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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • Protein Kinase Inhibitors

      • 1st Edition
      • May 19, 2022
      • Md. Imtaiyaz Hassan + 1 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 1 2 8 7 7
      • eBook
        9 7 8 0 3 2 3 9 1 3 4 9 2
      Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation. Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development.

    • Coenzyme B12 Enzymes Part A

      • 1st Edition
      • Volume 668
      • May 17, 2022
      • English
      • Hardback
        9 7 8 0 3 2 3 9 1 5 9 1 5
      • eBook
        9 7 8 0 3 2 3 9 1 5 9 2 2
      B12 Enzyme, Volume 667 in the Methods in Enzymology serial, highlights new advances in the field with this new volume presenting timely, interesting chapters, including Part I: B12 Biosynthesis and B12 Chaperones, Probing the preference and regioselectivity of lower ligand activation and its role in cobamide diversity, Biosynthesis of corrinoids, The human B12 trafficking chaperones: CblC, CblD and ATR, A method for the efficient adenosylation of corrinoids, Production, purification and liposome reconstitution of cobamide synthase, Extraction and Purification of Cobamides from Bacterial Cultures, Part II: The many faces of B12-dependent enzyme reactions, Methylcobalamin-depe... methionine synthase, and much more.

    • Large Animals as Models for Human Diseases

      • 1st Edition
      • Volume 189
      • May 17, 2022
      • Ya-Xiong Tao
      • English
      • Hardback
        9 7 8 0 3 2 3 9 9 4 4 1 5
      • eBook
        9 7 8 0 3 2 3 9 9 4 4 2 2
      Large Animals as Models for Human Diseases, Volume 189 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of important topics, including Sheep as a model for neuroendocrinology research, Relevance of dog as a model for urologic diseases, Relevance of lactocrine hypothesis to human maternal programming of development, Comparative aspects of embryo implantation, Pig as an animal model for obesity, Canine models of cancer, Bovine model for human ovarian diseases, Mutations in G protein-coupled receptors in large animals: Modeling human diseases, and more.

    • Unraveling the Complexities of Metastasis

      • 1st Edition
      • May 14, 2022
      • Ammad Ahmad Farooqi + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 1 7 8 9 4
      • eBook
        9 7 8 0 1 2 8 2 1 7 9 0 0
      Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer. The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism. This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis.

    • Biomolecular Interactions Part B

      • 1st Edition
      • Volume 169
      • May 12, 2022
      • English
      • Hardback
        9 7 8 0 1 2 8 2 3 3 5 3 5
      • eBook
        9 7 8 0 1 2 8 2 3 3 5 4 2
      Biomolecular Interactions: Part A, Volume 169, the latest release in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Emerging Mechanisms of Targeted Protein Degradation by Molecular Glues, Design and use of programmable DNA Hydrogels, Oligomerization of membrane receptors: Approaches to measure in live cells, Interactions of alpha-synuclein with biomolecules, Gel-electrophoresis based method for biomolecular interaction, Recombinant centrosome expression in bacterial system, Reconstituting CCL5-CCR5 complex for structural and mechanistic analysis, Protein engineering and design in ion channel receptors, and much more.

    • Artificial Intelligence in Bioinformatics

      • 1st Edition
      • May 12, 2022
      • Mario Cannataro + 4 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 9 5 2 1
      • eBook
        9 7 8 0 1 2 8 2 2 9 2 9 3
      Artificial Intelligence in Bioinformatics: From Omics Analysis to Deep Learning and Network Mining reviews the main applications of the topic, from omics analysis to deep learning and network mining. The book includes a rigorous introduction on bioinformatics, also reviewing how methods are incorporated in tasks and processes. In addition, it presents methods and theory, including content for emergent fields such as Sentiment Analysis and Network Alignment. Other sections survey how Artificial Intelligence is exploited in bioinformatics applications, including sequence analysis, structure analysis, functional analysis, protein classification, omics analysis, biomarker discovery, integrative bioinformatics, protein interaction analysis, metabolic networks analysis, and much more.

