Oxygenases

Contributors

Preface


1 History and Scope

I. Introduction

II. Dehydrogenases, Oxidases, and Oxygenases

III. Methodology

IV. Nomenclature and Classification

V. General Properties and Mechanisms of Action of Oxygenases

VI. Physiological Significance of Oxygenases

VII. Distribution of Oxygenases in Nature

References


2 Methodology of Oxygen Isotopes

I. Introduction

II. The Preparation of Materials

III. Problems and Restrictions in the Use of Oxygen-18

IV. The Separation and Purification of Compounds for Isotopic Analysis

V. Isotopic Analysis

VI. Conclusion

References


3 Phenolytic Oxygenases

I. Introduction

II. Catechol Oxygenases

III. Phenolic Oxygenases

IV. Other Aromatic Oxygenases

V. Reactions That May Be Oxygenations

VI. Speculation on Mechanism

VII. Coda

References


4 Aromatic Hydroxylations

I. Introduction

II. Conversion of Phenylalanine to Tyrosine

III. Conversion of Dopamine to Norepinephrine

IV. General Discussion of Mechanism of Aerobic Hydroxylation Reactions

References


5 Oxygenases in Lipid and Steroid Metabolism

I. Introduction

II. Oxygenases in the Biosynthesis of Cholesterol

III. Oxygenases in the Biosynthesis of the Bile Acids

IV. Oxygenases in the Biosynthesis of Steroid Hormones

V. Oxygenases of Animal Origin Acting on C18, C19, and C21 Steroids

VI. Oxygenases of Microbiological Origin

VII. Steroid Hydroxylation Mechanisms

VIII. Oxygenases in Fatty Acid Metabolism

IX. Summary

Addendum

References


6 Bacterial Oxidation of Hydrocarbons

I. Introduction

II. Involvement of Molecular Oxygen in Hydrocarbon Utilization

III. Anaerobic Oxidation of Alkanes

IV. Cyclic Hydrocarbons

Addendum

References


7 Peroxidase as an Oxygenase

I. Historical Introduction

II. The Mechanism of the Oxidase Reaction

III. The Physiological Role of the Oxidase Reaction

IV. Conclusions

Addendum

References


8 Phenolase

I. Introduction

II. Preparation and Physicochemical Properties

III. Oxidation of 0-Dihydroxyphenols

IV. Oxidation of Monohydroxyphenols

V. Concluding Remarks

References


9 Model Oxygenases and Theoretical Considerations on the Activation of Oxygen

I. Introduction

II. General Physicochemical Considerations on Reaction Mechanisms Involving Free Oxygen

III. General Phenomena Involving Free Oxygen

IV. Reaction Mechanisms in Biological and Model Oxidase Systems

References


10 Cytochrome Oxidase

I. Introduction

II. Preparation of Cytochrome Components

III. Cytochrome Oxidase System of Heart Muscle

IV. Pseudomonas Cytochrome Oxidase

V. Discussion

References


11 Hemoglobin and Myoglobin

I. Introduction

II. Preparation and Physicochemical Properties

III. Chemical Composition

IV. X-Ray and Paramagnetic Resonance Studies on Structure

V. Reactions with Oxygen, Carbon Monoxide, and Nitric Acid

VI. Dissociation and Reconstitution Studies

VII. Riddle of the Stability of Oxyhemoglobin and Oxymyoglobin

Addendum

References


12 Hemerythrin and Hemocyanin

I. Introduction

II. Hemerythrin

III. Hemocyanin

IV. Conclusions

References

Author Index

Subject Index