Books in Molecular biology cellular biology and genetics

The multitasking molecular chaperone Hsp60

1st Edition
October 19, 2024
Francesco Cappello + 2 more
English
Paperback
9 7 8 0 4 4 3 2 3 9 9 6 0
eBook
9 7 8 0 4 4 3 2 3 9 9 7 7

The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease provides an overview of this key component of the Chaperone System (CS). The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of Hsp60 chaperonopathies.Mol... mechanisms are briefly described with the purpose of illuminating roads toward accurate diagnosis, treatment, and patient monitoring. Consequently, the possibility of developing/applying chaperonotherapy centered on Hsp60, as a therapeutic tool or target, is analyzed in many sections of this book, across a variety of medical specialties. Over the last several years, the importance of the CS as a physiological system has been brought to prominence and its roles in health and disease made clear. The molecular chaperones, including Hsp60, are the key components of the CS that are typically cytoprotective, but they can also be etiopathogenic factors, causing diseases named chaperonopathies.

Marine Molecules from Algae and Cyanobacteria

1st Edition
October 17, 2024
Paz Otero Fuertes + 1 more
English
Paperback
9 7 8 0 4 4 3 2 1 6 7 4 9
eBook
9 7 8 0 4 4 3 2 1 6 7 5 6

The marine environment is a rich but underexploited source of commercially interesting natural products with different applications. Several marine organisms, such as seaweeds, microalgae, sponges, cyanobacteria, ascidians, and fungi, are sources of natural valuable molecules. These chemical compounds range from small molecules and enzymes to highly complex secondary metabolites that show bioactivities in physiological systems. It is thus of great importance to collect information concerning the discovery of these molecules and their characterization and relation to human diseases. Gathering data about novel technologies and sources to obtain and isolate such as precious molecules as well as new applications for them is extremely appreciated in the chemical field. It is very useful for chemists to obtain these molecules with high purity to be used as analytical standards to calibrate the chromatography equipment. Many of these compounds are not commercially available, so the isolation methods of these molecules from microalgae, seaweeds, and cyanobacteria is a challenging task. The availability of some marine molecules has been a long-term problem due to the difficulty of their synthesis. Because of the complexity of their structure, the total synthesis has been shown to be difficult. Developing protocols to obtain reference standards from natural sources has shown satisfactory results in the chemical industry. Marine Molecules From Algae and Cyanobacteria addresses these topics, highlighting fundamentals of biomolecules, their roll in living organism, structure elucidation, sources, important characteristics, and the industrial applications of these biomaterials for educational (academic) as well as industrial purposes. This book covers all methodologies used in the search of marine natural products: screening of marine molecules by chemical methods like HPLC, LC-MS/MS, the isolation of high-value compounds with biotechnological potential, discovery of new molecules, and the optimization of green extraction procedures of these molecules, such as supercritical fluid extraction and pressurized solvent extraction, and other alternative chemical techniques applied in the exploration for marine compound.

Advances in Host Genetics and Microbiome in Colorectal Cancer-Related Phenotypes

1st Edition
Volume 112
October 11, 2024
Adrian Odriozola Martínez
English
Hardback
9 7 8 0 4 4 3 2 2 2 9 0 0
eBook
9 7 8 0 4 4 3 2 2 2 9 1 7

Advances in Host Genetics and Microbiome in Colorectal Cancer-Related Phenotypes, Volume 112 in the Advances in Genetics series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as What we need in colorectal cancer research, and why?, Host Genetics and Microbiota procedures in colorectal cancer research, Host Genetics-associated mechanisms in colorectal cancer, Microbiota-associate... mechanisms in colorectal cancer, Inflammation regulation in colorectal cancer, Microbiota and detrimental protein metabolites in colorectal cancer, Microbiota and other detrimental metabolites in colorectal cancer, Microbiota and beneficial metabolites in colorectal cancer, and much more.

Targeting Signaling Pathways in Solid Tumors Part C

1st Edition
Volume 389
October 11, 2024
Sumit Mukherjee + 1 more
English
Hardback
9 7 8 0 4 4 3 2 3 5 5 0 4
eBook
9 7 8 0 4 4 3 2 3 5 5 1 1

Targeting Signaling Pathways in Solid Tumors, Part C, Volume 389 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Drugging the Undruggable: Advances in Targeting KRAS Signaling in Solid Tumors, Emerging Trends in Gastrointestinal Cancers: Targeting Developmental Pathways in their Carcinogenesis and Tumor Progression, Importance of targeting various cell signaling pathways in solid cancers, Targeting signaling pathways in cancer stem cells: a potential approach for developing novel anticancer therapeutics, Factors affecting heterogeneity in breast cancer microenvironment: A narrative review, and much more.Additional sections cover Exploring TLR Signaling Pathways as Promising Targets in Cervical Cancer: The Road Less Travelled

Immuno-oncology and immunotherapy Part A

1st Edition
Volume 189
October 9, 2024
Lorenzo Galluzzi + 2 more
English
Hardback
9 7 8 0 4 4 3 2 9 6 2 2 2
eBook
9 7 8 0 4 4 3 2 9 6 2 3 9

Immuno-Oncology And Immunotherapy – Part A Volume 189, in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Specific chapters to this release include, Generation of transmitochondrial cybrids in cancer cells, Methods for flow cytometry analysis for tumor infiltrating cells functions and phenotype, Innovative 2D and 3D methods of tumor cells culture, and more.

