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Elsevier

Books in Life sciences

  • Cooperative Phenomena in Biology

    • 1st Edition
    • George Karreman
    • English
    Cooperative Phenomena in Biology deals with cooperation in biology and covers topics such as cooperative specific adsorption; the kinetics of oxygen binding to hemoglobin; allosteric control of cooperative adsorption and conformation changes; and cooperativity in biological surfaces responding to topical treatment. The use of Monte Carlo methods to investigate the behavior of cooperative Ising models is also described. This book is comprised of five chapters and opens with a discussion on the phenomenon of cooperative specific adsorption and its importance for the understanding of fundamental biological phenomena. The derivation of the cooperative specific adsorption isotherm both stochastically and on the basis of statistical mechanics is explained. The next chapter reviews the theory of the allosteric control of cooperative adsorption and conformation changes and outlines a molecular model for physiological activities according to the association-inductio... hypothesis. The reader is also introduced to a kinetic equation for hemoglobin oxygenation based on the infinite chain; the use of bioelectrometric methods to study solute interactions with biocolloidal surfaces responding to topical treatment; and the use of Monte Carlo computations to determine the behavior of cooperative Ising models. This monograph is intended for biologists, physicists, chemists, and mathematicians.

  • Hormones and the Fetus

    • 1st Edition
    • J. R. Pasqualini + 2 more
    • English
    Volume One of Hormones and the Fetus contained a generalization of the role of hormones during fetal life. In this second volume, the main topics focus on hormonal binding to fetal and maternal plasma proteins, amniotic fluid and placenta; the presence of hormone receptors in the fetal compartment; and the mechanism of action of various hormones in different target tissues of the fetus and placenta. This up-to-date information is of major importance in the study of hormonal activity in fetal life, and the biological effect of hormones through the receptor. The mechanism of fetal sexual differentiation, in which hormones play an important role, is extensively covered.

  • Biological and Environmental Effects of Arsenic

    • 1st Edition
    • Volume 6
    • B.A. Fowler
    • English
    Topics in Environmental Health, Volume 6: Biological and Environmental Effects of Arsenic focuses on the properties, characteristics, and reactions of arsenic and its effects on the environment. The selection first tackles the mobilization of arsenic by natural and industrial processes and emissions, cycling, and effects of arsenic in soil ecosystems. Discussions focus on the effects of arsenic on plants and soil microorganisms, exposure through consumption, sources of arsenic, and mobilization of arsenic by natural processes and industrial activities. The publication then ponders on environmental reaction and analysis methods and arsenical metabolism and toxicity to freshwater and marine species. The text examines the metabolism of arsenic and epidemiology of human arsenic exposure, including acute and chronic effects by arsenic in man, absorption, tissue distribution and retention, and elimination and biological half-time. The publication then takes a look at the toxicity of arsenic and its compounds, as well as biological transformation of arsenic compounds in soil ecosystems and effects on plants; biotransformation of arsenic compounds and toxicity to freshwater and marine biota; and environmental transformation of arsenic in freshwater/marine ecosystems. The selection is a dependable reference for readers interested in the biological and environmental effects of arsenic.

  • Feed Energy Sources for Livestock

    • 1st Edition
    • Henry Swan + 1 more
    • English
    Feed Energy Sources for Livestock focuses on the compositions of animal feeds. The book first looks at the background of world grain supplies from 1972 to 1974 and 1975 onwards. The text discusses alternatives to conventional cereals. Fats in ruminants, pigs, and poultry diets; chemically treated straw; and less conventional raw materials are described. The book also looks at molasses and its by-products, processing of cereals, and the effects of an alkali technique on the nutritive value of straws. The text discusses as well the laboratory methods used in evaluating the energy value of feedstuffs. Neutral detergent fiber; in vitro rumen digestibility; Tilley and Terry in vitro rumen method; in vitro true digestibility; and modified acid detergent fiber are considered. The book then focuses on the sources, availability, and use of additional phosphorous for ruminants; selenium and Vitamin E in poultry rations; and the use of rapeseed meal in pig and poultry rations. The selection is a valuable source of information for readers wanting to study the contents of animal feeds.

  • Current Topics in Comparative Pathobiology

    Volume 1
    • 1st Edition
    • Thomas C. Cheng
    • English
    Current Topics in Comparative Pathobiology, Volume 1 covers topics on the pathobiology of animals, invertebrate and vertebrate. The book discusses diseases of the insect integument; neoplasia in fish; and the status of paralytic shellfish poisoning. The text also describes small, free-living amebas with regard to its cultivation, quantitation, identification, classification, pathogenesis, and resistance. Pathobiologists, cellular biologists, parasitologists, and microbiologists will find the book invaluable.

  • Ion Channels of Excitable Cells

    • 1st Edition
    • Volume 19
    • Toshio Narahashi + 1 more
    • English
    Because of the highly significant and widely recognized roles of ion channels in physiology, pathophysiology, pharmacology, and toxicology, the term ion channel has now become a household word in the biomedical sciences. This volume covers preparations and techniques for the study of various ion channels. Both voltage-gated and ligand-gated ion channels of neurons, axons, and cardiac and smooth muscles are covered. It includes not only patch clamp techniques but molecular biology and imaging techniques as well.

