Unraveling the Complexities of Metastasis
Transition from a Segmented View to a Conceptual Continuum
- 1st Edition - May 14, 2022
- Imprint: Academic Press
- Editors: Ammad Ahmad Farooqi, Muhammad Zahid Qureshi, Uteuliyev Yerzhan Sabitaliyevi
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 7 8 9 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 7 9 0 - 0
Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasi… Read more
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Request a sales quoteUnraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer.
The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism.
This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis.
- Explains the mechanism of metastasis from basic to advanced level through easy and comprehensive chapters written by internationally distinguished researchers
- Provides simplified version of important process of metastasis for the readers to comprehend the latest advancements made in the field
- Presents colorful diagrams to make different aspects of scientifically difficult topics easier for young researchers and newcomers in the field of cancer metastasis
Cancer researchers, oncologists, medical doctors, molecular biologists
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Role of TRAIL-mediated signaling as Jekyll and Hyde in metastasis: changing places, changing faces
- Introduction
- Darker side of caspase-8: nonapoptotic caspase-8–mediated functionalities
- TRAIL-mediated NF-κB activation: friend or foe
- Concluding remarks
- Chapter 2. Multiple roles of circulating tumor cells and exosomes in cancer metastasis: implications for therapeutic intervention
- Introduction
- CTCs involvement in metastatic progression
- Exosomes involvement in metastatic progression
- Clinical impact of CTCs and exosomes
- Conclusions and future perspectives
- Chapter 3. Diagnosis and treatment of metastatic prostate cancer: the role of imaging, liquid biopsies, and biomarkers for deciphering tumor heterogeneity
- Introduction
- Overview of prostate cancer disease states and treatment options
- Improved imaging and image-guided biopsy for prostate cancer
- Gene signature panels for prostate cancer risk stratification
- Next-generation sequencing and prostate cancer: cell-free nucleic acids and circulating tumor cells
- Conclusion
- Chapter 4. Prognostic and predictive role of bone metastasis in NSCLC: risk factors and clinical implications
- Introduction
- Incidence of BMs in NSCLC patients
- Prognostic role
- Predictive role
- Risk factors for bone metastasis
- Clinical implication and treatment
- Conclusion
- Chapter 5. Brain metastases in breast cancer
- Introduction
- The basis of breast cancer brain metastasis
- Risk factors for brain metastasis in breast cancer
- Diagnosis
- Treatment
- Prognosis
- Specific conditions
- Chapter 6. Noncoding way of the metastasis
- Introduction
- Dual role of small noncoding RNAs in metastasis
- Long noncoding RNAs and metastasis
- Future perspectives
- Chapter 7. Nanotechnology based docetaxel: upcoming avenue for breast cancer management
- Introduction
- Classification of breast cancer
- Pathogenesis of breast cancer
- Causative factors and associated risks of breast carcinoma
- Mortality
- Stages of breast cancer
- Diagnosis
- Treatment strategies for breast cancer
- Nanoparticle platforms currently employed or explored clinically in MBC
- Conclusion
- Chapter 8. Metastasis in gynecological cancers
- Introduction
- Key steps and patterns of metastasis among gynecological cancers
- Endometrial cancer
- Cervical cancer
- Ovarian cancer
- Vulvar cancer
- Vaginal cancer
- Metastasectomy
- Future directions: targeted therapy
- Conclusions
- Chapter 9. Regulation of HSP90 by noncoding RNAs in carcinogenesis and metastasis: harbingers of good or evil
- Introduction
- Oncogenic role of HSP90 and miRNAs
- Tumor suppressive role of HSP90 and miRNAs
- Targeting of HSP90 by tumor suppressor miRNAs
- Regulation of HSP90 by lncRNAs
- Tumor suppressor lncRNAs
- Partnership of lncRNAs with HSP90 to promote stability of oncogenic proteins: oncogenic role of lncRNAs
- Partnership of lncRNAs with HSP90 to promote stability of tumor suppressor proteins: tumor suppressor role of lncRNAs
- LncRNAs protect HSP90 from targeting by miRNAs
- Regulation of HSP90 by circular RNAs
- Concluding remarks
- Chapter 10. Role of circular RNAs in carcinogenesis and metastasis: closer analysis of unresolved mysteries
- Introduction
- Tumor suppressor circular RNAs
- Oncogenic role of circular RNAs
- Concluding remarks
- Chapter 11. Metastatic potential: focus on lipid transport with emphasis on CD36
- Introduction
- Cellular lipids for metastasis—where do they come from?
- Families of lipid transporters—positioning in classifications
- Dietary lipids can drive metastasis
- Supporting cancer cell colonization—pro-survival signalling
- Signaling via exosomes
- Low metastatic potential versus high metastatic potential
- CD36 - a special player?
