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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Pharmacology of 5-HT6 receptors, Part I

    • 1st Edition
    • Volume 94
    • English
    The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized and they show a modulatory role in learning and memory processes and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors.

  • Human Sleep and Cognition

    Basic Research
    • 1st Edition
    • Volume 185
    • English

  • Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

    • 1st Edition
    • Volume 95
    • English
    Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltra... inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

  • Science of Awakening

    • 1st Edition
    • Volume 93
    • English
    With recent advances of modern medicine more people reach the 'elderly age' around the globe and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into pathogenesis of this devastating group of diseases.

  • Developmental Disorders and Interventions

    • 1st Edition
    • Volume 39
    • English
    Volume 39 of the Advances in Child Development and Behavior series is concerned with Developmental Disorders and Interventions. This volume provides an overview of contemporary research into cognitive, neurodevelopmental and genetic disorders of learning. The social, emotional and cognitive functioning of children with William’s syndrome, Down syndrome, Fragile X and autism, reading difficulties, mathematical difficulties and working memory problems are discussed by some of the leading researchers in the field. Within each chapter, the authors consider current interventions and methods for remediating difficulties associated with each disorder, which will be of particular interest to clinical and educational practitioners.

  • MRI Atlas of Human White Matter

    • 2nd Edition
    • Kenichi Oishi + 3 more
    • English
    MRI Atlas of Human White Matter presents an atlas to the human brain on the basis of T 1-weighted imaging and diffusion tensor imaging. A general background on magnetic resonance imaging is provided, as well as the basics of diffusion tensor imaging. An overview of the principles and limitations in using this methodology in fiber tracking is included. This book describes the core white-matter structures, as well as the superficial white matter, the deep gray matter, and the cortex. It also presents a three-dimensional reconstruction and atlas of the brain white-matter tracts. The Montreal Neurological Institute coordinates, which are the most widely used, are adopted in this book as the primary coordinate system. The Talairach coordinate system is used as the secondary coordinate system. Based on magnetic resonance imaging and diffusion tensor imaging, the book offers a full segmentation of 220 white-matter and gray-matter structures with boundaries.

  • Year Book of Neurology and Neurosurgery

    • 1st Edition
    • Volume 2010
    • Alejandro A. Rabinstein
    • English

  • Mouse Behavioral Testing

    How to Use Mice in Behavioral Neuroscience
    • 1st Edition
    • Douglas Wahlsten
    • English
    Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level.

  • Recent Advances in Parkinsons Disease

    Part II: Translational and Clinical Research
    • 1st Edition
    • Volume 184
    • English
    This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

  • Dreams and Dreaming

    • 1st Edition
    • Volume 92
    • English
    With recent advances of modern medicine more people reach the 'elderly age' around the globe and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into pathogenesis of this devastating group of diseases.

  • Headache

    • 1st Edition
    • Volume 97
    • Giuseppi Nappi + 1 more
    • English
    Handbook of Clinical Neurology: Headache covers various aspects of headaches. It covers up-to-date information about the cultural developments and the scientific advances in the field of neurological science. One of the most frequent symptoms that people encounter is migraine or other type of headaches. At least 40% of neurological consultations are headache-related. With this, significant advances in basic and applied brain sciences have emerged in the field of headache-related problems. Divided into six sections, the book discusses the socioeconomic aspects of headaches, the contribution of biological sciences to the study of the pathophysiology of headache, and the management of headache and other related problems. It also deals with headache-related issues, such as pathogenic (chronobiological, endocrinological, and neuroimaging correlates), nosographic (i.e., migraine, vertigo, and headache in children), and treatment-related issues. The book will serve as a reference for researchers, clinical physicians, and other readers who want additional knowledge about the clinical features of headaches.

