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Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

BooksJournals

    • Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI Approach

      • 1st Edition
      • August 13, 2022
      • Anirudh Nath + 2 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 7 7 6 7
      • eBook
        9 7 8 0 3 2 3 9 0 7 7 7 4
      Nonlinear Control for Blood Glucose Regulation of Diabetic Patients: An LMI-Based Approach exposes readers to the various existing mathematical models that define the dynamics of glucose-insulin for Type 1 diabetes patients. After providing insights into the mathematical model of patients, the authors discuss the need and emergence of new control techniques that can lead to further development of an artificial pancreas. The book presents various nonlinear control techniques to address the challenges that Type 1 diabetic patients face in maintaining their blood glucose level in the safe range (70-180 mg/dl). The closed-loop solution provided by the artificial pancreas depends mainly on the effectiveness of the control algorithm, which acts as the brain of the system. APS control algorithms require a mathematical model of the gluco-regulatory system of the T1D patients for their design. Since the gluco-regulatory system is inherently nonlinear and largely affected by external disturbances and parametric uncertainty, developing an accurate model is very difficult.

    • Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease

      • 1st Edition
      • March 28, 2022
      • Julio A. Chirinos
      • English
      • Hardback
        9 7 8 0 3 2 3 9 1 3 9 1 1
      • eBook
        9 7 8 0 3 2 3 9 1 6 4 8 6
      Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease, Two Volume Set covers the principles, physiology, biologic pathways, clinical implications and therapeutics surrounding arterial stiffness and pulsatile hemodynamics, along with a thorough overview of the field. The book presents complex engineering concepts in a way that those in science and medicine can more easily understand. It includes detailed illustrations. Additionally, it presents advanced bioengineering concepts in boxes for readers who wants more in-depth biophysical knowledge. This is a must-have reference for students, researchers and clinicians interested in learning more about this field.

    • Multi-Objective Combinatorial Optimization Problems and Solution Methods

      • 1st Edition
      • February 9, 2022
      • Mehdi Toloo + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 3 7 9 9 1
      • eBook
        9 7 8 0 1 2 8 2 3 8 0 0 4
      Multi-Objective Combinatorial Optimization Problems and Solution Methods discusses the results of a recent multi-objective combinatorial optimization achievement that considered metaheuristic, mathematical programming, heuristic, hyper heuristic and hybrid approaches. In other words, the book presents various multi-objective combinatorial optimization issues that may benefit from different methods in theory and practice. Combinatorial optimization problems appear in a wide range of applications in operations research, engineering, biological sciences and computer science, hence many optimization approaches have been developed that link the discrete universe to the continuous universe through geometric, analytic and algebraic techniques. This book covers this important topic as computational optimization has become increasingly popular as design optimization and its applications in engineering and industry have become ever more important due to more stringent design requirements in modern engineering practice.

    • Clinical Ophthalmic Genetics and Genomics

      • 1st Edition
      • January 18, 2022
      • Graeme C.M. Black + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 3 9 4 4 8
      • eBook
        9 7 8 0 1 2 8 1 3 9 4 5 5
      Clinical Ophthalmic Genetics and Genomics provides an accessible, clinically-focused reference for the evolving field of Genetic Ophthalmology. This well-organised, easy-to-read textbook integrates key concepts with clinical practice and is designed to enhance effective learning and retention of complex material. It includes contributions from recognised leaders in the field and provides expert guidance on the complete spectrum of genetic ophthalmic disorders.

    • The Vasculome

      • 1st Edition
      • June 11, 2022
      • Zorina S. Galis
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 5 4 6 2
      • eBook
        9 7 8 0 1 2 8 2 2 5 4 7 9
      The Vasculome: From Many, One introduces the fundamental bases of the “unity in diversity” of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney. Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section. Zorina Galis' The Vasculome was named a finalist in the Clinical Medicine category of the American Association of Publishers’ 2023 PROSE Awards.

    • Genesis, Pathophysiology and Management of Venous and Lymphatic Disorders

      • 1st Edition
      • January 4, 2022
      • N. Radhakrishnan
      • English
      • Paperback
        9 7 8 0 3 2 3 8 8 4 3 3 4
      • eBook
        9 7 8 0 3 2 3 8 8 4 3 4 1
      Genesis, Pathophysiology Management of Venous Diseases is the must-have resource on venous disease. The book bridges the gap between basic science and clinical medicine, covering the history of venous surgery, the lymphatic system and anatomy, pathophysiology of various venous disease, etiology, clinical manifestations and diagnosis, management, and medical and surgical treatment options. It also places attention on genetic studies and pharmacological analysis of various anticoagulants which are widely used in treating venous diseases and deep vein thrombosis and highlights the importance of microscopic venous valves and their pathology in both normal and disease condition. The breadth of topics covered makes this reference suitable for a range of professionals in phlebolymphology and cardiology, including medical students, practicing clinicians, surgeons, researchers, radiologists, bioengineers, and more.

