Molecular biology cellular biology and genetics print books and ebooks | Elsevier

The Use of Radioautography in Investigating Protein Synthesis

1st Edition
April 28, 2025
C. P. Leblond + 1 more
English
Paperback
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eBook
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The Use of Radioautography in Investigating Protein Synthesis is a collection of papers that discusses the tracing of labeled proteins through photographic emulsion, particularly radioautography or autoradiography. The papers discuss proteins at the site of their synthesis, their subsequent migration through the cell, their secretions, and the formation of the basement lamella in salamanders. One paper outlines the primary aims in specimen preparation for electron microscope autoradiographic techniques and the procedures to achieve them. Another paper reports on migrating proteins (CNP) and nonmigrating proteins of the Amoeba proteus nucleus in which nonmigrating proteins are sedimentable by centrifugation in situ in the nucleus. One paper investigates the extent of protein synthesis for cell renewal in thoracic duct lymphocytes (TDL) or that for export or intracellular turnover. The protein synthesized by the large cell population in TDL is associated with mitosis and cell renewal. A major portion of that synthesized by the medium cells (80 per cent) and practically all of that produced by small cells are for purposes other than cell renewal. The collection can prove beneficial to biochemists, micro-biologists, bio-physicists, cytologists, histologists, pathologists, cellular researchers, and academicians involved in the study of cellular biology.

The Immunological Synapse Part C

1st Edition
Volume 193
February 4, 2025
English
Hardback
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eBook
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The Immunological Synapse - Part C, Volume 193 in the Methods in Cell Biology series provides state-of-the-art and detailed methods for the study of the T cell, natural killer (NK) cell and B cell immunological synapses. Topics covered in this third volume include tau-STED microscopy for 3D-quantitative colocalization of lytic granule markers, image processing approaches for 3D-analysis of markers and for microtubule remodeling quantification at the immunological synapse, flow cytometry to analyze NK cell-target cell conjugation, imaging flow cytometry to quantify a range of different subcellular processes at the immunological synapse, imaging techniques aimed at quantitatively analyzing B cell immunological synapse formation, quantification of force-mediated antigen extraction in the B cell immune synapse using DNA-based tension sensors, measuring interaction forces between T lymphocytes and their target cells using live microscopy and laminar shear flow chambers, measuring interaction kinetics between T cells and their target tumor cells with optical tweezers, and gauging antigen recognition by human primary T-cells featuring orthotopically exchanged TCRs of choice. Additionally, this volume includes methods to isolate and characterize primary NK cells and enrich the KIR2DL1+ population, and to expand γδ T cells and evaluate their cytotoxicity.

Advances in Management of Pediatric Brain Tumors

1st Edition
Volume 167
November 1, 2025
English
Hardback
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eBook
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Advances in Management of Pediatric Brain Tumors, Volume 167 encapsulates the latest developments in the field for various types of pediatric brain tumors. By examining these survival gaps, the volume offers insights into strategies for improving outcomes and bridging the gap in care on a global scale. Chapters in this new release include Pediatric-type diffuse low grade gliomak, Pediatric-type diffuse high grade glioma/Diffuse Midline glioma, Ependymoma, Choroid plexus tumors, Embryonal tumors/medulloblasto... Craniopharyngioma and other sellar-region tumors, and much more.Other sections cover Germ cell tumors, Immunotherapy for pediatric brain tumors, Emerging interventional treatments in the management of pediatric brain tumors, and Management of pediatric brain tumors in low-middle income countries.

Animal Models of Disease Part C

1st Edition
Volume 192
January 24, 2025
English
Hardback
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eBook
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Animal Models of Disease, Part C, Volume 192 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors, The current models unravel the molecular mechanisms underlying the intricate pathophysiology of Alzheimer’s disease using Zebrafish, Colitis mouse model, Matching model with mechanism: appropriate animal models for studying various aspects of diabetes pathophysiology, Human cancer cells xenografts to assess the efficacy of granulysin-based therapeutics, and much more.Additional sections cover Antimicrobial regime for gut microbiota depletion in experimental mice models, Evaluating polyglutamine protein aggregation and toxicity in transgenic Caenorhabditis elegans models of Huntington's disease, A model of intraperitoneal ovarian cancer to study tumor responses to radioimmunotherapy, Metallic nanoparticles biodistribution for the study of lymphoma in animal models, Stereotactic injection of murine brain tumor cells for neuro-oncology studies, Evaluating amyloid-beta aggregation and toxicity in transgenic Caenorhabditis elegans models of Alzheimer's disease, and much more.

Circadian Rhythms in Health and Disease

1st Edition
Volume 393
May 23, 2025
English
Hardback
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eBook
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Circadian Rhythms in Health and Disease, Volume 393 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Circadian Rhythms in Cardiac Health and Disease, Liver as a nexus of daily metabolic cross talk, Non-rhythmic modulators of the circadian system: A new class of circadian modulators, The emerging role of circadian rhythms in exosome-mediated cellular crosstalk, Circadian rhythms and muscle health, and Output circuits from the suprachiasmatic nucleus controlling diverse physiological functions.

