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Cerebrospinal Fluid and Subarachnoid Space

Volume 1: Clinical Anatomy and Physiology

1st Edition - October 8, 2022

Editors: R. Shane Tubbs, Joe Iwanaga, Elias B. Rizk, Anthony V. D'Antoni, Aaron S. Dumont

Hardback ISBN:

9 7 8 - 0 - 1 2 - 8 1 9 5 0 9 - 3

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 1 9 5 1 0 - 9

Cerebrospinal Fluid and Subarachnoid  Space: Volume 1: Clinical Anatomy and Physiology is the first book devoted to the comprehensive clinical anatomy of the cerebrospinal… Read more

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Cerebrospinal Fluid and Subarachnoid Space: Volume 1: Clinical Anatomy and Physiology is the first book devoted to the comprehensive clinical anatomy of the cerebrospinal fluid for neurosurgeons, neurologists, and neuroscientists. Knowledge of the cerebrospinal fluid (CSF) and the subarachnoid space is necessary for almost all fields of medicine. The book covers a wide swath of topics related to CSF with a focus on topics relevant to neuroscience specialists including researchers, neurologists, neurosurgeons, and neuroradiologists. Topics span from neuroanatomy, neurophysiology, CSF in different disease states and more. Various fresh and fixed cadaveric photographs helps readers obtain a better understanding of anatomy and complications related to CSF.

1. Historical perspectives

2. Development of the ventricles, choroid plexus and subarachnoid space

3. Anatomy of the ventricles and subarachnoid spaces and cisterns

4. Anatomy of choroid plexus, capillary endothelial cells, ependymal layer, pia and arachnoid granulations/villi, extracellular space

5. Spinal punctures

6. CSF in the animal kingdom

7. Animal models for CSF testing

8. CSF physiology: Production, circulation, absorption, function, extrachoroidal formation/absorption

9. CSF and basal lymphatic system in mammals

10. A new look at CSF circulation

11. Virchow Robin spaces

12. CSF and disposition of alpha synuclein

13. CSF in pediatrics: prematurity, neonates, infants, and toddlers

14. CSF imaging

15. CSF in neurodegenerative disease processes

16. CSF in trauma

17. CSF in pregnancy

18. CSF in space, high-altitude or deep sea diving

19. CSF fluid replacement

20. Glymphatic system and CSF

21. Lymphatic system and CSF

22. Blood brain barrier

23. Intracranial/intraspinal pressure

24. Intracranial pressure (ICP) in trauma and autoregulation

25. ICP in slit ventricle syndrome

26. ICP and over drainage

27. Non invasive ICP monitoring

28. NPH

29. ICP in normal pressure hydrocephalus (NPH)

30. Neuropsychological testing and NPH

31. Shunt infections

32. Shunt complications

33. Drugs and CSF production and ICP

34. Hydrocephalus treatment “historical perspective”

35. Hydrocephalus and shunt valves

36. Reasons for shunting and revision surgery: UK registry data

37. Infections of CSF

38. CSF and disease:
a. Primary tumors vs brain metastases
b. Carcinomatous meningitis
c. Developmental disorders
d. Neuromuscular disorders
e. Neurodegenerative disorders
f. Movement disorders
g. Diseases of the spinal cord
h. Epilepsy and seizures

