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Elsevier

Books in Life sciences

  • The Biochemistry of Poliomyelitis Viruses

    A Synopsis of Poliomyelitis Infection and Research
    • 1st Edition
    • Ernest Kovács
    • P. Alexander + 1 more
    • English
    The Biochemistry of Poliomyelitis Viruses deals with the interrelationships and differences of positions in the field of poliomyelitis research. This volume presents a general introduction to viruses as to their descriptions and biological, biochemical, and epidemiological aspects. Clinical poliomyelitis, test measurements in the cerebrospinal fluid, and the actions of the poliomyelitis virus are explained. The isolation of the poliomyelitis virus and some aspects of its immunology and serology through refinements of serologic tools and special techniques, plus the state of poliovirus purification, are noted. This book also gives assumptions about the virus' synthetic activities in vivo based on experiments conducted in other viral diseases other than the polio virus. This text also notes that important discoveries such as those made by Gierer and Schramm or Fraenkel-Conrat provide updated poliomyelitis research. Other research studies are taken into consideration and emphasis is given to the biochemical concept of the polio infection and the related features induced during infection such as the presence of tumors. The most promising trend in research is in the study of enzymes of infected cells leading to an understanding of the biochemistry of viral diseases. The use of inference microscopy and X-ray analysis of cell mass is recommended. This book will prove invaluable for microbiologists, disease investigators, clinical workers, and research scientists.

  • Vaccines

    New Approaches to Immunological Problems
    • 1st Edition
    • Ronald W. Ellis
    • English
    Vaccines: New Approaches to Immunological Problems presents the advances in the range of strategies and approaches for producing vaccines. The book is comprised of 20 chapters that cover the properties of different vaccines. The coverage of the text includes vaccines for cholera, malaria, helminth, and influenza. The book also discusses topics about the key elements of modern technologies that can be applied to different vaccines, such as active immunization strategies using anti-idiotypic antibodies; passive immunoprophylaxis with human monoclonal antibodies; and immunological adjuvants and their mode of action. The text will be of great use to scientists involved in the research and development of vaccines, such as molecular biologists, biochemists, and virologists.

  • Enzyme Chemistry of Phenolic Compounds

    Proceedings of the Plant Phenolics Group Symposium, Liverpool, April 1962
    • 1st Edition
    • J. B. Pridham
    • English
    Enzyme Chemistry of Phenolic Compounds documents the proceedings of the Plant Phenolics Group Symposium held at Liverpool on April 11-12 1962. This book focuses on the interaction of enzymes and phenolic compounds, oxidation-reduction systems in plants and microorganisms, and phenolase complex. Other topics discussed include purification of phenol oxidases; enzyme-substrate specificity in potato polyphenol oxidase; tocopherols; and role of ubiquinone and plastoquinone in plant metabolism. Hydrolytic enzymes; enzyme inhibition by phenolic compounds; tannin inhibition of plant mitochondria; and aromatic acid-reducing systems in fungi are also deliberated in this selection. This publication is beneficial to students and biochemists researching on enzyme and phenolic compounds.

  • Proceedings of the First International Congress of Parasitology

    Roma, 21-26 September 1964
    • 1st Edition
    • Augusto Corradetti
    • English

  • Urea as a Protein Supplement

    • 1st Edition
    • Michael H. Briggs
    • English
    Urea as a Protein Supplement presents the significant advances that have been made in ruminant nutrition. This book examines the role of the rumen flora and fauna as synthesizers of protein from non-protein nitrogen sources such as ammonium compounds and urea. Organized into four parts encompassing 23 chapters, this book starts with an overview of the use of urea and other non-protein nitrogen sources in ruminant nutrition. This text then explores the various methods that may be used for the preparation of urea, which involves the dehydration of ammonium carbamate produced by the reaction of carbon dioxide and ammonia at high pressure and temperature. Other chapters consider the ways in which urea could be utilized to increase protein supplies. The final chapter deals with the hydrolysis of urea by urease to ammonia and carbon dioxide, which has been used as a method for determining urea for many years. Agricultural scientists and farmers will find this book useful.

  • Proceedings of the Fifth International Seaweed Symposium, Halifax, August 25–28, 1965

    • 1st Edition
    • E. Gordon Young + 1 more
    • English

  • The Provision and Use of Library and Documentation Services

    Some Contributions from the University of Sheffield Postgraduate School of Librarianship
    • 1st Edition
    • W. L. Saunders
    • English
    The Provision and Use of Library and Documentation Services is a collection of papers that deals with library interdependent considerations of use and service. One paper discusses the value, organization, and exploitation of trade literature, citing the importance of maintaining a file of trade catalogues to narrow the gap between industrial activity and academic research. Another paper reports a high library membership (80% - 100%) on a survey of library provision and services in four correctional institutions in London. The author notes that professional advice should also be available to help the prisoner read effectively. One author reviews the library services for undergraduates particularly problems of inadequate services and facilities. Other authors discuss the pattern of borrowing in several libraries which generalizes the borrowing behavior of academic communities, such as the rising levels of foreign language and "off-subject" borrowing. Of interest is one author's analysis of the way scientists use libraries in terms of finding information, reading, and use of facilities. His conclusion: scientists have no clear-cut opinion on the best method of acquiring information. This book is suitable for librarians, administrators of private or public library systems, for students and academicians in the field of library science.

  • The Evolution of the Microscope

    • 1st Edition
    • S. Bradbury
    • English
    The Evolution of the Microscope covers some of the features of the history of the microscope and the rationale of the design features found in microscopes. The book discusses the first microscopes, the compound microscope in England (1650-1750), simple or single-lens microscopes, and the development of the achromatic microscope. The text also describes the microscope in Victorian times as well as the optical microscope since 1880. The search for greater resolving power such as the ultra-violet and electron microscopes is considered. Scientists and microscopists will find the book invaluable.

