LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code needed.
Rang & Dale's Pharmacology
- 9th Edition
- Authors: James M. Ritter, Rod J. Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Humphrey P. Rang
- Language: English
Comprehensive yet easy to use, Rang and Dale’s Pharmacology has been providing core basic and clinical science information to students and healthcare practitioners worldwide fo… Read more
Purchase options
Comprehensive yet easy to use, Rang and Dale’s Pharmacology has been providing core basic and clinical science information to students and healthcare practitioners worldwide for more than 25 years. The fully revised 9th Edition keeps you up to date with all that’s new in the field, including new and emerging drugs and recent studies. From cover to cover, you’ll progressively increase your knowledge of all relevant aspects of pharmacology, from a molecular understanding of receptors and drug actions through clinical uses of key groups of drugs.
- Keeps you up-to-date with new information in this fast-changing field, including significantly revised coverage of CNS drugs, cognitive enhancers, anti-infectives, biologicals/biopharmaceuticals, lifestyle drugs, and more.
- Includes access to unique features online, including more than 100 brand new chapter-specific multiple-choice questions and 6 new cases for immediate self-assessment.
- Features a color-coded layout for faster navigation and cross-referencing.
- Clarifies complex concepts with Key Points boxes, Clinical Uses boxes and full-color illustrations throughout.
- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Pharmacology, medicine, clinical pharmacology, pharmacy
- Cover image
- Title Page
- Table of Contents
- Copyright
- Rang and Dale's Pharmacology Ninth Edition Preface
- Acknowledgements
- Section 1 General principles
- 1 What is pharmacology?
- What Is a Drug?
- Origins and Antecedents
- Pharmacology in the 20Th and 21St Centuries
- References and Further Reading
- 2 How drugs act
- Introduction
- Protein Targets for Drug Binding
- Desensitisation and Tolerance
- Quantitative Aspects of Drug–Receptor Interactions
- The Nature of Drug Effects
- References and Further Reading
- 3 How drugs act
- Protein Targets for Drug Action
- Receptor Proteins
- Ion Channels as Drug Targets
- Control of Receptor Expression
- Receptors and Disease
- References and Further Reading
- 4 How drugs act
- Regulation of Intracellular Calcium
- Excitation
- Muscle Contraction
- Release of Chemical Mediators
- Epithelial Ion Transport
- References and Further Reading
- 5 How drugs act
- Introduction
- Protein and Oligonucleotide Biopharmaceuticals
- Oligonucleotides
- Gene Therapy
- Safety and Societal Issues
- Therapeutic Applications
- Concluding Remarks
- References and Further Reading
- 6 Cell proliferation, apoptosis, repair and regeneration
- Cell Proliferation
- Angiogenesis
- Apoptosis and Cell Removal
- Pathophysiological Implications
- Therapeutic Prospects
- References and Further Reading
- 7 Cellular mechanisms
- Introduction
- The Innate Immune Response
- The Adaptive Immune Response
- Systemic Responses in Inflammation
- References and Further Reading
- 8 Method and measurement in pharmacology
- Bioassay
- Animal Models of Disease
- Pharmacological Studies in Humans
- Clinical Trials
- References and Further Reading
- 9 Absorption and distribution of drugs
- Introduction
- Physical Processes Underlying Drug Disposition
- Drug Absorption and Routes of Administration
- Distribution of Drugs in the Body
- Special Drug Delivery Systems
- References and Further Reading
- 10 Drug metabolism and elimination
- Introduction
- Drug and Metabolite Excretion
- References and Further Reading
- 11 Pharmacokinetics
- Introduction: Definition and Uses of Pharmacokinetics
- Drug Elimination Expressed as Clearance
- Single-Compartment Model
- More Complicated Kinetic Models
- Population Pharmacokinetics
- Limitations of Pharmacokinetics
- References and Further Reading
- 12 Individual variation, pharmacogenomics and personalised medicine
- Introduction
- Epidemiological Factors and Inter-Individual Variation of Drug Response
- Genetic Variation in Drug Responsiveness
- Therapeutic Drugs and Clinically Available Pharmacogenomic Tests
- Conclusions
- References and Further Reading
- Section 2 Chemical mediators
- 13 Chemical mediators and the autonomic nervous system
- Historical Aspects
- The Autonomic Nervous System
- Some General Principles of Chemical Transmission
- Basic Steps in Neurochemical Transmission: Sites of Drug Action
- References and Further Reading
- 14 Cholinergic transmission
- Muscarinic and Nicotinic Actions of Acetylcholine
- Acetylcholine Receptors
- Nicotinic Receptors
- Physiology of Cholinergic Transmission
- Effects of Drugs on Cholinergic Transmission
- References and Further Reading
- 15 Noradrenergic transmission
- Catecholamines
- Classification of Adrenoceptors
- Physiology of Noradrenergic Transmission
- Drugs Acting on Noradrenergic Transmission
- References and Further Reading
- 16 5-Hydroxytryptamine and the pharmacology of migraine
- 5-Hydroxytryptamine
- Migraine and Other Clinical Conditions in Which 5-HT Plays a Role
- References and Further Reading
- 17 Purines
- Introduction
- Purinergic Receptors
- Adenosine as a Mediator
- ADP as a Mediator
- ATP as a Mediator
- Future Prospects
- References and Further Reading
- 18 Local hormones 1
- Introduction
- What Is a ‘Mediator’?
