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Elsevier

Books in Life sciences

  • Electrocardiography of Laboratory Animals

    • 2nd Edition
    • Jeffrey W. Richig + 1 more
    • English
    Electrocardiography of Laboratory Animals, Second Edition, is the only publication covering electrocardiography of laboratory animals. With countries instituting requirements for the care of laboratory animals in research, this publication offers a standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry, all important areas of discussion for biological and medical researchers, veterinarians, zoologists, and students who need to understand the electrocardiography of five species of animals used in research: canines, nonhuman primates, mini pigs, rodents (rats and mice), rabbits and cats.

  • Non-Enzymatic Protein Modifications in Health, Disease and Ageing

    • 1st Edition
    • Izabela Sadowska-Bartosz + 1 more
    • English
    Non-Enzymatic Protein Modifications in Health, Diseases and Ageing discusses each type of non-enzymatic protein, introducing non-enzymatic protein modifications, reviewing the state-of-the-art, and presenting updates and current trends. The book covers various aspects of the subject, including the formation and removal of modified proteins, their roles in disease, preventative methods, and possible roles in cellular signaling. This book not only provides well-established facts, but also discusses current hypotheses and controversies.

  • Simulation in Acute Neurology

    • 1st Edition
    • Sara E. Hocker + 1 more
    • English
    Simulation in Acute Neurology is a textbook on the execution of a simulation-based educational program in the management of acute neurologic emergencies. Simulation in Acute Neurology has practical value because it contains detailed descriptions of our simulation scenarios. The foundation of this book is our experience with neurosimulation―and it has been a very good one. Part I provides an overview of the principles of simulation in medicine and examines the many unique opportunities simulation provides as an educational tool. Barriers to simulating neurologic emergencies are also discussed. Simulation allows a physician-in-trainin... to be observed directly as he or she evaluates and manages acute neurologic disease. Part II is the core of the book. Fifteen acute neurologic emergencies, including complex neuroethical quandaries, are presented in detail, step by step, decision by decision, error after error. Each chapter in this section starts with an explanation of the essence of the discussed neuroemergency (THE PROBLEM BEFORE US), followed by a description of the scenario itself (THE PRESENTING CLINICAL PROBLEM), how scenarios can be adjusted to different types of learners (ADAPTING THE SCENARIO), and ends with a discussion of topics for feedback, which are generally focused around errors and pitfalls (DEBRIEFING). To show the flow of scenarios, we created two additional main headings: (THE IDEAL LEARNER) and (THE NOT-SO IDEAL LEARNER).

  • Changing Climate and Resource use Efficiency in Plants

    • 1st Edition
    • Amitav Bhattacharya
    • English
    Changing Climate and Resource Use Efficiency in Plants reviews the efficiencies for resource use by crop plants under different climatic conditions. This book focuses on the challenges and potential remediation methods for a variety of resource factors. Chapters deal with the effects of different climatic conditions on agriculture, radiation use efficiency under various climatic conditions, the efficiency of water and its impact on harvest production under restricted soil moisture conditions, nitrogen and phosphorus use efficiency, nitrogen use efficiency in different environmental conditions under the influence of climate change, and various aspects of improving phosphorus use efficiency. The book provides guidance for researchers engaged in plant science studies, particularly Plant/Crop Physiology, Agronomy, Plant Breeding and Molecular Breeding. In addition, it provides valuable insights for policymakers, administrators, plant-based companies and agribusiness companies.

  • Workbook for Pharmacology for Pharmacy Technicians

    • 3rd Edition
    • Kathy Moscou + 1 more
    • English
    Reinforce your comprehension of pharmacologic concepts with this hands-on workbook. Specially designed to parallel the material in Pharmacology for Pharmacy Technicians, 3rd Edition, this workbook provides in-depth study and review of the terminology, principles, and applications of pharmacology needed for certification and practice as a Pharmacy Technician. Its user-friendly format and engaging learning exercises include vocabulary quizzes, review questions, critical thinking exercises, research activities, and new case applications to help you build a solid foundation for pharmacy practice!