  • The Separation and Isolation of Proteins

    a Laboratory Manual of Analytical Methods of Protein Chemistry (Including Polypeptides)
    • 1st Edition
    • P. Alexander + 1 more
    • English
    A Laboratory Manual of Analytical Methods of Protein Chemistry (Including Polypeptides), Volume 1: The Separation and Isolation of Proteins deals with the techniques used in the separation and isolation of proteins, including fractionation and characterization by dialysis, multi-membrane electrodecantation, and zonal density gradient electrophoresis. The fractionation of proteins by adsorption and ion exchange is also described. This book is comprised of seven chapters and begins with a discussion on procedures for the separation of proteins, paying particular attention to the liberation of proteins from cellular material; removal of lipids from lipoproteins; and denaturation, fractionation, and purification of proteins. The next chapter focuses on the isolation of biologically active proteins such as cytochrome, bacterial amylases, and bacterial proteinases. The reader is methodically introduced to fractionation of proteins by adsorption and ion exchange; fractionation and characterization by dialysis; multi-membrane electrodecantation; and continuous and discontinuous partition. The final chapter explains how zonal density gradient electrophoresis works as a separation method for natural mixtures of proteins, their degradation products, and other substances carrying electric charges in solution or suspension. This volume will be of interest to chemists working with proteins.

  • Brucellosis

    • 1st Edition
    • M. Monir Madkour
    • English
    Brucellosis presents an overview of the conditions associated with the subject matter. It discusses the disease of protean manifestations affecting all types of tissues and organs in the body. It addresses the different facet of the disease studied in isolation. Brucellosis is a zoonotic disease common around the world. Some of the topics covered in the book are the historical origin of different species of Brucella strain; epidemiological features of brucellosis; occupational hazards of working in the meat processing environment; identification and taxonomy of bacteria carrying the Brucella strain; and methods for the identification of cultures. The pathology and immunology of brucellosis in humans are fully covered. The histopathological aspects of the brucella organisms are discussed in detail. The text describes in depth the cardiovascular complications of the disease. The diagnosis of brucella thrombophlebitis is completely presented. A chapter is devoted to the respiratory and gastrointestinal manifestations of brucella organisms. The book can provide useful information to veterinarians, doctors, chemists, students, and researchers.

  • Woman's Change of Life

    • 1st Edition
    • Isabel Hutton
    • English
    Woman's Change of Life provides information pertinent to the nature of the menopause and the climacteric is provided. This book presents an outline of a way of life suitable for the important phase in climacteric. Organized into 10 chapters, this book begins with an overview of the prevailing ignorance and fear that surround the whole subject of menopause. This text then provides advice for living and working according to a simple hygienic routine during any trying phase that may arise and thus make it possible to lead a full and efficient life throughout the menopause. Other chapters describe how women can keep fit by means of a wise diet, hydrotherapy, and exercise. This book discusses as well the aspect of marital life in its relation to the climacteric. The final chapter describes the normal climacteric symptoms and explains the necessity of seeking a doctor's help. This book is a valuable resource for physicians and women.

  • Haematin Enzymes

    A Symposium of the International Union of Biochemistry Organized by the Australian Academy of Science Canberra
    • 1st Edition
    • J. E. Falk + 2 more
    • English
    International Union of Biochemistry, Volume 19: Haematin Enzymes, Part 1 provides information pertinent to the fundamental aspects of hematin enzymes. This book covers a variety of topics, including porphyrin complexes, chemical reactions of iron complexes, hemoprotein molecules, metalloporphyrins, and oxyhemoglobins. Organized into 22 chapters, this volume begins with an overview of the relevance of magnetic susceptabilitty and magnetic resonance data. This text then examines studies on electron-transfer processes involving metal ions and shows how the electronic structures of the hem enzymes may be relevant to the types of electron-transfer that can take place. Other chapters consider the implications of the coordination of organic molecules to metal ions. This book presents as well a comparison between known properties and reactions of some simple iron complexes with chelating and conjugated ligands. The final chapter deals with the chemical structures of the prosthetic groups of the cytochromes of type a. This book is a valuable resource for scientists, theorists, and research workers.

  • Studies of the Development and Decay of the Human Frame

    • 1st Edition
    • Joseph Trueta
    • English
    Studies of the Development and Decay of the Human Frame provides information pertinent to the development of human skeleton. This book presents the study of the nature and reactions of the living tissues that constitute the skeleton. Organized into four parts encompassing 40 chapters, this book begins with an overview of the origin and characteristics of the chondroblast. This text then presents the investigations on the vascular characteristics of the blood supply in bone under variable experimental conditions. Other chapters consider the early descriptions of calcification, its role in osteogenesis, and the belief that calcification is a prerequisite to the laying down of bone. This book discusses as well the vascular anatomy of bone and the development of the nutrient arteries. The final chapter deals with the close origin and independence from the earliest stage of development of vessels and muscles on the one hand and bones and joint on the other. This book is a valuable resource for orthopedic surgeons.

  • The Chemistry and Metabolism of Drugs and Toxins

    An Introduction to Xenobiochemistry
    • 1st Edition
    • Michael Briggs + 1 more
    • English
    The Chemistry and Metabolism of Drugs and Toxins: An Introduction to Xenobiochemistry covers all chemical aspects of the interaction between an organism and foreign compounds. This book provides information pertinent to the fundamental aspects of human xenobiochemistry. Organized into four chapters, this book begins with an overview of the commonly used substances and mentions their actions and side-effects. This text then explains the various classes of pharmaceutical products and discusses the interactions between foreign compounds that may be of clinical significance. Other chapters consider the metabolism of selected pharmaceuticals and examine the addition of foreign compounds to foods as flavors, colors, etc. This book discusses as well the metabolism of food carcinogens as well as the metabolism of food toxins. The final chapter deals with the different enzymic activities in snake venoms. This book is a valuable resource for biologists, biochemists, microbiologists, pharmacologists, organic chemists, research scientists, and research workers.

  • Immunology in Clinical Medicine

    • 3rd Edition
    • J. L. Turk
    • English
    Immunology in Clinical Medicine is an introduction to immunology in clinical medicine, with emphasis on immunological concepts underlying disease processes. The effect of drugs known to suppress immunological processes are considered especially in relation to whether they operate by really suppressing immunological processes or whether they have other actions. Comprised of 17 chapters, this book begins with an overview of the nature of the immune response, followed by a discussion on reactionS in the tissues mediated by humoral antibodies. The reader is then introduced to reactions in the tissues caused by the cell-mediated immune response; immunological processes in infective diseases; and the concept of autoimmunity and its relation to disease. Subsequent chapters focus on the immunology of diseases such as cancer, skin diseases, connective tissue diseases, and diseases of the intestinal tract, respiratory tract, liver, and amyloidosis. The final chapter is devoted to the role of the clinical immunologist in patient care and therapy. This monograph is intended for students and practitioners of clinical medicine.