  • Biological Husbandry

    A Scientific Approach to Organic Farming
    • 1st Edition
    • B. Stonehouse
    • English
    Biological Husbandry: A Scientific Approach to Organic Farming covers a proceeding of a symposium organized by International Institute of Biological Husbandry on August 26-30, 1980 at Wye College in London, United Kingdom. Said symposium aims to promote the scientific development of biological or organic agriculture. The text covers topics such as the assessment of conventional, biological, and integrated agriculture; soil use in temperate climates, organic matter cycles in tropical soils, and plant-microbial interactions; biological pest control, the importance of chemical agents and biotechnology in biological husbandry, and allelochemicals in the future of agriculture. The book is recommended for biologists and agriculturists who would like to know more about the studies in biological husbandry and its implications in the field.

  • Drugs in Psychiatric Practice

    • 1st Edition
    • Sam Stuart
    • English
    Drugs in Psychiatric Practice present a comprehensive examination of the drug treatment in psychiatry. It discusses certain ways in which drugs behaved. It addresses the advances in pharmacology and the basis of prescription. Some of the topics covered in the book are the classification of psychotropic drugs; basic principles of pharmacokinetics and drug metabolism; anti-schizophrenic drugs; evaluation of psychotropic drugs; unconventional chemotherapy; anti-parkinsonian and anti-dyskinetic drugs; introduction of amitriptyline; and tricyclic antidepressants. The role of tricyclic drugs in the treatment of enuresis and the drug treatment of organic brain syndrome are fully covered. An in-depth account of the monoamine oxidase inhibitors and amine precursors are provided. The tolerance and pharmacological dependence on alcohol are completely presented. A chapter is devoted to the factors involve in ethanol metabolism. Another section focuses on the unwanted effects of psychotropic drugs. The book can provide useful information to doctors, pharmacists, psychologists, students, and researchers.

  • Sulfur Dioxide

    Applications in Foods, Beverages, and Pharmaceuticals
    • 1st Edition
    • Louis C. Schroeter
    • English
    Sulfur Dioxide discusses in detail the preparation and oxidation of sulfur dioxide. The book also covers the effect of the substance on organic and inorganic mixtures. The pharmaceutical application, safety, and effectiveness of the substance in the form of sulfites in food and beverage are comprehensively explained. A section of the book focuses on the physiological effects of sulfur dioxide in plants, animals, and humans. The book highlights the properties of sulfur dioxide in gaseous state and in aqueous solutions, with expanded section covering its ionic structure and spectral characteristics. Methods for determining trace amounts of sulfur dioxide in the atmosphere are summarized along with ways to identify the substance in complex mixtures such as food. The text is an excellent source of information about sulfur dioxide complexes and clathrates. The book will be a useful tool for pharmacists, scientists and chemists in the fields of medicine, and students doing research and experiment on the effect of sulfur dioxide on other compounds.

  • Frontiers in Colorectal Disease

    St. Mark's 150th Anniversary International Conference
    • 1st Edition
    • R. C. G. Russell + 1 more
    • English
    Frontiers in Colorectal Disease presents a compilation of articles from the international conference titled ‘Frontiers in Colorectal Disease’. It discusses the aspects of functional disorders, neoplastic disease and inflammatory bowel disease. It addresses the practical management of a variety of disorders of the colon, rectum, and anus. Some of the topics covered in the book are the basis of functional intestinal symptoms; nervous control of the gut; physiological reactions of the gastrointestinal tract to stress; visceral pain; mechanisms of flatulence and diarrhoea; pathophysiology of constipation; Arbuthnot Lane’s disease; and megacolon in adults. The results of surgical treatment of constipation are fully covered. The anorectal incontinence of electrophysiological tests is discussed in detail. The text describes in depth the risk factors in childbirth causing damage to the pelvic floor innervation. A retrospective study of the results of post-anal repair is presented completely. A chapter is devoted to the gracilis muscle transposition for anal incontinence. Another section focuses on the magnitude of risk for cancer in patients with colorectal adenomas. The book can provide useful information to doctors, surgeons, students, and researchers.

  • Cisplatin

    Current Status and New Developments
    • 1st Edition
    • Archie W. Prestayko
    • English
    Cisplatin: Current Status and New Developments is a collection of papers presented at a symposium sponsored by the University of Alabama in Birmingham Comprehensive Cancer Center and the Bristol Laboratories in Syracuse, ?ew York, and held on September 27-28, 1979, in Atlanta, Georgia. The symposium provided a forum for assessing developments with regards to cisplatin as an anticancer drug, with emphasis on its clinical application in a wide variety of adult and pediatric malignancies as well as the mechanism by which the drug appears to cause tumor cell death. Comprised of 39 chapters, this book begins with a preclinical overview of cisplatin, focusing on its mechanism of action, pharmacology, antitumor activity, analogs, and toxicity. The discussion then turns to the effects of cisplatin on DNA and the possible relationships to cytotoxicity and mutagenicity in mammalian cells; lethal activity of platinum compounds in combination with pyrimidine derivatives; and ultrastructural effects of cisplatin. Subsequent chapters focus on the rationale of combination chemotherapy; toxic side effects of platinum analogs; radiopharmacokinetic... of cisplatin; and the use of cisplatin for the treatment of malignancies such as ovarian cancer and advanced adenocarcinoma of the prostate. This monograph will be useful to oncologists and pharmacologists.

