are described together with results of studies on their occurrence in agricultural products, their metabolism in farm animals, and possibilities of elmination and detoxification during technological processes. Pathogenic Fusarium species are described from the point of view of their taxonomy, profiles of produced metabolites, ecology, pathogenicity and interaction with cereal tissues. Finally, some actual solutions to avoid cereal grain contamination are discussed, mainly in connection with agricultural practices and breeding programmes.The interdisciplinary and comprehensive nature of the book makes it particularly useful to all who are studying or teaching plant pathology, plant breeding, animal nutrition and any other area in which Fusaria and their metabolites play an important role.

  • In Vitro Methods in Cell-Mediated Immunity

    • 1st Edition
    • Barry R. Bloom + 1 more
    • English
    In Vitro Methods in Cell-Mediated Immunity focuses on methods for approaching cell-mediated immune responses in vitro. This book provides, in simplified in vitro systems, a basis for understanding the mechanism of the in vivo response and discusses useful and reliable in vitro tests for cell-mediated immune responses in humans, where in vivo testing is often not possible. The topics discussed include factors and activities produced in vitro by lymphocytes; biological implications of in vitro phenomena; and requirements and prospects for improved methodology. The leucocyte migration technique for in vitro detection of cellular hypersensitivity in man; proliferation of human blood lymphocytes stimulated by antigen in vitro; and virus plaque assay for antigen-sensitive are also elaborated in this text. This publication is a good reference for microbiologist and immunologists, including medical students researching on in vitro models for cell-mediated immune reactions.

  • The Role of Products of the Histocompatibility Gene Complex in Immune Responses

    • 1st Edition
    • David H. Katz + 1 more
    • English
    The Role of Products of the Histocompatibility Gene Complex in Immune Responses documents the proceedings of a conference held on 3-7 November 1975, which brought together an international group of scientists spanning three independent disciplines—genetics and immunogenetics, molecular biochemistry, and immunobiology—with clinical medicine overlapping these disciplines. This volume contains 42 papers organized according to the eight sessions held at the conference. The papers in Session I examined the genetics of the major histocompatibility complex. Session II presented studies on the biology of mixed lymphocyte interactions and cell-mediated cytotoxicity reactions. Session III discussed immune response gene systems while Session IV dealt with the genetic control of cell interactions. The papers in Session V covered idiotypic determinants on T cell receptors. Session VI investigated the properties of histocompatibility gene products involved in regulation of immune responses. Session VII focused on the biochemistry and immunocytology of cell surface products of the major histocompatibility complex. Finally, Session VIII discussed interrelationships between products of the major histocompatibility complex and their relevance to disease.

  • Immunobiology of Transfer Factor

    • 1st Edition
    • Charles H. Kirkpatrick + 2 more
    • English
    Immunobiology of Transfer Factor compiles research papers presented at the Fourth International Transfer Factor Workshop, held at the Given Institute of Pathobiology in Aspen, Colorado, on October 3-6, 1982. This book focuses on the immunologic effects of transfer factor, which are supported by in vitro and in vivo experiments that indicate immunologically specific interactions between transfer factor and antigens. The topics include the selective removal of transfer factor activity with antigen, antigen-specific suppressor factor in human leukocyte dialysates, and specific suppressor dialysates from mice. The kinetics of immune response and production of transfer factor in bovine, dialyzable leukocyte extracts in pulmonary diseases, and mechanisms of action of human transfer factor are also elaborated. This compilation is suitable for microbiologists, immunologists, and specialists researching on transfer factor.