- Histamine
- Eicosanoids
- Leukotrienes
- Other Important Fatty Acid Derivatives
- Platelet-Activating Factor
- Concluding Remarks
- References and Further Reading
- 19 Local hormones 2
- Introduction
- General Principles of Protein and Peptide Pharmacology
- Biosynthesis and Regulation of Peptides
- Bradykinin
- Neuropeptides
- Cytokines
- Proteins and Peptides That Down-Regulate Inflammation
- Concluding Remarks
- References and Further Reading
- 20 Cannabinoids
- Plant-Derived Cannabinoids and Their Pharmacological Effects
- Cannabinoid Receptors
- Endocannabinoids
- Synthetic Cannabinoids
- Clinical Applications
- References and Further Reading
- 21 Nitric oxide and related mediators
- Introduction
- Biosynthesis of Nitric Oxide and Its Control
- Degradation and Carriage of Nitric Oxide
- Effects of Nitric Oxide
- Therapeutic Aspects
- Clinical Conditions in Which Nitric Oxide May Play A Part
- Related Mediators
- References and Further Reading
- Section 3 Drugs affecting major organ systems
- 22 The heart
- Introduction
- Physiology of Cardiac Function
- Autonomic Control of the Heart
- Cardiac Natriuretic Peptides
- Ischaemic Heart Disease
- Drugs That Affect Cardiac Function
- References and Further Reading
- 23 The vascular system
- Introduction
- Vascular Structure and Function
- Control of Vascular Smooth Muscle Tone
- Vasoactive Drugs
- Clinical Uses of Vasoactive Drugs
- References and Further Reading
- 24 Atherosclerosis and lipoprotein metabolism
- Introduction
- Atherogenesis
- Lipoprotein Transport
- Prevention of Atheromatous Disease
- Lipid-Lowering Drugs
- References and Further Reading
- 25 Haemostasis and thrombosis
- Introduction
- Blood Coagulation
- Drugs That Act on the Coagulation Cascade
- Platelet Adhesion and Activation
- Fibrinolysis (Thrombolysis)
- References and Further Reading
- 26 Haematopoietic system and treatment of anaemia
- Introduction
- The Haematopoietic System
- Types of Anaemia
- Haematinic Agents
- Haematopoietic Growth Factors
- Haemolytic Anaemia
- References and Further Reading
- 27 Anti-inflammatory and immunosuppressant drugs
- Introduction
- Cyclo-Oxygenase Inhibitors
- Antirheumatoid Drugs
- Anticytokine Drugs and Other Biopharmaceuticals
- Drugs Used in Gout
- Antagonists of Histamine
- Possible Future Developments IN ANTIINFLAMMATORY THERAPY
- References and Further Reading
- 28 Skin
- Introduction
- Structure of Skin
- Common Diseases of the Skin
- Drugs Acting on Skin
- Principal Drugs Used in Skin Disorders
- Agents Acting by Other Mechanisms
- Concluding Remarks
- References and Further Reading
- 29 Respiratory system
- The Physiology of Respiration
- Pulmonary Disease and Its Treatment
- References and Further Reading
- 30 The kidney and urinary system
- Introduction
- Outline of Renal Function
- The Structure and Function of the Nephron
- Drugs Acting on the Kidney
- Drugs That Alter the pH of the Urine
- Drugs That Alter the Excretion of Organic Molecules
- Drugs Used in Renal Failure
- Drugs Used in Urinary Tract Disorders
- References and Further Reading
- 31 The gastrointestinal tract
- The Innervation and Hormones of the Gastrointestinal Tract
- Gastric Secretion
- Vomiting
- The Motility of the GI Tract
- Drugs for Chronic Bowel Disease
- Drugs Affecting the Biliary System
- Future Directions
- References and Further Reading
- 32 The control of blood glucose and drug treatment of diabetes mellitus
- Introduction
- Control of Blood Glucose
- Pancreatic Islet Hormones
- Diabetes Mellitus
- References and Further Reading
