
Enzyme Active Sites and their Reaction Mechanisms
- 1st Edition - December 2, 2020
- Author: Harry Morrison
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 0 6 7 - 3
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 1 9 4 - 4
Enzyme Active Sites and their Reaction Mechanisms provides a one-stop reference on how enzymes "work." Here, Dr. Harry Morrison, PhD and Professor Emeritus at Purdue Universit… Read more

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Request a sales quoteEnzyme Active Sites and their Reaction Mechanisms provides a one-stop reference on how enzymes "work." Here, Dr. Harry Morrison, PhD and Professor Emeritus at Purdue University, provides a detailed overview of the origin and function of forty enzymes, the chemical details of their active sites, their mechanisms of action, and associated cofactors. The enzymes featured highlight a step forward, along with possible areas of application, thus supporting new research in academic and industrial labs. Each chapter is written in a clear format, including a brief summary of enzyme function and structure, a detailed description of their mechanisms of action and associated co-factors.
- Offers a comprehensive, biochemical understanding of enzyme mechanisms and their reaction sites
- Supports new research in academic, medical and industrial labs, connecting discoveries powered by recent advances in technology and experimental approaches to areas of application
- Features short, carefully structured, actionable chapters on various enzyme classes, thus allowing for easy-use and searchability
Active researchers in biochemistry, medical chemistry, organic chemistry, molecular biology, cell biology, pharmacology; clinician scientists; researchers in industry and pharma
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface
- Acknowledgments
- Chapter 1. Acetylcholinesterase
- Abstract
- 1.1 Acetylcholinesterase
- 1.2 Physiological function
- 1.3 Key structural features
- 1.4 Reaction sequence
- 1.5 Mechanism and the role of active site residues
- Leading references
- Chapter 2. Aconitase
- Abstract
- 2.1 Aconitase
- 2.2 Physiological function
- 2.3 Key structural features
- 2.4 Reaction sequence
- 2.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 3. Adenosine deaminase
- Abstract
- 3.1 Adenosine deaminase (adenosine aminohydrolase)
- 3.2 Physiological function
- 3.3 Key structural features
- 3.4 Reaction sequence
- 3.5 Detailed mechanism and the role of active site residues
- Leading references
- Chapter 4. Alcohol dehydrogenase (horse liver)
- Abstract
- 4.1 Horse liver alcohol dehydrogenase
- 4.2 Physiological function
- 4.3 Key structural features
- 4.4 Reaction sequence
- 4.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 5. Aldehyde dehydrogenase
- Abstract
- 5.1 Aldehyde dehydrogenase
- 5.2 Physiological function
- 5.3 Key structural features
- 5.4 Reaction sequence
- 5.5 Detailed mechanism and the role of active site residues
- Leading references
- Chapter 6. Arginase I
- Abstract
- 6.1 Arginase
- 6.2 Physiological function
- 6.3 Key structural features
- 6.4 Reaction sequence
- 6.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 7. Carbonic anhydrase II
- Abstract
- 7.1 Human carbonic anhydrase II
- 7.2 Physiological function
- 7.3 Key structural features
- 7.4 Reaction sequence
- 7.5 Detailed mechanism and the role of active site residues
- Leading references
- Chapter 8. Carboxypeptidase A
- Abstract
- 8.1 Carboxypeptidase A
- 8.2 Physiological function
- 8.3 Key structural features
- 8.4 Reaction sequence
- 8.5 Detailed mechanism and the role of the active site residues. The “promoted water” mechanism
- Leading references
- Chapter 9. Chymotrypsin
- Abstract
- 9.1 α-Chymotrypsin
- 9.2 Physiological function
- 9.3 Key structural features
- 9.4 Reaction sequence
- 9.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 10. Citrate synthase