  • Assessing Ecological Risks of Biotechnology

    • 1st Edition
    • Lev R. Ginzburg
    • English
    Assessing Ecological Risks of Biotechnology presents a comprehensive analysis of ecological risk assessment for biotechnology as viewed predominantly by scientists doing research in this area, but also by regulators, philosophers, and research managers. The emphasis is on the ecological risks associated with the release of genetically engineered organisms into the environment. The book contains 17 chapters that are organized into four parts. Part I discusses the ecological experience gained from previous biological introductions. Part II explores the ecology and the genetics of microbial communities. Emphasis is given to the transport of microorganisms since one of the major ecological concerns about biotechnology is the danger of the spread of genetically engineered organisms to ecosystems other than the one to which they are released. Part III reviews mathematical models that can be used for ecological risk assessment at four different levels. Part IV concerns the regulation of biotechnology, current research trends, and social values.

  • Recent Progress in Mitral Valve Disease

    • 1st Edition
    • Carlos Duran + 2 more
    • English
    Recent Progress in Mitral Valve Disease presents a comprehensive examination of the proceedings that resulted from the International Symposium that transpired in Paris. It discusses the anatomy and physiology of the mitral valve. It addresses the cyclical motion of the mitral valve leaflets. Some of the topics covered in the book are the cyclical motion of the mitral annulus; analysis of hypertrophic cardiomyopathy; diagnoses of acute myocardial ischemia; characteristics of an abnormally functioning, structurally abnormal mitral valve; atrial function in normal cardiac cycle; and atrial function in acute mitral regurgitation. The factors that modify regurgitant volume are fully covered. An in-depth account of the methods for animal preparation and dynamics of acute experimental mitral regurgitation are provided. The uses and limitations of echocardiography in the examination of the mitral valve are completely presented. A chapter is devoted to the timing of surgical intervention in chronic mitral regurgitation. Another section focuses on the status of prosthetic valves in the mitral position. The book can provide useful information to doctors, cardiologists, students, and researchers.

  • Genetic Interactions Among Microorganisms in the Natural Environment

    • 1st Edition
    • E.M.H. Wellington + 1 more
    • English
    This book gives an overview of gene transfer and stability in those aquatic and terrestrial environments where bacteria and fungi can survive and interact genetically. It examines the role played by sex between microbes in the evolution of populations and their survival. Special emphasis is placed on methodology, including the analysis by novel techniques of genetic material extracted directly from soils, rivers and lakes. The natural spread of antibiotic resistance and the safe use of genetically manipulated microbes are matters of considerable scientific, medical and public concern upon which the investigations presented here have direct bearing. This unique collection will be of value to specialist researchers in applied microbiology, ecology and biotechnology as well as biomedical scientists interested in the environmental risks of genetic engineering.

  • New Protein Foods

    Technology
    • 1st Edition
    • Aaron M. Altschul
    • English
    New Protein Foods, Volume 2: Technology, Part B covers examples of mixtures of pure amino acids used in medicine, as well as of the vast social possibilities inherent in exploiting pure synthetic nutrients. The book discusses new approaches to marketing fish; new approaches to marketing milk products; and extrusion cooking. The text also describes the development of the particular knowledge in nutrition and food science and technology that allowed the first chemically defined, almost complete, synthetic foods to be produced. The role of flavor in new protein technologies; mass and institutional feeding of protein foods; and the use of nutrient intervention to improve nutritional status are also considered. The book further tackles the AID program for the introduction of new protein technologies; the notable happenings occurring in the technology and marketing of meat analogs; and the limits of technology.

  • Physical Properties of Tissues

    A Comprehensive Reference Book
    • 1st Edition
    • Francis Duck
    • English
    This unique reference book describes quantitatively the measured and predicted values of all the physical properties of mammalian tissue. Reported measurements are thoroughly documented and are complemented by a range of empirical mathematical models which describe the observed physical behavior of tissue.**Intended as a broad-ranging reference, this volume gives the bioengineer, physicist, radiologist, or physiologist access to a literature which may not be known in detail. It will also be of value for those concerned with the study of a range of environmental radiation hazards.

  • Form and Function

    Form and Function
    • 1st Edition
    • Volume 11
    • E. R. Trueman + 1 more
    • English
    This volume reviews the most important advances that have taken place in the interpretation of the structure and function of molluscan systems. A detailed treatment of each organ system is presented with particular emphasis on skin, shell, muscle, and excretory systems, and luminescences. Emphasis is given to recent research and the current status of each topic.

  • Advances in Drug Research

    • 1st Edition
    • Volume 17
    • Bernard Testa
    • English
    This volume comprises five authoritative reviews on timely topics in drug research. The first two chapters deal with chemotherapeutic agents (selective antiviral agents and cepham antibiotics) and subsequent chapters deal with the cardiovascular system and topics in neuropharmacology.

  • Pharmacology in Clinical Practice

    • 1st Edition
    • Richard Lancaster
    • English
    Pharmacology in Clinical Practice describes basic pharmacology, clinical pharmacology, including the pharmacology of important drug groups. The author reviews the general principles of clinical pharmacology including drug actions, absorption, disposition, and excretion. Most drugs are xenobiotics—compound... foreign and harmful to human living tissues. Drugs should be properly metabolized and converted to nontoxic substance before being excreted either through spontaneous changes not mediated by enzymes or through transformation by enzyme systems. The author also discusses pharmacokinetics, including drug plasma concentration, absorption, first-pass metabolism, distribution and elimination. The author addresses pharmacogenetics that deal with possible different responses to drug intake due to factors such as age, sex, liver or renal disease, smoking, diet. The book tackles other drugs, their uses, and characteristics such as antibacterial agents, obesity drug, cytotoxic drugs or those used in chemotherapy medicine. The author explains the diagnosis of drug ingestion, clinical signs of overdose, clinical course, and prophylactic measures for users to avoid drug overdose or self-poisoning. This book is intended for medical undergraduates, pharmaceutical technicians, pharmacists, students or professors in pharmacology or general medicine.

