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Coenzyme B12 Enzymes Part A

  • 1st Edition, Volume 668 - May 17, 2022
  • Latest edition
  • Editor: Neil Marsh
  • Language: English

B12 Enzyme, Volume 667 in the Methods in Enzymology serial, highlights new advances in the field with this new volume presenting timely, interesting chapters, including Par… Read more

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Description

B12 Enzyme, Volume 667 in the Methods in Enzymology serial, highlights new advances in the field with this new volume presenting timely, interesting chapters, including Part I: B12 Biosynthesis and B12 Chaperones, Probing the preference and regioselectivity of lower ligand activation and its role in cobamide diversity, Biosynthesis of corrinoids, The human B12 trafficking chaperones: CblC, CblD and ATR, A method for the efficient adenosylation of corrinoids, Production, purification and liposome reconstitution of cobamide synthase, Extraction and Purification of Cobamides from Bacterial Cultures, Part II: The many faces of B12-dependent enzyme reactions, Methylcobalamin-dependent methionine synthase, and much more.

Key features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in Methods in Enzymology serials
  • Includes the latest information on B12 Enzymes

Readership

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Table of contents

1. B12 Biosynthesis and B12 Chaperones
Martin Warren University of Kent, U.K.

2. Biosynthesis of corrinoids
Amrita Hazra IISER Pune, India

3. Guardian of cobamide diversity: probing the role of CobT in lower ligand activation in the biosynthesis of vitamin B12 and other cobamide cofactors
Michiko Taga University of California, Berkeley

4. Purification and Detection of Vitamin B12 Analogs
Jorge Escalante-Semerena University of Georgia

5. A method for the efficient adenosylation of corrinoids
Jorge Escalante-Semerena University of Georgia

6. A method for the production, purification and liposome reconstitution of cobamide synthase
Jorge Escalante-Semerena University of Georgia

7. A method for the Isolation of -ribazole from Vitamin B12, and its Enzymatic Conversion to -ribazole 5’-phosphate
Ruma Banerjee University of Michigan

8. The human B12 trafficking chaperones: CblC, CblD and ATR
Bernhard Kräutler University of Innsbruck, Austria

9. Synthesis and applications of "antivitamin" B12 derivatives B12-dependent enzyme reactions
Tetsuo Toraya Okayama University, Japan

10. Coenzyme B12-dependent eliminases: Diol and glycerol dehydratases and ethanolamine ammonia-lyase
Tetsuo Toraya Okayama University, Japan

11. Reactivating chaperones for coenzyme B12-dependent eliminases: Diol and glycerol dehydratases and ethanolamine ammonia-lyase
Wolfgang Buckel Marburg University

12. Glutamate mutase and 2-methyleneglutarate mutase
Ruma Banerjee University of Michigan

13. Human B12 dependent enzymes: Methionine synthase and methylmalonyl-CoA mutase
David Leys Manchester University

14. Heterologous production and biophysical characterisation of catabolic Nitratireductor pacificus pht-3B reductive dehalogenase
Nigel Scrutton Manchester University

15. An unusual light-sensing function for coenzyme B12 in bacterial transcription regulator CarH

Product details

  • Edition: 1
  • Latest edition
  • Volume: 668
  • Published: May 17, 2022
  • Language: English

About the editor

NM

Neil Marsh

I am currently Professor of Chemistry and Biological Chemistry at the University of Michigan in Ann Arbor. My research interests center on enzyme mechanisms and protein structure and design. We are currently working on a variety of research projects. In particular, we have a long-standing interest in enzymes that use free radicals to catalyze a variety of unusual chemical transformations. More recently, we have become interested in enzymes involved in hydrocarbon biosynthesis, many of which have novel mechanisms and are of practical interest for the biosynthesis of next-generation biofuels. We are also interested in understanding in molecular detail how enzymes interact with abiological surfaces as this is key to many industrial and biomedical applications where enzymes are immobilized on solid supports. More information about my research can be found here:http://www.lsa.umich.edu/chem/people/faculty/ci.marsheneilg_ci.detail
Affiliations and expertise
Dow Distinguished Faculty Fellow in Sustainability, Professor of Chemistry and Biological Chemistry, Department of Chemistry, University of Michigan, USA

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