- Abstract
- 10.1 Citrate synthase
- 10.2 Physiological function
- 10.3 Key structural features
- 10.4 Reaction sequence
- 10.5 Detailed mechanism and the role of active site residues
- Leading references
- Chapter 11. Cytochrome P450cam
- Abstract
- 11.1 Cytochrome P450cam
- 11.2 Physiological function
- 11.3 Key structural features
- 11.4 Reaction sequence
- 11.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 12. m5C Cytosine methyltransferase
- Abstract
- 12.1 m5C Cytosine methyltransferase
- 12.2 Physiological function
- 12.3 Key structural features
- 12.4 Reaction sequence
- 12.5 Detailed mechanism(s) and the role of the active site residues
- Leading references
- Chapter 13. Deoxyribodipyrimidine photolyase
- Abstract
- 13.1 Deoxyribodipyrimidine photolyase
- 13.2 Physiological function
- 13.3 Key structural features
- 13.4 Reaction sequence
- 13.5 Detailed mechanism and the role of active site residues
- Leading references
- Chapter 14. Dihydrolipoamide dehydrogenase
- Abstract
- 14.1 Dihydrolipoamide dehydrogenase
- 14.2 Physiological function
- 14.3 Key structural features
- 14.4 Reaction sequence
- 14.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 15. Dihydrolipoyl transacetylase
- Abstract
- 15.1 Dihydrolipoyl transacetylase
- 15.2 Physiological function
- 15.3 Key structural features
- 15.4 Reaction sequence
- 15.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 16. Farnesyl pyrophosphate synthase
- Abstract
- 16.1 Farnesyl pyrophosphate synthase
- 16.2 Physiological function
- 16.3 Key structural features
- 16.4 Reaction sequence
- 16.5 Detailed mechanism and the role of active site residues
- Leading references
- Chapter 17. Fructose-1,6-bisphosphate aldolase
- Abstract
- 17.1 Fructose-1,6-bisphosphate aldolase
- 17.2 Physiological function
- 17.3 Key structural features
- 17.4 Reaction sequence
- 17.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 18. Hepatitis C NS2/3 protease
- Abstract
- 18.1 Hepatitis C NS2/3 protease
- 18.2 Physiological function
- 18.3 Key structural features
- 18.4 Reaction sequence
- 18.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 19. HIV-1 protease
- Abstract
- 19.1 HIV-1 protease
- 19.2 Physiological function
- 19.3 Key structural features
- 19.4 Reaction sequence
- 19.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 20. Indoleamine 2,3-dioxygenase-1
- Abstract
- 20.1 Indoleamine 2,3-dioxygenase-1
- 20.2 Physiological function
- 20.3 Key structural features
- 20.4 Reaction sequence
- 20.5 Detailed mechanism and the role of active-site residues
- Leading references
- Chapter 21. Lysine 2,3-aminomutase
- Abstract
- 21.1 Lysine 2,3-aminomutase
- 21.2 Physiological function
- 21.3 Key structural features
- 21.4 Reaction sequence
- 21.5 Detailed mechanism and the role of active site residues
- Leading references
- Chapter 22. Lysozyme
- Abstract
- 22.1 Lysozyme
- 22.2 Physiological function
- 22.3 Key structural features
- 22.4 Reaction sequence
- 22.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 23. Methyl-coenzyme M reductase
- Abstract
- 23.1 Methyl-coenzyme M reductase
- 23.2 Physiological function
- 23.3 Key structural features
- 23.4 Reaction sequence
- 23.5 Detailed mechanism and role of active site residues
- Leading references
- Chapter 24. Methylmalonyl coenzyme A mutase
- Abstract
- 24.1 Methylmalonyl coenzyme A mutase
- 24.2 Physiological function
- 24.3 Key structural features
- 24.4 Reaction sequence
- 24.5 Detailed mechanism and the role of active site residues
- Leading references
- Chapter 25. Nonheme iron halogenase
- Abstract
- 25.1 Syringomycin halogenase
- 25.2 Physiological function
- 25.3 Key structural features
- 25.4 Reaction sequence
- 25.5 Detailed mechanism and the role of active site residues
- Leading references
- Chapter 26. Peptidyl arginine deiminase 4
- Abstract
- 26.1 Peptidyl arginine deiminase 4
- 26.2 Physiological function