  • Research in Protozoology

    • 1st Edition
    • Tze-Tuan Chen
    • English
    Research in Protozoology is the fourth volume of a series that covers the progress being made in protozoology. This book is comprised of four chapters and begins with a discussion of synchronized cell division in protozoa, including the species Tetrahymena pyriformes, Astasia longa, Plasmodium lophurae, Amoeba proteus and Acanthamoeba sp., and Physarum polycephalum. The following chapters discuss nuclear phenomena during conjugation and the relationship between protozoa and other animals, with emphasis on parasitism, relations between parasite and host groups, and host specificity. The final chapter focuses on chromosomes and nucleoli in some opalinid protozoa. The book is highly recommended for biologists, microbiologists, zoologists, and parasitologists who want to be updated about the developments in the field of protozoology.

  • Ultrastructural Pathology of the Cell and Matrix

    A Text and Atlas of Physiological and Pathological Alterations in the Fine Structure of Cellular and Extracellular Components
    • 3rd Edition
    • Feroze N. Ghadially
    • English
    Ultrastructural Pathology of the Cell and Matrix: Third Edition Volume 2 presents a comprehensive examination of the intracellular lesion. It discusses the analysis of pathological tissues using electron microscope. It addresses the experimental procedures made on the cellular level. Some of the topics covered in the book are the structure, distribution, and variations of rod-shaped microtubulated bodies; morphology of intracytoplasmic filaments; melanosome-producing and melanosome-containin... cells in tumours; myofilaments in striated muscle; and pathological variations in size, shape, and numbers of microbodies. The intracytoplasmic and intranuclear annulate lamellae are fully covered. An in-depth account of the classification, history, and nomenclature of lysosomes are provided. The morphology and normal variations of melanosomes and anchoring fibrils are completely presented. A chapter is devoted to the endocytotic structures and cell processes. Another section focuses on the classification and nomenclature of fibrous components. The book can provide useful information to cytologists, pathologists, students, and researchers.

  • Cellular and Molecular Mechanisms of Inflammation

    Signal Transduction in Inflammatory Cells, Part A
    • 1st Edition
    • Charles G. Cochrane + 1 more
    • English
    Cellular and Molecular Mechanisms of Inflammation: Signal Transduction in Inflammatory Cells, Part A is a collection of papers that discusses the mechanisms of the transduction of signals linking stimulated receptors and cellular function. This book describes the pathways of signal transduction involved in stimulating functions of inflammatory cells connected with host defense and development of inflammatory injury. One paper notes the potential of using fluorescence methodology in analyzing ligand-receptor interactions in living systems during the natural abundance of cell surface receptors. Another paper discusses the structure and function of GTP-binding proteins in neutrophil signal transduction, particularly the role of oligomeric G proteins in signal transduction. One concern in signal transduction research is the physiological significance of the presence of multiple forms of proteins that can have identical functions. One paper reviews phosphatidylcholine breakdown and hormone action in the rat liver, focusing on G proteins and on inositol phospholipid breakdown. This book also discusses calcium translocation in signal transduction, as well as, a novel signal transduction pathway involving phosphatidylinositol 3-kinase. This book can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

  • The Physiology of Insect Reproduction

    International Series of Monographs in Pure and Applied Biology: Zoology
    • 1st Edition
    • Franz Engelmann
    • G. A. Kerkut
    • English
    The Physiology of Insect Reproduction provides a comprehensive coverage of insect reproductive system. The title details basic phenomena governing reproductive processes in insects, with the whole spectrum of an insect reproductive cycle. The text first covers insect genitalia, and proceeds to discussing sex determination. Next, the selection talks about the development of unfertilized eggs in insects. The text also deals with gonadal development, along with insect mating behavior. Chapter 7 details the factors that affect egg production and fecundity, while Chapter 8 tackles hormonal control of egg maturation. The ninth chapter covers endocrine influence on reproduction in the male insect. The next chapters discuss oviposition, heterogony, and viviparity. The last two chapters deal with functional hermaphroditism and insect societies, respectively. The book will be of great use to students and researchers in the field of entomology.

  • Recent Advances in Animal Nutrition

    • 1st Edition
    • W. Haresign + 1 more
    • English
    Recent Advances in Animal Nutrition 1989 focuses on the compositions of animal feeds. The book first discusses legislation and its implication for the feed compounder, including marketing of feeds, medicated feeds, and feed additives. The text highlights residues of veterinary drugs in animal products. Licensing of veterinary products; assessment of the safety of veterinary medicines; and development of performance-enhancin... drugs are discussed. The book also looks at the vitamin requirements and allowances for poultry; effect of pellet quality on the performance of meat birds; and nutrition of rabbits. The text then discusses the prediction of the nutritive value of silage. History of silage energy evaluation; energy prediction and energy prediction relationships; and nutrient response based systems of rationing are described. The book focuses also on the effect of silage additives and wilting on animal performance; optimizing compound feed use in dairy cows with high intakes of silage; and nutrition of lambs. The text then looks at amino acid nutrition of pigs and poultry and etiology of diarrhea in pigs and pre-ruminants. The selection is vital for readers interested in conducting studies on the compositions of animal feeds.