  • The Status of Enzymes and Hormones in Therapy

    • 1st Edition
    • G. F. Walker
    • English
    The Status of Enzymes and Hormones in Therapy reviews the status of therapy with enzymes and hormones, with emphasis on endocrine preparations of thyroid and parathyroid, ovarian hormones, pituitary hormones, thymus, and suprarenal glands as well as testis, spleen, brain and muscle tissue, and other organs such as the bile and placenta. The landmarks used are the British Pharmacopoeia, the British Pharmaceutical Codex published in September 1934, and clinical records selected from the literature. Comprised of two chapters, this book begins with an introduction to endocrine therapy, focusing on the need for clinicians to properly assess the clinical potency of the remedies they use based on considerations such as whether they clearly recognize in their patient a hormonic lack, or whether the preparation is smoothly active when administered by the route they propose. The second chapter deals with various endocrine preparations, including commercial preparations of thyroid; ovarian and pituitary hormones; stomach; pancreas; bone marrow; hemoglobin; and pineal, mammary, lymphatic, and prostate glands. This monograph is intended for clinicians interested in the therapeutic uses of enzymes and hormones.

  • An Introduction to Parasitology

    • 1st Edition
    • John M. Watson
    • J. B. Stenlake
    • English
    Pharmaceutical Monographs, Volume 2: An Introduction to Parasitology focuses on the principles, methodologies, and approaches involved in parasitology, including treatment, infections, and parasitism. The book first offers information on the nature of parasitism, characteristics of parasites, relationship of parasites to hosts, physiology and ecology of parasites, infection, transmission and dissemination of parasites, and resistance and immunity to parasitic infections. The text then examines protozoology and helminthology. Discussions focus on the nature and classification of parasitic worms, biology of parasitic worms, pathogenic effects of parasitic worms, and nature and classification of Protozoa. The manuscript ponders on entomology, malacology, and diagnosis, treatment, and prevention. Topics include classification of mollusks, bionomics and control, nature and classification of Arthropoda of medical and veterinary importance, mosquitoes, bugs, fleas, and mites and ticks. The publication is a vital reference for researchers interested in parasitology.

  • Human Chromosomes

    An Illustrated Introduction to Human Cytogenetics
    • 1st Edition
    • Audrey Bishop + 1 more
    • English
    Human Chromosomes: An Illustrated Introduction to Human Cytogenetics focuses on the processes, methodologies, and approaches involved in the study of human chromosomes. The publication first offers information on the cell and its activity, particularly noting that the cell is the basic unit that forms the organs and tissues of the human body. The differentiation of cells and the process of cell division are discussed. The text then focuses on the culture of human cells for the investigation of the chromosomes. The book elaborates on the identification of human chromosomes, including further methods of identification and the use of radioactive isotopes. The publication also ponders on the numerical changes in the karyotype, structural changes, and X chromosomes. Discussions focus on the processes of mitosis and meiosis, translocation, deletion, duplication, and ring formation, and the behavior, transformation, and characteristics of X chromosome. The text is a valuable reference for researchers interested in the study of human chromosomes.

  • An Introduction to Microbiology for Nurses

    • 3rd Edition
    • N. A. Simmons
    • English
    An Introduction to Microbiology for Nurses is an introductory text on microbiology for nurses, written in simple language and restricting those sections on the fundamentals of bacteriology (for example, the physiology of bacteria) to a minimum. Instead of presenting systematic bacteriology and describing organisms genus by genus, disease-causing bacteria are considered together in each particular part of the human body. Only the common and important infections are included. Comprised of 16 chapters, this book begins with a historical background on bacteriology, followed by a discussion on the biology of bacteria. A classification of bacteria is then presented, and infections caused by bacteria are described. Subsequent chapters focus on body defenses against bacterial infections; killing of bacteria through disinfection and sterilization; antibacterial therapy; and collection of bacteriological specimens as part of bacteriological diagnosis. Infections of the respiratory tract, gastrointestinal tract, and the nervous system are also analyzed. The final chapter is devoted to elementary parasitology. This monograph is intended for nurses interested in learning more about microbiology and bacteriology.

  • Essentials of ABO -Rh Grouping and Compatibility Testing

    Theoretical Aspects and Practical Application
    • 1st Edition
    • W. John Lockyer
    • English
    Essentials of ABO-Rh Grouping and Compatibility Testing: Theoretical Aspects and Practical Application focuses on overall safety in blood transfusion, including accurate ABO and Rh-D grouping of both patient and donor. The book first elaborates on the ABO blood group system and the Rh blood group system and hemolytic disease of the newborn. Discussions focus on the Rh-D antigen, Rh genotyping, Rh testing of blood donors and recipients of blood, antenatal and postnatal serology in cases other than Rh and ABO hemolytic disease, selection and preparation of Rh anti-D grouping reagent, dangerous group O donor blood, alternative sources of anti-A and anti-B blood grouping reagent, and development of the A and B red cell antigens. The manuscript then takes a look at compatibility testing (crossmatching) and transfusion reaction investigations, as well as compatibility testing and preparation of blood for patients with antibodies to serum proteins; compatibility testing of patients with known irregular antibodies; non-urgent compatibility testing of blood; and compatibility testing for patients requiring platelets. The publication takes a look at practical procedures, including grades of agglutination, control of anti-human globulin serum, preparation of low ionic strength saline, and preparation of platelet concentrates. The text is a valuable source of information for researchers interested in ABO-Rh grouping and compatibility testing.

  • MCQ Tutor for Students of Microbiology

    • 1st Edition
    • John Gordon
    • English
    MCQ Tutor for Students of Microbiology provides a series of multiple choice questions with annotated answers, mainly in bacteriology but also including parasitology, virology, and immunology. This book focuses on clinical applications. Organized into four parts, this book begins with an overview of the pre-clinical aspects of microbiology and host defense mechanisms. This text then deals with microbial systematics as well as the detailed properties of the various microorganisms. Other parts cover the nature and manifestation of a wide spectrum of infective diseases. This book discusses as well the laboratory diagnosis, treatment, and prevention of infective diseases. The final part deals with other examples of other forms of multiple choice question. This book is intended to be suitable for medical students in the second and third undergraduate years as an aid to preparation for their third MB examination. Students of medical and laboratory sciences as well as candidates for diploma and college examinations will also find this book useful.

