Basic Immunology
- 1st Edition - January 1, 1970
- Imprint: Butterworth-Heinemann
- Authors: E. R. Gold, D. B. Peacock
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 1 - 7 7 4 9 - 6
- eBook ISBN:9 7 8 - 1 - 4 8 3 1 - 9 3 3 0 - 4
Basic Immunology focuses on substances that take part in serological reactions, including antigens, antibodies, and the physicochemical nature of immunological reactions. The… Read more
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Request a sales quoteBasic Immunology focuses on substances that take part in serological reactions, including antigens, antibodies, and the physicochemical nature of immunological reactions. The selection first elaborates on the basic notions of immunity, antigens, immunoglobulins, and the production of antibody. Discussions focus on factors which increase the immune response, production of antibody, biological properties of immunoglobulins, evolution and control of immunoglobulin structure, antigenicity, specific immunity, and resistance. The text then takes a look at the complement system, antigen-antibody reactions, and immediate hypersensitivity. The book ponders on cell-mediated immunity and delayed hypersensitivity, transplantation immunology, and tumor immunology. Topics include production of immunity to neoplasms, immunological aspects of carcinogenesis and growth of established tumors, immunotherapy for experimental neoplasms, donor selection in human-organ transplantation, elicitation of delayed hypersensitivity, and the role of humoral factors in the transfer of delayed hypersensitivity. The selection is a valuable reference for medicine students and researchers interested in basic immunology.
1. Basic Notions of Immunity Introduction Resistance Specific Immunity2. Antigens Introduction Antigenicity Molecular Size Chemical Structure Chemical Composition Specificity Protein Antigens Polysaccharide Antigens Lipid Antigens Heterophile Antigens3. Immunoglobulins Introduction Pathological Immunoglobulins: Prototypes of Immunoglobulin Structure Animal Immunoglobulins General Structure Detailed Structure and Antigen Composition Structure of Light Chains Structure of Heavy Chains Subdivisions of Immunoglobulin Classes Evolution and Control of Immunoglobulin Structure Biological Properties of Immunoglobulins The Whole Molecule The Combining Site4. The Production of Antibody The Fate of Antigen Production of Antibody Natural Antibody The Primary Response The Secondary Response Quantitative Aspects of Antibody Production Cellular Aspects of Antibody Production Factors Which Increase the Immune Response Factors Which Depress the Immune Response Summary and Conclusions5. The Complement System Introduction Components of Complement Mechanism of Immune Lysis Other Biological Functions of Complement Components Conglutinin Deficiencies of Complement6. Antigen-Antibody Reactions Introduction Mechanisms of Reactions Forces involved Thermodynamics and Kinetics Secondary Reactions Precipitation Theories of Precipitation Immunodiffusion and Immuno-Electrophoresis Agglutination Passive Agglutination Passive Haemagglutination Theories of Agglutination Antigen-Antibody Reactions Involving Complement Cross-Reactions7. Immediate Hypersensitivity Introduction Anaphylaxis Biochemical Mediators Passive Cutaneous Anaphylaxis Reagins Blocking Antibodies Anaphylatoxin Arthus Reaction Serum Sickness Shwartzman Reaction8. Cell-Mediated Immunity in Vitro Studies Introduction Macrophage Migration Inhibition Summary Lymphocyte Transformation Non-Specific Stimulation Transformation as a Specific Secondary Immune Response Transformation as a Primary Immune Response Summary Specific Cell-Mediated Cytotoxicity in Vitro Summary9. Cell-Mediated Immunity and Delayed Hypersensitivity Introduction The Elicitation of Delayed Hypersensitivity The Tuberculin Reaction and its Histology Delayed Hypersensitivity to Other Antigens and its Histology The Induction of Delayed Hypersensitivity Inducing Antigens The Role of the Skin and Lymph-Nodes Antigenic Specificity in Delayed Hypersensitivity Transfer of Delayed Hypersensitivity by Cells The Role of Humoral Factors in the Transfer of Delayed Hypersensitivity Antibody and Delayed Hypersensitivity Macrophage Cytophilic Antibodies High Affinity Antibodies The Role of Antibody in Delayed Hypersensitivity The Role of the Thymus in Delayed Hypersensitivity Factors Affecting Delayed Hypersensitivity Delayed Hypersensitivity and Immunity10. Transplantation Immunology Introduction The Fate of Grafts The Mechanism of the Homograft Reaction Historical Aspects Active Immunity Factors Influencing the Intensity of the Homograft Reaction Methods for Abrogating the Homograft Reaction Specific Immunological Tolerance Graft-Versus-Host Reactions Chimaeras Donor Selection in Human-Organ Transplantation11. Tumour Immunology Introduction Transplantation of Tumours Production of Immunity to Neoplasms Immunological Enhancement Tumour-Specific Antigens Immunological Aspects of Carcinogenesis and the Growth of Established Tumours Immunotherapy for Experimental Neoplasms12. Auto-Immunity Introduction Causes of Auto-Immunization Auto-Immunization Following Antigenic Stimulation Auto-Immunization Due to Abnormality of the Immunological Apparatus Experimental Auto-Immune Disease Production of Auto-Immune Disease Prevention of Experimental Auto-Immune Disease The Spontaneous Auto-Immune Disease of New Zealand Black Mice Mechanisms of Tissue Damage Auto-Immunity and Disease in Man The Auto-Immune Haemolytic Anaemias Hashimoto's Thyroiditis and Related Conditions Systemic Lupus Erythematosus Glomerulonephritis Ulcerative Colitis Myasthenia Gravis and the Role of the Thymus in Auto-Immune Disease ConclusionsIndex
- Edition: 1
- Published: January 1, 1970
- No. of pages (eBook): 428
- Imprint: Butterworth-Heinemann
- Language: English
- Paperback ISBN: 9781483177496
- eBook ISBN: 9781483193304
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