  • Endocrine Aspects of Disease Processes

    Proceedings of the Conference Held in Honor of Hans Selye, Mont Tremblant, Quebec
    • 1st Edition
    • Gaëtan Jasmin
    • English
    Endocrine Aspects of Disease Processes presents a critical review of hypothalamic hormones regulating the secretion of the anterior pituitary. The book discusses calcitonin as a hormone of ultimobranchials; the brain monoamines and thyroid hormones on emotional stress induced by sympathomimetic agents; and the pharmacology of aggression. Some of the topics covered in the book are the characteristics of brain plasticity under stress; the sleep-wakefulness patterns; the endocrine factors in the etiology of peptic ulcer; and blood sugar levels and allergies. The inflammation and structure of thymus; the cause of coronary and cerebral artery thrombosis in human; and the definition of serum aminopexy are also considered. The book further tackles corticosterone-bindi... by transcortin; the pituitary-thyroid-ad... interaction in the rat; and the description of polypeptides and biogenic amines in the acute inflammatory reactions. The text also looks into the pathogenesis of adrenal-regeneration and methyl-androstenedio... hypertension; and the peripheral vasodilation and thymic tumors in magnesium-deficient rats. A chapter is devoted to the role of the adrenal cortex in the pathogenesis of a spontaneous hereditary congestive heart failure. The book can provide useful information to endocrinologist, doctors, students, and researchers.

  • Advances in Drug Research

    • 1st Edition
    • Volume 18
    • Bernard Testa
    • English
    Each volume in this distinguished series presents authoritative reviews, both generally, on topics of broad interest in drug research, and specifically, on novel and established therapeutic classes. Acknowledged experts contribute in areas such as drug design, clinical and molecular pharmacology, drug metabolism, and mechanisms of action. Reviewers have consistently praised Advances in Drug Research for its comprehensive and lucid summaries of up-to-date knowledge.

  • Mitochondrial Disorders in Neurology

    Butterworth-Heinemann International Medical Reviews
    • 1st Edition
    • Anthony H.V. Schapira + 1 more
    • English
    Mitochondrial Disorders in Neurology provides an overview of mitochondrial diseases. This book discusses the effects of mitochondrial dysfunction based on the relevant biochemistry and molecular genetics. The abnormal muscle and mitochondrial morphology in a variety of clinical presentations from isolated ophthalmoplegia to severe encephalopathy are also elaborated. This text likewise deliberates Leber's hereditary optic neuropathy, neurodegenerative disorders, and respiratory chain defects. Other topics covered include mitochondrial DNA and the genetics of mitochondrial disease; cytochrome oxidase deficiency; use of tissue culture in the diagnosis of mitochondrial disease; and advances in mitochondrial genetics. This publication is a good source for clinicians and students concerned with the defective mitochondrial function.

  • Neurosciences Research

    Volume 3
    • 1st Edition
    • S Ehrenpreis + 1 more
    • English
    Neurosciences Research, Volume 3 covers research problems concerned with the central nervous system. The book discusses the transport processes at the brain cell; the life history of the microglial cell; and studies on the choroid plexus. The text also describes the role of the cerebral peduncle in movements, as well as the pathobiological aspects of the action of tetanal toxin in the nervous system and skeletal muscle. Neuroscientists, neurochemists, and neuropathologists will find book useful.

  • Business of Biotechnology

    From the Bench to the Street
    • 1st Edition
    • R. Ono
    • English
    The Business of Biotechnology: From the Bench to the Street thoroughly examines the existing and future business challenges for biotechnology, providing a unique insight into the intricate web of critical factors with which biotechnology entrepreneurs must come to terms if they wish to be successful. The book begins with discussions of the evolution of biotechnology; entrepreneurship in the biotechnology industry; university-industry technology transfer process; and the life cycle of a biotechnology company. It considers the prospects for biotechnology, from the perspective of a venture capitalist and human resource practitioner. There are separate chapters that deal with the cloning and expression of recombinant gene products; developing strategies to reduce the cost-to-produce (CTP) therapeutic proteins; intellectual property protection; and the regulation of commercial biotechnology. The final chapters cover the marketing of biotechnology companies and products; the performance of biotechnology stocks; mergers and acquisitions in the biotechnology industry, and prospects for the Japanese and European biotechnology industry.

  • Neurobiology of Cytokines

    Methods in Neurosciences, Vol. 16
    • 1st Edition
    • Errol B. De Souza
    • English
    Neurobiology of Cytokines, Part A provides an overview of the effects of cytokines in the brain and in the endocrine system. The book discusses the general aspects of cytokines, including the endogenous agonists and antagonists, their receptors, their second messengers, and transport mechanisms for cytokines across the blood-brain barrier. The text also describes the anatomical localization of cytokines, cytokine receptors, and their respective mRNA in brain and in endocrine tissues. The methods for evaluating the in vivo as well as in vitro actions of cytokines on hormone secretion are also considered. The book further tackles the synthesis and release of cytokines and their central nervous system actions; and the methodology for studying the role of cytokines in human neuropathological conditions.