    • The Essentials of Charcot Neuroarthropathy

      • 1st Edition
      • May 11, 2022
      • Claude Pierre-Jerome
      • English
      • Paperback
        9 7 8 0 3 2 3 9 9 3 5 2 4
      • eBook
        9 7 8 0 3 2 3 9 9 5 7 8 8
      The Essential Charcot Neuroarthropathy: Biomechanics, Pathophysiology, and MRI Findings provides a comprehensive analysis of Charcot neuroarthropathy (or Charcot Foot) in diabetic patients. All aspects are covered, including epidemiology, biomechanics, pathophysiology, socioeconomic impacts, radiological findings, and differential diagnosis, with an emphasis on MRI. Chapters address the challenges of pre-and-post surgical management of Charcot neuroarthropathy and the role of unconventional imaging modalities in diagnosis. The book presents an analysis of the normal biomechanics of the ankle and foot, the biomechanical derangements of the ankle-foot unit (including abnormal gait) caused by diabetes Type II, and more. Finally, there is also a reference of the pathophysiology of diabetes-induced peripheral neuropathy and its direct link with the development of Charcot neuroarthropathy foot. Diabetes-induced Charcot foot is frequently misunderstood, misinterpreted and misdiagnosed which can lead to confusion and detrimental management with reported high morbidity.

    • Stomata Regulation and Water Use Efficiency in Plants under Saline Soil Conditions

      • 1st Edition
      • Volume 103
      • May 10, 2022
      • English
      • Hardback
        9 7 8 0 3 2 3 9 1 2 1 7 4
      • eBook
        9 7 8 0 3 2 3 9 1 4 7 4 1
      Advances in Botanical Research, Volume 103 provides a timely and comprehensive update on the current knowledge of stomata development and operation in salt-grown plants. The range of topics covered includes evolution of stomata for adaptation to saline conditions, comparative analysis of proteomic, transcriptomic and metabolomic profiles of stomata guard cells between halophytes and glycophyte species and their reprogramming under salt stress, the molecular nature of the signals that control stomata aperture and their integration at the cellular and whole-plant level, and ecophysiological aspects of stomata operation in crop and halophytes species.

    • Pseudokinases

      • 1st Edition
      • Volume 667
      • May 5, 2022
      • English
      • Hardback
        9 7 8 0 3 2 3 9 1 5 4 1 0
      • eBook
        9 7 8 0 3 2 3 9 1 5 4 2 7
      Pseudokinases, Volume 667, the latest release in the Methods in Enzymology serial, highlights new advances in the field with this new volume presenting interesting chapters, including the Production and Purification of the PEAK pseudokinases for structural and functional studies, Structural biology and biophysical characterization of Tribbles pseudokinases, Detecting endogenous TRIB protein expression and its downstream signaling, Analysis of human Tribbles 2 pseudokinase, Expression, purification and examination of ligand-binding to IRAK pseudokinases, Characterization of pseudokinase ILK-mediated actin assembly, Biochemical examination of Titin pseudokinase, Approaches to study pseudokinase conformations, CRISPR editing cell lines for reconstitution studies of pseudokinase function, and much more.

    • Bioprinting

      • 1st Edition
      • May 5, 2022
      • Michele Conti + 1 more
      • English
      • Hardback
        9 7 8 0 3 2 3 8 5 4 3 0 6
      • eBook
        9 7 8 0 3 2 3 8 5 4 3 1 3
      Bioprinting: From Multidisciplinary Design to Emerging Opportunities describes state-of-the-art techniques and highlights open issues of different aspects that affect the efficiency of bioprinting protocols. Starting from a description of the main bioprinting technologies, the book addresses the most advanced approaches for the design of "on-demand" biomaterials suitable for incorporating biological components, along with the challenges associated with the development of a cellular model, and with the biological read-out. Coverage includes intelligent process design techniques, emerging technologies, and specific applications. Written by a highly interdisciplinary team of authors and presenting a unified approach to bioprinting, this book is ideal for doctoral and postdoctoral researchers in biotechnology, engineering, and physics, as well as industrial researchers interested in the applications of bioprinting.

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