Frontiers of Cancer Biology

1st Edition
December 1, 2025
Devavarapu Kasi Viswa Prasad + 1 more
English
Paperback
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eBook
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Frontiers of Cancer Biology: Current Trends in Cancer Research presents the latest research in cancer, which is advancing day by day. This book provides an introduction to cancer genetics, as well as the roles of genomic instability, oncogenes, proto-oncogenes, tumor suppressor genes, and DNA damage and repair in relation to cancer. It then goes on to discuss viral genomics and cancer, epigenetics and cancer, cancer genetics, gene therapy in precision medicine. Finally, this book reviews the future direction of cancer genetics. Frontiers of Cancer Biology: Current Trends in Cancer Research is a valuable resource for researchers and professionals working in cancer biology, as well as academics that want to keep up to date with the field.

Genome Chaos

2nd Edition
November 7, 2025
Henry H. Heng
English
Paperback
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eBook
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Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genomes as distinct biological entities where the genome, rather than individual genes, defines system-level inheritance and represents a clear unit of selection for macroevolution. In this thought-provoking text, Dr. Henry Heng invigorates fresh discussions in Genome Architecture Theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.In this timely new edition, Dr. Heng fully embraces the integration of system information with genome-mediated evolutionary mechanisms, and supports this framework with recent findings and growing, interdisciplinary research. Ten evidence-based chapters discuss 4D genomics, genes and genomes as distinct biological entities, genome chaos and cellular macroevolution, karyotype coding and fuzzy inheritance, as well as an entirely novel model of evolution driven by information flow, and more. Brand-new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary framework. This synthesis offers a revolutionary paradigm of evolutionary theory. It also hypothesizes about how information flow, matter arrangement, and energy interact.

Immuno-oncology and immunotherapy Part C

1st Edition
Volume 191
January 16, 2025
English
Hardback
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eBook
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Immuno-oncology and immunotherapy, Part C, Volume 191 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Extraction and quantification of histones from human cells, Expression and characterization of Phosphatidylserine-t... antibodies for biochemical and therapeutic applications, ILC differentiation from HSCs in vitro, Methods to expand human Treg cells and assay their function, Monitoring rapid activation of human gamma/delta T cells by multicolor flow cytometry, Methods to induce T cell exhaustion in vitro, Ex vivo assessment of human neutrophil motility and migration, and much more.Additional chapters focus on Flow cytometry-based monitoring of myeloid-derived suppressor cells in the peripheral blood of patients with solid tumors, Deciphering human blood and tumor neutrophil heterogeneity: Methods for isolation and assessing suppression of T-cell proliferation, Splenocyte anticancer citotoxicity assessment after prophylactic vaccination or drug treatment of tumor-bearing mice, Therapeutic treatment of tumor-bearing mice with drug-killed cancer cells: a method to confirm immunogenic cell death and assess its therapeutic effectiveness, and much more.

Immuno-oncology and Immunotherapy Part E

1st Edition
Volume 199
November 1, 2025
English
Hardback
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eBook
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Immuno-oncology and immunotherapy, Part E, Volume 199 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including an Evaluation of agents that affect anti-tumor function of CD8+ T cells at activation, Cancer cyro-immunotherapy: Models and methods, Methods for analysis of cancer- and TLS-associated immune infiltrates by multiplex immunofluorescence histology, In-vivo measurement of the extracellular ATP concentration by bio-luminescent probes, and much more.Additional sections cover the Analysis of the tumor microenvironment using imaging mass cytometry data, Saphenous vein blood collection for different immune analyses of living mice, Use of mouse KO models to validate the specificity of monoclonal antibodies, Imaging mass cytometry to analyze the immune TME, Autoimmune arthritis: Transgenic mouse models and methods, Assessment of human and mouse tumor-antigen specific CD8+ T cells by multimer staining in multiple compartments, and more.

The Microbiome in Cancer and Autoimmunity - Part B

1st Edition
Volume 395
July 14, 2025
English
Hardback
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eBook
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Microbiome in Cancer and Autoimmunity - Part B, Volume 395 offers a comprehensive exploration of the intricate relationship between the human microbiome and the development of cancer and autoimmune diseases. Delving into cutting-edge research and clinical insights, this groundbreaking work elucidates the role of microbial communities in influencing immune responses, disease pathways, and therapeutic outcomes. Specific chapters cover the Effect of Microbial Dysbiosis on Autoimmune-Associate... Inflammation, Gut Microbiota and Systemic Immune Responses in Cancer, The role of microbiome in gastrointestinal cancer, Cancer and Microbiome-Targeted Therapies, Autoimmune disease and Microbiome Targeted Therapies, and the Effect of Diet and Lifestyle on Microbiome Composition.

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