  • Foundations of Mathematical Biology

    Subcellular Systems
    • 1st Edition
    • Robert J. Rosen
    • English
    Foundations of Mathematical Biology, Volume 1, Subcellular Systems, provides an introduction the place of mathematical biology in relation to the other biological, physical, and organizational sciences. It discusses the use of mathematical tools and techniques to solve biological problems. The book contains four chapters and begins with a discussion of the nature of hierarchical control in living matter. This is followed by a chapter on chemical kinetics and enzyme kinetics, covering the physicomathematical principles, models, and approximations underlying transition-state theory and the unimolecular reaction. Subsequent chapters deal with quantum genetics and membrane excitability.

  • Advances in Immunopharmacology

    Proceeding of the Fourth International Conference on Immunopharmacology, Osaka, Japan, 16-19 May 1988
    • 1st Edition
    • J. W. Hadden
    • English
    The Fourth International Conference on Immunopharmacology took place in Osaka, Japan, May 1988. It was attended by over 900 participants from a variety of fields, illustrating the broad interest and wide-ranging applications of the subject. This Proceedings volume provides a comprehensive record of the Conference and is organized according to the sectional headings employed at the meeting. The topics covered include basic and clinical immunology, and preclinical and clinical aspects of immunopharmacology. The material presented is referenced and indexed throughout, and illustrated with photographs, diagrams and tables.

  • Comprehensive Insect Physiology, Volume 3

    Integument, Respiration and Circulation
    • 1st Edition
    • G. A. Kerkut
    • English
    This volume is primarily devoted to the analysis of the integument (epidermis, cuticle), the fat body, the connective tissues, the circulatory and respiratory systems. It discusses the organization and functioning of the insect systems implicated in growth, intermediary metabolism, homeostasis and defence mechanisms. Much of the volume is devoted to anatomical and structural developments, which appear as introductions to corresponding biochemical and physiological aspects. Many diagrams, drawings and photographs accompany the text throughout. Altogether, this volume presents a clear and up-to-date account of the most recent and important discoveries in the fields and shows the extent of progress which is expected in the near future.

  • Antarctic Fish Biology

    Evolution in a Unique Environment
    • 1st Edition
    • Joseph T. Eastman
    • English
    This important volume provides an original synthesis and novel overview of Antarctic fish biology, detailing the evolution of these fish in some of the most unusual and extreme environments in the world. Focusing on one group of fish, the notothenoioids, which contain the majority of the current organismal diversity, this book describes a fauna that has evolved in isolation and experienced incredible adaptive radiation by acquiring numerous physiological specializations. Darwin's finches and African cichlids may be joined by Antarctic fishes as exemplars of adaptive radiation.The books' coverage is detailed and comprehensive, and the author clearly recognizes the fact that these fish are a component of a most interesting and biologically unique ecosystem and environment. Topics in Antarctic Fish Biology include past and present environments, fossil records, taxonomic composition of fauna, systematic relationships, diversification, and physiological adaptations.

  • Flash Photolysis and Pulse Radiolysis

    Contributions to the Chemistry of Biology and Medicine
    • 1st Edition
    • R. V. Bensasson + 2 more
    • English
    Flash Photolysis and Pulse Radiolysis: Contributions to the Chemistry of Biology and Medicine presents the interaction of radiation with biomolecules, which is either beneficial o deleterious to life. This book discusses the biochemical reactions that are not radiation-induced by selectively generating certain types of free radicals present in normal metabolic processes. Organized into nine chapters, this book begins with an overview of the principle of both pulse radiolysis and flash photolysis with photoelectric detection. This text then examines the applications of flash photolysis and pulse radiolysis to the chlorophylls, bile pigments, hemoglobin and myoglobin, and the porphyrins. Other chapters consider the carotenoids related to photosynthesis. This book discusses as well the role of proteins in nearly all biological processes, including enzymatic catalysis, muscular contraction, immune protection, mechanical support, and genetic information. The final chapter deals with the structures and importance of radiosensitizers. This book is a valuable resource for chemists and biochemists.

  • Wheat Studies - Retrospect and Prospects

    • 1st Edition
    • Volume 3
    • H. Kihara
    • English
    This authoritative work has been written by a man whose career as an active wheat geneticist has spanned sixty years and has earned him a world-wide reputation. The book contains descriptions and much original data on genetical and cytogenetical findings concerning cultivated wheats and their relatives. It covers chromosomal analyses, genome analyses, ancestors of wheat, artificial synthesis of wheat, evidence of cytoplasmic inheritance and variations of wild species. The author explains how these facts and concepts have been discovered, points out the importance inherent in these discoveries, and shows how they can be utilized in genetical and breeding studies. Special emphasis is placed on the motives, processes and development of the studies.

  • Freshwater Ecosystems

    Modelling and Simulation
    • 1st Edition
    • A.H. Gnauck + 1 more
    • English
    Ecosystem analysis and ecological modelling is a rapidly developing interdisciplinary branch of science used in theoretical developments in ecology and having practical applications in environmental protection. In this book, the authors introduce new holistic, particularly cybernetic, concepts into ecosystem theory and modelling, and provide a concise treatment of mathematical modelling of freshwater ecosystems which covers methods, subsystem models, applications and theoretical developments.Part I begins with a brief introduction to the principles of systems theory and their applications to ecosystems, and provides a summary of various methods of systems analysis. In Part II emphasis is laid on the pelagic processes in standing water, characterised by relatively uninvolved structures from which models can be readily developed. Part III describes applications of the technique of modelling to solutions of theoretical and practical problems, with different modelling methods and objectives being used in the various chapters. More recent developments in the methods and theory of ecosystem modelling are covered in Part IV which also includes a discussion of future trends. The book is addressed to practising ecologists and engineers in the fields of ecology, limnology, environmental protection, and water quality managements, as well as to graduate/post-gradua... university students in science and engineering. Students and researchers involved in environmental applications of mathematics and cybernetics will also find the book of interest.