- Conclusion
- Chapter 12. Developmental genes: the bridge between development and cancer metastasis
- Introduction
- Transforming growth factor beta
- WNT
- Sonic hedgehog
- Notch
- Fibroblast growth factor
- Conclusion
- Chapter 13. Heat shock proteins in tumor progression and metastasis
- Introduction
- Structure–function relationship of HSPs
- Role of distinct HSPs in oncogenic progression and in metastasis
- Epigenetic alterations of HSPs in cancer
- Posttranslational modifications of HSP90
- microRNA-mediated regulation of heat shock proteins in different cancers
- Diagnostic, prognostic, and predictive implications of diverse classes of HSP
- HSP inhibitors
- Conclusion
- Chapter 14. Role of kisspeptin-mediated signaling pathway in carcinogenesis and metastasis: opposite sides of the same coin
- Introduction
- Antimetastatic role of KISS1
- Prometastatic role of kisspeptin-driven signaling
- Regulation of kisspeptin by noncoding RNAs
- Concluding remarks
- Chapter 15. Tumor microenvironment manipulation and cancer metastasis (taming the beast)
- Introduction
- Invasion and metastasis
- The complexity of metastatic colonization
- The tumor microenvironment
- Tumor genesis and metastasis
- Epithelial–mesenchymal transition
- Relation between epithelial mesenchymal transition and vascularization
- Component of tumor microenvironment
- Implication in translational research
- Targeting TME in therapy
- Futures research and challenges
- Understanding TMI for effective immunotherapy
- Chapter 16. Metastasis inhibitory role of hydroxycinnamic acid and its derivatives
- Introduction
- Hydroxycinnamic acid
- Ferulic acid
- Caffeic acid
- Concluding remarks
- Chapter 17. Regulatory role of SMURF1 and SMURF2 in metastasis: multitalented SMURFs take the central stage
- Introduction
- Prometastatic role of SMURF1
- Metastasis inhibitory role of SMURF1
- SMURF2
- Darker side of SMURF2
- Concluding remarks
- Chapter 18. Antimetastatic effects of curcumin
- Introduction of curcumin
- Metastasis inhibitory role of curcumin
- Curcumin and nanotechnology
- Concluding remarks
- Chapter 19. Metastasis inhibitory role of blueberries: time to play gooseberry with oncogenic cascades and metastasis
- Introduction
- Inhibition of carcinogenesis and metastasis by different berries: preclinical studies
- Metastasis inhibitory roles of blueberry
- Concluding remarks
- Chapter 20. The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior
- Introduction
- The EMT process in thyroid cancer progression
- ABC-binding cassette transporters in ETC progression
- Future perspectives: the ABC transporters and EMT paradigm in ETC
- Chapter 21. The role of epigenetics in cancer metastasis
- Introduction
- DNA methylation and metastasis
- Histone modifications
- Noncoding RNA
- Exosomes and premetastatic niche formation
- Clinical correlations
- Conclusions
- Chapter 22. Regulation of angiogenesis in tumor metastasis via Ets-related ERG and micro-RNAs; one hand washes the other
- ERG structure
- ERG functions
- Crosstalk of ERG with other proteins or signaling cascades
- ERG regulation
- ERG can turn the table
- Conclusion
- Index
- Edition: 1
- Published: May 14, 2022
- No. of pages (Paperback): 342
- No. of pages (eBook): 342
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128217894
- eBook ISBN: 9780128217900
AF
Ammad Ahmad Farooqi
Ammad Ahmad Farooqi is currently serving as a Senior Scientist at Institute of Biomedical and Genetic Engineering (IBGE). His research-work is tightly focused on cell signaling cascades and how these pathways can be therapeutically exploited. He has published more than 200 articles in International peer-reviewed Journals and has guest edited 2 Books. He has over 5000 citations and an H-index above 37. He is editor of various national and international Journals. He has guest edited various thematic issues related to molecular oncology. He has authored/co- authored more than 25 chapters in various books published by internationally distinguished publishers. He was ranked in the top 10 scientists of biological sciences for 2017/2018 by most prestigious national research steering body, Pakistan Council of Science and Technology (PCST). He was ranked in top 2% scientists of the world in the field of oncology in 2019/2020. According to recently published research, he was ranked as No. 1 Scientist in the field of breast cancer research in Pakistan.
Affiliations and expertise
Senior Scientist, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, PakistanMQ
Muhammad Zahid Qureshi
Muhammad Zahid Qureshi, PhD is a Professor of Biochemistry in Qassim University, Saudi Arabia. He received his PhD from Quaid-i-Azam University Islamabad and post-doctorate from Brunel University, London. He has notable contributions in Biochemistry and Molecular Biology. He has authored/co-authored many articles in international Journals and has published seven chapters. His research is focused on molecular cancer and nanotechnology.
Affiliations and expertise
Professor of Biochemistry, Government College University, Lahore, Pakistan
Professor of Biochemistry, Qassim University, Malidah Al Qassim, Saudi ArabiaUS
Uteuliyev Yerzhan Sabitaliyevi
Uteuliyev Yerzhan Sabitaliyevich is an academician and reputed scientist from Kazakhstan. He has previously served as a Vice-Rector for academic affairs and research and innovation activities of Kazakhstan Medical University "KSPH". He has notable contributions in scientifically distinguished international journals. He has played key role in inspiring young researchers to make progress in medical field. He has organized series of medical conferences in Kazakhstan to maximize the interaction of local researchers with scientifically eminent researchers from technically advanced countries.
Affiliations and expertise
Scientific Center for Innovative Technologies and Research, KazakhstanRead Unraveling the Complexities of Metastasis on ScienceDirect