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Books in Toxicology

Elsevier's Toxicology collection provides essential insights for researchers and scientists into mitigating the adverse effects of contaminants on organisms, covering research, analysis, risk assessment, detection, prevention, diagnosis, and treatment of toxic exposure. Including toxicity testing, environmental toxicology it offers valuable knowledge for addressing public health and safety challenges by examining the adverse effects of contaminants on human health, animals, and the environment.

  • The Nervous System

    Autonomic Nervous System Drugs
    • 1st Edition
    • Walter S. Root + 1 more
    • English
    Physiological Pharmacology: A Comprehensive Treatise, Volume IV: The Nervous System — Part D: Autonomic Nervous System Drugs focuses on the effects of drugs on the nervous system, including how adrenergic drugs affect the heart and systemic circulation, metabolism, and adrenergic compounds. The selection first offers information on the effects of adrenergic drugs on the heart and systemic circulation. Topics include actions of adrenergic drugs, possible drug actions on the heart, epinephrine and arterenol, and other sympathomimetic drugs. The book then examines the effects of adrenergic compounds on pulmonary circulation, including physiologic considerations and general considerations of adrenergic compounds. The manuscript ponders on the effects of adrenergic agents on smooth muscles other than those of the vascular system and the effects of sympathomimetic amines and adrenergic blocking agents on metabolism. The book also touches on veratrum alkaloids and neurotoxins, as well as botulism, tetanus, therapeutic use, and chemistry of veratrum alkaloids. The selection is a dependable reference for readers interested in the effects of drugs on the nervous system.

  • Chemical Structure–Biological Activity Relationships: Quantitative Approaches

    Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
    • 1st Edition
    • F. Darvas
    • English
    Chemical Structure-Biological Activity Relationships: Quantitative Approaches, Volume III, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. This volume focuses on the methodological aspects of QSAR. It also aims to inform the reader about the QSAR research conducted in East-European countries. This volume contains 38 presentations organized into six sections. Several lecturers deal with ""real prediction"" cases, i.e. activity estimation prior to the synthesis of the compounds. A particularly abundant section is devoted to the question of how the receptor models can be built up by means of QSAR calculations. Other sections present mathematical models and algorithms which could be applied to improve further the effectiveness of QSAR calculations. As another unique feature, a separate section treats the quantitative aspects of peptide structure-activity relationships—a field seemingly backward despite its evident importance. Hydrophobicity and its influence on biological potency along with the relationship of steric properties and biological activity are also discussed.

  • Receptors and Cellular Pharmacology

    Proceedings of the Sixth International Congress of Pharmacology
    • 1st Edition
    • E. Klinge
    • English
    Receptors and Cellular Pharmacology is a collection of the proceedings of the Sixth International Congress of Pharmacology held in Helsinki, Finland, on July 20-25, 1975 and organized by the Finnish Pharmacological Society. The papers explore developments relating to receptors and cellular pharmacology and address a wide range of topics such as the hydrophobic properties of the neuromuscular blocking agents and the use of toxins as tools in receptor studies. Comprised of 21 chapters, this volume begins with an introduction to histamine receptors, their pharmacological taxonomy and classification, their presence in the gastric mucosa, and their applications in medicine. The discussion then turns to pharmacological investigations on cells in culture; the acetylcholine receptor of intact and cultured chicken retina cells; actions of neurotoxins on the acetylcholine receptor; and the isolation and characterization of membrane receptors. Subsequent chapters deal with cyclic nucleotides as mediators of drug action, with particular reference to the mechanism of the relaxation-promoting effects of epinephrine on the mammalian heart. This book should be of interest to pharmacologists, internists, psychiatrists, neurologists, and anesthesiologists.

  • Anabolic Steroids

    • 1st Edition
    • H.-L. Krüskemper
    • English
    Anabolic Steroids attempts to trace the development of anabolic steroids in the chemical, experimental biological, and clinical disciplines, and presents a precise outline of the current state of substantiated knowledge. This book deals with anabolic steroids derived from natural androgens and characterized by their stimulatory action on the biosynthesis of tissue protein and by their simultaneous low androgenicity. The biochemical part is a review of substantiated and current knowledge based largely on experimental results with animals, while the clinical part attempts to bring out the pathophysiological rationale of therapy with anabolic steroids, again based on experimental data. The book begins with a discussion of the nomenclature and chemistry of anabolic steroids. This is followed by separate chapters on the metabolism, activities, and mechanism of action of anabolic steroids; clinical application of anabolic steroids, side effects, and test procedures.

  • Drug Design

    Medicinal Chemistry: A Series of Monographs, Vol. 6
    • 1st Edition
    • E. J. Ariëns
    • English
    Drug Design, Volume VI covers practical approaches to the development of bioactive compounds, with focus on antiradiation agents, organ-imaging radiopharmaceuticals... X-ray contrast media, proteinase inhibitors, and pesticide formulations. The book discusses the chemical routes available for the synthesis of diphenhydramine derivatives, the biological activities, the relationships between structure and activity, and the phase of manipulation in the design of diphenhydramine derivatives. The text also describes the design of antiradiation agents, organ-imaging radiopharmaceuticals... and X-ray contrast media, as well as the rational approach to proteinase inhibitors. The chemical and physical methods of formulation of agricultural pesticides are also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design and manufacture will find the book invaluable.