  • Phosphorus in Fresh Water and the Marine Environment

    Progress in Water Technology
    • 1st Edition
    • S. H. Jenkins + 1 more
    • English
    Phosphorus in Fresh Water and the Marine Environment investigates sources of phosphorus in fresh water and the marine environment and the problems it causes. The importance of phosphate precipitation as an inbuilt safety device against overproduction of algae in the oceans is discussed, along with the deposition and absorption of phosphates in sediments. The source of the phosphorus in lakes and rivers is considered in relation to population density and distribution. This book is comprised of 26 chapters and begins with a discussion on natural phosphate sources in relation to phosphate budgets, paying particular attention to eutrophication and soil erosion. The significance of man-made sources of phosphorus, such as fertilizers and farming, detergents and sewage, is then examined. Subsequent chapters focus on the role of phosphorus in the growth of plants and animals in rivers, lakes, and the sea; the hydrogeochemical cycling of phosphorus; phosphorus analysis in sea water; and safety evaluation of substitutes for phosphates in detergents. The microbiology of an activated sludge wastewater treatment plant chemically treated for phosphorus removal is also explored. This monograph will be of interest to policymakers concerned with water pollution control.

  • Structure

    Structure Part 2
    • 2nd Edition
    • Geoffrey Bourne
    • English
    The Structure and Function of Muscle, Second Edition: Volume II: Structure, Part 2 deals with various aspects of muscle structure, including physiology and microanatomy. The structure of the motor end plate is discussed, together with muscle regeneration and postmortem changes in muscle. Membranous systems in muscle fibers as well as the ultrastructural and physiological aspects of heart muscle are also considered. This volume is comprised of nine chapters and begins with an overview of how basic studies in uterine function and regulation promoted developments in reproduction, obstetrics, and regulatory biology, with emphasis on the basic mechanism of function and regulation of smooth muscles. The following chapters explore the capacitative, resistive, and syncytial properties of heart muscle; contractile structures in some Protozoa such as ciliates and gregarines; the microanatomy of smooth muscle, cardiac muscle, and voluntary, somatic, or skeletal muscle; postmortem changes in the physical characteristics of muscle; and morphology of spontaneous degeneration and regeneration in skeletal muscle. The morphology, ultrastructure, and cytochemistry of the muscle spindle are also outlined. The final chapter deals with membraneous systems in muscle fibers and includes a discussion on correlation between physiology and morphology of fiber types in vertebrates and invertebrates. This book will be a useful resource for students, researchers, and practitioners of anatomy, physiology, biology, and medicine.

  • Specific Heart Muscle Disease

    • 1st Edition
    • Cecil Symons + 2 more
    • English
    Specific Heart Muscle Disease presents the primary syndromes in which heart muscle disease is an intrinsic part of another clinical syndrome. This book discusses the cardiomyopathies and shows how they are related to the different forms of specific heart muscle disease. Organized into 11 chapters, this book begins with an overview of the recognition of the various types of cardiomyopathy based on a detailed analysis of function and structure. This text then examines the structure of the amyloid fibril and the pattern of deposition of it in the body. Other chapters consider the possible link between endomyocardial disease and adherent thrombi. This book discusses as well the therapeutic measures to remove the majority of the iron load in hemochromatosis. The final chapter deals with the survival rates in cardiac transplantation and reviews some of the homograft pathology affecting survival in long-term cardiac recipients. This book is a valuable resource for cardiologists and general physicians.

  • Infections of the Nervous System

    Butterworths International Medical Reviews
    • 1st Edition
    • Peter G. E. Kennedy + 1 more
    • English
    Infections of the Nervous System aims to continue the legacy of its predecessor, Modern Trends in Neurology. Its goal is to produce annually a monograph on a topic in clinical neurology in which progress through research has brought about new concepts of patient management. This book is organized into 13 chapters. It highlights the areas or subjects in which significant advances have been made which also have relevance to the treatment of patients. It covers a number of important aspects of different infectious diseases of the nervous system including acute bacterial meningitis, tuberculosis of the nervous system, spirochaetal infections of the nervous system, and fungal diseases of the central nervous system. This book is intended for use by physicians who deal with the problems of neurological disorder on a daily basis, whether they are neurologists, neurologists in training, or those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

  • Experimental Analysis of Behavior

    • 1st Edition
    • Volume 6
    • I.H. Iversen + 1 more
    • English
    This volume is dedicated to the late B.F. Skinner as a tribute to his pioneering work on the Experimental Analysis of Behavior. This science that he initiated studies the behavior of individual organisms under laboratory conditions.The volume describes a broad collection of representative and effective research techniques in the Experimental Analysis of Behavior; techniques derived solely from infrahuman subjects, which have been selected both for their utility in behavior analysis and for their potential value in expanding the use of behavior analysis in the neurosciences. By bringing together under one cover the expertise of individual authors regarding techniques based on their particular laboratory experiences, the book provides an informative and practical source of methods and techniques for those practising or interested in Experimental Analysis of Behaviour.