39. CSF and headaches

40. CSF markers and exosomes

41. CSF in Chiari I malformation

42. CSF in Chiari II malformation

43. Neurophysiological consequences of hydrocephalus

44. Hemorrhage and hydrocephalus

45. Arrested hydrocephalus

46. Aqueductal stenosis

47. Hydrocephalus and genetic disorders

48. Biomarkers of hydrocephalus

49. Long-term prognosis of fetal hydrocephalus

50. Circumventricular organs

51. Endoscopic third ventriculostomy and choroid plexus coagulation

52. Failure of ETV

53. Learning disabilities in hydrocephalus

54. Hydrocephalus in craniosynostosis

55. Syringomyelia

56. Arachnoid cysts

57. Neuro endoscopic anatomy

58. Endoscopy technique

59. Hydrocephalus in the developing world

60. Economics of hydrocephalus

61. Hydrocephalus and Fetal surgery for myelomeningocele

62. Ventricular anatomy in Chiari II malformation

63.Venous outflow obstruction and hydrocephalus

64. CSF markers before and after shunting

65. Spinal CSF compartments

66. Ventricular access devices in neonatal hemorrhage

67. Body position and lumbar CSF leak

68. Spontaneous CSF leak

69. Visual pathway and hydrocephalus

70. Effect of decompressive craniectomy on CSF pulsatility

71. Direct control of CSF pulsatility and its effect on cerebral blood Flow

72. The pulsating brain

73. Choroid plexus transport

74. Amyloid, tau, alpha synuclein and CSF dynamics

R. Shane Tubbs

R. Shane Tubbs, MS, PA-C, PhD is a native of Birmingham, Alabama, USA and a is a clinical anatomist, author, editor, educator, and researcher. He is Professor of Neurosurgery, Neurology, Surgery, and Structural & Cellular Biology, Director of Surgical Anatomy at Tulane School of Medicine and Program Director of Anatomical Research in the Clinical Neuroscience Research Center at Tulane University School of Medicine, New Orleans, Louisiana and Department of Neurosurgery and Ochsner Neuroscience Institute Ochsner Health System, New Orleans, LA. He has multiple honorary professorships/faculty positions both in the US and abroad. Dr. Tubbs is President-elect of the American Association of Clinical Anatomists (AACA) and serves as its Journal’s (Clinical Anatomy) Editor-in-Chief. Dr. Tubbs’ research interests are centered around what has been termed “reverse translational anatomy research” where clinical/surgical problems are identified and solved/explained with anatomical studies. This investigative paradigm in anatomy has resulted in over 1,800 peer reviewed publications from his laboratory. Dr. Tubbs’ laboratory has made novel discoveries in human anatomy and in 2018, he was listed as a “hyperprolific author” in the journal Nature. Dr. Tubbs sits on the editorial board of over 10 anatomical journals and over 30 clinical journals and has reviewed for over 150 various scientific journals. He has authored/edited over 50 books and over 80 book chapters primarily in anatomical and neurosurgical textbooks. Lastly, Dr. Tubbs is Chair of the Federative International Programme on Anatomical Terminologies (FIPAT) and oversees six working groups dedicated to this topic. Under his leadership, the second edition of Terminologia Anatomica was just published.

Affiliations and expertise

Professor and Program Director, Tulane University School of Medicine, New Orleans, Louisiana and Department of Neurosurgery and Ochsner Neuroscience Institute Ochsner Health System, New Orleans, LA

Joe Iwanaga

Joe Iwanaga, DDS, PhD, is a clinical anatomist and an oral and maxillofacial surgeon. He is the author of more than 400 articles in peer-reviewed journals. Dr. Iwanaga is a Councilor-at-Large of the American Association of Clinical Anatomists, and Coordinator of the FIPAT Oral Anatomy Working Group of the International Federation of Associations of Anatomists. He is a Dental, Oral and Maxillofacial Section editor of the journal Clinical Anatomy.

Affiliations and expertise

Associate Professor of Neurosurgery and Neurology at Tulane University School of Medicine, New Orleans, Louisiana, USA. Associate Professor of Anatomy and Dental and Oral Medical Center at Kurume University School of Medicine, Kurume, Fukuoka, Japan.

Elias B. Rizk

Dr. Rizk is a neurosurgeon at the Penn State Hershey Medical Center with a clinical specialty in pediatric peripheral nerve surgery. He has multiple publications on the PNS and is active in basic science research regarding peripheral nerve regeneration.

Affiliations and expertise

Neurosurgeon, Pennsylvania State University, Hershey, PA, USA

Anthony V. D'Antoni

Anthony V. D'Antoni works in the Department of Radiology at Weill Cornell Medicine, New York, NY, USA.

Affiliations and expertise

Department of Radiology, Weill Cornell Medicine, New York, NY, USA

Aaron S. Dumont

Aaron S. Dumont works at Tulane University in New Orleans, Louisiana, USA.

Affiliations and expertise

Tulane University, New Orleans, Louisiana, USA