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Advances in Host Genetics and Microbiome in Colorectal Cancer-Related Phenotypes
- 1st Edition, Volume 112 - October 11, 2024
- Editor: Adrian Odriozola Martínez
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 2 2 9 0 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 2 2 9 1 - 7
Advances in Host Genetics and Microbiome in Colorectal Cancer-Related Phenotypes, Volume 112 in the Advances in Genetics series, highlights new advances in the field with this new… Read more
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Request a sales quoteAdvances in Host Genetics and Microbiome in Colorectal Cancer-Related Phenotypes, Volume 112 in the Advances in Genetics series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as What we need in colorectal cancer research, and why?, Host Genetics and Microbiota procedures in colorectal cancer research, Host Genetics-associated mechanisms in colorectal cancer, Microbiota-associated mechanisms in colorectal cancer, Inflammation regulation in colorectal cancer, Microbiota and detrimental protein metabolites in colorectal cancer, Microbiota and other detrimental metabolites in colorectal cancer, Microbiota and beneficial metabolites in colorectal cancer, and much more.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Advances in Genetics series
- Includes the latest information on new advancements in the study of genetics
Molecular geneticists, clinical geneticists, neurologists, neuroscientists, molecular biologists, and biochemists
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: What we need in colorectal cancer research, and why?
- Abstract
- Highlights
- 1 Introduction
- 2 Key aspects
- 3 Current limitations
- 4 Future challenge
- 5 Conclusion
- References
- Chapter Two: Host genetics and microbiota data analysis in colorectal cancer research
- Abstract
- Highlights
- 1 Introduction
- 2 Analyses of host genetics data analysis in colorectal cancer research
- 3 Microbiome data analysis in colorectal cancer research
- 4 Limitations and future perspectives
- 5 Conclusions
- References
- Chapter Three: Host genetics-associated mechanisms in colorectal cancer
- Abstract
- Highlights
- Abbreviations
- 1 Introduction
- 2 Colonic crypt: Components, organisation and oncogenesis
- 3 Colorectal cancer progression
- 4 Colorectal cancer classification
- 5 Limitations and future perspectives
- 6 Conclusions
- References
- Chapter Four: Microbiota-associated mechanisms in colorectal cancer
- Abstract
- Highlights
- 1 Introduction
- 2 Role of microbiota in colorectal cancer oncogenesis
- 3 Gut barrier dysfunction
- 4 Inflammation
- 5 Immune system
- 6 Biofilm
- 7 Genotoxins
- 8 Pathogenic bacteria and virulence factors
- 9 Oxidative stress
- 10 Current limitations and future challenges
- 11 Conclusions
- References
- Chapter Five: Construction of an immune gene expression meta signature to assess the prognostic risk of colorectal cancer patients
- Abstract
- Highlights
- 1 Introduction
- 2 Materials and Methods
- 3 Meta Gene Prioritisation
- 4 Prognostic Model
- 5 Analysis of Clinical Parameters according to risk groups
- 6 Functional Enrichment
- 7 Gene Set Enrichment Analysis
- 8 Analysis of the Immune Microenvironment Infiltration
- 9 Validation Cohort
- 10 Protein expression patterns of unfavorable prognostic genes
- 11 Statistical Analysis
- 12 Results
- 13 Construction of the prognostic risk score
- 14 Association Between Immune‐Related Gene Signature and Clinical Parameters
- 15 Gene set enrichment analysis GSEA
- 16 Estimation of the Stromal and Immune Cells Infiltration Analysis
- 17 Validation of the immune meta-signature
- 18 Protein expression patterns of unfavorable prognostic genes
- 19 Discussion
- 20 Future Perspectives
- 21 Conclusions
- References
- Chapter Six: Microbiota and detrimental protein derived metabolites in colorectal cancer
- Abstract
- Highlights
- 1 Introduction
- 2 Red meat and processed meat in colorectal cancer risk
- 3 Protein fermentation
- 4 Gut microbiota metabolic pathways involved in protein fermentation
- 5 Metabolites
- 6 Limitations and future perspectives
- 7 Conclusions
- References
- Chapter Seven: Microbiota and other detrimental metabolites in colorectal cancer
- Abstract
- Highlights
- 1 Introduction
- 2 Heterocyclic amines and polycyclic aromatic hydrocarbons
- 3 Heme iron
- 4 Secondary bile acids
- 5 Alcohol
- 6 Aromatic amines
- 7 Limitations and future perspectives
- 8 Conclusions
- References
- Chapter Eight: Microbiota and beneficial metabolites in colorectal cancer
- Abstract
- Highlights
- 1 Introduction
- 2 Short-chain fatty acids
- 3 Tryptophan-derived metabolites
- 4 Conjugated linoleic acid
- 5 Phytochemicals
- 6 Other metabolites
- 7 Limitations and future perspectives
- 8 Conclusions
- References
- Chapter Nine: Personalised medicine based on host genetics and microbiota applied to colorectal cancer
- Abstract
- Highlights
- 1 Introduction
- 2 Diagnosis of colorectal cancer
- 3 Diagnostic biomarkers in colorectal cancer
- 4 Contextualising current treatment for colorectal cancer
- 5 Prognostic and predictive biomarkers in colorectal cancer
- 6 New approaches in the treatment of colorectal cancer
- 7 Modulation of gut microbiota for the prevention and treatment of colorectal cancer
- 8 Limitations and future perspectives
- 9 Conclusions
- References
- No. of pages: 500
- Language: English
- Edition: 1
- Volume: 112
- Published: October 11, 2024
- Imprint: Academic Press
- Hardback ISBN: 9780443222900
- eBook ISBN: 9780443222917
AO
Adrian Odriozola Martínez
Dr. Adrian Odriozola. Professor of Genetics at the University of the Basque Country (UPV/EHU). Doctor in Biochemistry. Extraordinary Doctorate Award from the UPV/EHU. Euskadi Innovation Award. Director of the Hologenomiks Research Group of the Department of Genetics, Physical Anthropology, and Animal Physiology of the UPV/EHU. Professor of Genetics and Microbiome influence in Nutrition, Sport, and Health at different European and American Universities. Inventor in several National and International patents in Human Genetics and Microbiome. Author of numerous articles published in magazines of international impact. Broad experience in Entrepreneurship and Knowledge Management in Biosciences, collaborating with public and private entities.
Affiliations and expertise
Professor of Genetics, University of the Basque Country (UPV/EHU), SpainRead Advances in Host Genetics and Microbiome in Colorectal Cancer-Related Phenotypes on ScienceDirect