  • Pharmaceutical and Cosmetic Products for Topical Administration

    Pharmaceutical Monographs
    • 1st Edition
    • N. J. Van Abbé + 2 more
    • J. B. Stenlake
    • English
    Pharmaceutical and Cosmetic Products for Topical Administration , Volume 9 provides the product characteristics, formulation, and rationale of topical therapeutic preparations. The book attempts to take the reader logically from the physiological and pathological aspects through to the reasoning behind topical medication. The text discusses such topics as the physiology and structure of the skin; the differential diagnosis of various skin diseases; the theoretical basis of emulsion technology; and the mechanism of percutaneous absorption. Undergraduate students and teachers of pharmacy and allied subjects will find the monograph very useful.

  • Micro Aerosol

    Physiology, Pharmacology, Therapeutics
    • 1st Edition
    • Lucien Dautrebande
    • English
    Microaerosols: Physiology, Pharmacology, Therapeutics presents a summary of the experimental and technical data on aerosols. This book focuses on the production, measurement, sampling, and biological importance of submicroscopic and submicronic air-borne particles and to their pharmacological, therapeutic, and physiological effects after their deposition in the respiratory tract. Organized into 22 chapters, this book begins with an overview of the process of obligatory liquid filtration. This text then examines the factors that affect the sizing and numbering of aerosols, including the duration of the aerosol dispersion into a closed space, the duration of aerosol sampling, and the location of the particles. Other chapters consider the authenticity of the penetration of aerosols into the pulmonary depths. This book discusses as well the recommendations for preparations of airway dilating solutions. The final chapter deals with the effects on the lungs of airway constricting substances dispersed in aerosols. This book is a valuable resource for physicians.

  • Biological and Environmental Effects of Arsenic

    • 1st Edition
    • Volume 6
    • B.A. Fowler
    • English
    Topics in Environmental Health, Volume 6: Biological and Environmental Effects of Arsenic focuses on the properties, characteristics, and reactions of arsenic and its effects on the environment. The selection first tackles the mobilization of arsenic by natural and industrial processes and emissions, cycling, and effects of arsenic in soil ecosystems. Discussions focus on the effects of arsenic on plants and soil microorganisms, exposure through consumption, sources of arsenic, and mobilization of arsenic by natural processes and industrial activities. The publication then ponders on environmental reaction and analysis methods and arsenical metabolism and toxicity to freshwater and marine species. The text examines the metabolism of arsenic and epidemiology of human arsenic exposure, including acute and chronic effects by arsenic in man, absorption, tissue distribution and retention, and elimination and biological half-time. The publication then takes a look at the toxicity of arsenic and its compounds, as well as biological transformation of arsenic compounds in soil ecosystems and effects on plants; biotransformation of arsenic compounds and toxicity to freshwater and marine biota; and environmental transformation of arsenic in freshwater/marine ecosystems. The selection is a dependable reference for readers interested in the biological and environmental effects of arsenic.

  • Screening Methods in Pharmacology

    • 1st Edition
    • Robert Turner
    • English
    Screening Methods in Pharmacology focuses on the methods for screening substances for pharmacological activities and discussions of organization of screening programs. The manuscript first offers information on the biochemistry of the nervous system and organization of screening, as well as mechanisms of drug effects within the autonomic system; mechanisms within the parasympathetic and symphatetic systems; and neuropharmacological tests in blind screening. The book also takes a look at general and quantal responses. The publication reviews depressants of the central nervous system and ataractic (tranquillizing, neuroleptic) agents. Topics include natatory exhaustion, motor deficit, righting reflex, pentylenetetrazol (metrazol) antagonism, head-withdrawal reflex, and avoidance of electrical shock. The book also ponders on analgesics and oxytoxic, antiserotonin, and anti-inflammatory agents. Discussions focus on narcotic and nonnarcotic analgesics, erythema, inhibition of ascites, and pleural fluid. The manuscript is a valuable reference for readers interested in the screening methods in pharmacology.

  • Drugs and Enzymes

    Proceedings of The Second International Pharmacological Meeting, Vol. 4
    • 1st Edition
    • Bernard B. Brodie + 1 more
    • English
    Second International Pharmacological Meeting, Volume 4: Drugs and Enzymes is a collection of papers presented at the Second International Pharmacological Meeting on August 20-23, 1963. This volume is organized into two sections encompassing 41 chapters. The first section discusses the relationship between biochemical effects of drugs in vitro and their pharmacological effect in vivo. This section specifically examines the correlation between the action of substances on isolated smooth muscle and on the central nervous system, as well as the behavior of a centrally-acting drug and enzyme in the ion movement in the system. The second section surveys the biochemical mechanisms of drug toxicity. Considerable chapters in this section are devoted to the effect of drug toxicity, such as altered drug metabolism, enzyme induction, morphological changes, hepatic effects, and photosensitivity. This book will prove useful to pharmacologists, neurologists, biochemists, and researchers who are interested the fields of drugs and drug toxicity.

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