- 26.3 Key structural features
- 26.4 Reaction sequence
- 26.5 Detailed mechanism and the role of the active-site residues
- Leading references
- Chapter 27. Peptidylglycine α-hydroxylating monooxygenase
- Abstract
- 27.1 Peptidylglycine α-hydroxylating monooxygenase
- 27.2 Physiological function
- 27.3 Key structural features
- 27.4 Reaction sequence
- 27.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 28. Phosphatidylinositol-specific phospholipase C
- Abstract
- 28.1 Phosphatidylinositol-specific phospholipase C
- 28.2 Physiological function
- 28.3 Key structural features
- 28.4 Reaction sequence
- 28.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 29. Protein kinase A
- Abstract
- 29.1 Protein kinase A
- 29.2 Physiological function
- 29.3 Key structural features
- 29.4 Reaction sequence
- 29.5 Detailed mechanism and the role of the active site residues
- Leading references
- Chapter 30. Pyruvate carboxylase
- Abstract
- 30.1 Pyruvate carboxylase
- 30.2 Physiological function
- 30.3 Key structural features
- 30.4 Reaction sequence
- 30.5 Detailed mechanism and the role of active site residues
- Leading references
- Chapter 31. Pyruvate dehydrogenase
- Abstract
- 31.1 Pyruvate dehydrogenase
- 31.2 Physiological function
- 31.3 Key structural features
- 31.4 Reaction sequence
- 31.5 Detailed mechanism and role of the active site residues
- Leading references
- Chapter 32. Ribonuclease A
- Abstract
- 32.1 Bovine pancreatic ribonuclease A
- 32.2 Physiological function
- 32.3 Key structural features
- 32.4 Reaction sequence
- 32.5 Detailed mechanism including the role of His12 and His119 at the active site
- Leading references
- Chapter 33. Ribonucleotide reductase
- Abstract
- 33.1 Ribonucleotide reductase
- 33.2 Physiological function
- 33.3 Key structural features
- 33.4 Reaction sequence
- 33.5 Detailed mechanisms and the role of the active site residues
- Leading references
- Chapter 34. Serine racemase
- Abstract
- 34.1 Serine racemase
- 34.2 Physiological function
- 34.3 Key structural features
- 34.4 Reaction sequence
- 34.5 Detailed mechanism and the role of active site residues
- Leading references
- Chapter 35. Soluble quinoprotein glucose dehydrogenase
- Abstract
- 35.1 Soluble quinoprotein glucose dehydrogenase
- 35.2 Physiological function
- 35.3 Key structural features
- 35.4 Reaction sequence
- 35.5 Detailed mechanism and the role of active-site residues
- Leading references
- Chapter 36. Tetrachloroethene reductive dehalogenase—PceA
- Abstract
- 36.1 PceA
- 36.2 Physiological function
- 36.3 Key structural features
- 36.4 Reaction sequence
- 36.5 Detailed mechanism and the role of active-site residues
- Leading references
- Chapter 37. Thymidylate synthase
- Abstract
- 37.1 Thymidylate synthase
- 37.2 Physiological function
- 37.3 Key structural features
- 37.4 Reaction sequence
- 37.5 Detailed mechanism(s) and the roles of active site residues
- Leading references
- Chapter 38. The 20S proteasome
- Abstract
- 38.1 The 20S proteasome
- 38.2 Physiological function
- 38.3 Key structural features
- 38.4 Reaction sequence
- 38.5 Detailed mechanism and the role of active-site residues
- Leading references
- Chapter 39. Uracil-DNA glycosylase
- Abstract
- 39.1 Uracil-DNA glycosylase
- 39.2 Physiological function
- 39.3 Key structural features
- 39.4 Reaction sequence
- 39.5 Detailed mechanism and role of active-site residues
- Leading references
- Chapter 40. Vanadium-dependent chloroperoxidase
- Abstract
- 40.1 Vanadium chloroperoxidase
- 40.2 Physiological function
- 40.3 Key structural features
- 40.4 Reaction sequence
- 40.5 Detailed mechanism and the role of active-site residues
- Leading references
- Index
- No. of pages: 280
- Language: English
- Edition: 1
- Published: December 2, 2020
- Imprint: Academic Press
- Paperback ISBN: 9780128210673
- eBook ISBN: 9780128231944
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