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Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • The Histamine H<INF>3</INF> Receptor

    A Target for New Drugs
    • 1st Edition
    • Volume 30
    • December 9, 1998
    • R. Leurs + 1 more
    • English
    In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H3 agonist and the H3 antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues.In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H3 paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H3 receptor, especially as a target for drug development.

  • Brain Warping

    • 1st Edition
    • November 17, 1998
    • Arthur W. Toga
    • English
    Brain Warping is the premier book in the field of brain mapping to cover the mathematics, physics, computer science, and neurobiological issues related to brain spatial transformation and deformation correction. All chapters are organized in a similar fashion, covering the history, theory, and implementation of the specific approach discussed for ease of reading. Each chapter also discusses the computer science implementations, including descriptions of the programs and computer codes used in its execution. Readers of Brain Warping will be able to understand all of the approaches currently used in brain mapping, incorporating multimodality, and multisubject comparisons.

  • Nitric Oxide in Brain Development, Plasticity, and Disease

    • 1st Edition
    • Volume 118
    • November 9, 1998
    • R.R. Mize + 3 more
    • English
    Nitric oxide, "Molecule of the Year" in 1995, continues to be one of the most widely studied molecules in brain research. This excellent volume elucidates the implications of this gas in a variety of brain processes.The volume is divided into five sections, describing: the mechanisms underlying the release and action of Nitric Oxide in the CNS, and the distribution of Nitric Oxide in the brain using various techniques; how Nitric Oxide interacts with and regulates the N-methyl-D-aspartate receptor; the role of Nitric Oxide in pathway refinement and synapse stabilization in the developing CNS; the role of Nitric Oxide in adult brain plasticity including long-term potentiation and depression; and the role of Nitric Oxide in brain injury such as occurs during ischemia and other events produced by glutamate neurotoxicity, and in neuroprotective mechanisms that promote neuron survival.Nitric Oxide in Brain Development, Plasticity, and Disease is the first Progress in Brain Research volume to be published in abstracted form on the World Wide Web. It includes title pages, abstracts, selected figures, and complete references. It also includes a digital brain atlas for readers to view a mouse brain in a three-dimensional full-color rendition, and much more.

  • The Glutamate Synapse as a Therapeutic Target

    • 1st Edition
    • Volume 116
    • November 9, 1998
    • English
    This volume provides a comprehensive update on basic glutamate research, from a clinical perspective. Thus, emphasis is placed on how the different molecular players at the glutamate synapse interact to produce a postsynaptic response, how synaptic transmission is perturbed in epilepsy and other pathological conditions, and how glutamate may acquire toxic properties and lead to acute or chronic neurodegeneration. Promising targets for therapeutic strategies are discussed.A coherent picture is provided of the glutamate synapse and its molecular organization. The book therefore deals with each step in the signal process, from synthesis and vesicular uptake of glutamate to its clearance following receptor activation.

  • Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy

    • 1st Edition
    • Volume 117
    • November 9, 1998
    • F.W. Van Leeuwen + 4 more
    • English
    This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases.The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.

  • The Epilepsies

    Etiologies and Prevention
    • 1st Edition
    • October 27, 1998
    • Prakash Kotagal + 1 more
    • English
    Tremendous advances in our understanding of epilepsy have occurred in the last two decades. Techniques such as electroencephalograp... neuroimaging, neurosurgery and neuropsychology are giving us a better understanding of the pathogenesis of epilepsy. Additionally major breakthroughs are taking place in the laboratories of scientists studying genetics, embryogenesis, neuropathology, neurochemistry and pharmacology. These advances provide a much better understanding of why patients develop epilepsy, reshaping the way in which the epileptic patient is cared for. This book presents the most current information on the various etiologies of epilepsy, their treatments, and their possible prevention. Kotagal and Lüders have assembled 80 internationally known experts to compile this authoritative, comprehensive, and well-rounded work.The Epilepsies is a one-of-a-kind reference that will be of interest to specialists and basic scientists involved in the study of epilepsy, adult and pediatric neurologists, neurosurgeons, residents and fellows in these areas, and pediatricians who frequently encounter children with neurological problems. This major work brings together the most up-to-date research on the causes of epilepsy and other associated diseases which cause seizures. It presents data on infections, trauma, mesial temporal sclerosis, cerebral dysgenesis, brain tumors, vascular lesions, stroke, as well as genetic, metabolic and toxic causes of epilepsy. The book also looks at drug treatment and new surgical techniques that have proven useful in alleviating epileptic and other related seizures.

  • Handbook of Behaviorism

    • 1st Edition
    • October 21, 1998
    • William O'Donohue + 1 more
    • English
    Handbook of Behaviorism provides a comprehensive single source that summarizes what behaviorism is, how the various "flavors" of behaviorism have differed between major theorists both in psychology and philosophy, and what aspects of those theories have been borne out in research findings and continue to be of use in understanding human behavior.

  • CNS Regeneration

    Basic Science and Clinical Advances
    • 1st Edition
    • October 19, 1998
    • Mark H. Tuszynski + 1 more
    • English
    CNS Regeneration focuses on some of the leading current neurological disease models and methods for promoting central nervous system regeneration. Editors and authors are experts in the field, with experience in basic as well as applied neuroscience. In a comprehensive, logical manner, the book unites important basic science advances in neuroscience with novel medical strategies.

  • The Psychology of Music

    • 2nd Edition
    • September 21, 1998
    • Diana Deutsch
    • English
    The aim of the psychology of music is to understand musical phenomena in terms of mental functions--to characterize the ways in which one perceives, remembers, creates, and performs music. Since the First Edition of The Psychology of Music was published the field has emerged from an interdisciplinary curiosity into a fully ramified subdiscipline of psychology due to several factors. The opportunity to generate, analyze, and transform sounds by computer is no longer limited to a few researchers with access to large multi-user facilities, but rather is available to individual investigators on a widespread basis. Second, dramatic advances in the field of neuroscience have profoundly influenced thinking about the way that music is processed in the brain. Third, collaborations between psychologists and musicians, which were evolving at the time the First Edition was written, are now quite common; to a large extent now speaking a common language and agreeing on basic philosophical issues.The Psychology of Music, Second Edition has been completely revised to bring the reader the most up-to-date information, additional subject matter, and new contributors to incorporate all of these important variables.

  • The Primate Nervous System, Part II

    • 1st Edition
    • Volume 14
    • September 17, 1998
    • T. Hokfelt + 2 more
    • English
    This volume is the second in the planned coverage of the neurochemical circuitry of the primate central nervous system. While this volume contains only two chapters, their topics and the extraordinarily comprehensive coverage with which the authors have dealt with their topics, will nevertheless contribute equal amounts of knowledge, wisdom, and opportunities for future research extensions as have every volume in this unique series. As such, these chapters extend the goals of this primate series to develop a broad coverage of human and non-human primate chemical neuroanatomic details in a volume which makes clear the known and desirable appreciation for differences between and among subsets of primate brains.The first chapter covers the primate thalamus with equal emphases on new world, old world, pro-simian and human anatomic details and their differences. The second undertakes a comparably comprehensive examination of one of the most intensively studied regions of the primate brain, namely the primate visual cortex. While much has been studied, both chapters also reveal how much remains for future efforts in these enormously important regions which are the archetypes of primate sub-cortical and cortical function.

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