  • The Brain

    An Introduction to Functional Neuroanatomy
    • 1st Edition
    • Charles Watson + 2 more
    • English
    The authors of the most cited neuroscience publication, The Rat Brain in Stereotaxic Coordinates, have written this introductory textbook for neuroscience students. The text is clear and concise, and offers an excellent introduction to the essential concepts of neuroscience. Based on contemporary neuroscience research rather than old-style medical school neuroanatomy Thorough treatment of motor and sensory systems A detailed chapter on human cerebral cortex The neuroscience of consciousness, memory, emotion, brain injury, and mental illness A comprehensive chapter on brain development A summary of the techniques of brain research A detailed glossary of neuroscience terms Illustrated with over 130 color photographs and diagrams This book will inspire and inform students of neuroscience. It is designed for beginning students in the health sciences, including psychology, nursing, biology, and medicine.

  • Functional Plasticity and Genetic Variation

    Insights into the Neurobiology of Alcoholism
    • 1st Edition
    • Volume 91
    • English
    With recent advances of modern medicine more people reach the 'elderly age' around the globe and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into pathogenesis of this devastating group of diseases.

  • International Review of Research in Mental Retardation

    Health Issues Among Persons with Down Syndrome
    • 1st Edition
    • Volume 39
    • Richard C. Urbano
    • English
    International Review of Research in Developmental Disabilities is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of mental retardation. This thematic volume, "Health Issues in Down Syndrome," will cover health issues for individuals across the life span. With the life expectancy of individuals now reaching 60 years or more, it has transformed from an acute condition with a short life span to a chronic condition that needs to be managed over a close to normal life span. The extra chromosome 21 that defines most cases of Down syndrome affects the functioning of many biological processes and organ systems. The cascade of events triggered by the extra chromosome 21 creates a complex set of medical conditions needing to managed over the life span. The ability to manage these conditions has led to an improvement in longevity and quality of life for individuals with Down syndrome.

  • Stress of War, Conflict and Disaster

    • 1st Edition
    • George Fink
    • English
    Stress is a universal phenomenon that impacts adversely on most people. Following on the heels of Stress Science: Neuroendocrinology and Stress Consequences: Mental, Neuropsychological and Socioeconomic, this third derivative volume will provide a readily accessible and affordable compendium that explains the phenomenon of stress as it relates physically and mentally to war, conflict and disaster. The first section will be dedicated to study of the link between stress and various forms of conflict. Specific instances of conflict will be discussed - the Gulf wars, Korea, Hiroshima bombing, the Holocaust, 9/11, Northern Ireland, terrorism in general, torture. The second section will explore the stress impact of more general physical disasters such as airline and vehicle accidents, earthquakes, floods, and hurricanes. The final section will focus on the clinical relationship between conflict stress and various mental diseases – PTSD, suicide, disaster syndrome, etc – as well as the adverse impact of stress on human physical health in general. Comprised of about 100 top articles selected from Elsevier’s Encyclopedias of Stress, the volume will provide a valuable desk reference that will put relevant articles readily at the fingertips of all scientists who consider stress.

  • Signal Processing for Neuroscientists, A Companion Volume

    Advanced Topics, Nonlinear Techniques and Multi-Channel Analysis
    • 1st Edition
    • Wim van Drongelen
    • English
    The popularity of signal processing in neuroscience is increasing, and with the current availability and development of computer hardware and software, it is anticipated that the current growth will continue. Because electrode fabrication has improved and measurement equipment is getting less expensive, electrophysiological measurements with large numbers of channels are now very common. In addition, neuroscience has entered the age of light, and fluorescence measurements are fully integrated into the researcher’s toolkit. Because each image in a movie contains multiple pixels, these measurements are multi-channel by nature. Furthermore, the availability of both generic and specialized software packages for data analysis has altered the neuroscientist’s attitude toward some of the more complex analysis techniques. This book is a companion to the previously published Signal Processing for Neuroscientists: An Introduction to the Analysis of Physiological Signals, which introduced readers to the basic concepts. It discusses several advanced techniques, rediscovers methods to describe nonlinear systems, and examines the analysis of multi-channel recordings.

  • Recent Advances in Parkinsons Disease

    Part I: Basic Research
    • 1st Edition
    • Volume 183
    • English
    This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods.