Next Generation eHealth

1st Edition
September 30, 2024
Miltiadis Lytras + 3 more
English
Paperback
9 7 8 0 4 4 3 1 3 6 1 9 1
eBook
9 7 8 0 4 4 3 1 3 6 2 0 7

Next Generation eHealth: Applied Data Science, Machine Learning and Extreme Computational Intelligence discusses the emergence, the impact, and the potential of sophisticated computational capabilities in healthcare. This book provides useful therapeutic targets to improve diagnosis, therapies, and prognosis of diseases, as well as helping with the establishment of better and more efficient next-generation medicine and medical systems. Machine learning as a field greatly contributes to next-generation medical research with the goal of improving medicine practices and medical Systems. As a contributing factor to better health outcomes, this book highlights the need for advanced training of professionals from various health areas, clinicians, educators, and social professionals who deal with patients. Content illustrates current issues and future promises as they pertain to all stakeholders, including informaticians, professionals in diagnostics, key industry experts in biotech, pharma, administrators, clinicians, patients, educators, students, health professionals, social scientists and legislators, health providers, advocacy groups, and more. With a focus on machine learning, deep learning, and neural networks, this volume communicates in an integrated, fresh, and novel way the impact of data science and computational intelligence to diverse audiences.

The Charnolosome as a Novel Nanothereranostic Biomarker

1st Edition
September 27, 2024
Sushil Sharma
English
Paperback
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eBook
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The Charnolosome as a Novel Nanothereranostic Biomarker: Overcoming Future Challenges in Medicine provides an overview of the charnolosome and its potential as a biomarker of cell injury. Based on the author’s original discovery of the charnoly body in the developing, undernourished rat cerebellar Purkinje neurons, this book delves into the potential for utilizing this mitochondria and lysosomal-derived intracellular organelle as a nanotheranostic biomarker to prevent and cure various diseases.The book discusses the cellular, molecular, genetic, and epigenetic mechanisms of charnolosomes and charnolosome-derived nano-vesicles. It also investigates the molecular mechanisms underlying auto-inflammatory, autoimmune, and infectious diseases resulting from their compromised mitochondrial bioenergetics, and the potential use of the charnolosome in preventing and curing such conditions.

Artificial Intelligence in Biomedical and Modern Healthcare Informatics

1st Edition
September 27, 2024
M. A. Ansari + 4 more
English
Paperback
9 7 8 0 4 4 3 2 1 8 7 0 5
eBook
9 7 8 0 4 4 3 2 1 8 7 1 2

Artificial Intelligence in Biomedical and Modern Healthcare Informatics provides a deeper understanding of the current trends in AI and machine learning within healthcare diagnosis, its practical approach in healthcare, and gives insight into different wearable sensors and its device module to help doctors and their patients in enhanced healthcare system.The primary goal of this book is to detect difficulties and their solutions to medical practitioners for the early detection and prediction of any disease.The 56 chapters in the volume provide beginners and experts in the medical science field with general pictures and detailed descriptions of imaging and signal processing principles and clinical applications.With forefront applications and up-to-date analytical methods, this book captures the interests of colleagues in the medical imaging research field and is a valuable resource for healthcare professionals who wish to understand the principles and applications of signal and image processing and its related technologies in healthcare.

The Physics of Protein Structure and Dynamics

1st Edition
September 23, 2024
Reinhard Schweitzer-Stenner
English
Paperback
9 7 8 0 4 4 3 1 5 9 6 4 0
eBook
9 7 8 0 4 4 3 1 5 9 6 5 7

The Physics of Protein Structure and Dynamics looks at various aspects of protein structure and dynamics from a physico-chemical point of view. It goes into some depth regarding the description of non-covalent forces that determine the relative stability of folded and unfolded proteins. Anharmonic protein dynamics involving motions between different minima of a rugged Gibbs energy landscape is described in great detail. The book combines various aspects of the protein folding/unfolding processes with an overview of intrinsically disordered proteins, which have attracted considerable interest of the protein community over the last 25 years but are thus far underrepresented in classroom-oriented textbooks. The book looks at protein folding and intrinsically disordered proteins as heavily interrelated topics that need to be viewed together. Furthermore, it presents some basic physico-chemical aspects of protein/peptide self-assembly into nanoscale fibrils. Intrinsically disordered peptides and proteins play a major role particularly in aggregation and self-assembly processes that lead to various diseases (Alzheimer, Parkinson, Huntington, Mad-Cow). Therefore, the relevance of protein disorder for protein self-assembly deserves a closer look. Protein self-assembly cannot be separated from protein folding since it is frequently the product of misfolding. With regard to modern theories, the folding processes are linked to insights on protein dynamics and the discovered relationship between proteins and spin glasses.

Planning, Writing and Reviewing Medical Device Clinical and Performance Evaluation Reports (CERs/PERs)

1st Edition
September 19, 2024
Joy Frestedt
English
Paperback
9 7 8 0 4 4 3 2 2 0 6 3 0
eBook
9 7 8 0 4 4 3 2 2 0 6 4 7

A Practical Guide to Planning, Writing, and Reviewing Medical Device Clinical Evaluation Reports guides readers through clinical data evaluation of medical devices that is in compliance with the EU MDR requirements and other similar regulatory requirements throughout the world. This book brings together knowledge learned as the author constructed hundreds of CERs and taught thousands of learners on how to conduct clinical data evaluations. This book will support training for clinical engineers, clinical evaluation scientists, and experts reviewing medical device CERs, and will help individual writers, teams and companies to develop stronger, more robust CERs.

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