Comprehensive Organic Synthesis, Third Edition, Eleven Volume Set will build upon the highly respected previous editions - the 2nd edition won the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers - in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline.Fully revised and updated, comprising of around 200 advanced chapters, this new edition will continue to constitute an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Third Edition an invaluable source, providing an authoritative overview of core concepts
Drug Discovery and One Health Approach in Combating Infectious Diseases: A Multi-sectoral Approach to address Infections explores the intersection of drug discovery and the One Health Approach, along with the effectiveness of interdisciplinary approaches to combating infectious diseases. The book covers both holistic and innovative drug discovery methodologies and technologies such as natural compounds, harnessing genomics, proteomics, and nanotechnology. Additionally, the book reviews zoonotic diseases, vaccine development, ethical considerations, and regulatory pathways. Practice case studies demonstrate successful One Health and interdisciplinary initiatives to combating infectious disease.This catalogue of knowledge provides a toolbox of innovative and interdisciplinary solutions of complex issues in drug discovery and infectious disease. It will be a valuable resource to professionals and researchers working in the fields of biomedical sciences, pharmaceutical sciences, infectious disease research, and public health, as well as those engaged in drug discovery, development, and the management of infectious diseases.
Chalcone is one of the most versatile scaffolds with wide range of applications. It is used as a precursor for diverse classes of organic molecules, natural flavonoids and possesses interesting biological activities and physical properties like semiconductor, non-linear optical, fluorescence, and electronic properties to name a few. Chalcones have been the subject of intense research due to their biological activities and the ability to tweak their biological activity and other properties by small changes along the a, b-unsaturated backbone. Besides their inherent biological activities, they have found uses in food industry and cosmetic industry as additives, due to their UV protection properties. They have also found applications as chemosensors and probes. These diverse features make chalcones one of the most fascinating molecules Chalcones and their Derivatives: From Synthesis to Applications features this molecule, different methods and approaches to synthesis, significance of this scaffold in biology, and other diverse fields. It serves as a comprehensive literature guide for researchers and a reference material for the postgraduate students involved with the development and use of chalcone based molecules.
Functional Groups in Biochemistry: Tailored Chemistry in Biological Contexts includes detailed mechanisms of reactions, focusing on functional groups and their chemical/biochemical properties that determine the biological functions of macromolecules, a connection often overlooked or under-emphasized in standard textbooks. The book provides a deeper understanding of the governing principles of biochemical reactions, as well as how key chemical and biochemical reactions are thought to occur at the atomic/molecular level. With an emphasis on common themes that govern biochemical reactivity, this book fills the gap between organic/bioorganic chemistry and biochemistry texts.
Robust Theoretical Models in Medicinal Chemistry: QSAR, Artificial Intelligence, Machine Learning, and Deep Learning serves as a valuable resource chock full of applications extending into multiple knowledge domains. The meticulous construction of a robust model holds significance, not only in drug discovery but also in engineering, chemistry, pharmaceutical, and food-related research, illustrating the broad spectrum of fields where QSAR methodologies can be instrumental. The activities considered in QSAR span chemical measurements and biological assays, making this approach a versatile tool applicable across various scientific domains. Currently, QSAR finds extensive use in diverse disciplines, prominently in drug design and environmental risk assessment.Quantitative Structure-Activity Relationships (QSAR) represent a concerted effort to establish correlations between structural or property descriptors of compounds and their respective activities. These physicochemical descriptors encompass a wide array of parameters, accounting for hydrophobicity, topology, electronic properties, and steric effects, and can be determined empirically or, more recently, through advanced computational methods.
Over the past 50 years, more than 20,000 natural compounds have been identified in the marine environment, with an increasing focus on marine metabolites as potential sources for developing effective therapeutic agents. The field of marine drug discovery has seen remarkable growth in recent years, with numerous marine-derived therapeutic candidates in various stages of clinical trials or awaiting approval. The ocean is a potential source of natural products with diverse pharmacological properties, including antimicrobial, anticancer, antiviral, antioxidative, and anti-inflammatory activities. However, commercializing marine natural products has been challenging due to low yields and specificity of specialized (secondary) metabolites. Marine Specialized (Secondary) Metabolites and their Diverse Applications provides a broad overview of marine specialized metabolites and their potential in various industries. With comprehensive coverage, relevance to current trends, interdisciplinary approach, and practical applications, this book includes specific compounds or organisms, with a particular focus on addressing the challenges and limitations associated with them.
Phosphonate Chemistry: Technology and Applications gathers important information on the synthetic aspects of phosphonic acids, metal phosphonate hybrid materials, phosphonates as scale inhibitors, phosphonates as corrosion inhibitors, catalytic properties of metal phosphonates, magnetic and optical properties of metal phosphonates, phosphonates as drugs for calcium-related disorders, metal-bisphosphonates as controlled release systems, metal phosphonates for energy applications, gas capture and storage, imaging applications, electrocatalytic transformations, water splitting, sensing applications, for photodynamic applications, and several others.This comprehensive book includes crucial bibliographic information and covers the latest developments of the past decade. Expanding its thematic scope significantly, it explores the world of organic phosphonate compounds, surpassing conventional boundaries. This exploration includes diverse applications derived from these compounds, enhancing the reader's grasp of this dynamic and evolving field.
The Organic Chemistry of Drug Design and Drug Action, Fourth Edition presents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action. The book's coverage allows readers to extrapolate core principles and mechanisms to many related classes of drug molecules. It reflects the significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while also including significant changes in format and coverage.It is designed for undergraduate and graduate students in chemistry who are studying medicinal chemistry or pharmaceutical chemistry. Users, including research chemists and biochemists working in pharmaceutical and biotechnology industries will find this update to be useful in their daily work.
Studies in Natural Products Chemistry, Volume 85 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts on fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects.With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.
VOCs available in exhaled human breath are the products of metabolic activity in the body and, therefore, any changes in their control level can be utilized to diagnose specific diseases. More than 1000 VOCs have been identified in exhaled human breath along with the respiratory droplets which provide rich information on overall health conditions. This book cover the introductory information on VOCs, their source in the human body, associated diseases, potential sensing materials used for selective detection, and the advancement in their sensing technology. These VOCs offer great potential as a biomarker for a disease that can be sampled non-invasively from exhaled breath with breath biopsy. However, it is still a great challenge to develop a rapid responsive, highly selective, and sensitive VOC-sensing system. This book analyzes all the challenges and their possible solutions that can be used to achieve target-specific detection and real-time monitoring of the VOC molecules in the exhaled breath. It also covers a detailed discussion of all the sensing materials developed for selective and sensitive detection of VOC molecules and their integration with photonic devices in order to develop miniature technology. It covers various miniature sensing systems that are being exploited in VOC sensing such as interferometer, Bragg grating, microstructured fiber, 3D printed optical sensing systems, etc. The book will also provide an overview of the FEM technique and computation methods used to optimize the optical sensing devices before their practical realization. Photonic sensors for detection of VOC biomarkers aims to provide comprehensive information to early career professionals and boost their existing knowledge in the area of Chemistry and Biomedical Engineering.