  • Transcranial Sonography in Movement Disorders

    • 1st Edition
    • Volume 90
    • English

  • Statistical Signal Processing for Neuroscience and Neurotechnology

    • 1st Edition
    • Karim G. Oweiss
    • English
    This is a uniquely comprehensive reference that summarizes the state of the art of signal processing theory and techniques for solving emerging problems in neuroscience, and which clearly presents new theory, algorithms, software and hardware tools that are specifically tailored to the nature of the neurobiological environment. It gives a broad overview of the basic principles, theories and methods in statistical signal processing for basic and applied neuroscience problems.Written by experts in the field, the book is an ideal reference for researchers working in the field of neural engineering, neural interface, computational neuroscience, neuroinformatics, neuropsychology and neural physiology. By giving a broad overview of the basic principles, theories and methods, it is also an ideal introduction to statistical signal processing in neuroscience.

  • GABAb Receptor Pharmacology: A Tribute to Norman Bowery

    • 1st Edition
    • Volume 58
    • English
    This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABAB receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABAB agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABAB activity receptor in the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse. The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular.

  • Treatment of Eating Disorders

    Bridging the Research-practice Gap
    • 1st Edition
    • Margo Maine + 2 more
    • English
    Eating disorders (EDs) affect at least 11 million people in the United States each year and spread across age, race, ethnicity and socio-economic class. While professional literature on the subject has grown a great deal in the past 30 years, it tends to be exclusively research-based and lacking expert clinical commentary on treatment. This volume focuses on just such commentary, with chapters authored by both expert clinicians and researchers. Core issues such as assessment and diagnosis, the correlation between EDs and weight and nutrition, and medical/psychiatric management are discussed, as are the underrepresented issues of treatment differences based on gender and culture, the applications of neuroscience, EDNOS, comorbid psychiatric disorders and the impact of psychiatric medications. This volume uniquely bridges the gap between theoretical findings and actual practice, borrowing a bench-to-bedside approach from medical research.

  • Mathematics for Neuroscientists

    • 1st Edition
    • Fabrizio Gabbiani + 1 more
    • English
    Virtually all scientific problems in neuroscience require mathematical analysis, and all neuroscientists are increasingly required to have a significant understanding of mathematical methods. There is currently no comprehensive, integrated introductory book on the use of mathematics in neuroscience; existing books either concentrate solely on theoretical modeling or discuss mathematical concepts for the treatment of very specific problems. This book fills this need by systematically introducing mathematical and computational tools in precisely the contexts that first established their importance for neuroscience. All mathematical concepts will be introduced from the simple to complex using the most widely used computing environment, Matlab. This book will provide a grounded introduction to the fundamental concepts of mathematics, neuroscience and their combined use, thus providing the reader with a springboard to cutting-edge research topics and fostering a tighter integration of mathematics and neuroscience for future generations of students.

  • Neuroendocrinology

    Pathological Situations and Diseases
    • 1st Edition
    • Volume 182
    • English
    Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience. Volumes 181 and 182 of Progress in Brain Research provide a rapid view of the major points presently discussed at biological and clinical levels. The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques. The volumes cover of the role of genetics in many endocrine-related events, like neuroendocrinologica... diseases and endocrine depenedent cancers (prostate, breast, etc,). Interesting information is also provided on possibile treatments of neurodegenerative brain diseases (e.g., Alzheimer and similar syndromes).

  • Quantum Magnetic Resonance Imaging Diagnostics of Human Brain Disorders

    • 1st Edition
    • Madan M Kaila + 1 more
    • English
    Magnetic resonance imaging (MRI) is a medical imaging technique used to visualize detailed internal structure of the body. This book discusses the recent developments in the field of MRI and its application to the diagnosis of human brain disorders. In addition, it reviews the newly emerging concepts and technology, based on the multi-coherence imaging (MQCI). It explains how computer packages can be used to generate images in diseased states and compare them to in vivo results. This will help improve the diagnosis of brain disorders based on the real-time events happening on atomic and molecular quantum levels. This is important since quantum-based MRI would enable clinicians to detect brain tumors at the very early stages.