  • Current Topics in Bioenergetics

    Volume 11
    • 1st Edition
    • D. Rao Sanadi
    • English
    Current Topics in Bioenergetics, Volume 11 provides information pertinent to the ATP utilizing or synthesizing parts of the major bioenergetics reactions of cells. This book discusses the individual proteins comprising each of the energy-transducing ATPases and their organization into a functional structure. Organized into six chapters, this volume begins with an overview of the role of ATPases in the production and utilization of the H+ gradient from a genetic and biochemical viewpoint. This text then examines the ATPase associated with bacterial membranes, which is known to have an analogous function and a similar structure to that found in membranes of chloroplasts and mitochondria. Other chapters consider the composition and the biogenesis of chromaffin granules. This book discusses as well the models for the mode of action of peptide molecules. The final chapter deals with the various forms of energy transduction. This book is a valuable resource for biologists, physiologists, and pharmacologists.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 11
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 11 is a seven-chapter text that discusses a wide range of topics in the field, including steroid metabolism, phytosterols, and fatty acid transport. The first chapter reviews the metabolic role of lecithin: cholesterol acyltransferase. The next chapter deals with the simple means of separation and quantitation of serum lipoproteins. This chapter describes the variations of the reaction involving lipoproteins, divalent cations, and polyanionic substances, both organic and inorganic. Other chapters discuss the fatty acid metabolism by brain tissue, the concept of the blood-brain barrier and its role in fatty acid uptake, as well as the many alterations in bile acid structure due to their interaction with the intestinal microflora. A chapter focuses on the multiple aspects of plant sterol chemistry, function, and metabolism. The last chapters examine the mechanism of insect utilization and metabolism of dietary sterol. These chapters also cover the role of lipids in viral structure and metabolism. This book will prove useful to lipid chemistry, biochemists, and researchers.

  • Analytical Applications of Immobilized Enzymes and Cells

    Applied Biochemistry and Bioengineering, Vol. 3
    • 1st Edition
    • Volume 3
    • Lemuel B. Wingard + 2 more
    • English
    Analytical Applications of Immobilized Enzymes and Cells, Volume 3 presents a survey of the interdisciplinary interactions, developments, and trends on research in immobilized enzymes and cells. This volume is comprised of eight chapters. Chapters 1 to 4 are devoted to the description of methodologies and instrumentations which are used in routine analysis. Among those described are enzyme tubes, enzyme thermistors, and enzymic or microbial electrodes. Chapter 4 provides a theoretical analysis of electrode design. Subsequent chapters focus on solid-phase enzyme immunoassays and on techniques for in vivo monitoring of metabolites; economic evaluation of the use of high-purity enzymes in analysis; and an assessment of the significance of microprocessors and computer science in enzyme based analysis. Chemists and chemical engineers will find the book very useful.

  • Molybdenum and Molybdenum-Containing Enzymes

    • 1st Edition
    • Michael P. Coughlan
    • English
    Molybdenum and Molybdenum-Containin... Enzymes is a collection of papers that deals with the various concerns with molybdenum-containin... enzymes. The text first covers the organometallic chemistry of molybdenum, and then proceeds to tackling molybdenum-containin... enzymes, such as xanthine oxidase, aldehyde oxidase, and sulphite oxidase. The text also discusses the advancement in the understanding of molybdenum-containin... enzymes. The remaining chapters deal with the genetics of molybdoenzymes and the nutritional aspects of molybdenum. The book will be of great use to students, researchers, and practitioners of biochemistry.

  • Immunodermatology

    • 1st Edition
    • D. M. Macdonald
    • English
    Immunodermatology presents a comprehensive examination of the proceedings that resulted from the International Immunodermatology Symposium which happened in London. It discusses the relationship of immuno-histochemical study to skin disease. It addresses the function and recognition of lymphocytes. Some of the topics covered in the book are the immunological observations in 12 cases of Kaposi’s herpetic eruption; anti-inflammatory effects of adrenoceptor agonists in patients with atopic eczema; a study of the sensitivity and specificity of cutaneous vascular immunofluorescence; and functional activity of granulocytes from patients with neutrophilic dermatoses. The mechanisms of cutaneous lupus erythematosus are fully covered. An in-depth account of the cytochemical and immunological findings in cutaneous multilobated cell lymphoma are provided. The immunohistological analysis of dermal leprous granulomas is completely presented. A chapter is devoted to the study of human epidermal cell differentiation using monoclonal antibodies. Another section focuses on the prognostic significance of melanoma-associated antigens in primary and metastatic melanomas. The book can provide useful information to doctors, dermatologists, students, and researchers.