  • An Introduction to Microbiology

    Pharmaceutical Monographs
    • 2nd Edition
    • W. B. Hugo
    • J. B. Stenlake
    • English
    Pharmaceutical Monographs, Second Edition, Volume 1: An Introduction to Microbiology provides information pertinent to the behavior of cells during growth and considers the factors affecting growth. This book discusses the relevance of cell growth to applied aspects of bacteriology. Organized into four chapters, this edition begins with an overview of the main features of the anatomy of the bacterial cell. This text then presents the chemical reactions that occur in the bacterial cell and are responsible for the breakdown of food supplies. Other chapters consider the synthesis of new cells and the formation of by-products, which are catalyzed by enzymes. This book discusses as well the properties and cultivation of the more important organisms encountered in medicine and pharmacy. The final chapter deals with the methods for the identification of the common medical bacteria. This book is a valuable resource for undergraduate students of pharmacy and allied subjects. Bacteriologists and microbiologists will also find this book useful.

  • Immunological and Blood Products

    Pharmaceutical Monographs
    • 1st Edition
    • Mary Dawson + 1 more
    • J. B. Stenlake
    • English
    Pharmaceutical Monographs, Volume 5: Immunological and Blood Products provides an introduction to immunology and immunological products. This monograph describes various tissue culture techniques, which are important both in the preparation and standardization of certain immunological products. Organized into two parts encompassing 13 chapters, this volume begins with an overview of the types of immunity. This text then examines the substances which when introduced parenterally into the tissues, stimulates the production of an antibody. Other chapters consider antibodies as substances appearing in the blood or body fluids in response to the stimulus provided by the introduction of an antigen. This monograph discusses as well the preparations capable of stimulating active immunity. The final chapter deals with the causation of hemolytic disease of the newborn. This monograph is a valuable resource for medical students as well as undergraduate students of pharmacy. Students of veterinary medicine will also find this book extremely useful.

  • The Peptides

    Volume II Synthesis, Occurrence, and Action of Biologically Active Polypeptides
    • 1st Edition
    • Eberhard Schröder + 1 more
    • English
    The Peptides, Volume II: Synthesis, Occurrence, and Action of Biologically Active Polypeptides focuses on the synthesis of biologically active polypeptides and analogues. The publication first offers information on linear peptides and heterodetic cyclic peptides. Discussions focus on depsipeptides, polycyclic and monocyclic disulfides, naturally occurring biologically active peptides, glandular hormones, and tissue hormones. The text then ponders on homodetic cyclic peptides, including homodetic cyclic homomeric peptide antibiotics, polycyclic biologically active polypeptides, and homodetic cyclic heteromeric peptide antibiotics. The manuscript takes a look at the problems related with the synthesis of biologically active polypeptides, giving emphasis to a number of movements which elaborated on the matter and the advancements of preparative techniques and approaches leading to the purification of intermediates and end products. The publication is a valuable reference for researchers interested in the occurrence, synthesis, and action of biologically active polypeptides.

  • A Text-Book of Medical Bacteriology

    • 1st Edition
    • R. W. Fairbrother
    • English
    A Text-Book of Medical Bacteriology provides information pertinent to the medical aspects of bacteriology. This book presents the biological relationship of allied organisms. Organized into three parts encompassing 37 chapters, this book begins with an overview of the salient features of the development of bacteriology. This text then explores the food requirements of the bacteria as well as the elements necessary for the synthesis of the bacterial protoplasm. Other chapters consider the numerous and complex factors involved in the reproduction of bacteria. This book discusses as well the presence of antitoxins in the serum of an individual, which is an indication of increased resistance to infection with the homologous organism. The final chapter deals with serological reactions that are most widely used, including agglutination, precipitation, and complement-fixation. This book is a valuable resource for medical students, physicists, bacteriologists, chemists, biochemists, and research workers.

  • Chemistry and Methods of Enzymes

    • 3rd Edition
    • James B. Sumner + 1 more
    • English
    Chemistry and Methods of Enzymes, Third Edition focuses on the processes, methodologies, and reactions in enzyme chemistry, as well as kinetics, nucleases, esterases, and carbohydrates. The publication first underscores the general properties of enzymes, including chemical nature, occurrence, numerical characterization of enzyme concentration, kinetics of enzyme reactions, preparation of commercial enzymes, purification and preservation of enzymes, relations of vitamins to enzymes, and zymogens and kinases. The text then takes a look at esterases and carbohydrates. Topics include pectin depolymerase, heparinase, xylanase, chitinase, dextranase, trehalase, nucleotide phosphatases, glucosulfatase, and gastric lipase. The manuscript examines nucleases, nuclein deaminases, amidases, proteolytic enzymes, and hydrases. Discussions focus on enolase, aconitase, peptidases as metalloproteins, glutaminases, aspartase, urease, adenosine deaminase, and nucleoside phosphorylase. The book also elaborates on iron and copper enzymes, dehydrogenases containing coenzymes I and II, and yellow enzymes. The text is a dependable source of data for chemists and researchers wanting to dig deeper into the chemistry and methods of enzymes.

  • Gel Electrophoresis of Proteins

    • 1st Edition
    • Michael J Dunn
    • English
    Gel Electrophoresis of Proteins focuses on the techniques, methodologies, reactions, and approaches involved in gel electrophoresis of proteins. The selection first covers steady-state gel electrophoresis systems and one-dimensional PAA-gel electrophoretic techniques to separate functional and denatured proteins. Discussions focus on affinity electrophoresis, structure and physico-chemical properties of polyacrylamide gels, moving boundary electrophoresis, isotachophoresis, fundamental steady-state electrophoresis systems, and fundamental properties of steady-state electrophoresis systems. The text then reviews conventional isoelectric focusing and immobilized pH gradients and high resolution two-dimensional polyacrylamide-gel electrophoresis. Topics include production of narrow pH gradients, extended pH gradients, polymerization kinetics, IEF in agarose matrices, titration curves, two-dimensional electrophoresis under non-denaturing conditions, and IEF in polyacrylamide matrices. The book tackles quantifying patterns from two-dimensional PAGE, protein staining and detection methods, and immunoelectrophoreti... methods. Concerns include post-electrophoretic organic protein stains, silver and enzyme stains, detection of radioactive proteins, and programming languages. The selection is highly recommended for researchers wanting to conduct studies on gel electrophoresis of proteins.