  • Neuroendocrinology

    The Normal Neuroendocrine System
    • 1st Edition
    • Volume 181
    • English
    Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience. Volumes 181 and 182 of Progress in Brain Research provide a rapid view of the major points presently discussed at biological and clinical levels. The chapters have been written by top scientists who are directly involved in basic or clinical research and who use the most sophisticated biotechnological techniques. The volumes cover of the role of genetics in many endocrine-related events, like neuroendocrinologica... diseases and endocrine depenedent cancers (prostate, breast, etc,). Interesting information is also provided on possibile treatments of neurodegenerative brain diseases (e.g., Alzheimer and similar syndromes).

  • Biochemical and Pharmacological Mechanisms Underlying Behaviour

    • 1st Edition
    • Volume 36
    • English

  • Encyclopedia of Behavioral Neuroscience

    • 1st Edition
    • George F. Koob
    • English
    Behavioral Neuroscientists study the behavior of animals and humans and the neurobiological and physiological processes that control it. Behavior is the ultimate function of the nervous system, and the study of it is very multidisciplinary. Disorders of behavior in humans touch millions of people’s lives significantly, and it is of paramount importance to understand pathological conditions such as addictions, anxiety, depression, schizophrenia, autism among others, in order to be able to develop new treatment possibilities. Encyclopedia of Behavioral Neuroscience is the first and only multi-volume reference to comprehensively cover the foundation knowledge in the field. This three volume work is edited by world renowned behavioral neuroscientists George F. Koob, The Scripps Research Institute, Michel Le Moal, Université Bordeaux, and Richard F. Thompson, University of Southern California and written by a premier selection of the leading scientists in their respective fields. Each section is edited by a specialist in the relevant area. The important research in all areas of Behavioral Neuroscience is covered in a total of 210 chapters on topics ranging from neuroethology and learning and memory, to behavioral disorders and psychiatric diseases.

  • Mental and Neurological Public Health

    A Global Perspective
    • 1st Edition
    • Vikram Patel + 4 more
    • English
    Colin Mathers who leads the Global Burden of Disease group in WHO has confirmed that, in the 2004 GBD, 13.1% of global Daily Adjusted Life Years are attributable to mental or neurological disorders. While the proportions vary very widely from about 10% in low income countries to over 25% in high income countries, it is clear that there is a need for understanding how to address this issue. This volume aims to provide a comprehensive overview of the public health principles of mental and neurological disorders. This vast range of health conditions affects people across the life course, from developmental disabilities in childhood, to schizophrenia and substance abuse in adults, and dementia in old age. Despite this diversity, they all share many features: they are mostly mediated through brain dysfunction or abnormalities, are often chronic in course, typically benefit from multi-component interventions, and are amongst the most neglected conditions in global health. The volume will bring together chapters from the Psychiatry, Neurology, Substance Abuse and Child Development sections of the Encyclopedia of Public Health. The volume will be the first comprehensive text on a public health approach to this diverse group of health conditions and has no obvious competitor.

  • Practice Management in Neurology, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 28-2
    • Orly Avitzur
    • English
    In the fast-paced world of health care clinical effectiveness relies not only upon medical, but also administrative competence. This issue of Neurologic Clinics features 14 articles from experts in their respective areas of office management. Articles include practice and compensation models; negotiating with payers; using benchmarks; web based neurology resources (clinical); web based neurology resources (practice management); use of electronic health records in neurology practice; hot topics in risk management; HIPPA and other regulatory issues; ethical issues; new concepts in residency and fellowship training; using evidence based medicine; P4P and PQRI; patient education; and the future of neurology.

  • The Psychology of Learning and Motivation

    • 1st Edition
    • Volume 52
    • English
    The Psychology of Learning and Motivation series publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter thoughtfully integrates the writings of leading contributors, who present and discuss significant bodies of research relevant to their discipline. Volume 51 includes chapters on such varied topics as emotion and memory interference, electrophysiology, mathematical cognition, and reader participation in narrative.

