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The Molecular Nutrition of Fats

  • 1st Edition - October 29, 2018
  • Latest edition
  • Editor: Vinood Patel
  • Language: English

The Molecular Nutrition of Fats presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell,… Read more

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Description

The Molecular Nutrition of Fats presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell, and their role in health and disease. Subject areas include molecular mechanisms, membranes, polymorphisms, SNPs, genomic wide analysis, genotypes, gene expression, genetic modifications and other aspects. The book is divided into three sections, providing information on the general and introductory aspects, the molecular biology of the cell, and the genetic machinery and its function. Topics discussed include lipid-related molecules, dietary lipids and lipid metabolism, high fat diets, choline, cholesterol, membranes, trans-and saturated fatty acids, and lipid rafts.

Other sections provide comprehensive discussions on G protein-coupled receptors, micro RNA, transcriptomics, transcriptional factors, cholesterol, triacylglycerols, beta-oxidation, cholesteryl ester transfer, beta-oxidation, lysosomes, lipid droplets, insulin mTOR signaling and ligands, and more.

Key features

  • Summarizes molecular nutrition in health as related to fats
  • Discusses the impact of fats on cancer, heart disease, dementia, and respiratory and intestinal disease
  • Includes preclinical, clinical and population studies
  • Covers the genome, the whole body and whole communities
  • Includes key facts, a mini dictionary of terms and summary points

Readership

Researchers, professionals (including nutritionists, dieticians, health scientists, health care professionals, policy makers), educators, and students

Table of contents

Section 1: General and Introductory Aspects

1. Intestinal health and bioactive lipids

2. C-reactive protein and plasma fatty acids: public health concerns and implications

3. The role of a fatty acid chain elongase, Elovl,1 in zebrafish and implications fcor human kidney

4. Dietary lipids and lipid metabolism: An overview

5. Fatty acids use in neurological disease

6. The Neurocan-cartilage intermediate layer protein NCAN-CILP2 region and plasma lipid levels

7. Role of cholesterol on controlling membrane phospholipid asymmetry

8. Adipose tissue and peritoneal dialysis

9. Lipid biomarkers and cancer

10. Absorption of dietary fat and their metabolism in enterocytes

11. The lipid-lowering action of iodothyronines

12. Dietary Omega-3s and Muscle Composition in adults

13. An overview of cholesterol absorption

14. Triacylglycerols and use of docosahexaenoic acid at the sn-2 position

15. Safety of Docosahexaenoic acid (DHA) ethyl ester and implications for human studies

16. Fish oil supplementation and depression

17. Drugs to counter SFA-mediated lipointoxication

18. Lipoprotein (a) [Lp(a)]

19. Endoplasmic reticulum (ER) stress, and white adipose tissue lipolysis

20. Trans-fat intake and behaviour

21. Glycemic index meal feeding and lipid profiling

22. Beef Fat

23. Lipid pathway in liver cells and its modulation by dietary extracts

Section 2: Molecular Biology of the Cell

24. Subcellular organelles: lipid droplets

25. Optimized omega-3 EPA:DHA 6:1 and pulmonary arterial hypertension

26. Omega-3 fatty acids and epilepsy

27. Docosahexaenoic acid (DHA): A dietary supplement with promising anticancer potential

28. Periaortic adipose tissue in obesogenic diets

29. Genomics, statins and lipid metabolism

30. Cholesterol metabolism in atherosclerosis development

31. Lipid metabolism in dyslipidemia and familial hypercholesterolemia

32. Lipid Profile of Progenitor Cells

33. Trans-fatty acids and mortality

34. Saturated and monounsaturated fatty acids associate with development and prematurity

35. Hedgehog signaling and liver lipid metabolism

36. Cyclosporin A-Induced Dyslipidemia and LDL Receptors

37. Hypoxia and adipose tissue lipid breakdown

38. Intramyocellular fat storage

Section 3: Genetic Machinery and Its Function

39. Fatty acid binding protein 2 genes and public health implications for diabetes

40. Transcriptional factor modulation by lipid peroxidation-derived aldehydes

41. Heterogeneity of white adipose tissue

42. Nomenclature, classes and functions of lipids and lipid-related molecules, Dietary lipids

43. Lipid metabolism: an overview - The mitochondria as a site of fatty acid beta-oxidation

44. Fatty acids, gut bacteria and immune cell function

Product details

  • Edition: 1
  • Latest edition
  • Published: November 1, 2018
  • Language: English

About the editor

VP

Vinood Patel

Vinood B. Patel, BSc, PhD, FRSC, is currently Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress in neurological disorders and iron dysregulation in diabetes. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. These books include The Handbook of Nutrition, Diet, and Epigenetics, Branched Chain Amino Acids in Clinical Nutrition, Cancer: Oxidative Stress and Dietary Antioxidants, Toxicology: Oxidative Stress and Dietary Antioxidants, Molecular Nutrition: Vitamins, The Neuroscience of Pain, Cognitive Behavioural Therapy. He is Editor of the ten-volume series Biomarkers in Disease: Methods, Discoveries and Applications.
Affiliations and expertise
Professor, Clinical Biochemistry, School of Life Sciences University of Westminster, London, UK

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