  • Chemical Pathways of Metabolism

    • 1st Edition
    • David M. Greenberg
    • English
    Chemical Pathways of Metabolism, Volume I focuses on the chemical steps involved in the metabolism of the major constituents of living organisms. The selection first elaborates on free energy and metabolism, enzymes in metabolic sequences, and glycolysis. Discussions focus on comparative biochemistry of glycolysis, enzymes of the glycolytic cycle, oxidative conversion of glucose to tetrose, transmethylation, and free energy and its determination. The manuscript then examines the tricarboxylic acid cycle and other pathways of carbohydrate metabolism. The text ponders on the biosynthesis of complex saccharides, including mechanisms of disaccharide formation, syntheses of branched polysaccharides, synthesis of levan from sucrose, and reversibility reactions by hydrolytic enzymes. The publication then elaborates on fat metabolism and acetoacetate formation and sterol and steroid metabolism. Topics include androgens, sterols, phospholipides or phosphatides, path of fat absorption, and theories of fatty acid breakdown and acetoacetate formation. The selection is a dependable reference for researchers interested in the chemical pathways of metabolism.

  • A Text - Book of Bacteriology

    • 4th Edition
    • R. W. Fairbrother
    • English
    A Textbook of Bacteriology, Fourth Edition provides information pertinent to the medical aspects of bacteriology. This book presents the importance of sulfonamide compounds in the treatment of many bacterial diseases. Organized into three parts encompassing 38 chapters, this edition begins with an overview of the salient features of the development of bacteriology. This text then explores the food requirements of the bacteria as well as the elements necessary for the synthesis of the bacterial protoplasm. Other chapters consider the numerous and complex factors involved in the reproduction of bacteria. This book discusses as well the presence of antitoxins in the serum of an individual, which is an indication of increased resistance to infection with the homologous organism. The final chapter deals with serological reactions that are most widely used, namely, agglutination, precipitation, and complement-fixation. This book is a valuable resource for medical students, physicists, bacteriologists, chemists, biochemists, and research workers.

  • Bacteriology for Nurses

    • 2nd Edition
    • Geoffrey A. Taylor
    • English
    Bacteriology for Nurses provide nurses and others who are associated with medicine with a simple outline of basic bacteriology and the applications of bacteriology to medicine and to nursing. The fundamentals of medical bacteriology, namely the anatomy and physiology of bacteria, infection, and the body defenses against infection are discussed. The bacteria which cause common diseases of various sites in the body, such as the respiratory tract and the gastrointestinal tract, are considered together. Only common and important infections are included. Comprised of 15 chapters, this book begins with a historical background on bacteriology, followed by a discussion on the biology of bacteria. A classification of bacteria is then presented, and infections caused by bacteria are described. Subsequent chapters focus on body defenses against bacterial infections; rickettsiae and viruses; pyogenic and chronic bacterial infections; and collection of bacteriological specimens as part of bacteriological diagnosis. Infections of the respiratory tract, gastrointestinal tract, and the nervous system are also analyzed. The final chapter is devoted to elementary parasitology. This monograph will be of interest to nurses as well as immunologists, bacteriologists, pathologists, physiologists, clinicians, and research workers in the field of medicine.

  • The Kidney

    Morphology, Biochemistry, Physiology
    • 1st Edition
    • Charles Rouiller + 1 more
    • English
    The Kidney: Morphology, Biochemistry, Physiology, Volume I focuses on present knowledge about the kidney under normal and pathological conditions, as manifested by morphological, biochemical, and physiological studies. The selection first takes a look at the embryonic kidney and the general anatomy and histology of the kidney. Discussions focus on the morphogenesis of transient kidneys, physiology of the fetal nephron, renal malformations, vascularization of the kidney, uriniferous tubules, and innervation of the kidney. The book then examines the histochemistry of the kidney and ultrastructure of the normal and pathological glomerulus. The manuscript ponders on electron microscopy of uriniferous tubules and ultrastructural pathology of tubules and interstitial tissue. Topics include proximal convoluted tubule, basement membranes of the tubules, capillaries, interstitial cells, morphology and functions of the tubular epithelium, fixation and preparation of tissues for electron microscopy, and structure of the submammalian vertebrate tubule. The selection is highly recommended for morphologists, biochemists, physiologists, pathologists, pharmacologists, and clinicians.

  • Physical and Chemical Methods

    Methods in Immunology and Immunochemistry, Vol. 2
    • 1st Edition
    • Curtis A. Williams + 1 more
    • English
    Methods in Immunology: Volume II, Physical and Chemical Methods is a collection of papers dealing with electrophoresis, analytical ultracentrifugation, dialysis, ultrafiltration, cellulose ion exchangers, and chromatographic separation of macromolecules on porous gels. Some papers explain the applications of radioisotopes, optical analysis, and chemical analysis of proteins, carbohydrates, lipids, and nucleic acid. One paper describes the theory of electro-migration. Factors such as electrical charge or frictional coefficients govern the rate of migration of charged particles in an electric field. The differences found in their velocities can be used to separate substances or analyze them. Mobility is a characteristic property of molecules and can also be influenced by the composition of the medium or solution. Dialysis separates solvents too large to diffuse through a barrier from smaller solutes; ultrafiltration (reverse osmosis) forces solvent and solutes up to a certain critical size through the barrier by a high pressure on one side. The book notes that the membrane never becomes plugged in dialysis because of some opposite movement of the solvent. Another paper points out that the significance of radioactive tracers in immunochemistry employed to identify and label macromolecules functioning as antigens and antibodies. The collection can prove valuable to bio-chemists, cellular biologists, micro-biologists, developmental biologists, and scientists involved in immunological research.