  • Cognition, Brain, and Consciousness

    Introduction to Cognitive Neuroscience
    • 2nd Edition
    • Bernard J. Baars + 1 more
    • English
    Cognition, Brain, and Consciousness, Second Edition, provides students and readers with an overview of the study of the human brain and its cognitive development.It discusses brain molecules and their primary function, which is to help carry brain signals to and from the different parts of the human body. These molecules are also essential for understanding language, learning, perception, thinking, and other cognitive functions of our brain. The book also presents the tools that can be used to view the human brain through brain imaging or recording.New to this edition are Frontiers in Cognitive Neuroscience text boxes, each one focusing on a leading researcher and their topic of expertise. There is a new chapter on Genes and Molecules of Cognition; all other chapters have been thoroughly revised, based on the most recent discoveries.This text is designed for undergraduate and graduate students in Psychology, Neuroscience, and related disciplines in which cognitive neuroscience is taught.

  • Handbook of Basal Ganglia Structure and Function

    • 1st Edition
    • Volume 24
    • Heinz Steiner + 1 more
    • English
    The Basal Ganglia comprise a group of forebrain nuclei that are interconnected with the cerebral cortex, thalamus and brainstem. Basal ganglia circuits are involved in various functions, including motor control and learning, sensorimotor integration, reward and cognition. The importance of these nuclei for normal brain function and behavior is emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson’s disease, Tourette’s syndrome, Huntington’s disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction. The Handbook of Basal Ganglia provides a comprehensive overview of the structural and functional organization of the basal ganglia, with special emphasis on the progress achieved over the last 10-15 years. Organized in six parts, the volume describes the general anatomical organization and provides a review of the evolution of the basal ganglia, followed by detailed accounts of recent advances in anatomy, cellular/molecular, and cellular/physiologic... mechanisms, and our understanding of the behavioral and clinical aspects of basal ganglia function and dysfunction.

  • Bacterial Infections of the Central Nervous System

    • 1st Edition
    • Volume 96
    • Karen L. Roos + 1 more
    • English
    Bacterial Infections of the Central Nervous System aims to provide information useful to physicians taking care of patients with bacterial infections in the central nervous system (CNS), which can lead to morbidity and mortality. The increased number of patients suffering from this infection has led to the development of vaccines and antibiotics. Comprised of four chapters, the book explains the general approach to patients with bacterial CNS infection. It also discusses various CNS infection concepts and terms. These include the characteristic neuroimaging appearance of specific bacterial infections, the limitations of neuroimaging, the cerebrospinal fluid analysis, the pathogenesis and pathophysiology of bacterial CNS infections, the developments of specific adjunctive strategies, and the principles of antimicrobial therapy. It also includes discussions on various diseases that target the CNS, such as meningitis, focal CNS infections, neurological complications of endocarditis, suppurative venous sinus thrombosis, infections in the neurosurgical patient, and CNS diseases caused by selected infectious agents and toxins. This book will serve as a guide for clinical physicians who have patients suffering from bacterial CNS infection.

  • Neurology and Systemic Disease, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 28-1
    • Alireza Minagar
    • English
    This issue of Neurologic Clinics features 17 articles that address the neurologic implications of systemic illnesses. Articles include neurologic presentations of infective endocardititis; neurologic presentations of acid-base imbalance, electrolyte abnormalities, and endocrine emergencies; neurologic presentation of renal disease; neurologic manifestations of systemic lupus erythematosus in children and adults; neurologic complications of respiratory disease; neurologic presentations of nutritional deficiencies; neurologic presentations of gastrointestinal disease; neurotoxicity of radiation therapy; neurologic presentation of lyme disease and syphilis; neurologic aspects of drug abuse; neurologic manifestations of transplant complications; neurologic presentations of sarcoidosis; neurologic presentations of fungal infections; neurologic presentations of cardiac disease; neurologic presentation of AIDS; neurologic presentation of systemic vasculitis; and neurologic presentations of hepatic disease.

  • The Brain and Host Defense

    • 1st Edition
    • Volume 9
    • English
    It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems.Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system.

  • Nanoneuroscience and Nanoneuropharmacology

    • 1st Edition
    • Volume 180
    • Hari S. Sharma
    • English
    This volume presents articles from the leading experts in the field in nanobiotechnology, providing students and researchers with a comprehensive review of the newly emerging area of neuroscience. All aspects of nanomaterials induced alteration in brain function are considered. Basic chapters on methods and ways to enhance nano-drug delivery into the brain are presented as well as chapters on functional and structural changes in the CNS, including gene expression and related issues. Particular attention is given to possible therapeutic advancement regarding nano-drug formulation and their role in neuroprotection.

