Chemical Pathways of Metabolism

Contributors to Volume II

List of Abbreviations and Symbols

Content of Volume I


9. Nitrogen Metabolism of Amino Acids

I. Scope

II. Deamination

III. Deamidation

IV. Transamination

V. Amino Acid Racemases

VI. Urea Synthesis

VII. Summary Remarks

Addendum


10. Carbon Catabolism of Amino Acids

I. Scope of the Chapter

II. Amino Acids Linked with the Citric Acid Cycle

III. Glycine

IV. The β-Hydroxyamino Acids

V. The Aliphatic Branched-Chain Amino Acids

VI. Certain Amino Acids of Uncertain Biological Significance

VII. The Sulfur Amino Acids

VIII. Lysine

IX. Arginine and Ornithine

X. Proline and Hydroxyproline

XI. The Aromatic Amino Acids

XII. Tryptophan

XIII. Histidine

Addenda


11. Synthetic Processes Involving Amino Acids

I. Introduction

II. The Glycine-Serine Interconversion

III. Formation of Phosphatide Bases

IV. Interconversions of Glutamic Acid, Ornithine, and Proline

V. Biosynthesis of Branched-Chain Amino Acids

VI. Lysine Biosynthesis

VII. Biosynthesis of Aromatic Amino Acids

VIII. Reactions Involving Tyrosine

IX. Synthetic Reactions Involving Tryptophan

X. Biosynthesis of Histidine

Addenda


12. Metabolism of Sulfur-Containing Compounds

I. Biologically Important Sulfur Compounds

II. Relationships of Methionine and Cysteine

III. Oxidation of Sulfur-Containing Amino Acids

IV. The Desulfhydrase Reaction

V. Thiosulfate and Thiocyanate

VI. Reactions of Sulfur-Containing Coenzymes


13. Enzymatic Syntheses of Peptide Bonds

I. Thermodynamic Considerations

II. Classification of Enzymatic Peptide Syntheses According to the Sign and Magnitude of the Free Energy Change (-△F)

III. Peptide Syntheses Where -△F Is Negative and Large: Coupled with High-Energy Phosphate

IV. Mechanism of Amino Acid Incorporation into Proteins

V. Addendum


14. Purines and Pyrimidines

I. The Purines

II. The Pyrimidines


15. Nucleotides and Nucleosides

I. Nucleosides

II. Nucleotides

III. Deamination of Nucleosides and Nucleotides

IV. The Enzymatic Splitting of Certain Coenzyme Nucleotides

V. The Enzymatic Synthesis of Certain Coenzyme Nucleotides


16. Metabolism of Heme and Chlorophyll

I. Introduction

II. Compounds of the Biosynthetic Chain Leading to the Formation of Protoporphyrin

III. Biochemical Lesions in the Porphyrin Metabolism of Human Beings

IV. Tracer Studies of Protoporphyrin Biosynthesis

V. The Iron Branch of the Biosynthetic Chain and Some General Properties of Heme Compounds

VI. The Magnesium Branch and the Biosynthesis of Chlorophyll

VII. Decomposition of Iron Protoporphyrin to Bile Pigments

Author Index

Subject Index

Errata: Volume I