  • Digestive Diseases in Sub-Saharan Africa

    Changes and Challenges
    • 1st Edition
    • Isidor Segal
    • English
    Digestive Diseases in Sub-Saharan Africa: Changes and Challenges provides an in-depth examination into the rise of western digestive diseases in Sub-Saharan Africa (SSA). For those interested in the causes of the major diseases of the ‘West’, the patterns in Africa have always reflected on the emergence of western diseases and elucidated the pattern of these conditions and their clinical course. Coverage includes the present epidemiology of GI diseases in SSA, the trends that are occurring, and the context of other emerging diseases. Appropriate for researchers, gastroenterologists and internists, this book brings together the latest research in a single, complete volume.

  • Membrane Transport in Plants

    • 1st Edition
    • Volume 87
    • English
    Plant Transporters, Volume 87, the latest release in the Advances in Botanical Research series, brings together the experiences and critical information teachers, researchers and managers must consider from scientific and legal points-of-view as they relate to biotechnology. New chapters in this updated volume include sections on P-type ATPases, ABC transporters, Nitrate transport, Metal transporters, Hormone transporters, Plant aquaporins, Ion channel regulation in guard cells, Ion transport in pollen tube growth, Xylem loading under stress, and Transporters during arbuscular mycorrhizal symbiosis.

  • Sport and the Brain: The Science of Preparing, Enduring and Winning, Part C

    • 1st Edition
    • Volume 240
    • English
    Sport and the Brain: The Science of Preparing, Enduring and Winning, Part C, Volume 240, reflects recent advancements in the understanding of how elite athletes prepare for, and perform at, peak levels under the demands of competition. Topics discussed in this new release include The influence of challenge and threat states on affect, perceived exertion, attention, and performance during a competitive sprint cycling task, Prior self-control exertion and perceptions of pain and task importance during a physically demanding task, Enhancing cardiac vagal activity in sport psychology, The influence of cardiac vagal activity on peripheral perception performance under pressure, and much more.

  • Modern Approaches in Drug Discovery

    • 1st Edition
    • Volume 610
    • English
    Modern Approaches in Drug Discovery, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Target Identification and Validation, Cell Painting/High Content Imaging, Target ID using chemical probes, Mining the microbiome for targets, Data driven approaches for diversity and drug-likeness, Affinity-based screening, Fragment screening (X-ray), Array-based approaches, Hit-to-lead: assessment and improvement of drug-like properties, Hit assessment and prioritization, Lead Optimization: fine tuning and risk mitigation, and more.

  • Postharvest Physiology and Biochemistry of Fruits and Vegetables

    • 1st Edition
    • Elhadi M. Yahia + 1 more
    • English
    Postharvest Physiology and Biochemistry of Fruits and Vegetables presents an updated, interrelated and sequenced view of the contribution of fruits and vegetables on human health, their aspects of plant metabolism, physical and chemical/composition... changes during the entire fruit development lifecycle, the physiological disorders and biochemical effects of modified/controlled atmospheres, and the biotechnology of horticultural crops. The book is written specifically for those interested in preharvest and postharvest crop science and the impact of physiological and biochemical changes on their roles as functional foods.

  • Side Effects of Drugs Annual

    A Worldwide Yearly Survey of New Data in Adverse Drug Reactions
    • 1st Edition
    • Volume 40
    • English
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 40, first published in 1977, and continually published as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs, presents clinicians and medical investigators with a reliable and critical survey of new data and trends in the area of adverse drug reactions and interactions, with an international team of specialists contributing each year. Topics covered in this release include Central Nervous System Stimulants and Drugs that Suppress Appetite, Antidepressant drugs, Lithium, Drugs of abuse, Hypnotics and sedatives, Antipsychotic Drugs, and much more.

  • Oncogenomics

    From Basic Research to Precision Medicine
    • 1st Edition
    • Franco Dammacco + 1 more
    • English
    Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies.