- 33 Obesity
- Introduction
- Obesity as a Health Problem
- Homeostatic Mechanisms Controlling Energy Balance
- The Pathophysiology of Human Obesity
- Pharmacological Approaches to the Problem of Obesity
- New Approaches to Obesity Therapy
- References and Further Reading
- 34 The pituitary and the adrenal cortex
- The Pituitary Gland
- The Adrenal Cortex
- New Directions in Glucocorticoid Therapy
- References and Further Reading
- 35 The thyroid
- Synthesis, Storage and Secretion of Thyroid Hormones
- Regulation of Thyroid Function
- Actions of the Thyroid Hormones
- Transport and Metabolism of Thyroid Hormones
- Abnormalities of Thyroid Function
- Drugs Used in Diseases of the Thyroid
- References and Further Reading
- 36 The reproductive system
- Introduction
- Endocrine Control of Reproduction
- Drugs Affecting Reproductive Function
- Drugs Used for Contraception
- The Uterus
- Erectile Dysfunction
- References and Further Reading
- 37 Bone metabolism
- Introduction
- Bone Structure and Composition
- Bone Remodelling
- Disorders of Bone
- Drugs Used in Bone Disorders
- Potential New Therapies
- References and Further Reading
- Section 4 Nervous system
- 38 Chemical transmission and drug action in the central nervous system
- Introduction
- Chemical Signalling in the Nervous System
- Targets for Drug Action
- Drug Action in the Central Nervous System
- The Classification of Psychotropic Drugs
- References and Further Reading
- 39 Amino acid transmitters
- Excitatory Amino Acids
- Glutamate
- γ-Aminobutyric Acid (GABA)
- Glycine
- Concluding Remarks
- References and further reading
- 40 Other transmitters and modulators
- Introduction
- Noradrenaline
- Dopamine
- 5-Hydroxytryptamine
- Acetylcholine
- Purines
- Histamine
- Other CNS Mediators
- A Final Message
- References and Further Reading
- 41 Neurodegenerative diseases
- Protein Misfolding and Aggregation in Chronic Neurodegenerative Diseases
- Mechanisms of Neuronal Death
- Ischaemic Brain Damage
- Alzheimer's Disease
- Parkinson's Disease
- Huntington's Disease
- Amyotrophic Lateral Sclerosis
- Spinal Muscular Atrophy
- Multiple Sclerosis
- References and Further Reading
- 42 General anaesthetic agents
- Introduction
- Mechanism of Action of Anaesthetic Drugs
- Intravenous Anaesthetic Agents
- Inhalation Anaesthetics
- Individual Inhalation Anaesthetics
- Balanced Anaesthesia
- References and Further Reading
- 43 Analgesic drugs
- Neural Mechanisms of Pain
- Analgesic Drugs
- References and further reading
- 44 Local anaesthetics and other drugs affecting sodium channels
- Local Anaesthetics
- Other Drugs That Affect Sodium Channels
- References and Further Reading
- 45 Anxiolytic and hypnotic drugs
- The Nature of Anxiety and Its Treatment
- Measurement of Anxiolytic Activity
- Drugs Used to Treat Anxiety
- Delayed Anxiolytic Effect of SSRIs and Buspirone
- Drugs Used to Treat Insomnia (Hypnotic Drugs)
- References and Further Reading
- 46 Antiepileptic drugs
- Introduction
- The Nature of Epilepsy
- Antiepileptic Drugs
- Muscle Spasm and Muscle Relaxants
- References and Further Reading
- 47 Antipsychotic drugs
- Introduction
- The Nature of Schizophrenia
- Antipsychotic Drugs
- Future Developments
- References and Further Reading
- 48 Antidepressant drugs
- The Nature of Depression
- Theories of Depression
- Antidepressant Drugs
- Clinical Effectiveness of Antidepressant Treatments
- Future Antidepressant Drugs
- Brain Stimulation Therapies
- Drug Treatment of Bipolar Disorder
- References and Further Reading
- 49 Psychoactive drugs
