An Introduction to Biological Membranes
From Bilayers to Rafts
- 1st Edition - April 20, 2013
- Author: William Stillwell
- Language: English
An Introduction to Biological Membranes: From Bilayers to Rafts covers many aspects of membrane structure/function that bridges membrane biophysics and cell biology. Offeri… Read more
An Introduction to Biological Membranes: From Bilayers to Rafts covers many aspects of membrane structure/function that bridges membrane biophysics and cell biology. Offering cohesive, foundational information, this publication is valuable for advanced undergraduate students, graduate students and membranologists who seek a broad overview of membrane science.
- Brings together different facets of membrane research in a universally understandable manner
- Emphasis on the historical development of the field
- Topics include membrane sugars, membrane models, membrane isolation methods, and membrane transport
Graduate students, postdoctoral fellows, and researchers in biology, cell biology, biochemistry, and biophysics
DedicationPreface1. Introduction to Biological MembranesA What is a Biological Membrane?B General Membrane FunctionsC Eukaryote Cell StructureD Size of DomainsE Basic Composition of MembranesSummaryReferences2. Membrane HistoryA Oil On Water: Interface StudiesB The Lipid Bilayer MembraneSummaryReferences3. Water and the Hydrophobic EffectA Water – Strength in NumbersB Structure of WaterC Properties of Water – No Ordinary JoeD Surface TensionE The Hydrophobic EffectSummaryReferences4. Membrane Lipids: Fatty AcidsA What are Lipids?B Why are there so Many Different Lipids?C Lipid Classification SystemsD Fatty AcidsSummaryReferences5. Membrane Polar LipidsA Bonds Connecting to Acyl ChainsB PhospholipidsC SphingolipidsD SterolsE Membrane Lipid DistributionF Plant LipidsG Membrane Lipids Found in Low AbundanceSummaryReferences6. Membrane ProteinsA IntroductionB The Amino AcidsC How Many Membrane Protein Types are there?SummaryReferences7. Membrane SugarsA IntroductionB GlycolipidsC GlycoproteinsD GPI-Anchored ProteinsSummaryReferences8. From Lipid Bilayers to Lipid RaftsA Development of Membrane ModelsB The Danielli-Davson Pauci-Molecular ModelC The Robertson Unit Membrane ModelD Benson and Green’s Lipoprotein Subunit ModelsE The Singer-Nicolson Fluid Mosaic ModelF Simons’ Lipid Raft ModelSummaryReferences9. Basic Membrane Properties of the Fluid Mosaic ModelA Size and Time DomainsB Membrane ThicknessC Membrane AsymmetryD Lateral DiffusionE Lipid Trans-membrane Diffusion (Flip-Flop)F Lipid Melting BehaviorG Membrane ‘Fluidity’SummaryReferences10. Lipid Membrane PropertiesA Complex Lipid InteractionsB Non-Lamellar PhasesC Lipid Phase DiagramsD Lipid–Protein InteractionsE Lipid InterdigitationSummaryReferences11. Long-Range Membrane PropertiesA Membrane Bilayer Lipid PackingB Membrane Protein DistributionC Imaging of Membrane DomainsD Homeoviscous AdaptationSummaryReferences12. Membrane Isolation MethodsA IntroductionB Breaking Open the Cell: HomogenizationC Membrane Fractionation: CentrifugationD Membrane Fractionation: Non-Centrifugation MethodsE Membrane MarkersSummaryReferences13. Membrane ReconstitutionA DetergentsB Membrane Protein IsolationC Membrane Lipid IsolationD Model Lipid Bilayer Membranes – LiposomesE Membrane ReconstitutionF Lipid RaftsSummaryReferences14. Membrane TransportA IntroductionB Simple Passive DiffusionC Facilitated DiffusionD Active TransportE IonophoresF Gap JunctionsG Other Ways to Cross the MembraneSummaryReferences15. Membranes and Human HealthA Liposomes as Drug-Delivery AgentsB Effect of Dietary Lipids on Membrane Structure/FunctionSummaryReferencesAppendix A. Chronology of Membrane StudiesIndex
"It is well written, with a welcome emphasis on the history of lipid biochemistry and membrane biology… his book is readable, current, and well organized...Students of membrane structure and function, as well as experienced researchers in the area, will benefit from reading this book; it can also serve as a course resource. Summing Up: Highly recommended."—Choice Reviews Online, May 2014"William Stillwell, who for 30 years taught a course on biological membranes, is successful in delivering a broad textbook that can be used in a beginning graduate course on biological membranes… it offers much more extensive coverage of the field of biological membranes than that found in almost any current biochemistry, cell biology, or physiology textbook. This book will be treasured by all who are interested in biological membranes."Rating: 3 Stars —Doody.com, February 14, 2014"Stillwell…presents a textbook that discusses many aspects of membrane structure and function and bridges membrane biophysics and cell biology without delving into technical matters only specialists can understand. He writes primarily for advanced undergraduate and beginning graduate students, but suggests that even specialists in some aspect of membranes might appreciate a broad overview of the whole field."—Reference & Research Book News, December 2013
- Edition: 1
- Published: April 20, 2013
- Language: English
WS
William Stillwell
Dr. Stillwell was a faculty member at Indiana University-Purdue University Indianapolis for 32 years where he taught a senior level course in Biological Chemistry and a graduate level course in Biological Membranes. He also led an active research lab on the effect of omega-3 fatty acids on model membrane structure and function. He has published 140 papers and 400 abstracts on membranes. He has been an Associate Editor of Chemistry and Physics of Lipids. He retired in 2010 and now maintains Professor Emeritus status.
Affiliations and expertise
Faculty member at Indiana University-Purdue University IndianapolisRead An Introduction to Biological Membranes on ScienceDirect