Skip to main content
Elsevier

Books in Molecular biology cellular biology and genetics

This collection offers insights into gene expression, cell signalling, and genetic regulation. Supporting researchers, clinicians, and students, it features advanced techniques, genetic engineering, and disease mechanisms, fostering innovations in personalized medicine, regenerative therapies, and molecular diagnostics.

  • Cryo-EM Methods and Management

    • 1st Edition
    • Edward T. Eng + 2 more
    • English
    Cryo-EM Methods and Management provides a detailed introduction to the latest advances of cryo-EM, from technical innovations to the logistical challenges of maintaining a modern cryo-EM facility. The book consists of four parts, beginning with an overview of cryo-EM. It then moves on to discuss Cryo-EM workflows, with chapters focusing on sample handling and preparation, data collection and hardware, and data procession and visualization. The third part centers on aspects of cryo-EM infrastructure and community building, considering facility set-up and management, monitoring facility performance, instrumentation monitoring , data sharing and standards, and training and development standards. The book then closes with a section looking towards future prospects for cryo-EM. This is an ideal reference for cryo-EM facility and lab managers, providing guidance to the often-overlooked aspect of facility building and management. Additionally researchers working with cryo-EM across molecular biology, structural biology, cell biology and biochemistry will benefit from this book.

  • Gene Therapy in Neurodegenerative Disorders

    From Bench to Bedside
    • 1st Edition
    • Vahid Mansouri + 1 more
    • English
    Gene Therapy in Neurodegenerative Disorders: From Bench to Bedside offers a comprehensive review of gene therapy modalities and their applications in treating neurodegenerative disorders. Initial chapters focus on the fundamentals of gene therapy strategies, including gene delivery methods and CNS-targeted gene delivery. Subsequent chapters delve into specific neurodegenerative disorders such as Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis (ALS), Duchenne Muscular Dystrophy (DMD), and Alzheimer's Disease (AD), highlighting the latest gene therapy approaches for each condition. Each chapter provides a detailed introduction to the relevant field before exploring specific tools and applications.With contributions from leading experts, the book addresses current and ongoing clinical trials, potential challenges, and promising advances in gene therapy for neurodegenerative disorders. It also discusses regulatory and ethical considerations in translating research from bench to bedside. This book is an essential resource for basic science researchers in gene therapy, geneticists, biotechnologists, and clinical researchers seeking new and effective treatments for neurodegenerative diseases. It equips readers with the knowledge and tools needed to advance their work and drive innovation in gene therapy.

  • Cell Death Part E

    • 1st Edition
    • Volume 210
    • English
    Cell Death: Part E, Volume 210 presents the latest advances and comprehensive reviews in the rapidly evolving field of cell death. This volume explores the molecular mechanisms, regulatory pathways, and biological consequences of various forms of cell death—including apoptosis, necrosis, autophagy, and other non-canonical processes. Chapters in this new release include Flow cytometry analysis of mitochondrial apoptotic priming with BH3 profiling on senescent cells, Methods to study PIDDOsome and caspase 2 signaling, Isolation, characterization, and experimental applications of apoptotic bodies in vitro, Lipid ROS Measurement by Spectral Flow Cytometry based on the ratiometric dye BODIPYTM C11 581/591, and much more.Additional chapters cover CRISPR-Cas9 Screen to Identify Genes Regulating Cell Death, Flow cytometry-assisted discrimination of early apoptotic, late apoptotic and primary necrotic morphological markers in Saccharomyces cerevisiae, Cytofluorometric analysis of cell death in primary human neutrophils, Real-time tracking of cell death in human intestinal organoids: a quantitative imaging approach, and more.

  • Thiamine and Thiamine-Pyrophosphate (TPP) Riboswitches

    • 1st Edition
    • Volume 735
    • English
    This volume of "Methods in Enzymology" series is devoted to the cofactor thiamine, also known as vitamin B1, and its phosphorylated derivatives. The biosynthesis of thiamine is discussed in terms of key enzymes and their regulation, the evolution of metabolic pathways, and its importance in plant and yeast metabolism. The importance of quantifying and distinguishing between phosphorylated and unphosphorylated thiamine in animal and human tissues using chromatographic, enzymatic, and nanopore methods is also discussed. In addition to these methods, thiamine riboswitches are a major focus of this book, covering everything from their identification in plants and the elucidation of their structure to their application in detection.This book presents state-of-the-art methods and detailed protocols intended for all researchers interested in thiamine metabolism or its detection.

  • Chromatin Signaling and Diseases

    • 2nd Edition
    • Olivier Binda + 2 more
    • English
    Chromatin Signaling and Diseases, Second Edition, a volume in the Translational Epigenetics series, covers the molecular mechanisms that regulate gene expression, which governs embryonic development, growth, and human pathologies associated with aging, such as cancer. Although human genome sequencing continues to improve, molecular mechanisms regulating gene expression remain largely misunderstood. The impact of gene expression defects associated with malfunctioning chromatin signaling are considered in this update. In addition, this new edition has addresses developments in the field, from phase separation of membrane-less organelles and local segregation of factors to chromatinization of naked foreign DNA and cancer evolution as regulated by chromatin signaling.Chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these are also considered.