  • Strategies for Successful Animal Shelters

    • 1st Edition
    • Laura A. Reese
    • English
    Strategies for Successful Animal Shelters is the first book to assess the relationship between shelter traits, activities and critical outcome variables, such as live release or save rates. This book provides a data-based evaluation of shelter processes and practices with explicit recommendations for improved shelter activities. Using a survey of licensed animal shelters, case studies, and data on state inspections, complaints, and save rates, this book provides an assessment of the activities, processes, and procedures that are most likely to lead to positive outcomes for a variety of animal shelters. The book also contributes to community debate around animal sheltering and provides best practices, methods and means to assess local shelters to ensure the highest level of animal welfare. It is a valuable resource for animal shelter professionals and rescue groups, as well as students in disciplines such as animal science, animal welfare and shelter medicine.

  • Artificial Intelligence in the Age of Neural Networks and Brain Computing

    • 1st Edition
    • Robert Kozma + 3 more
    • English
    Artificial Intelligence in the Age of Neural Networks and Brain Computing demonstrates that existing disruptive implications and applications of AI is a development of the unique attributes of neural networks, mainly machine learning, distributed architectures, massive parallel processing, black-box inference, intrinsic nonlinearity and smart autonomous search engines. The book covers the major basic ideas of brain-like computing behind AI, provides a framework to deep learning, and launches novel and intriguing paradigms as future alternatives. The success of AI-based commercial products proposed by top industry leaders, such as Google, IBM, Microsoft, Intel and Amazon can be interpreted using this book.

  • Sustainable Meat Production and Processing

    • 1st Edition
    • Charis M. Galanakis
    • English
    Sustainable Meat Production and Processing presents current solutions to promote industrial sustainability and best practices in meat production, from postharvest to consumption. The book acts as a guide for meat and animal scientists, technologists, engineers, professionals and producers. The 12 most trending topics of sustainable meat processing and meat by-products management are included, as are advances in ingredient and processing systems for meat products, techno-functional ingredients for meat products, protein recovery from meat processing by-products, applications of blood proteins, artificial meat production, possible uses of processed slaughter co-products, and environmental considerations. Finally, the book covers the preferred technologies for sustainable meat production, natural antioxidants as additives in meat products, and facilitators and barriers for foods containing meat co-products.

  • Starches for Food Application

    Chemical, Technological and Health Properties
    • 1st Edition
    • Maria Teresa Pedrosa Silva Clerici + 1 more
    • English
    Starches for Food Application: Chemical, Technological and Health Properties examines the scientific, technological and nutritional knowledge of different types of starches, including their production and application in food, health and the environment. The book covers the links between biosynthesis, structure and the environmental impact on processing and nutrition. In addition, it covers starch identification and evaluation methods, along with production methodologies for food application, new sources of starch, modified starches for food application, and the relationship between starch, nutrition and health.

  • Epigenetics of Chronic Pain

    • 1st Edition
    • Volume 7
    • English
    Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs.

  • Viral Polymerases

    Structures, Functions and Roles as Antiviral Drug Targets
    • 1st Edition
    • Satya Prakash Gupta
    • English
    Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs.

  • The Molecular Nutrition of Fats

    • 1st Edition
    • Vinood Patel
    • English
    The Molecular Nutrition of Fats presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell, and their role in health and disease. Subject areas include molecular mechanisms, membranes, polymorphisms, SNPs, genomic wide analysis, genotypes, gene expression, genetic modifications and other aspects. The book is divided into three sections, providing information on the general and introductory aspects, the molecular biology of the cell, and the genetic machinery and its function. Topics discussed include lipid-related molecules, dietary lipids and lipid metabolism, high fat diets, choline, cholesterol, membranes, trans-and saturated fatty acids, and lipid rafts. Other sections provide comprehensive discussions on G protein-coupled receptors, micro RNA, transcriptomics, transcriptional factors, cholesterol, triacylglycerols, beta-oxidation, cholesteryl ester transfer, beta-oxidation, lysosomes, lipid droplets, insulin mTOR signaling and ligands, and more.

  • Scrotoscopic Surgery

    • 1st Edition
    • Jinrui Yang
    • English
    Scrotoscopic Surgery presents a systematic approach to the theory, procedures and clinical application of scrotoscopic techniques for the improved treatment of scrotal diseases. Currently, open operations remain the most common choices to treat scrotal content diseases, such as epididymal cyst and hydrocele. However, open surgeries also bring disadvantages, including discomfort, damage and complications. To solve these problems, this book presents best practices for scrotoscopic surgery, providing practitioners with tactics that will help them ensure the best outcomes for patients.

