Nanomedicine-Based Approaches for the Treatment of Dementia

1st Edition - October 11, 2022
Imprint: Academic Press
Editors: Umesh Gupta, Prashant Kesharwani
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 3 3 1 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 0 6 - 6

Nanomedicine-Based Approaches for the Treatment of Dementia explores a wide range of promising approaches for the diagnosis and treatment of dementia. The book begins with intr… Read more

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Nanomedicine-Based Approaches for the Treatment of Dementia explores a wide range of promising approaches for the diagnosis and treatment of dementia. The book begins with introductory sections on dementia and brain ailments that are followed by further chapters that discuss detailed information about challenges of drug delivery across the blood-brain barrier as well as the current status. This book helps readers design and develop novel drug delivery systems and devices for the treatment of dementia that take advantage of recent advances in nanomedical technologies.

Numerous drug delivery systems have been developed recently for dementia. Unfortunately, most of them are ineffective since dementia is not a single disease. It is an umbrella term for several neurodegenerative conditions which alter brain functions. Due to this, there is an urgent need for innovative technologies/nano drug delivery systems to improve the targeting and delivery of therapeutic as well as diagnostic agents specifically for treating dementia.

Cover Image
Title Page
Copyright
Dedication
Table of Contents
Contributors
Preface
Chapter 1 Dementia and neurodegenerative disorder: An introduction
1.1 Introduction
1.2 Dementia
1.3 Etiology intended for dementia
1.4 Genetic effects
1.5 Age
1.6 Physical activity
1.7 Comorbidity
1.8 Drugs
1.9 Psychometric symptoms
1.10 Pathophysiology of neurodegenerative disorder; AD
1.11 Pathogenesis of Parkinson’s disease
1.12 Pathogenesis of vascular dementia
1.13 Pathogenesis of Huntington’s disease
1.14 Treatment of neurodegenerative disorders
1.15 Blood–brain barrier
1.16 Structure of blood–brain barrier
1.17 Tight junction involved in BBB
1.18 Features of endothelial and specialized cells forming BBB
1.19 Mechanisms to permeate the blood–brain barrier
1.20 Conclusion
Conflict of interest
Consent
Acknowledgments
References
Chapter 2 Dementia: A journey from cause to cure
2.1 Introduction
2.2 Types of dementia
2.3 Alzheimer’s disease
2.4 Etiopathogenesis
2.5 Lewy body dementia
2.6 Etiopathogenesis
2.7 Vascular dementia
2.8 Etiopathogenesis
2.9 Frontotemporal dementia
2.10 Etiopathogenesis
2.11 Current treatments and drugs under clinical investigations
2.12 Conclusion
References
Chapter 3 Receptor attacking ligands for active targeting to brain
3.1 Introduction
3.2 Receptor-mediated nanocarrier platforms for brain drug delivery
3.3 Conclusion
References
Chapter 4 Dendrimers in the effective management of Alzheimer’s and dementia
4.1 Introduction
4.2 History and definition of dendrimers
4.3 Properties of dendrimers
4.4 Types of dendrimers
4.5 Dendrimer-mediated brain delivery approaches
4.6 Dendrimers in Alzheimer’s disease
4.7 Dendrimers in dementia
4.8 Conclusion
References
Chapter 5 Polymeric nanoparticles as drug delivery systems for dementia
5.1 Introduction
5.2 Dementia
5.3 Polymeric nanoparticles
5.4 Polymeric nanoparticles for treatment and diagnosis of dementia
5.5 Functionalization or modification strategies of polymeric nanoparticles for dementia
5.6 Conclusions
Acknowledgements
References
Chapter 6 Solid lipid nanoparticles-based drug delivery for dementia
6.1 Introduction
6.2 Nano-based drug delivery systems in dementia
6.3 Solid lipid nanoparticles as drug delivery systems
6.4 Penetration of SLN to the central nervous system
6.5 Application SLN in dementia
6.6 Conclusion and final remarks
References
Chapter 7 Liposome: A potential drug delivery vector to treat dementia
Abbreviations
7.1 Introduction
7.2 Types of dementia
7.3 Need of novel drug carrier
7.4 Liposome
7.5 Conclusion
Acknowledgment
Funding
Conflict of Interest
References
Chapter 8 Micelles-based drug delivery for dementia
Abbreviations
8.1 Introduction
8.2 Interaction of micelles with β-amyloid
8.3 Different routes for micelles delivery in dementia
8.4 Preparation methods of different micelles
8.5 Modified micelles for cellular targeting
8.6 Therapeutics-loaded micellar systems for different types of dementia
8.7 Conclusion
References
Chapter 9 Biologics for the management of dementia
9.1 Introduction
9.2 Existing treatments
9.3 Biological drug product-based approaches
9.4 Biological products-based combination therapy
9.5 Nanotechnology-based biological drug products
9.6 Future direction in the management of dementia
Concluding remark
References
Chapter 10 Nanocarriers-based noninvasive approaches for dementia
10.1 Introduction
10.2 Approaches for the treatment of dementia
10.3 Nanocarrier-based invasive approaches
10.4 Nanocarrier-based noninvasive approaches
10.5 Clinical trial and future aspects
10.6 Conclusion
References
Chapter 11 Futuristic aspect of nanocarriers on targeted delivery for dementia
11.1 Introduction
11.2 Pathophysiology of Alzheimer’s disease
11.3 Protein degradation in Alzheimer’s disease
11.4 Conventional treatment approached and their limitation
11.5 Traditional drug delivery technologies confront difficulties in targeting exact parts of the brain to treat the neurodegenerative disorders
11.6 Novel drug delivery strategies for targeting brain to treat neurodegenerative disorders
11.7 Novel proteolytic therapies for Alzheimer’s disease
11.8 Conclusion and prospects for the future
References
Index