  • Handbook of the Behavioral Neurobiology of Serotonin

    • 1st Edition
    • Volume 21
    • Christian P. Muller + 1 more
    • English
    Serotonin (5-hydroxytryptamine... often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft. The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour. This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise. The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders.

  • Cultural Neuroscience: Cultural Influences on Brain Function

    • 1st Edition
    • Volume 178
    • Juan Y. Chiao
    • English
    This volume presents recent empirical advances using neuroscience techniques to investigate how culture influences neural processes underlying a wide range of human abilities, from perception and scene processing to memory and social cognition. It also highlights the theoretical and methodological issues with conducting cultural neuroscience research. Section I provides diverse theoretical perspectives on how culture and biology interact are represented. Sections II –VI is to demonstrate how cultural values, beliefs, practices and experience affect neural systems underlying a wide range of human behavior from perception and cognition to emotion, social cognition and decision-making. The final section presents arguments for integrating the study of culture and the human brain by providing an explicit articulation of how the study of culture can inform the study of the brain and vice versa.

  • Genetic Models of Schizophrenia

    • 1st Edition
    • Volume 179
    • Akira Sawa
    • English
    This is a well-established international series that examines major areas of basic and clinical research within neuroscience (as well as emerging and promising subfields): neuroanatomy, neurophysiology, neuroimaging, neurobiology, neuropharmacology, neuroendocrinology, neuropathology, neuropsychiatry, and neurobehavior. This volume provides a thorough treatment of gene models of schizophrenia, presenting articles from leading contributors in this important area.

  • Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders

    • 1st Edition
    • Volume 89
    • XIAO-HONG LU
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.

  • New Concepts of Psychostimulants Induced Neurotoxicity

    • 1st Edition
    • Volume 88
    • Hari Shanker Sharma
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. With recent advancements in new knowledge, it has become evident that psychostimulants and related drugs of abuse are influencing our central nervous system (CNS) remarkably and could alter their function for a longtime. This volume is the first to focus on substance abuse induced brain pathology in the widest sense as it covers alterations in neuronal, glial and endothelial cell functions under the influence of acute or chronic usage of substance abuse.

  • Handbook of Mammalian Vocalization

    An Integrative Neuroscience Approach
    • 1st Edition
    • Volume 19
    • Stefan M Brudzynski
    • English
    Handbook of Mammalian Vocalization is designed as a broad and comprehensive, but well-balanced book, written from the neuroscience point of view in the broad sense of this term. This well-illustrated Handbook pays particular attention to systematically organized details but also to the explanatory style of the text and internal cohesiveness of the content, so the successive chapters gradually develop a consistent story without losing the inherent complexity. Studies from many species are included, however rodents dominate, as most of the brain investigations were done on these species. The leading idea of the Handbook is that vocalizations evolved as highly adaptive specific signals, which are selectively picked up by the brain. The brain serves as a receptor and behavioural amplifier. Brain systems will be described, which allow vocal signals rapidly changing the entire state of the organism and trigger vital biological responses, usually also with accompanying emission of vocalizations. Integrative brain functions leading to vocal outcome will be described, along with the vocalization generators and motor output to larynx and other supportive motor subsystems. The last sections of the Handbook explains bioacoustic structure of vocalizations, present understanding of information coding, and origins of the complex semiotic/ semantic content of vocalizations in social mammals. The Handbook is a major source of information for professionals from many fields, with a neuroscience approach as a common denominator. The handbook provides consistent and unified understanding of all major aspects of vocalization in a monographic manner, and at the same time, gives an encyclopaedic overview of major topics associated with vocalization from molecular/ cellular level to behavior and cognitive processing. It is written in a strictly scientific way but clear enough to serve not only for specialized researchers in different fields of neuroscience but also for academic teachers of neuroscience, including behavioural neuroscience, affective neuroscience, clinical neuroscience, neuroethology, biopsychology, neurolingusitics, speech pathology, and other related fields, and also for research fellows, graduate and other advanced students, who widely need such a source publication.