  • Red Wine Technology

    • 1st Edition
    • Antonio Morata
    • English
    Red Wine Technology is a solutions-based approach on the challenges associated with red wine production. It focuses on the technology and biotechnology of red wines, and is ideal for anyone who needs a quick reference on novel ways to increase and improve overall red wine production and innovation. The book provides emerging trends in modern enology, including molecular tools for wine quality and analysis. It includes sections on new ways of maceration extraction, alternative microorganisms for alcoholic fermentation, and malolactic fermentation. Recent studies and technological advancements to improve grape maturity and production are also presented, along with tactics to control PH level.This book is an essential resource for wine producers, researchers, practitioners, technologists and students.

  • Applications of Nanocomposite Materials in Orthopedics

    • 1st Edition
    • Inamuddin + 2 more
    • English
    Applications of Nanocomposite Materials in Orthopedics provides a solid understanding of recent developments in the field of nano-composites used in orthopedics. The book covers joint replacement, the load bearing capability of fractured bones, bone soft tissue regeneration, hard tissue replacement, artificial bone grafting, bone repair, bone tissue transplantations, and related topics, thus helping readers understand how to resolve problems associated with bone fracture and orthopedic surgery. A variety of nanocomposite materials are discussed, with their properties and preparation methods given.

  • Recent Developments in Applied Microbiology and Biochemistry

    • 1st Edition
    • Viswanath Buddolla
    • English
    Recent Developments in Applied Microbiology and Biochemistry provides a comprehensive treatment and understanding on application oriented microbial concepts, giving readers insights into recent developments in microbial biotechnology and medical, agricultural and environmental microbiology.

  • The Science of Animal Growth and Meat Technology

    • 2nd Edition
    • Steven M. Lonergan + 2 more
    • English
    The Science of Animal Growth and Meat Technology, Second Edition, combines fundamental science- based and applied, practical concepts relating to the prenatal and postnatal growth of cattle, sheep and pigs. It provides the necessary components to understand the production and growth of livestock for safe and quality meat products and presents an understanding of the principles of meat science and technology that is needed to understand the meat industry. Information on the slaughter process of animals, muscle structure and meat tenderness, meat quality, meat safety, and microbiology makes this a valuable self-study reference for students and professionals entering the field.

  • A Pharmacology Primer

    Techniques for More Effective and Strategic Drug Discovery
    • 5th Edition
    • Terry P. Kenakin
    • English
    A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 80
    • Jean-Francois Hamel
    • English
    Advances in Marine Biology, Volume 80, the latest release in a series that has been providing in-depth and up-to-date reviews on all aspects of marine biology since 1963, updates on many topics that will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology and biological oceanography.

  • Nutrition and Skeletal Muscle

    • 1st Edition
    • Stéphane Walrand
    • English
    Nutrition and Skeletal Muscle provides coverage of the evidence of dietary components that have proven beneficial for bettering adverse changes in skeletal muscle from disuse and aging. Skeletal muscle is the largest tissue in the body, providing elements of contraction and locomotion and acting as an important contributor to whole body protein and amino metabolism, glucose disposal and lipid metabolism. However, muscle loss, atrophy or weakness can occur when there are metabolic imbalances, disuse or aging. This book addresses the topic by providing insight and research from international leaders, making it the go-to reference for those in skeletal muscle physiology.

  • Microbiology of Atypical Environments

    • 1st Edition
    • Volume 45
    • English
    Microbiology of Atypical Environments, Volume 45, presents a comprehensive reference text on the microbiological methods used to research the basic biology of microorganism in harsh, stressful and sometimes atypical environments (e.g. arctic ice, space stations, extraterrestrial environments, hot springs and magnetic environments). Chapters in this release include Biofilms in space, Methods for studying the survival of microorganisms in extraterrestrial environments, Persistence of Fungi in Atypical (Closed) Environments Based on Evidence from the International Space Station (ISS): Distribution and Significance to Human health, Methods for visualizing microorganisms in Icy environments, Measuring microbial metabolism at surface-air interfaces and nuclear waste management, amongst others.