  • Polysaccharides Peptides and Proteins

    Pharmaceutical Monographs
    • 1st Edition
    • R. T. Coutts + 1 more
    • J. B. Stenlake
    • English
    Pharmaceutical Monographs, Volume 4: Polysaccharides Peptides and Proteins provides information pertinent to a wide variety of naturally-occurring macromolecules that are either peptide, protein, or polysaccharide in nature, which are important as medicinal and pharmaceutical agents. This monograph presents the basic physical and chemical properties of polysaccharides. Organized into four chapters, this volume begins with an overview of the pharmaceutical importance of the class of compounds known as polysaccharides. This text then provides data on the structure of the polysaccharides that is obtained by isolating and identifying the product formed on hydrolysis of the molecule itself. Other chapters consider plant gums and mucilages as important medicinal and pharmaceutical products. This monograph discusses as well the autohydrolysis of gum arabic. The final chapter deals with the clinical applications of various peptide-type antibiotics. This monograph is a valuable resource for undergraduate students of pharmacy and allied subjects.

  • Normal and Malignant Cell Growth

    Recent Results in Cancer Research: Fortschritte der Krebsforschung, Progrès dans les Recherches sur le Cancer
    • 1st Edition
    • R. J. M. Fry + 2 more
    • English
    Normal and Malignant Cell Growth is a compendium of papers from the "Proceedings of the Third Cancer Training Grant" of the University of Chicago that deals with the processes associated with malignant neoplasia, as well as the cell proliferation kinetics of normal tissues. One paper presents the techniques used in the study on the proliferation kinetics of hemopoietic stem cells, suggesting that the hemopoietic stem cell population is not homogenous but consists of a "primitive pluripotential stem cell." A series of experiments at the Brookhaven National Laboratory investigates the relationship of cell survival, specifically that of stem cells, to the survival of the irradiated test animal. One result of the experiment shows a rapid migration of a number of stem cells from shielded marrow into unshielded marrow at the pressure of a rapid circulating pool. The numbers of stem cells are somewhat dependent on the dose given to the unshielded marrow, and are greater with the greater dose. Another paper also investigates the four methods that are used in the study of cellular kinetics in human tumors. This compendium can prove helpful for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.

  • Immunological Methods

    Volume IV
    • 1st Edition
    • Ivan Lefkovits + 1 more
    • English
    Immunological Methods, Volume IV provides information pertinent to the methods in immunological research. This book focuses on cells, clones, and cell lines, as well as on their components and secreted products. Organized into 21 chapters, this volume begins with an overview of hybridoma methodology as the most celebrated immunological method. This text then discusses cell fusion, hybridoma technology, and everything related to monoclonal antibodies. Other chapters consider another molecular biology method, which describes the procedure required for establishing a partitioned cDNA-library. This book provides as well a comprehensive analysis of mRNA populations in which every messenger species appears as a distinct element, and so provides accurate answers to questions concerning genetic complexity. The final chapter provides an example of how transgenic mice can be used to study the development of T cell repertoires. This book is a valuable resource for cell biologists, scientists, immunologists, and research workers.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske
    • English
    The Alkaloids: Chemistry and Physiology, Volume V: Pharmacology deals with the chemistry and pharmacology of the alkaloids. This book discusses the general pharmacology of morphine, cryptopine-like compounds, toad poisons, and respiratory stimulants. The appraisal of the utility of alkaloids as antimalarials, uterine stimulants, metabolism of cocaine, and optical isomerism-activity relationship are also elaborated. This publication likewise covers the parasympathetic blocking agents as mydriatics, methods of measuring mydriatic activity, alkaloids exhibiting curariform activity, and minor alkaloids of unknown structure. Other topics include the fate of morphine, tropane group, factors affecting cocaine anesthesia, and sympathomimetic mydriatics. This volume is intended for chemists and pharmacologists concerned with alkaloids.

  • Immunocytochemistry

    Practical Applications in Pathology and Biology
    • 1st Edition
    • Julia M. Polak + 1 more
    • English
    Immunocytochemistry: Practical Applications in Pathology and Biology focuses on the processes, principles, methodologies, and approaches involved in the applications of immunocytochemistry in pathology and biology. The selection first takes a look at the development and scope of immunocytochemistry; techniques and practice used in immunocytochemistry; and raising and testing antibodies for immunocytochemistry. The book then ponders on raising antibodies to small peptides, use of semithin frozen sections in immunocytochemistry, and colloidal gold probes in immunocytochemistry. Discussions focus on the production of gold probes, localization of mouse serum albumin in the mammary gland, immunogens and the immune response, production of antisera, and antibody specificity in immunocytochemistry. The publication takes a look at double immunoenzymatic labelling, lectin histochemistry, immunocytochemical localization of noradrenaline, adrenaline, and serotonin, and immunocytochemistry of cell and tissue cultures. Immunocytochemistry in endocrine pathology and indirect immunofluorescence in the study and diagnosis of organ-specific autoimmune diseases are also discussed. The selection is a dependable source of information for researchers interested the practical applications of immunocytochemistry in pathology and biology.

  • Determination of the Size and Shape of Protein Molecules

    A Laboratory Manual of Analytical Methods of Protein Chemistry (Including Polypeptides), Vol. 3
    • 1st Edition
    • P. Alexander + 1 more
    • English
    Analytical Methods of Protein Chemistry, Volume 3: Determination of the Size and Shape of Protein Molecules provides information pertinent to the analysis and isolation of protein. This book deals with the measurement of the macromolecular properties of proteins. Organized into seven chapters, this volume begins with an overview of the theory and practice of the electron microscope to allow an understanding of the type of object that may be examined. This text then describes the methods of making protein molecules conform to such an ideal, which are the techniques of specimen preparation. Other chapters consider the determinations of osmotic pressures of proteins. This book discusses as well the experimental basis for the theory of the diffusion process in liquids. The final chapter deals with the technical problem characteristics of light-scattering. This book is a valuable resource for electron microscopists, protein chemists, biologists, physicist, physico-chemists, scientists, and research workers.