  • Coma Science

    • 1st Edition
    • Volume 177
    • Professor Laureys
    • English
    This serial is firmly established as an extensive documentation of the advances in contemporary brain research. Each volume presents authoritative reviews and original articles by invited specialists.This volume concentrates on coma and consciousness science. presenting articles from leading figures in the area on the clinical and ethical implications of work in this field. The book provides a thorough review of the various aspects of coma science from a review of the concepts, questioning of recent advances, case studies, through to where research in the field is heading.

  • Essential Bioimaging Methods

    • 1st Edition
    • P. Michael Conn
    • English
    Need a tested, reliable method that works? Put Essential Bioimaging Methods to work for you. Editor Michael Conn has hand-picked the most robust methods from his previously-published volumes in the Methods in Enzymology series. Many of these methods have been briefly updated by the authors that created them and use them in their research, and this book further refines and organizes existing content and focuses on methods that work, including MRI, fMRI, PET, Microscopic optical imaging and other. Part of the Reliable Lab Solution series, this volume provides clear advice and explicit protocols, providing updates to classic, tried-and-true methods and an essential addition to the bookshelf or workbench of any researcher in the field.

  • Developmental Neurobiology

    • 1st Edition
    • Greg Lemke
    • English
    Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbook reference exists on the market that provides researchers with more in-depth, high-level information on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole. This reference is the first of its kind to fill this need. It pulls together the relevant articles on the topic from the 10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and serves as an affordable and immediate resource for scientists, postdocs, graduate students with an interest beyond the basic textbook materials on the subject.

  • Intercellular Communication in the Nervous System

    • 1st Edition
    • Robert Malenka
    • English
    Intercellular communication is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their environment is the basis of growth and development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, diabetes, and neurological and psychiatric disorders. There is substantial drug development concentrating on this and intercellular communication is the basis of much of neuropharmacology. By understanding cell signaling, diseases may be treated effectively and, theoretically, artificial tissues may be yielded. Neurotransmitters/re... synaptic structure and organization, gap junctions, neurotrophic factors and neuropeptides are all explored in this volume, as are the ways in which signaling controls neuroendocrinology, neuroimmunology and neuropharmacology. Intercellular Communication in the Nervous System provides a valuable desk reference for all scientists who consider signaling.

  • Mechanisms of Memory

    • 2nd Edition
    • J. David Sweatt
    • J. David Sweatt
    • English
    This fully revised second edition provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader’s understanding.

  • Stress Science

    Neuroendocrinology
    • 1st Edition
    • George Fink
    • English
    Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that explains the phenomenon of stress, the neural, endocrine and molecular mechanisms involved, the clinical effects, and the impact on individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing’s Syndrome: Addison’s Disease) and the adverse impact of stress on human physical and mental health . Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease, as well as stress-immune-inflam... interactions in relation to cancer and autoimmune and viral diseases. Emphasis is also placed on the role of stress in obesity, hypertension, diabetes type II and other features of the metabolic syndrome which has now reached epidemic proportions in the USA and other countries.

  • Guide to Research Techniques in Neuroscience

    • 1st Edition
    • Matt Carter + 1 more
    • English
    Neuroscience is by definition a multidisciplinary field: some scientists study genes and proteins at the molecular level while others study neural circuitry. A single topic such as the auditory system can be studied using techniques from genetics, imaging, biochemistry, or electrophysiology. A young scientist must learn how to read the primary literature and then develop their own experiments. This book offers that scientist an overview of mainstream research techniques, provides guidelines on how to choose one technique over another, offers tips on analyzing data, and provides a list of references for additional detailed study. This book can also assist an experienced scientist understand published studies conducted outside their own subfield.

  • The Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 51
    • English
    The Psychology of Learning and Motivation series publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter thoughtfully integrates the writings of leading contributors, who present and discuss significant bodies of research relevant to their discipline. Volume 51 includes chapters on such varied topics as emotion and memory interference, electrophysiology, mathematical cognition, and reader participation in narrative.

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