  • Clinical Immunobiology

    • 1st Edition
    • Volume 1
    • Fritz H. Bach + 1 more
    • English
    Clinical Immunobiology, Volume 1 is a 12-chapter introductory text to the several aspects of immunobiology field. The opening chapters describe the structural and functional development, as well as the molecular and cellular nature of the immune apparatus. The subsequent chapters deal with the relation of structure to function in the lymphoid system and its molecules. These topics are followed by discussions of the fundamental issues of tolerance, inflammation, immunological mediators and amplifiers, and immunogenetics. The remaining chapters explore the immunobiological aspects of transplantation, allergy, tumor immunity, autoimmunity, immunodeficiency, and immunosuppression. This book will be of great value to clinical immunobiologists, practicing physicians, researchers, and medical and biology students.

  • Virus Structure

    • 1st Edition
    • Robert W. Horne
    • English
    Virus Structure describes the physical characteristics of isolated viruses that represent typical structural groups, with particular reference to those features analyzed with the aid of the electron microscope. For descriptive purposes, the book has been divided into sections starting with the small icosahedral viruses and leading to the larger and more sophisticated structures, regardless of whether they are animal, plant, or bacterial viruses. These include double-stranded DNA icosahedral viruses, herpesvirus, viruses with helical symmetry, and viruses with complex or a combination of symmetries. Many common architectural features will be found in those viruses selected for discussion in each of the sections, and for these reasons the introduction places some emphasis on the symmetry elements rather than the shapes of viruses. The mechanism by which viruses enter host cells and the events that follow once the cell has been infected are only mentioned briefly as the virus-host interaction is a relatively complex one.

  • Fish Immunology

    • 1st Edition
    • Margaret J. Manning + 1 more
    • English
    Fish Immunology contains the proceedings of a symposium organized by the Fisheries Society of the British Isles, held in Plymouth, England, 11-13 July 1983. This volume contains 29 chapters and opens with a study on the prevention of disease outbreak or treatment of disease in fish farms with drugs or chemicals. Separate chapters follow on topics such as immune phenomena in Teleostei or Anura; phagocytosis in fish; the granulocytes of three elasmobranch species, namely Scyliorhinus canicula, Raja clavata and R. microcellata; and phagocytic cells in the dogfish (Scyliorhinus canicula l.); and levels of α-precipitin in two groups of wild fish: a group believed to be suffering from Ulcerative Dermal Necrosis (UDN) and a healthy group showing no external evidence of disease. Subsequent chapters deal with sequential antigenic competition in teleosts challenged with the fish-furunculosis bacterium Aeromonas salmonicida; the occurrence of vaccine uptake at the skin surface of rainbow trout; and vaccination and development of immunological memory in carp.

  • Advances in Lipid Research

    • 1st Edition
    • Volume 23
    • Rodolfo Paoletti + 1 more
    • English
    Advances in Lipid Research, Volume 23 provides information pertinent to mammalian as well as plant metabolism. This book presents important data on apoproteins, which may offer a foothold for further probes of the genetics underlying increased susceptibility to ischemic heart disease. Organized into seven chapters, this volume begins with an overview of the molecular biology of human apolipoproteins B and E. This text then explains the lipid metabolism of dermatophytes and describes their lipid composition and how it may be modulated. Other chapters consider the function, distribution, and biosynthesis of the sterols of fungi and examine the influences of fungal sterols on membrane fluidity. This book discusses as well the biosynthesis and degradation of platelet-activating factor (PAF) as well as its physiological function. The final chapter deals with one specific area of PAF activity, namely, renal processes. This book is a valuable resource for biologist, biochemists, chemists, and clinicians.