  • Proceedings of the First International Congress of Parasitology

    Roma, 21-26 September 1964
    • 1st Edition
    • Augusto Corradetti
    • English
    Proceedings of the First International Congress of Parasitology, Volume One focuses on the advancements of processes, methodologies, approaches, and reactions involved in parasitology. The selection first offers information on the role of molluscan hosts in trematode speciation; ecological analysis of the fluke fauna of birds in the USSR; digenetic trematodes of fishes as indicators of the ecology, phylogeny, and zoogeography of their hosts; and aspects of the biology of a monogenean skin parasite. The text then examines bacterial flora as one of the etiological factors influencing the establishment of parasites in the bowel of their host, responses of helminths to temperature gradients, and reservoir parasitism in helminths. The publication takes a look at the physical and biochemical characteristics of helminth glycogens; effect of insulin on glucose uptake and glycogen synthesis in the liver fluke Fasciola hepatica L.; regulation of glycogen synthesis in the liver fluke Fasciola hepatica L.; and changes in catalase activity during embryonation of Ascaris eggs and its relationship to respiration and cytochrome oxidase activity. The selection is a vital reference for researchers interested in parasitology.

  • Biochemistry and Physiology of Protozoa

    • 1st Edition
    • André Lwoff
    • English
    Biochemistry and Physiology of Protozoa, Volume I focuses on the chemical and physiological features of Protozoa, including nutrition, metabolism, and growth of phytoflagellates, Trypanosomidae and Bodonidae, biochemistry of ciliates and Plasmodium, and the influence of antimalarials. The selection first offers information on the biochemistry of Protozoa and phytoflagellates, including sexuality in Chlamydomonas, growth factors and chemical asepsis, descriptive chemistry and phylogenetic relationships, evolutionary aspects of photosynthesis, nutrition and biochemistry of Protozoa, and the biochemical evolution of Protozoa. The text then ponders on the nutrition of parasitic flagellates and metabolism of Trypanosomidae and Bodonidae. The publication takes a look at the nutrition of parasitic amebae, biochemistry of Plasmodium and the influence of antimalarials, and the biochemistry of ciliates in pure culture. Topics include carbon metabolism and respiration, nitrogen metabolism, antimalarial compounds and their influence on the metabolism of malarial parasites, metabolism of malarial parasites, and nutrition of the dysentery ameba, Entamoeba histolytica. The selection is a valuable reference for cytologists, geneticists, and pathologists interested in the biochemistry and physiology of protozoa.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske + 1 more
    • English
    The Alkaloids: Chemistry and Physiology, Volume IV contains an account of the chemistry and biosynthesis of the various classes of isoquinolines. This book discusses the extraction and separation of the anhalonium alkaloids, other natural simple isoquinolines, and anhalonium isoquinolines. The location of the alkaloids in tissues of the cacti, monophenolic bases of the laudanosine type, and extraction of cactus alkaloids are elaborated in detail. This text also describes the several types of alkaloids such as protoberberine, aporphine, protopine, phthalideisoquinolin... and bisbenzylisoquinolin... The cularine, a-naphthaphenanthrid... erythrophleum, aconitum, and delphinium alkaloids are likewise included. This publication is recommended for chemists, specialists, and students interested in isoquinolines.

  • Recombinant DNA Laboratory Manual

    • 1st Edition
    • Judith W. Zyskind + 1 more
    • English
    Recombinant DNA Laboratory Manual is a laboratory manual on the fundamentals of recombinant DNA techniques such as gel electrophoresis, in vivo mutagenesis, restriction mapping, and DNA sequencing. Procedures that are useful for studying either prokaryotes or eukaryotes are discussed, and experiments are included to teach the fundamentals of recombinant DNA technology. Hands-on computer sessions are also included to teach students how to enter and manipulate sequence information. Comprised of nine chapters, this book begins with an introduction to bacterial growth parameters, how to measure bacterial cell growth, and how to plot cell growth data. The discussion then turns to the isolation and analysis of chromosomal DNA in bacteria and Drosophila; plasmid DNA isolation and agarose gel analysis; and introduction of DNA into cells. Subsequent chapters deal with Tn5 mutagenesis of pBR329; DNA cloning in M13; DNA sequencing; and DNA gel blotting, probe preparation, hybridization, and hybrid detection. The book concludes with an analysis of lambda phage manipulations. This manual is intended for advanced undergraduate or beginning graduate students and should also be helpful to established investigators who are changing their research focus.

  • Metabolic Pathways

    Second Edition of Chemical Pathways of Metabolism
    • 2nd Edition
    • David M. Greenberg
    • English
    Metabolic Pathways, Volume II focuses on the metabolism, biosynthesis, and catabolism of amino acids. The selection first offers information on nitrogen and carbon metabolism of amino acids. Discussions focus on amino acids linked with citric acid cycle, sulfur amino acids, proline and hydroxyproline, histidine, hydroxyamino acids, urea biosynthesis and related systems, and deamidation. The text then ponders on the biosynthesis of amino acids and related compounds and metabolism of sulfur-containing compounds. Topics include metabolism of methionine, biotin, biological importance of sulfur in animals, interconversions of glutamic acid, ornithine, and prolines, and biosynthesis of the branched-chain amino acids. The publication takes a look at the synthesis of proteins, purines and pyrimidines, and nucleotides and nucleosides, including the components of nucleotides, purine degradation, and incorporation of preformed purine compounds into nucleic acids. The selection is a valuable reference for researchers interested in the metabolism, catabolism, and biosynthesis of amino acids.

  • Immunological Influence on Human Fertility

    Proceedings of the Workshop on Fertility in Human Reproduction, University of Newcastle, Australia, July 11-13, 1977
    • 1st Edition
    • Barry Boettcher
    • English
    Immunological Influence on Human Fertility covers the proceedings of the Workshop on Fertility in Human Reproduction, held at the Department of Biological Science, University of Newcastle, Australia on July 11 -13, 1977. The book focuses on topics on the immunological control of human and animal fertility. The selection first discusses the zona pellucida as a possible target in immunocontraception, immunological aspects of vasectomy, and the clinical significance of antibodies to spermatozoa. Topics include performance and significance of the SCMC-test, antibodies and fertility after vasovasostomy, vasectomy and the blood-testis barrier, cellular immune response, active and passive immunization, and tissue and species specificity. The book then tackles the nature of the barrier to autoimmunity in the excurrent ducts of the mammalian testis, immune activities of the male and female reproductive tracts, and isolation of spermatozoal antigens. The manuscript examines the immunological capacity of the male genital tract, clinical significance of antibodies to antigens of the reproductive tract, immunological aspects of vasectomy, and antigens of human trophoblasts. The text also takes a look at the immunological and anti-tumor effects of orchidectomy, immune infertility and approaches to treatment, natural insemination as an immune phenomenon, and modified seminal plasma antigens and subfertility. The selection is a valuable source of information for researchers wanting to study the immunological control of human and animal fertility.