    • The Lymphatic System in Colorectal Cancer

      • 1st Edition
      • February 11, 2022
      • Wim Ceelen
      • English
      • Paperback
        9 7 8 0 1 2 8 2 4 2 9 7 1
      • eBook
        9 7 8 0 1 2 8 2 4 2 9 8 8
      The Lymphatic System in Colorectal Cancer: Basic Concepts, Pathology, Imaging, and Treatment Perspectives provides an in-depth overview on the role of the lymphatic system in the pathogenesis and treatment of colorectal cancer. This is the first book to provide a comprehensive, multidisciplinary approach to the lymphatic system in colorectal cancer, with topics ranging from cancer biology and mathematical modeling to surgical approaches and novel imaging techniques. This book is valuable for cancer researchers, oncologists and anyone interested in the biology and treatment of colorectal cancer. Bringing together internationally renowned experts, the book's chapters encompass relevant content to help readers understand complex subjects. Lymphatic spread is one of the hallmarks of locally advanced colorectal cancer that adversely affects prognosis. Nevertheless, the molecular pathogenesis, dynamics and prognostic significance of lymphatic spread remain poorly understood. At the same time, novel surgical approaches such as complete mesocolic excision and sentinel node identification are being introduced, but their value remains uncertain.

    • Genomic Data Sharing

      • 1st Edition
      • November 29, 2022
      • Jennifer B. Mccormick + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 9 8 0 3 2
      • eBook
        9 7 8 0 1 2 8 1 9 8 0 4 9
      Genomic Data Sharing: Case Studies, Challenges, and Opportunities for Precision Medicine provides a comprehensive overview of current and emerging issues in genomic data sharing. In this book, international leaders in genomic data examine these issues in-depth, offering practical case studies that highlight key successes, challenges and opportunities. Sections discuss the eMERGE Network, Undiagnosed Disease Network, Vanderbilt Biobank, Marshfield Clinic Biobank, Minnesota Authorization, Rochester Epidemiology Project, NIH sponsored biobanks, GINA, and Global Alliance for Genomics and Health (GA4GH). In addition to these perspectives from the frontlines, the book also provides succinct overviews of ethical, legal, social and IT challenges.Clinician investigators, clinicians affiliated with academic medical centers, policymakers and regulators will also gain insights that will allow them to navigate the increasingly complex ethical, social and clinical landscape of genomic data sharing.

    • New Frontiers and Applications of Synthetic Biology

      • 1st Edition
      • January 12, 2022
      • Vijai Singh
      • English
      • Paperback
        9 7 8 0 1 2 8 2 4 4 6 9 2
      • eBook
        9 7 8 0 3 2 3 8 5 9 8 6 8
      New Frontiers and Applications of Synthetic Biology presents a collection of chapters from eminent synthetic biologists across the globe who have established experience and expertise working with synthetic biology. This book offers several important areas of synthetic biology which allow us to read and understand easily. It covers the introduction of synthetic biology and design of promoter, new DNA synthesis and sequencing technology, genome assembly, minimal cells, small synthetic RNA, directed evolution, protein engineering, computational tools, de novo synthesis, phage engineering, a sensor for microorganisms, next-generation diagnostic tools, CRISPR-Cas systems, and more. This book is a good source for not only researchers in designing synthetic biology, but also for researchers, students, synthetic biologists, metabolic engineers, genome engineers, clinicians, industrialists, stakeholders and policymakers interested in harnessing the potential of synthetic biology in many areas.

    • Bidirectional Gene Promoters

      • 1st Edition
      • November 23, 2022
      • Fumiaki Uchiumi
      • English
      • Paperback
        9 7 8 0 1 2 8 1 8 7 8 7 6
      • eBook
        9 7 8 0 1 2 8 1 9 4 6 1 4
      • eBook
        9 7 8 0 1 2 8 1 9 0 6 8 5
      Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5’-upstream regions of gene pairs are referred to as bi-directional promoters and are thought to have a key role in biological regulatory mechanisms. For example, tumor suppressor protein-encoding TP53 and BRCA1 genes are head-head bound with WRAP53 and NBR2, respectively. DNA-repair factor-encoding ATM and PRKDC (DNA-PKcs) genes have bidirectional partner NPAT and MCM4, respectively. Surveillance of the human DNA database has revealed that the numbers of DNA repair/mitochondrial function/immune response-associated genes are bound with other genes that are transcribed to opposite direction. The observations may encourage us to investigate in the molecular mechanisms how DNA repair/mitochondrial function/immune response-associated genes are regulated by bidirectional promoters. Not only protein-coding genes, but also quite a few ncRNAs, which play important roles in various cellular events, are transcribed under the regulation of the bidirectional promoters. More importantly, we know that dysregulation in the promoter activity and transcription initiation of genes might cause human diseases.

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