- Introduction
- Psychomotor Stimulants
- Cognition-Enhancing Drugs
- Psychedelic Drugs
- Ketamine and Related Drugs
- Depressants
- Tolerance and Dependence
- Synthetic Cannabinoids
- References and Further Reading
- 50 Drug abuse and dependence
- Drug Use and Abuse
- References and Further Reading
- Section 5 Drugs used for the treatment of infections and cancer
- 51 Basic principles of antimicrobial chemotherapy
- Background
- The Molecular Basis of Chemotherapy
- Resistance to Antibacterial Drugs
- Current Status of Antibiotic Resistance in Bacteria
- References and Further Reading
- 52 Antibacterial drugs
- Introduction
- Antibacterial Agents That Interfere With Folate Synthesis or Action
- β-Lactam Antibiotics and Other Agents That Interfere With Bacterial Wall or Membrane Synthesis
- Antimicrobial Agents Affecting Bacterial Protein Synthesis
- Antimicrobial Agents Affecting Topoisomerase
- Miscellaneous Antibacterial Agents
- Antimycobacterial Agents
- Possible New Antibacterial Drugs
- References and Further Reading
- 53 Antiviral drugs
- Background Information About Viruses
- The Host–Virus Interaction
- HIV and AIDS
- Antiviral Drugs
- Combination Therapy for HIV
- Prospects for New Antiviral Drugs
- References and further reading
- 54 Antifungal drugs
- Fungi and Fungal Infections
- Drugs Used to Treat Fungal Infections
- Future Developments
- References and Further Reading
- 55 Antiprotozoal drugs
- Background
- Host–Parasite Interactions
- Malaria and Antimalarial Drugs
- Amoebiasis and Amoebicidal Drugs
- Trypanosomiasis and Trypanocidal Drugs
- Other Protozoal Infections and Drugs Used to Treat Them
- Future Developments
- References and Further Reading
- 56 Antihelminthic drugs
- Helminth Infections
- Antihelminthic Drugs
- Resistance to Antihelminthic Drugs
- Vaccines and Other Novel Approaches
- References and Further Reading
- 57 Anticancer drugs
- Introduction
- The Pathogenesis of Cancer
- General Principles of Cytotoxic Anticancer Drugs
- Anticancer Drugs
- Future Developments
- References and Further Reading
- Section 6 Special topics
- 58 Harmful effects of drugs
- Introduction
- Classification of Adverse Drug Reactions
- Drug Toxicity
- Immunological Reactions to Drugs
- References and further reading
- 59 Lifestyle and drugs in sport
- What Are Lifestyle Drugs?
- Classification of Lifestyle Drugs
- Drugs and Sex
- Drugs in Sport
- Conclusion
- References and Further Reading
- 60 Drug discovery and development
- The Stages of a Project
- Biopharmaceuticals
- Commercial Aspects
- Future Prospects
- A Final Word
- References and Further Reading
- Index
- Language: English
- Edition: 9
- Published:
- Imprint: Elsevier
JR
James M. Ritter
Affiliations and expertise
Emeritus Professor of Clinical Pharmacology, King’s College London, and Medical Research Director, Quintiles, London, UKRF
Rod J. Flower
Affiliations and expertise
Professor, Biochemical Pharmacology, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London, UKGH
Graeme Henderson
Affiliations and expertise
Professor of Pharmacology, University of Bristol, Bristol, UKYL
Yoon Kong Loke
Affiliations and expertise
Senior Lecturer in Clinical Pharmacology, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UKDM
David MacEwan
Affiliations and expertise
Professor of Molecular Pharmacology/Toxicology & Head of Department, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United KingdomHR
Humphrey P. Rang
Affiliations and expertise
Emeritus Professor of Pharmacology, University College London, London, UK