  • Advances in Immunology

    • 1st Edition
    • Volume 140
    • Frederick Alt
    • English
    Advances in Immunology, Volume 140, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology.

  • The Science of Hormesis in Health and Longevity

    • 1st Edition
    • Suresh Rattan + 1 more
    • English
    The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work.

  • New Look to Phytomedicine

    Advancements in Herbal Products as Novel Drug Leads
    • 1st Edition
    • Mohd Sajjad Ahmad Khan + 2 more
    • English
    New Look to Phytomedicine: Advancements in Herbal Products as Novel Drug Leads is a compilation of in-depth information on the phytopharmaceuticals used in modern medicine for the cure and management of difficult-to-treat and challenging diseases. Readers will find cutting-edge knowledge on the use of plant products with scientific validation, along with updates on advanced herbal medicine in pharmacokinetics and drug delivery. This authoritative book is a comprehensive collection of research based, scientific validations of bioactivities of plant products, such as anti-infective, anti-diabetic, anti-cancer, immune-modulatory and metabolic disorders presented by experts from across the globe. Step-by-step information is presented on chemistry, bioactivity and the functional aspects of biologically active compounds. In addition, the pharmacognosy of plant products with mechanistic descriptions of their actions, including pathogenicity is updated with information on the use of nanotechnology and molecular tools in relation to herbal drug research.

  • Mesoporous Silica-based Nanomaterials and Biomedical Applications - Part B

    • 1st Edition
    • Volume 44
    • English
    Cancer Therapy and Diagnosis, Part B, Volume 44 in The Enzymes series highlights new advances in the field, with this new volume presenting interesting chapters on Mesoporous silica nanoparticle synthesis, Periodic mesoporous organosilica, Nanovalves and other nanomachine-equipped nanoparticles and controlled release, Two-photon light control and photodynamic therapy, Biodegradable PMO nanoparticles, Cationic mesoporous silica and protein delivery, Drug loading, stimuli-responsive delivery and cancer treatment, Animal models and cancer therapy, siRNA delivery and TWIST shutdown for ovarian cancer treatment, and TBC (mesoporous silica nanoparticles and cancer therapy or biodistribution of MSN).

  • Membranes in Pulmonary Vascular Disease

    • 1st Edition
    • Volume 82
    • English
    Membranes in Pulmonary Vascular Disease, Volume 82, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters from recognized experts on topics such as Sphingolipids in Vascular Lung Disease, Endothelial Glycocalyx, Cholesterol Regulation of Endothelial Cell Calcium Homeostasis in Pulmonary Hypertension, Mechanosensitive Channels and Gap Junction Channels in EC, Endothelial Protrusions in Junctional Integrity and Barrier Function, Cortical Actin Dynamics in Endothelial Permeability, Endothelial Microparticles and Exosomes, Store Operated TRP Channels and Endothelial Responses, and Caveolin and Endothelial NO signaling.

  • Toxicology in Antiquity

    • 2nd Edition
    • English
    Toxicology in Antiquity provides an authoritative and fascinating exploration into the use of toxins and poisons in antiquity. It brings together the two previously published shorter volumes on the topic, as well as adding considerable new information. Part of the History of Toxicology and Environmental Health series, it covers key accomplishments, scientists, and events in the broad field of toxicology, including environmental health and chemical safety. This first volume sets the tone for the series and starts at the very beginning, historically speaking, with a look at toxicology in ancient times. The book explains that before scientific research methods were developed, toxicology thrived as a very practical discipline. People living in ancient civilizations readily learned to distinguish safe substances from hazardous ones, how to avoid these hazardous substances, and how to use them to inflict harm on enemies. It also describes scholars who compiled compendia of toxic agents. New chapters in this edition focus chiefly on evidence for the use of toxic agents derived from religious texts.

  • The History of Alternative Test Methods in Toxicology

    • 1st Edition
    • English
    The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reducti... Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. 　 The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.