  • Foundation of Microfluidics Device Technology

    • 1st Edition
    • Volume 225
    • English
    Foundation of Microfluidics Device Technology, Volume 225 presents the fundamentals of microfluidics and microfluidics devices, including computational design and fabrication, artificial intelligence and internet of things for microfluidics devices, materials, surface modifications and functionalization of microfluidics, fabrication of paper based microfluidics. Additional topics include microfluidics for generation of biomaterials, microfluidics for multi-omics analysis, lab-on-the-chip, microfluidics for 2D and 3D cell culture systems, microfluidics for drug and gene delivery, biomimetic models, and the economic considerations associated with microfluidics devices development.Specific chapters in this new release include An introduction to microfluidics and devices, Computational design and modeling of microfluidics devices, Artificial intelligence and IoT for microfluidics devices, Fabrication techniques for design of microfluidics devices, Materials, surface modification and functionalization of microfluidic devices, Fabrication of paper based microfluidics, Microfluidics in biomaterials generation and formulation, Microfluidics for chemical and biological analysis, and more.

  • Advances in Genomics and Neurosciences for Neurologic and Behavioral Disorders

    • 1st Edition
    • Moyra Smith
    • English
    Advances in Genomics and Neurosciences for Neurologic and Behavioral Disorders explores the latest breakthroughs in genomics and neurosciences, providing essential insights for understanding, diagnosing, and managing neurodevelopmental, psychiatric, and neurodegenerative disorders. The book highlights the intersection of genetic and genomic diagnostic techniques with brain function and structure analysis to enhance therapeutic strategies. Sections cover a wide range of topics, including the analysis of brain circuits, synapses, and neural activity, as well as the role of ion channels and neurotrophins in brain function. It examines advanced genetic and genomic diagnostic methods such as chromosome studies, gene sequencing, RNA analysis, and metabolite profiling.The book also addresses neurodevelopmental disorders like cerebral palsy, epilepsy, and autism, psychiatric disorders such as schizophrenia and thought disorders, and the molecular biology of memory and age-related cognitive decline. Organized into five sections, the book includes chapters on the latest techniques for brain analysis, genetic diagnostics, neurodevelopmental and psychiatric disorders, aging-related impairments, and new therapeutic approaches. Key topics include brain regions and circuits, new methods for studying these areas, and the relevance of this information for accurate diagnosis and patient care.

  • Enzyme Microfluidics

    • 1st Edition
    • Volume 737
    • English
    Enzyme Microfluidics, Volume 737 in the Methods in Enzymology series, presents detailed methodological descriptions and protocols that cover a wide range of microfluidics-based approaches for mechanistic enzymology, high-throughput screening, and enzyme engineering campaigns. The volume includes both established methods as well as advances in the field. Sections in this new release cover four unique sections, including Chips and Reagents, Enzyme Characterization, Enzyme Engineering, and Moving Beyond Microfluidics (from micro to nanoscale). Specific chapters delve into Joint Methods for Fabricating Microfluidic Chips, A liquid handling robotic workflow for quantifying the activity of antibiotic resistance genes (ARGs) in cell-free protein synthesis, and much more.Additional chapters cover Preparation of uniform microcrystals by droplet microfluidics for time-resolved serial crystallography, Droplet microfluidic HDX for investigating highly dynamic proteins, An Accessible, Low-Cost Platform for High-Throughput Microfluidic Enzyme Kinetics, High-Throughput Data Processing, DA-MEK, Mass Spectrometry of Droplets, Digital Bioassay Using a Femtoliter Reactor Array Device, Confocal absorbance droplet sorting, Sequence-Function Data Analysis from Microfluidics Screening, and much more.

  • Advanced Technologies for Disease Intervention

    Innovations Across Precision Medicine, Nutrition and Holistic Therapies
    • 1st Edition
    • Ranbir Chander Sobti + 3 more
    • English
    Advanced Technologies for Disease Intervention: Innovations Across Precision Medicine, Nutrition and Holistic Therapies, Two Volume Set investigates current and emerging advances in disease detection, diagnosis, treatment and prevention, and how molecular medicine and biotechnology have contributed to this changing landscape. Volume One focuses on sustainable health practices through biotechnology, exploring traditional health systems, diagnostic innovations, and integrative therapies. Key topics include: the role of traditional medicine and practices in sustainable health; contemporary and emerging technologies such as aptamer diagnostics, telemedicine, nanomaterials and AI in healthcare, and much more.Volume Two then delves deeper into emerging technologies for disease intervention, focusing on drug development, delivery systems, nutrition, and natural products for health. Themes explored here include: developments and trends in drug discovery; drug repurposing; contemporary drug delivery systems; phototherapeutics; personalized drug delivery; innovations in vaccine development; the role of nutraceuticals in disease prevention; and the use of natural products and herbal interventions for sustainable health.

  • Erythropoiesis/Hematopoiesis

    • 1st Edition
    • Volume 170
    • English
    Erythropoiesis/Hemat... Volume 170 provides a comprehensive overview of erythropoiesis and hematopoiesis—the processes by which blood cells are formed, developed, and maintained in the body. The book covers the molecular, cellular, and physiological mechanisms that regulate the formation of red blood cells (erythropoiesis) and all other blood cell lineages (hematopoiesis), including stem cell biology, signaling pathways, and genetic regulation. Timely chapters in this new release include Ribosomal RNA transcription in normal and leukemic hematopoiesis, Regulation of erythroid development by iron metabolism, Mediator at the Helm: Coordinating Transcription and Biomolecular Condensates in Hematopoiesis, and much more.Additional chapters explore Cell fate decision and lineage specification mechanisms in hematopoiesis, Hijacking the Host: Red Blood Cell Remodeling and Extracellular Vesicle Release During Babesia Infection, How advances in chromosome conformation capture methods are reshaping our understanding of gene regulation in haematopoiesis, Post-transcriptional regulation in erythropoiesis, Erythropoiesis resolved through spatial omics, and Transcription elongation mechanisms that control gene expression in erythropoiesis.

Related subjects