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Large Animals as Models for Human Diseases

1st Edition - May 17, 2022

Editor: Ya-Xiong Tao

Hardback ISBN:

9 7 8 - 0 - 3 2 3 - 9 9 4 4 1 - 5

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 9 9 4 4 2 - 2

Large Animals as Models for Human Diseases, Volume 189 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new… Read more

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Large Animals as Models for Human Diseases, Volume 189 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of important topics, including Sheep as a model for neuroendocrinology research, Relevance of dog as a model for urologic diseases, Relevance of lactocrine hypothesis to human maternal programming of development, Comparative aspects of embryo implantation, Pig as an animal model for obesity, Canine models of cancer, Bovine model for human ovarian diseases, Mutations in G protein-coupled receptors in large animals: Modeling human diseases, and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter One: Sheep as a model for neuroendocrinology research
Abstract
1: Introduction
2: Reproduction
3: Kisspeptin and KNDy neurons
4: Puberty
5: Pregnancy
6: Hypothalamic and neuroendocrine sexual dimorphism
7: Polycystic ovarian syndrome
8: Growth hormone regulation
9: Caveats and conclusions
References
Chapter Two: Relevance of dog as an animal model for urologic diseases
Abstract
1: Introduction
2: Comparison of human and dog lower urinary tract anatomy and physiology
3: Comparison of human and dog urine production, storage, and excretion
4: Top 5 human urologic diseases: Comparison to spontaneous disease in dog, past/current use of dogs in research, and recommendations for future studies using dogs as large animal models
5: Concluding thoughts
References
Chapter Three: Canine models of human cancer: Bridging the gap to improve precision medicine
Abstract
1: Cancer and the precision medicine approach to treatment
2: Limitations of rodent models
3: Emergence of the canine model
4: Osteosarcoma
5: B-cell lymphoma
6: Melanoma
7: Canine mammary tumors/human breast cancer
8: Urothelial carcinoma/bladder cancer
9: Soft tissue sarcomas
10: Summary and conclusion
References
Chapter Four: Bovine models for human ovarian diseases
Abstract
1: Introduction
2: Practical aspects of using the bovine ovary model
3: Ovarian development during gestation and before puberty
4: Puberty and the ovarian cycle
5: Mesenchymal influence in ovarian function
6: Age related changes in ovaries
7: Nutrition and stress effects on ovaries
8: Effects of toxins on ovaries
9: Premature ovarian insufficiency (POI)
10: Polycystic ovary syndrome (PCOS)
11: Ovarian follicular dysplasia
12: Ovarian cancer
13: Ovarian disease biomarkers
14: Ovarian therapeutic interventions
15: Concerns of using bovine model for human ovarian diseases
16: Summary
References
Chapter Five: Mutations in rhodopsin, endothelin B receptor, and CC chemokine receptor 5 in large animals: Modeling human diseases
Abstract
1: Introduction
2: Rhodopsin mutations and retinitis pigmentosa
3: EDNRB nutation and Hirschsprung disease
4: CCR5 mutations and susceptibility to HIV infection
5: Conclusions
References
Chapter Six: Melanocortin-1 receptor mutations and pigmentation: Insights from large animals
Abstract
1: Introduction
2: MC1R and pigmentation
3: MC1R variants in human
4: MC1R variants in large animals
5: Potential therapeutic strategies and perspectives
6: Conclusion
References
Chapter Seven: Mutations in melanocortin-4 receptor: From fish to men
Abstract
1: Introduction
2: Mutations in human MC4R
3: Mutations in pig MC4R
4: Mutations in dog MC4R
5: Mutations in other mammalian MC4R
6: Mutations in avian MC4R
7: Mutations in fish mc4r
8: Conclusions
Conflict of interest
References
Chapter Eight: Patient-derived organoids as a model for tumor research
Abstract
1: Introduction
2: The comparison between the organoid model and previous models
3: Emergence and culture of cancer organoids
4: The applications of PDOs in various cancers
5: Limitations and prospects
6: Conclusion
References
Index