  • Neglected Diseases: Extensive Space for Modern Drug Discovery

    • 1st Edition
    • Volume 51
    • English
    Neglected Diseases: Extensive Space for Modern Drug Discovery provides in-depth reviews on the last progresses about neglected tropical diseases research. Topics covered in this volume include Leishmaniasis, Tripanosomiasis, Onchocerciasis and Ebolavirus infections, with insights on the future of the research on them. Part of the volume is devoted to recent contributions this field received from X-Ray crystallography.

  • Analysis in Nutrition Research

    Principles of Statistical Methodology and Interpretation of the Results
    • 1st Edition
    • George Pounis
    • English
    Analysis in Nutrition Research: Principles of Statistical Methodology and Interpretation of the Results describes, in a comprehensive manner, the methodologies of quantitative analysis of data originating specifically from nutrition studies. The book summarizes various study designs in nutrition research, research hypotheses, the proper management of dietary data, and analytical methodologies, with a specific focus on how to interpret the results of any given study. In addition, it provides a comprehensive overview of the methodologies used in study design and the management and analysis of collected data, paying particular attention to all of the available, modern methodologies and techniques. Users will find an overview of the recent challenges and debates in the field of nutrition research that will define major research hypotheses for research in the next ten years. Nutrition scientists, researchers and undergraduate and postgraduate students will benefit from this thorough publication on the topic.

  • New and Future Developments in Microbial Biotechnology and Bioengineering

    Microbial Genes Biochemistry and Applications
    • 1st Edition
    • H.B Singh + 2 more
    • English
    New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Genes Biochemistry and Applications consolidates the most widely used genetic methods available, bringing together the fields of biochemistry, biotechnology, and microbiology. The chapters outlined give clear and concise direction on both standard and applied microbial genetic improvements, presenting undergraduates, postgraduates, and researchers with the latest developments in microbial gene technology. In addition, the book describes the background and usefulness of each experiment in question. All chapters covered in the book are derived from current peer-reviewed literature as accepted by the international scientific community.

  • The Human Body

    Linking Structure and Function
    • 1st Edition
    • Bruce M. Carlson
    • English
    The Human Body: Linking Structure and Function provides knowledge on the human body's unique structure and how it works. Each chapter is designed to be easily understood, making the reading interesting and approachable. Organized by organ system, this succinct publication presents the functional relevance of developmental studies and integrates anatomical function with structure.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 87
    • English
    Advances in Clinical Chemistry, Volume 87, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Thermodynamics of Phase Equilibria in Food Engineering

    • 1st Edition
    • Camila Gambini Pereira
    • English
    Thermodynamics of Phase Equilibria in Food Engineering is the definitive book on thermodynamics of equilibrium applied to food engineering. Food is a complex matrix consisting of different groups of compounds divided into macronutrients (lipids, carbohydrates, and proteins), and micronutrients (vitamins, minerals, and phytochemicals). The quality characteristics of food products associated with the sensorial, physical and microbiological attributes are directly related to the thermodynamic properties of specific compounds and complexes that are formed during processing or by the action of diverse interventions, such as the environment, biochemical reactions, and others. In addition, in obtaining bioactive substances using separation processes, the knowledge of phase equilibria of food systems is essential to provide an efficient separation, with a low cost in the process and high selectivity in the recovery of the desired component. This book combines theory and application of phase equilibria data of systems containing food compounds to help food engineers and researchers to solve complex problems found in food processing. It provides support to researchers from academia and industry to better understand the behavior of food materials in the face of processing effects, and to develop ways to improve the quality of the food products.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 105
    • English
    Advances in Applied Microbiology, Volume 105 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas, with this updated volume including chapters covering The Genus Macrococcus: an insight into its evolution, biology and relationship with Staphylococcus, The use of electrobiochemical reactors for in vitro and in vivo metabolic engineering, Advances in the Microbial Ecology of Biohydrometallurgy, Optimizing yeast alcoholic fermentations, Methods to reduce spoilage and microbial contamination of plant produce, Microbial Diversity and Functional Analysis, and more.