  • Molecular Breeding and Genetics of Applied Microorganisms

    • 1st Edition
    • Kenji Sakaguchi + 1 more
    • English
    Molecular Breeding and Genetics of Applied Microorganisms provides expert reviews on the developments in the field of applied microbiology in Japan. The book presents areas where further progress in applied microbiology is possible. Articles on these possibilities such as the use of recombinant DNA techniques to link fragments of DNA from unrelated organisms; creation of new strains of microorganisms to control pollution; construction of a ""biological battery"" using a photosynthetic system; and breeding of plant species tolerant to various plant diseases are explored in detail. Microbiologists, biologists, geneticists, biochemists, pharmacologists, and researchers will find the book insightful.

  • Hip Disorders in Children

    Postgraduate Orthopaedics Series
    • 1st Edition
    • G.C. Lloyd-Roberts + 1 more
    • A. Graham Apley
    • English
    Postgraduate Orthopedics Series: Hip Disorders in Children is a seven-chapter text that reviews the disorders of the developing hip. This book discusses the broad spectrum of mal-development in the structure of femur and the classification of femoral dysplasia and prognosis of the hip. The first chapters cover the general observations upon cause, nature, and conditions of congenital dislocation of the hip; management of congenital dislocation beyond the neonatal stage; application of Hey Groves-Colonna capsular arthroplasty; management of primary subluxation; and pyogenic arthritis of infancy. The subsequent chapters deal with the pathogenesis, classification, and treatment of Perthes’ disease. The discussion then shifts to the fractures of the neck of femur in children and the analysis of slipped upper femoral epiphysis. The last chapters are devoted to the sundry disorders of the soft tissues and the disorders of the hemopoietic system. The book can provide useful information to pediatricians, orthopedics, students, and researchers.

  • Progress in Behavior Modification

    Volume 2
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 2 reviews issues and developments in the field of behavior modification, with emphasis on a wide spectrum of child and adult disorders. Topics covered range from behavioral assessment and treatment of alcoholism to sexual arousal in male sexual deviates, along with aversion therapy and research methods in behavior modification. Comprised of eight chapters, this volume begins with a discussion on the status and future trends in behavior assessment of alcoholism and behavior modification with alcoholics. The next chapter deals with therapy models, focusing on the domain of social learning, removal of fears, and assertive and social skill training. The discussion then turns to the measurement and generation of sexual arousal in male sexual deviates; applications of behavior modification in nursing practice; aversion therapy and its clinical effects; deceleration of aberrant behavior among retarded individuals; and research methods in behavior modification. The final chapter examines clinical issues regarding behavioral self-control. This book should be of value to theoreticians, researchers, or practitioners in the fields of psychiatry, psychology, and behavior therapy as well as social work, speech therapy, education, and rehabilitation.

  • Genetics in Aquaculture

    Proceedings of the Fourth International Symposium on Genetics in Aquaculture
    • 1st Edition
    • Graham A.E. Gall + 1 more
    • English
    This volume, the proceedings of the Fourth International Symposium on Genetics in Aquaculture, builds on the foundations laid down at the first symposium, held in Galway, Ireland in 1982 (Aquaculture, Volume 33), as well as those laid down at the second, held in Davis, California, USA in 1985 (Genetics in Aquaculture II), and the third, held in Trondheim, Norway in 1988 (Genetics in Aquaculture III). It addresses specific problems and developments in this field, demonstrating the tremendous breadth of research activity as well as the complexity of issues in aquaculture genetics. This book will be of great value to aquaculturists, fisheries scientists and marine biologists.(The above-mentioned proceedings of the first three conferences are still available).

  • Biomaterials for Cancer Therapeutics

    Diagnosis, Prevention and Therapy
    • 1st Edition
    • Kinam Park
    • English
    Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease.The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction.This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials.

  • Pharma's Prescription

    How the Right Technology Can Save the Pharmaceutical Business
    • 1st Edition
    • Kamal Biswas
    • English
    The pharmaceutical industry needs a shot in the arm – and not a moment too soon. The executive suite is mired in a bygone era, a time when extensive, well-funded pharmaceutical R&D produced blockbuster drugs, kept everything in-house and reaped the financial rewards. But that way of working needs to change. Executives now need to know what the technologists in their companies are doing in order to survive the next decade. Written for those new to industry, as well as for experienced professionals or specialists looking to expand their knowledge, this book is a must-read for business executives and information technologists alike. Pharma’s Prescription bridges the knowledge gap between current business practices and the most valuable technologies today. This book is filled with practical, real-life examples from industry and is a straightforward guide for all pharmaceutical and information technology executives who need to improve their businesses.

  • Catalytic RNA

    • 1st Edition
    • Volume 120
    • English
    This special volume of Progress in Molecular Biology and Translational Science focuses on catalytic RNA. Written by experts in the field, the reviews cover a range of topics, from hammerhead ribozymes to spliceosome catalysis to Varkud satellite and hairpin ribozymes.

  • From Academia to Entrepreneur

    Lessons from the Real World
    • 1st Edition
    • Eugene Khor
    • English
    From Academia to Entrepreneur: Lessons from the Real World provides practical advice on entrepreneurship, interspersed with insights the author gained from starting up his own business and in associations with other ventures. These same insights can be applied to bringing a technology concept from academia to an enterprise. A few of the questions From Academia to Entrepreneur: Lessons from the Real World answers: How do I pragmatically appraise business opportunities? What traits should I look for in an enterprise? What can and should I do with my concept while in academia, before entering such an endeavor? How do I overcome risk aversion? And most importantly, why should I be the one to build this business?

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