  • Current Topics in Bioenergetics

    Volume 9
    • 1st Edition
    • D. Rao Sanadi
    • English
    Current Topics in Bioenergetics, Volume 9 presents the theoretical, thermodynamic perspective of energy transducing reactions. This book provides a detailed kinetic analysis of a specific aspect of an ion pump. Organized into seven chapters, this volume begins with an overview of the quantitative relations between measurable parameters of energy-transducing systems. This text then examines the probes for intracellular pH determination, which stimulate the development of additional methods and their application in pathology and pharmacology. Other chapters consider studies with isolated proteins or protein complexes derived from the membranes. This book discusses as well the chemistry of photosynthesis and oxidative phosphorylation. The final chapter deals with the advances in the use of photo affinity labeling in the study of the structure of ligand sites on proteins, which became possible only in conjunction with the development of methods for the isolation of peptides and their sequence determination. This book is a valuable resource for biologists and biochemists.

  • Pyrrole Pigments, Isoprenoid Compounds and Phenolic Plant Constituents

    • 1st Edition
    • Volume 9
    • Marcel Florkin + 1 more
    • English
    Comprehensive Biochemisty, Volume 9: Pyrrole Pigments, Isoprenoid Compounds and Phenolic Plant Constituents focuses on the organic and physical chemistry of the major organic constituents of living material. This book discusses the correlations between structure and visible spectrum, theoretical interpretation of the visible absorption spectra, and spectrophotometric determination of chlorophyll. The quantitative aspects of hemoglobin breakdown, monocyclic and bicyclic carbon systems, and substances related to retinol are also elaborated. This publication likewise covers the naturally occurring quinones, phenolic compounds derived by linear condensation of two-carbon units, and single-carbon incorporation into ring systems. This volume is useful to biochemists and specialists researching on pyrrole pigments, isoprenoid compounds, and phenolic plant constituents.

  • Hormones

    • 1st Edition
    • Anthony W. Norman + 1 more
    • English
    Hormones provides a comprehensive treatment of human hormones viewed in the light of modern theories of hormone action and in the context of current understanding of subcellular and cellular architecture and classical organ physiology. The book begins with discussions of the first principles of hormone action and the seven classes of steroid hormones and their chemistry, biosynthesis, and metabolism. These are followed by separate chapters that address either a classical endocrine system, e.g., hypothalamic hormones, posterior pituitary hormones, anterior pituitary hormones, ,thyroid hormones, pancreatic hormones, gastrointestinal hormones, calcium regulating hormones, adrenal corticoids, hormones of the adrenal medulla, androgens, estrogens and progestins, and pregnancy and lactation hormones; or newer domains of hormone action which are essential to a comprehensive understanding of hormone action, including prostaglandins, thymus hormones, and pineal hormones. The book concludes with a presentation of hormones of the future, i.e., cell growth factors. This book is intended for use by first-year medical students, graduate students, and advanced undergraduates in the biological sciences. It is also hoped that this book will fill the void that exists for resource materials for teaching cellular and molecular endocrinology and that it will be employed as an equal partner with most standard biochemistry textbooks to provide a comprehensive and balanced coverage of this realm of biology.

  • Pheromone Biochemistry

    • 1st Edition
    • Glenn D. Prestwich + 1 more
    • English
    Pheromone Biochemistry covers chapters on Lepidoptera, ticks, flies, beetles, and even vertebrate olfactory biochemistry. The book discusses pheromone production and its regulation in female insects; as well as reception, perception, and degradation of pheromones by male insects. The text then describes the pheromone biosynthesis and its regulation and the reception and catabolism of pheromones. Researchers in the areas of chemistry, biochemistry, entomology, neurobiology, molecular biology, enzymology, morphology, behavior, and ecology will find the book useful.

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