  • Pharmacoepidemiology and Pharmacovigilance

    Synergistic Tools to Better Investigate Drug Safety
    • 1st Edition
    • Sabrina Nour + 1 more
    • English
    Pharmacoepidemiology and Pharmacovigilance: Synergistic Tools to Better Investigate Drug Safety examines the role of pharmacoepidemiologi... studies in drug development and its use as a prevention tool in pharmacovigilance activities. The book introduces the various epidemiologic tools and study designs commonly used for the surveillance of drug-related adverse effects and reviews the strengths and weaknesses of each. Criticisms surrounding pharmacoepidemiologi... research and issues that often interfere or complicate the conduct and interpretation of these studies are also explored. Case studies illustrate the passive and active surveillance of adverse drug reactions in clinical situations, covering important pharmacoepidemiologi... concepts like health risk management and safety. The book helps pharmaceutical industry groups engaged in drug safety, clinical investigators, medical evaluators and those seeking regulatory approval enhance the safety of the drug development process for all patient populations.

  • Vaccines for Cancer Immunotherapy

    An Evidence-Based Review on Current Status and Future Perspectives
    • 1st Edition
    • Nima Rezaei + 1 more
    • English
    Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines.

  • Progress in Molecular Biology and Translational Science

    • 1st Edition
    • Volume 159
    • David B. Teplow
    • English
    Progress in Molecular Biology and Translational Science, Volume 159, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series includes in-depth knowledge on molecular biological aspects of organismal physiology, along with insights on how this knowledge may be applied to understand and ameliorate human disease. New chapters in this release discuss timely topics, such as Targeting recently deorphanized GPR83 for the treatment of infection, stress, and drug addiction, Arrestin Structure-Function, Arrestins in the Cardiovascular System, Analysis of biased agonism, and more.

  • Encyclopedia of Cancer

    • 3rd Edition
    • Paolo Boffetta + 1 more
    • English
    Encyclopedia of Cancer, Third Edition, Three Volume Set provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented.

  • Sorghum and Millets

    Chemistry, Technology, and Nutritional Attributes
    • 2nd Edition
    • John Taylor + 1 more
    • English
    Sorghum and Millets: Chemistry, Technology and Nutritional Attributes, Second Edition, is a new, fully revised edition of this widely read book published by AACC International. With an internationally recognized editorial team, this new edition covers, in detail, the history, breeding, production, grain chemistry, nutritional quality and handling of sorghum and millets. Chapters focus on biotechnology, grain structure and chemistry, nutritional properties, traditional and modern usage in foods and beverages, and industrial and non-food applications. The book will be of interest to academics researching all aspects of sorghum and millets, from breeding to usage. In addition, it is essential reading for those in the food industry who are tasked with the development of new products using the grains.

  • Water Quality Monitoring and Management

    Basis, Technology and Case Studies
    • 1st Edition
    • Daoliang Li + 1 more
    • English
    Water Quality Monitoring and Management: Basis, Technology and Case Studies presents recent innovations in operations management for water quality monitoring. It highlights the cost of using and choosing smart sensors with advanced engineering approaches that have been applied in water quality monitoring management, including area coverage planning and sequential scheduling. In parallel, the book covers newly introduced technologies like bulk data handling techniques, IoT of agriculture, and compliance with environmental considerations. Presented from a system engineering perspective, the book includes aspects on advanced optimization, system and platform, Wireless Sensor Network, selection of river water quality, groundwater quality detection, and more. It will be an ideal resource for students, researchers and those working daily in agriculture who must maintain acceptable water quality.

  • Sprouted Grains

    Nutritional Value, Production, and Applications
    • 1st Edition
    • Hao Feng + 2 more
    • English
    Sprouted Grains: Nutritional Value, Production and Applications is a complete and comprehensive overview of sprouted grains, with coverage from grain to product. Sections includes discussions on the process of grain germination from both a genetic and physiological perspective, the nutrients and bioactive compounds present in spouted grains, and the equipment and technical innovation of use to manufacturers of sprouted grains and sprouted grain products. This book is essential reading for cereal science academics and postgraduate students interested in the subject of cereal processing, but is also ideal for industrial product developers in cereal companies. This edited volume brings together the world’s leading researchers on sprouted grains.

  • The Opioid System as the Interface between the Brain’s Cognitive and Motivational Systems

    • 1st Edition
    • Volume 239
    • English
    The Opioid System as the Brain’s Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain’s cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain’s cognitive system, the Brain’s motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more.

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