Umesh Gupta

Dr. Umesh Gupta, currently working as Assistant Professor at Department of Pharmacy, Central University of Rajasthan, India, did his bachelor's, master's and doctorate degree in Pharmaceutical Sciences from Dr. H. S. Gour University, India under the mentorship of Prof. NK Jain. He has recently been awarded for “DAAD Research Stays for Academics and Scientists” at Leibniz-institut fur Polymerforschung Dresden, Germany. He has the past experience of Research Scientist at Ranbaxy Research Laboratories, India and Post-Doctoral Research Associate at South Dakota State University, USA. HE is also recipient of Young Scientist Award by Department of Science and Technology, Government of India as well as Ranbaxy Science Scholar Award 2008 by Ranbaxy Research Laboratories, India. He has been awarded more than 3-4 times the overseas travel award by different funding agencies of Indian government to share and present his research at international platform in countries like Germany, USA and Singapore etc. He has more than ten years of research and academic experience. The area of research is mainly focused on dendrimer mediated drug delivery, solubilization and targeting. His laboratory equally focuses on effective brain delivery through nanotechnological carriers such as polymeric micelles, nanoparticles and dendrimers. He has more than 48 publications and seven book chapters to his credit with total citations of more than 2300 (h index of 23 as per Google Scholar).

Affiliations and expertise

Assistant Professor, Department fo Pharmacy, Central University of Rajasthan, India

Prashant Kesharwani

Dr. Prashant Kesharwani is assistant professor of Pharmaceutics at Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India. He has more than 12 years of teaching, research, and industrial experience at international levels from various countries, including the United States, Malaysia, and India. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He has more than 350 international publications in well-reputed journals and more than 25 international books (Elsevier). He is a recipient of many research grants from various funding bodies. He is also the recipient of several internationally acclaimed awards, such as “USERN Laureate award”, most prestigious “SERB-Ramanujan Fellowship Award”. He actively participates in outreach and scientific dissemination for the service of the wider community. His Number of citations is = 26779; h-index = 85; i-10 index = 370 (According to google scholar on March 2025). He has more than 30 international publications published in very high impact factor journals (Progress in Polymer Sciences IF 32.063, Molecular Sciences IF 41.444, Progress in Material Sciences IF 48.580, Advanced Materials IF 29.4, Drug Resistance Update IF 22.841 and Material Todays IF 32.072). He has presented many invited talks and oral presentations at prestigious scientific peer-conferences, received international acclaims and awards for research contribution, supervised students/junior researchers and actively participated in outreach and scientific dissemination for the service of the wider community.

Affiliations and expertise

Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, 470003, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health