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Elsevier

Academic Press

  • Immunotherapeutic Strategies for the Treatment of Glioma

    • 1st Edition
    • Christopher Jackson + 1 more
    • English
    Immunotherapeutic Strategies for the Treatment of Glioma provides a review of the current state of immunotherapy for primary brain tumors. The topic is of interest to patients, clinicians, and researchers alike, particularly given the recent failure of large clinical trials. This book serves as an overview of the most promising approaches in the field and provides a foundation for considering novel and combination therapies moving forward.The book discusses several types of immunotherapies for glioma, such as peptide, dendritic cell and heat shock protein vaccines; immune checkpoint blockade; myeloid cells as target; oncolytic viruses; and CAR T cell therapy. Additionally, it discusses the mechanisms of immune suppression in patients and immunogenomics.This volume is a valuable source for cancer researchers, oncologists and several members of biomedical field who are interested in novel strategies to fight glioblastoma.

  • Connectomic Deep Brain Stimulation

    • 1st Edition
    • Andreas Horn
    • English
    Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery.

  • Electricity Cost Modeling Calculations

    Regulations, Technology, and the Role of Renewable Energy
    • 2nd Edition
    • Monica Greer
    • English
    Reducing greenhouse gases and increasing the use of renewable energy continue to be critical goals for the power industry and electrical engineers to promote energy cost reductions. Engineers and researchers must keep up to date with the evolution of the power system sector, new energy regulations, and how different pricing techniques apply in today’s market. Electricity Cost Modeling Calculations, Second Edition delivers an updated view on pricing models, regulation, technology and the role renewable energy is starting to take in electricity. Starting with fundamental concepts relating to market structure, an increase in international regulations is added to expand the engineer’s knowledge. Cubic cost modeling and new modeling cases are included along with updated literature reviews for deeper research. The reference then extends into more advanced quantitative methods such as updated rate designs, and a new chapter is included on the marginal cost pricing of electricity in the United States with applications to reduce greenhouse gas emissions, making the reference relevant for today’s power markets. This book provides engineers with a practical guide on the latest techniques in electricity pricing and applications for today’s markets.

  • Renewable Energy Systems

    Modelling, Optimization and Control
    • 1st Edition
    • Ahmad Taher Azar + 1 more
    • English
    Renewable Energy Systems: Modelling, Optimization and Control aims to cross-pollinate recent advances in the study of renewable energy control systems by bringing together diverse scientific breakthroughs on the modeling, control and optimization of renewable energy systems by leading researchers. The book brings together the most comprehensive collection of modeling, control theorems and optimization techniques to help solve many scientific issues for researchers in renewable energy and control engineering. Many multidisciplinary applications are discussed, including new fundamentals, modeling, analysis, design, realization and experimental results. The book also covers new circuits and systems to help researchers solve many nonlinear problems. This book fills the gaps between different interdisciplinary applications, ranging from mathematical concepts, modeling, and analysis, up to the realization and experimental work.

  • Similarity Solutions for the Boundary Layer Flow and Heat Transfer of Viscous Fluids, Nanofluids, Porous Media, and Micropolar Fluids

    • 1st Edition
    • John H. Merkin + 3 more
    • English
    Similarity Solutions for the Boundary Layer Flow and Heat Transfer of Viscous Fluids, Nanofluids, Porous Media, and Micropolar Fluids presents new similarity solutions for fluid mechanics problems, including heat transfer of viscous fluids, boundary layer flow, flow in porous media, and nanofluids due to continuous moving surfaces. After discussing several examples of these problems, similarity solutions are derived and solved using the latest proven methods, including bvp4c from MATLAB, the Keller-box method, singularity methods, and more. Numerical solutions and asymptotic results for limiting cases are also discussed in detail to investigate how flow develops at the leading edge and its end behavior. Detailed discussions of mathematical models for boundary layer flow and heat transfer of micro-polar fluid and hybrid nanofluid will help readers from a range of disciplinary backgrounds in their research. Relevant background theory will also be provided, thus helping readers solidify their computational work with a better understanding of physical phenomena.

  • Design, Analysis and Applications of Renewable Energy Systems

    • 1st Edition
    • Ahmad Taher Azar + 1 more
    • English
    Design, Analysis and Applications of Renewable Energy Systems covers recent advancements in the study of renewable energy control systems by bringing together diverse scientific breakthroughs on the modeling, control and optimization of renewable energy systems as conveyed by leading energy systems engineering researchers. The book focuses on present novel solutions for many problems in the field, covering modeling, control theorems and the optimization techniques that will help solve many scientific issues for researchers. Multidisciplinary applications are also discussed, along with their fundamentals, modeling, analysis, design, realization and experimental results. This book fills the gaps between different interdisciplinary applications, ranging from mathematical concepts, modeling, and analysis, up to the realization and experimental work.

  • Brain Seizure Detection and Classification Using EEG Signals

    • 1st Edition
    • Varsha K. Harpale + 1 more
    • English
    Brain Seizure Detection and Classification Using Electroencephalograp... Signals presents EEG signal processing and analysis with high performance feature extraction. The book covers the feature selection method based on One-way ANOVA, along with high performance machine learning classifiers for the classification of EEG signals in normal and epileptic EEG signals. In addition, the authors also present new methods of feature extraction, including Singular Spectrum-Empirical Wavelet Transform (SSEWT) for improved classification of seizures in significant seizure-types, specifically epileptic and Non-Epileptic Seizures (NES). The performance of the system is compared with existing methods of feature extraction using Wavelet Transform (WT) and Empirical Wavelet Transform (EWT). The book's objective is to analyze the EEG signals to observe abnormalities of brain activities called epileptic seizure. Seizure is a neurological disorder in which too many neurons are excited at the same time and are triggered by brain injury or by chemical imbalance.

  • Practical Aspects of Vaccine Development

    • 1st Edition
    • Parag Kolhe + 1 more
    • English
    Practical Aspects of Vaccine Development provides an academic and industry perspective on vaccine development and manufacturing. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and challenges being encountered. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges. Vaccines include a wide range of components including proteins, polysaccharides, protein-polysacchari... conjugates, adjuvants, and more. The container closure system may also be unique, and the product may require freezing storage or lyophilization based on the stability of the vaccine components. Based on the route of delivery, novel technologies and devices may be required. Covering formulation development, manufacture, and delivery considerations of vaccine production, this book is essential to formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students.

  • Application of Polyphenols in Foods and Food Models

    • 1st Edition
    • Volume 98
    • English
    Phenolic compounds are secondary metabolites found in legumes, grains, fruits, algae, leaves and many other dietary sources. However, the abundance and differences in chemical structure, solubility, toxicological safety and, therefore, bioactivity and functional effects in humans. This book covers the basic chemical composition and structure of phenolic compounds and focus on their technological applications in food models and products: nondairy and dairy beverages, bakery, and meat-based foods. Additionally, food preservation aspects, including the effects of polyphenols additions on the product’s shelf-life, processing and recovery of polyphenols from plant materials, antioxidant and antiproliferative aspects of polyphenol-rich extracts are considered and holistically debated.

  • Chromatin and Genomic Instability in Cancer

    • 1st Edition
    • Volume 364
    • English
    Chromatin and DNA Repair in Cancer, Volume 364 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release cover Genomic Instability and metabolism in cancer, Histones variants and Histones modifications in cancer and Aging, DNA Double-stranded breaks Repair in Cancer, Reactive oxygen species and DNA damage response in cancer, Transcription-Associ... DNA Breaks and Cancer: A Matter of DNA Topology, Mechanisms of Base Excision Repair: Its Significance to Human Health, and more. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology.

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