  • Biophysical Chemistry

    Thermodynamics, Electrostatics, and the Biological Significance of the Properties of Matter
    • 1st Edition
    • John T. Edsall + 1 more
    • English
    Biophysical Chemistry, Volume I: Thermodynamics, Electrostatics, and the Biological Significance of the Properties of Matter focuses on the biological aspects of the properties of matter, putting emphasis on the chemical elements, water and carbon dioxide, complex molecules, and proteins. The publication first elaborates on biochemistry and geochemistry, water and its biological significance, and the problems of protein structure. Discussions focus on the number of peptide chains in the molecule and nature of terminal groups, latent heat of fusion, characteristics of the amino acids derived from proteins, expansion of water in freezing, and the relative abundance of chemical elements in the universe. The text then takes a look at thermodynamics and the application to polar molecules and ionic solutions of electrostatics, including free energy of a charged sphere, image charges, salting-out effect, expressions for the change of fundamental thermodynamic functions, and chemical potentials. The book examines the conductivity of electrolytes, acid-base equilibria, and polybasic acids, bases, and ampholytes, including proteins. Topics include ionization of cysteine, isoelectric points of polyvalent ampholytes, hemoglobin, nature of acids and bases, measurement of conductivity, electrolytes as conductors, and the moving boundary method of determining transference numbers. The manuscript is a dependable reference for chemists and researchers interested in thermodynamics, electrostatics, and the biological value of the properties of matter.

  • Symposium on the Rehabilitation of the Cancer Disabled

    At the Royal College of Surgeons of England, Lincoln's Inn Fields, London
    • 1st Edition
    • Ronald W. Raven
    • English
    Symposium on the Rehabilitation of the Cancer Disabled provides information pertinent solutions provided for disabilities of various kinds, created by the cancerous diseases in different parts of the body. This book discusses special rehabilitation problems that are created by other amputations, including removal of external genitalia and the breast. Organized into 17 chapters, this book begins with an overview of the subject of rehabilitation of the cancer disabled. This text then presents the mortality and morbidity caused by the cancerous diseases. Other chapters consider various case histories that demonstrate some of the problems that are presented by patients suffering from cancerous diseases and who are rehabilitated. This book discusses as well the advantage of treatment by a linear accelerator or cobalt source. The final chapter deals with spiritual healing. This book is a valuable resource for physiotherapists, clinicians, radiotherapists, and researchers.

  • Basic Immunology

    • 1st Edition
    • E. R. Gold + 1 more
    • English
    Basic Immunology focuses on substances that take part in serological reactions, including antigens, antibodies, and the physicochemical nature of immunological reactions. The selection first elaborates on the basic notions of immunity, antigens, immunoglobulins, and the production of antibody. Discussions focus on factors which increase the immune response, production of antibody, biological properties of immunoglobulins, evolution and control of immunoglobulin structure, antigenicity, specific immunity, and resistance. The text then takes a look at the complement system, antigen-antibody reactions, and immediate hypersensitivity. The book ponders on cell-mediated immunity and delayed hypersensitivity, transplantation immunology, and tumor immunology. Topics include production of immunity to neoplasms, immunological aspects of carcinogenesis and growth of established tumors, immunotherapy for experimental neoplasms, donor selection in human-organ transplantation, elicitation of delayed hypersensitivity, and the role of humoral factors in the transfer of delayed hypersensitivity. The selection is a valuable reference for medicine students and researchers interested in basic immunology.

  • An Introduction to General Virology

    • 1st Edition
    • Thomas M. Bell
    • English
    An Introduction to General Virology provides information pertinent to all aspects of virology. This book discusses the viruses affecting plants and insects. Organized into 25 chapters, this book begins with an overview of prevention of disease that can be effected by the immunization of susceptible hosts to produce circulating antibodies that neutralize viral infectivity. This text then discusses the general properties of the viruses. Other chapters consider the methods of preparing tissue cultures and explain the methods used for titrations of serum antibodies and serological identification of viruses. This book discusses as well the spread of diseases, the various invasion routes of the body, and the multitude of viruses which cause respiratory symptoms and which cannot easily be conquered. The final chapter deals with the types of vaccine in use. This book is a valuable resource for undergraduates in Medicine and Science and for postgraduates in the class of Public Health.

  • Illustrated Guide for Theatre Nurses

    • 1st Edition
    • A. Marjorie Matthias + 2 more
    • English
    Illustrated Guide for Theatre Nurses provides practical instruction on how to perform correctly the many duties of a nurse. It presents the various procedures that are described in a series of photographs. This text begins with a series of photographs showing how the nurse should carry out her duties in the operating room. It then demonstrates the fundamental principles that underlie all modern operating techniques. This book is a valuable resource for nurses, technicians, student nurses, medical students, and clinical instructors.

  • Analytical Microbiology

    • 1st Edition
    • Frederick Kavanagh
    • English
    Analytical Microbiology focuses on the processes, methodologies, developments, and approaches involved in analytical microbiology, including microbiological, antibiotic, and amino acid assays and dilution methods. The selection first offers information on the theory of antibiotic inhibition zones, microbiological assay using large plate methods, and dilution methods of antibiotic assays. Discussions focus on serial dilution assay, requirements for accurate assay, microbiological assay of riboflavin, laws of adsorption and partition, mechanisms of antibiotic action, and biological considerations affecting the use of statistical methods. The text then ponders on the elements of photometric assaying and automation of microbiological assays. The manuscript elaborates on antibiotic substances, vitamins, and amino acids. Topics include assay organisms, validity, specificity, reliability, and calculation of results of amino acid assays, bacitracin, chloramphenicol, dihydrostreptomycin, erythromycin, neomycin, and streptomycin. The selection is a dependable reference for researchers interested in analytical microbiology.

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